JP6072106B2 - 皮膚漂白のための無色カロテノイド - Google Patents
皮膚漂白のための無色カロテノイド Download PDFInfo
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- JP6072106B2 JP6072106B2 JP2015034713A JP2015034713A JP6072106B2 JP 6072106 B2 JP6072106 B2 JP 6072106B2 JP 2015034713 A JP2015034713 A JP 2015034713A JP 2015034713 A JP2015034713 A JP 2015034713A JP 6072106 B2 JP6072106 B2 JP 6072106B2
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- phytoene
- phytofluene
- skin
- carotene
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- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
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- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
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- 150000003505 terpenes Chemical group 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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Description
本発明の他の目的、特徴及び利点は、以下の説明及び図から明らかになるであろう。
本明細書では、「フィトエン」という用語は、7,7’,8,8’,11,11’,12,12’−オクタヒドロ−ψ−ψ−カロテンを意味する。
フィトエンとフィトフルエンの合剤は、皮膚に局所的に塗布したとき又は経口的に摂取したときに、皮膚に対してその漂白効果を発揮することができる。組成物内のカロテノイドの量は、投与の経路、治療すべき現象並びに年齢、性別及び適用計画を含めた使用者に関連するパラメーターによって決まることを理解されたい。
局所適用の場合、先に記載された方法のいずれかによって得られた油溶性カロテノイド調製物を、それだけには限らないが、スクアラン、流動パラフィン及びポリデセンからなる群から選択される化粧品として許容される希釈剤と混合する。このように調製した化粧用組成物は、皮膚による許容度が高く、したがって局所適用によって漂白の効果を達成するのに適している。現在好ましいいくつかの実施形態によれば、スクアランは天然源由来である。天然スクアランのための通常の供給源には、オリーブ油、小麦胚芽及びゴマがある。
食事カロテノイドが皮膚中に存在することがこれまでにわかっている。Hataら(J.Invest.Dermatology 115:441〜448,2000)は、数ある中で、フィトエン、フィトフルエン及びζ−カロテンが、ヒト腹皮抽出物中にかなりの量で存在することを示した。
原料及び方法
細胞及び培養条件
細胞タイプ:6代継代した正常ヒト表皮メラノサイト(NHEM−2)を使用。
培地: 培地254(Tebu 058M−254−500)+PMA
(Tebu 058S−016−5)を含まない補完HMGS−2
ペニシリン50UI/ml及びストレプトマイシン50μg/ml
(Invitrogen 15070063)
細胞タイプ:5代継代したB16ネズミ黒色腫細胞系(B16)を使用。
培地: DMEM(Invitrogen 21969035)
L−グルタミン 2mM(Invitrogen 25030024)
ペニシリン/ストレプトマイシン 50UI/ml/50μg/ml
(Invitrogen 15070063)
ウシ胎児血清10%(v/v、Invitrogen 10270098)
培養: 37℃及び5%CO2
正常ヒト表皮メラノサイト
R6−NHEM−2細胞を24ウェルプレート中で培養した(120,000細胞/ウェル)。50%集密状態で、培地を、試験化合物、KA又はIBMX(基準)或いは0.5%最終におけるDMSO(対照DMSO)を含む又は含まない(対照)新鮮な培地と交換した。各実験条件を3通り行った(対照については6通り)。細胞は、3日毎に培地を交換しながら37℃で240時間インキュベートした。
