JP6078211B2 - 自閉症および自閉症の表現型に関連する遺伝子変化ならびに自閉症の診断および治療に対するその使用方法 - Google Patents
自閉症および自閉症の表現型に関連する遺伝子変化ならびに自閉症の診断および治療に対するその使用方法 Download PDFInfo
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| US3013608P | 2008-02-20 | 2008-02-20 | |
| US61/030,136 | 2008-02-20 | ||
| US10716308P | 2008-10-21 | 2008-10-21 | |
| US61/107,163 | 2008-10-21 | ||
| PCT/US2009/034784 WO2009105718A1 (en) | 2008-02-20 | 2009-02-20 | Genetic alterations associated with autism and the autistic phenotype and methods of use thereof for the diagnosis and treatmemt of autism |
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| JP2011512163A JP2011512163A (ja) | 2011-04-21 |
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| BRPI0918868B8 (pt) | 2008-09-18 | 2021-05-25 | Naurex Inc | compostos moduladores do receptor de nmda e composições compreendendo os mesmos |
| JP5881420B2 (ja) * | 2008-11-12 | 2016-03-09 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | 自閉症関連遺伝子マーカー |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| US8772242B2 (en) | 2009-10-26 | 2014-07-08 | Thomas Julius Borody | Therapy for enteric infections |
| CA2807505A1 (en) * | 2010-08-24 | 2012-03-01 | The Children's Hospital Of Philadelphia | Association of rare recurrent genetic variations to attention-deficit, hyperactivity disorder (adhd) and methods of use thereof for the diagnosis and treatment of the same |
| CA2834286A1 (en) * | 2011-04-27 | 2012-11-01 | Northwestern University | Methods of treating alzheimer's disease, huntington's disease, autism, and other disorders |
| WO2012173809A2 (en) * | 2011-06-02 | 2012-12-20 | Ehli Erik | Method of identifying de novo copy number variants (cnv) using mz twins discordant for attention problems/disorders |
| CA2798906A1 (en) * | 2011-12-22 | 2013-06-22 | Mohammed Uddin | Genome-wide detection of genomic rearrangements and use of genomic rearrangements to diagnose genetic disease |
| US20130210657A1 (en) * | 2012-01-25 | 2013-08-15 | The Hospital For Sick Children | Method of Determining Risk of Autism Spectrum Disorder |
| AU2013230045A1 (en) * | 2012-03-05 | 2014-09-11 | Berg Llc | Compositions and methods for diagnosis and treatment of pervasive developmental disorder |
| JP2015510756A (ja) * | 2012-03-09 | 2015-04-13 | アンテグラージェン | 自閉症のリスクを評価するため遺伝子型決定テスト |
| WO2013139861A1 (en) | 2012-03-20 | 2013-09-26 | Luc Montagnier | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| MX357392B (es) | 2012-04-02 | 2018-07-06 | Berg Llc | Ensayos basados en interrogatorios celulares y uso de los mismos. |
| WO2014012144A1 (en) * | 2012-07-20 | 2014-01-23 | The University Of Melbourne | Method of diagnosing or prognosing a neurological disorder |
| JP2016506962A (ja) | 2013-01-29 | 2016-03-07 | ノーレックス, インコーポレイテッドNaurex, Inc. | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| PE20151416A1 (es) | 2013-01-29 | 2015-10-10 | Naurex Inc | Moduladores de receptores nmda de espiro-lactama y sus usos |
| KR102410989B1 (ko) | 2013-01-29 | 2022-06-17 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| US9758525B2 (en) | 2013-01-29 | 2017-09-12 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| US11219617B2 (en) | 2014-05-30 | 2022-01-11 | The Children's Hospital Of Philadelphia | Methods of diagnosing and treating autism |
| CN114203296B (zh) | 2014-09-11 | 2025-10-17 | 布普格生物制药公司 | 基于患者数据的用于健康护理诊断和治疗的贝叶斯因果关系网络模型 |
| WO2016057810A1 (en) * | 2014-10-08 | 2016-04-14 | The Broad Institute, Inc. | Markers for assessing risk of developing or having obsessive compulsive disorder |
| WO2016109449A1 (en) * | 2014-12-29 | 2016-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of diagnosing autism spectrum disorders |
| PL4023222T3 (pl) | 2015-09-08 | 2025-03-24 | The Children's Hospital Of Philadelphia | Nieselektywny aktywator metabotropowych receptorów glutaminianu do leczenia zespołu 22q |
| PE20190174A1 (es) | 2016-05-19 | 2019-02-01 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| KR102465758B1 (ko) | 2016-08-01 | 2022-11-09 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| WO2018026798A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| AU2017306158B2 (en) | 2016-08-01 | 2021-10-14 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
| IL286107B2 (en) | 2016-08-01 | 2024-09-01 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and usesthereof |
| JP7036792B2 (ja) | 2016-08-01 | 2022-03-15 | アプティニックス インコーポレイテッド | スピロ－ラクタムｎｍｄａ受容体修飾因子およびその使用 |
| PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
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| WO2003052086A1 (en) * | 2001-12-14 | 2003-06-26 | President And Fellows Of Harvard College | Immune related neuronal receptors and therapeutic uses thereof |
| EP1554403A1 (en) * | 2002-10-10 | 2005-07-20 | K.U. Leuven Research and Development | Autism gene |
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| CA2716375A1 (en) | 2009-08-27 |
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| EP2257644A1 (en) | 2010-12-08 |
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| EP2257644A4 (en) | 2011-07-06 |
| AU2009217278A1 (en) | 2009-08-27 |
| US9783851B2 (en) | 2017-10-10 |
| AU2009217278B2 (en) | 2015-08-20 |
| EP2257644B1 (en) | 2015-06-24 |
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