R7−B16細胞を24ウェルプレート中で培養した(1000細胞/ウェル)。20%集密状態で、培地を、試験化合物、KA又はIBMX(基準)或いは0.5%最終におけるDMSO(対照DMSO)を含む又は含まない(対照)新鮮な培地と交換した。各実験条件を3通り行った。細胞は、3日後に培地を交換しながら(2×72h)37℃で144時間インキュベートした。
インキュベーション後、細胞単層をすすぎ、細胞を溶解させ、0.5M NaOH溶液によってメラニンを抽出した。
生データをPRISM(登録商標)ソフトウェア(Graph Pad Software)に移し、分析した。ダネットの多重比較試験を用いた分散分析(ANOVA)によってグループ間比較を行った。
B16ネズミ黒色腫細胞系のメラニン含有量に対するIBR−TCLC(商標)の効果
下の表1及び図1は、B16ネズミ黒色腫(B16)によるメラニン合成に対するIBR−TCLC(商標)及び基準化合物の効果を示す。
下の表2及び図2は、これらの細胞によるメラニン合成に対するIBR−TCLC(商標)及び基準化合物の効果を示す。
フィトエン及びフィトフルエンのトマト由来組成物をオリーブ油由来のスクアラン中に溶解させた(フィトエン及びフィトフルエン濃度:0.724mg/ml)。他のカロテノイドは、この組成物中で検出不可能であった。この組成物を最終濃度0.3%、0.5%及び1.0%で使用して、B16ネズミ黒色腫細胞に対するその漂白効果を評価した。
A.後述の成分(1)〜(7)を混合し、加熱しながら溶解させて混合物Aを得た。
(1)ラウリン酸 5.0
(2)ミリスチン酸 18.5
(3)ステアリン酸 6.0
(4)グリセリン 12.0
(5)ポリエチレングリコール1500 5.0
(6)水酸化カリウム 6.5
(7)精製水 残余
(8)ココナッツ油脂肪酸ジエタノールアミド 5.0
(9)ココナッツ油脂肪酸メチルタウリンナトリウム 1.8
(10)ポリオキシエチレン(7.5E.O.)ラウリルエーテル 2.0
(11)ジステアリン酸エチレングリコール 1.0
(12)ヒドロキシルプロピルメチルセルロースの1%水性液剤 5.0
(13)スクアラントマト抽出物* 0.1
(14)芳香剤 q.s.
*実施例1Aの場合のように生成
q.s.十分量
A.後述の成分(1)〜(6)を混合し、溶解させて混合物Aを得た。
(1)クエン酸 0.05
(2)クエン酸ナトリウム 0.2
(3)ナトリウムピロリドンカルボキシレート(50%)溶液 0.5
(4)グリチルリチン酸二カリウム 0.1
(5)グリセリン 3.0
(6)1,3−ブチレングリコール 8.0
(7)精製水 残余
(8)エタノール 10.0
(9)スクアラントマト抽出物* 0.1
(10)芳香剤 q.s.
(11)防腐剤 q.s.
(12)モノオレイン酸ポリオキシエチレン(20E.O.)ソルビタン
0.5
*実施例1Aの場合のように生成
q.s.十分量
A.後述の成分(1)〜(13)を混合し、加熱しながら溶解させ、70℃に保持して混合物Aを得た。
(1)ステアリン酸 1.0
(2)セチルアルコール 0.5
(3)親水性型モノステアリン酸グリセリン 0.5
(4)流動パラフィン 2.0
(5)スクアラン 3.0
(6)ホホバ油 3.0
(7)パルミチン酸セチル 0.2
(8)パルミチン酸レチノール 0.2
(9)酢酸トコフェロール 0.05
(10)スクアラントマト抽出物* 0.1
(11)防腐剤 q.s.
(12)モノステアリン酸ソルビタン 0.3
(13)モノオレイン酸ポリオキシエチレン(20E.O.)ソルビタン
0.5
(14)トリエタノールアミン 0.5
(15)1,3−ブチレングリコール 15.0
(16)グリセリン 3.0
(17)ポリエチレングリコール 6000 0.5
(18)精製水 残余
(19) カルボキシビニルポリマーの1%溶液 8.0
(20)芳香剤 q.s.
*実施例1Aの場合のように生成
A.後述の成分(1)〜(14)を混合し、加熱しながら溶解させ、70℃で保持して混合物Aを得た。
(1)ステアリン酸 2.5
(2)セチルアルコール 2.5
(3)親水性型モノステアリン酸グリセリン 2.0
(4)ワセリン 2.0
(5)ジペンタエリスリトール脂肪酸エステル* 2.0
(6)ミリスチン酸イソトリデシル 5.0
(7)流動パラフィン 8.0
(8)スクアラン 5.0
(9)黄蝋 1.0
(10)スクアラントマト抽出物** 0.1
(11)パルミチン酸セチル 2.0
(12)セスキオレイン酸ソルビタン 0.5
(13)モノオレイン酸ポリオキシエチレン(20E.O.)ソルビタン
1.5
(14)防腐剤 q.s.
(15)トリエタノールアミン 1.2
(16)1,3−ブチレングリコール 8.0
(17)グリセリン 2.0
(18)ポリエチレングリコール 20000 0.5
(19)精製水 残余
(20)カルボキシビニルポリマーの1%水溶液 10.0
(21)芳香剤 q.s.
*日清オイリオ株式会社製「COSMOL 168AR」
**実施例1Aの場合のように生成
なお本願は以下の態様を包含する。
[1]
皮膚を漂白するのに有効な量で無色カロテノイドフィトエン及びフィトフルエンを含む組成物を、それを必要とする対象に投与することを含む、皮膚漂白を促進させるための方法。
[2]
組成物がζ−カロテンをさらに含む、[1]に記載の方法。
[3]
組成物がフィトエン及びフィトフルエン以外に最大0.5重量%のカロテノイドを含む、[1]に記載の方法。
[4]
組成物が本質的に無色である、[1]から[3]までのいずれか一項に記載の方法。
[5]
フィトエン、フィトフルエン及びζ−カロテンからなる群から選択されるカロテノイドのそれぞれが天然源由来である、[1]から[4]までのいずれか一項に記載の方法。
[6]
天然源がトマト果実である、[5]に記載の方法。
[7]
フィトエン、フィトフルエン、ζ−カロテン又はその任意の組合せがトマト果実の油溶性抽出物内に存在する、[6]に記載の方法。
[8]
トマト果実の油溶性抽出物が、リコペン及びβ−カロテンを実質的に欠いている、[7]に記載の方法。
[9]
天然源が藻類である、[5]に記載の方法。
[10]
藻類がデュナリエラ(Dunaliella)種のものである、[9]に記載の方法。
[11]
フィトエン、フィトフルエン、ζ−カロテン又はその任意の組合せが、藻類デュナリエラの油溶性抽出物内に存在する、[10]に記載の方法。
[12]
藻類デュナリエラの油溶性抽出物が、β−カロテンを実質的に欠いている、[11]に記載の方法。
[13]
天然源が微生物である、[5]に記載の方法。
[14]
フィトエン、フィトフルエン及びζ−カロテンからなる群から選択されるカロテノイドのそれぞれが化学合成によって調製される、[1]から[4]までのいずれか一項に記載の方法。
[15]
フィトエン、フィトフルエン及びζ−カロテンからなる群から選択されるカロテノイドのそれぞれが組換え法によって調製される、[1]から[4]までのいずれか一項に記載の方法。
[16]
組成物が局所投与のために製剤された化粧用組成物である、[1]に記載の方法。
[17]
組成物が化粧品として許容される希釈剤又は担体をさらに含む、[16]に記載の方法。
[18]
組成物が、防腐剤、増粘剤、分散剤、界面活性剤、乳化剤、緩衝剤、キレート剤、着色剤、香料又はその任意の組合せからなる群から選択される少なくとも1種の薬剤をさらに含む、[16]に記載の方法。
[19]
組成物が、酸化防止剤、抗炎症薬、保湿剤、ビタミン、カロテノイド、紫外線吸収剤、紫外線保護剤又はその任意の組合せからなる群から選択される少なくとも1種の有効成分をさらに含む、[16]に記載の方法。
[20]
組成物が希釈剤としてスクアランを含む、[17]に記載の方法。
[21]
スクアランが天然由来スクアランである、[20]に記載の方法。
[22]
組成物が経口投与用に製剤された、[1]に記載の方法。
[23]
組成物が賦形剤、希釈剤又は担体をさらに含む、[22]に記載の方法。
[24]
組成物が、カプセル剤、糖衣錠、丸剤、錠剤、ゲル剤、液剤、スラリー、懸濁剤及びシロップ剤からなる群から選択される形態に製剤された、[22]に記載の方法。
[25]
化粧用組成物を少なくとも1日1回対象の皮膚に局所的に投与する、[16]に記載の方法。
[26]
経口組成物を少なくとも1日1回対象に投与する、[22]に記載の方法。
[27]
局所組成物及び経口組成物を同時に投与する、[25]又は[26]に記載の方法。
Claims (4)
- 皮膚細胞中のメラニン含有量を低減することにより皮膚漂白を促進するのに有効な量で無色カロテノイドフィトエン及びフィトフルエンを含む、皮膚細胞中のメラニン含有量を低減することによる皮膚漂白を促進するための組成物であって、経口投与のために処方されている上記組成物。
- 賦形剤、希釈剤又は担体をさらに含む、請求項1に記載の組成物。
- カプセル剤、糖衣錠、丸剤、錠剤、ゲル剤、液剤、スラリー、懸濁剤及びシロップ剤からなる群から選択される形態に製剤された、請求項1に記載の組成物。
- 少なくとも1日1回対象に投与するための、請求項1に記載の組成物。
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IL176668 | 2006-07-02 | ||
IL176668A IL176668A0 (en) | 2006-07-02 | 2006-07-02 | Colorless carotenoids for skin whitening |
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JP2007030836A Active JP5319070B2 (ja) | 2006-07-02 | 2007-02-09 | 皮膚漂白のための無色カロテノイド |
JP2013117825A Active JP5799055B2 (ja) | 2006-07-02 | 2013-06-04 | 皮膚漂白のための無色カロテノイド |
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JP2013117825A Active JP5799055B2 (ja) | 2006-07-02 | 2013-06-04 | 皮膚漂白のための無色カロテノイド |
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US (1) | US8398958B2 (ja) |
EP (1) | EP2046456B1 (ja) |
JP (3) | JP5319070B2 (ja) |
KR (1) | KR101448317B1 (ja) |
CN (2) | CN103393545A (ja) |
HK (1) | HK1131356A1 (ja) |
IL (2) | IL176668A0 (ja) |
WO (1) | WO2008004206A2 (ja) |
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JP5103273B2 (ja) * | 2008-05-22 | 2012-12-19 | マイクロアルジェコーポレーション株式会社 | 美白用配合剤 |
CN102440926B (zh) * | 2011-02-10 | 2013-06-19 | 漳州市格莱雅化妆品有限公司 | 一种水仙花美白霜化妆品 |
BR112013033532B1 (pt) | 2011-06-30 | 2020-06-02 | E. & J. Gallo Winery | Composição corante natural |
FR3017798B1 (fr) * | 2014-02-27 | 2017-03-24 | Etienne Soudant | Composition cosmetique a base d'homologue en c30 de carotenoides |
CN104686863A (zh) * | 2015-03-24 | 2015-06-10 | 江苏省农业科学院 | 血鹦鹉淡化黑色素饲料添加剂及其应用 |
WO2017029674A1 (en) * | 2015-08-20 | 2017-02-23 | I.B.R. Israeli Biotechnology Research Ltd. | Carotenoid compositions having antiviral activities and uses thereof |
US20180280266A1 (en) * | 2015-09-28 | 2018-10-04 | Omniactive Health Technologies Limited | Xanthophyll compositions for skin lightening |
US11221179B2 (en) | 2018-10-26 | 2022-01-11 | E. & J. Gallo Winery | Low profile design air tunnel system and method for providing uniform air flow in a refractance window dryer |
CA3153568A1 (en) * | 2019-10-10 | 2021-04-15 | Tal Offer | Compositions comprising caroternoids and methods for inhibiting collagen loss |
CN111568783A (zh) * | 2020-06-23 | 2020-08-25 | 昆仑技术研究(广州)有限公司 | 一种白番茄提取物脂质体冻干粉的制备方法及其应用 |
WO2023137015A2 (en) * | 2022-01-12 | 2023-07-20 | Unibar Corporation | Manufacture of cosmetic carotenoid compositions |
CN115399478A (zh) * | 2022-08-19 | 2022-11-29 | 何直源 | 一种美容美白组合物以及美白保健品 |
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FR2664164A1 (fr) | 1990-07-04 | 1992-01-10 | Texinfine Patrinove | Composition dermatologique ou cosmetique. |
JPH06279257A (ja) | 1993-03-31 | 1994-10-04 | Kitasato Inst:The | メラニン生合成阻害剤 |
FR2749758B1 (fr) * | 1996-06-12 | 1998-08-07 | Oenobiol Sa Lab | Composition a activite bronzante et photoprotectrice et ses applications esthetiques |
IL121320A (en) * | 1997-02-23 | 2000-12-06 | Ibr Ltd | Extracts from cells or tissue of organisms which are capable of entering dormancy for inhibition of proliferation of target cells or tissue |
US5747006A (en) * | 1997-05-14 | 1998-05-05 | Amway Corporation | Skin whitener composition containing acerola cherry fermentate |
JPH1135444A (ja) * | 1997-07-18 | 1999-02-09 | Nikko Chem Kk | 新規化粧料 |
IL126076A (en) | 1998-09-04 | 2005-05-17 | Ibr Ltd | Transparent composition comprising phytoene and phytofluene |
US5980904A (en) * | 1998-11-18 | 1999-11-09 | Amway Corporation | Skin whitening composition containing bearberry extract and a reducing agent |
AU1365400A (en) | 1998-12-28 | 2000-07-31 | Sudzucker Aktiengesellschaft Mannheim/Ochsenfurt | Food product containing amylopectin and method for producing same |
DE60117971T2 (de) * | 2000-05-12 | 2006-10-12 | Bengt Krister Olson | Zusammensetzungen mit kombinierten extrakten aus knorpelgewebe und pflanzen |
DK1289383T3 (da) * | 2000-05-30 | 2006-08-14 | Nestle Sa | Grundsammensætning indeholdende en lipofil bioaktiv forbindelse |
JP4169244B2 (ja) * | 2000-06-28 | 2008-10-22 | キッコーマン株式会社 | 抗アレルギー剤およびその製造方法 |
DE10036797A1 (de) | 2000-07-28 | 2002-02-07 | Beiersdorf Ag | Verwendung von Kombinationen mit einem Gehalt an Carnitinen |
IL141039A (en) * | 2001-01-23 | 2006-10-31 | Lycored Natural Prod Ind Ltd | The composition for the prevention of atherosclerosis containing carotenoids and use for the preparation of drugs to inhibit LDL oxidation |
IL141038A (en) * | 2001-01-23 | 2006-10-05 | Lycored Natural Prod Ind Ltd | Use of carotenoids for the preparation of substances for the treatment of high blood pressure |
US7575766B2 (en) * | 2001-06-29 | 2009-08-18 | Ball Horticultural Company | Tagetes erecta with altered carotenoid compositions and ratios |
IL146496A0 (en) * | 2001-11-14 | 2002-07-25 | Lycored Natural Prod Ind Ltd | Carotenoid composition and method for protecting skin |
US7025957B2 (en) * | 2002-09-06 | 2006-04-11 | Desert Whale Jojoba Company | Composition and method to whiten skin |
JP2004300117A (ja) | 2003-04-01 | 2004-10-28 | Rasheru Seiyaku Kk | 化粧料組成物 |
US6994874B2 (en) * | 2003-04-16 | 2006-02-07 | Access Business Group International, Llc | Skin whitening compositions containing asparagus extract |
RU2006132336A (ru) * | 2004-02-10 | 2008-03-20 | Нестек С.А. (Ch) | Композиции, содержащие цис-изомеры каротиноидного соединения, и способ их получения |
JP6279257B2 (ja) | 2013-08-30 | 2018-02-14 | 矢崎総業株式会社 | 電子部品と端子金具との接続構造 |
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Also Published As
Publication number | Publication date |
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JP2015108013A (ja) | 2015-06-11 |
JP5799055B2 (ja) | 2015-10-21 |
US8398958B2 (en) | 2013-03-19 |
KR20090031603A (ko) | 2009-03-26 |
HK1131356A1 (en) | 2010-01-22 |
JP5319070B2 (ja) | 2013-10-16 |
IL196212A (en) | 2016-10-31 |
CN101484212B (zh) | 2013-10-30 |
CN103393545A (zh) | 2013-11-20 |
WO2008004206A2 (en) | 2008-01-10 |
KR101448317B1 (ko) | 2014-10-07 |
JP2013177441A (ja) | 2013-09-09 |
EP2046456B1 (en) | 2017-08-16 |
IL176668A0 (en) | 2006-10-31 |
CN101484212A (zh) | 2009-07-15 |
EP2046456A2 (en) | 2009-04-15 |
IL196212A0 (en) | 2009-09-22 |
US20090311204A1 (en) | 2009-12-17 |
WO2008004206A3 (en) | 2008-04-17 |
JP2008013541A (ja) | 2008-01-24 |
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