JP6063385B2 - Ｈｉｖ関連の下痢を治療するための方法および組成物 - Google Patents

Ｈｉｖ関連の下痢を治療するための方法および組成物 Download PDF

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JP6063385B2
JP6063385B2 JP2013536904A JP2013536904A JP6063385B2 JP 6063385 B2 JP6063385 B2 JP 6063385B2 JP 2013536904 A JP2013536904 A JP 2013536904A JP 2013536904 A JP2013536904 A JP 2013536904A JP 6063385 B2 JP6063385 B2 JP 6063385B2
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JP2013540826A5 (OSRAM
JP2013540826A (ja
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ウィリアム フォーブス
ウィリアム フォーブス
エノク ボーティー
エノク ボーティー
スティーブン キング
スティーブン キング
プラビン チャトゥルベディ
プラビン チャトゥルベディ
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ナポ ファーマシューティカルズ インコーポレイテッド
ナポ ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2013536904A 2010-10-31 2011-10-31 Ｈｉｖ関連の下痢を治療するための方法および組成物 Active JP6063385B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40862210P 2010-10-31 2010-10-31
US61/408,622 2010-10-31
US40933510P 2010-11-02 2010-11-02
US61/409,335 2010-11-02
US41624910P 2010-11-22 2010-11-22
US61/416,249 2010-11-22
US201161434379P 2011-01-19 2011-01-19
US61/434,379 2011-01-19
PCT/US2011/058549 WO2012058664A1 (en) 2010-10-31 2011-10-31 Methods and compositions for treating hiv-associated diarrhea

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016151656A Division JP6310971B2 (ja) 2010-10-31 2016-08-02 Ｈｉｖ関連の下痢を治療するための方法および組成物

Publications (3)

Publication Number Publication Date
JP2013540826A JP2013540826A (ja) 2013-11-07
JP2013540826A5 JP2013540826A5 (OSRAM) 2014-12-18
JP6063385B2 true JP6063385B2 (ja) 2017-01-18

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JP2013536904A Active JP6063385B2 (ja) 2010-10-31 2011-10-31 Ｈｉｖ関連の下痢を治療するための方法および組成物
JP2016151656A Active JP6310971B2 (ja) 2010-10-31 2016-08-02 Ｈｉｖ関連の下痢を治療するための方法および組成物

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JP2016151656A Active JP6310971B2 (ja) 2010-10-31 2016-08-02 Ｈｉｖ関連の下痢を治療するための方法および組成物

Country Status (20)

Country Link
US (4) US8962680B2 (OSRAM)
EP (1) EP2632550B1 (OSRAM)
JP (2) JP6063385B2 (OSRAM)
CN (2) CN103370101A (OSRAM)
AU (1) AU2011320155B2 (OSRAM)
BR (1) BR112013010774A2 (OSRAM)
CA (1) CA2816416C (OSRAM)
DK (1) DK2632550T3 (OSRAM)
EC (1) ECSP13012650A (OSRAM)
ES (1) ES2635435T3 (OSRAM)
HK (1) HK1249036A1 (OSRAM)
HU (1) HUE035393T2 (OSRAM)
MX (1) MX348184B (OSRAM)
PE (1) PE20140036A1 (OSRAM)
PH (1) PH12013500857A1 (OSRAM)
PL (1) PL2632550T3 (OSRAM)
PT (1) PT2632550T (OSRAM)
RU (1) RU2597746C2 (OSRAM)
WO (1) WO2012058664A1 (OSRAM)
ZA (1) ZA201303136B (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009535419A (ja) 2006-05-01 2009-10-01 ナポ ファーマシューティカルズ インク． 便秘型過敏性腸症候群の治療方法
US8852649B2 (en) 2006-05-01 2014-10-07 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer
US20070254050A1 (en) 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
BR112013010774A2 (pt) 2010-10-31 2017-03-21 Napo Pharmaceuticals Inc "usos de crofelemer no tratamento de diarreia associada ao hiv"
US20140163096A1 (en) * 2012-12-07 2014-06-12 Pam Golden Methods and compositions for treating hiv-associated diarrhea
US11389424B2 (en) 2017-03-09 2022-07-19 Napo Pharmaceuticals, Inc. Methods and compositions for treating chemotherapy-induced diarrhea
JOP20190276A1 (ar) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة
JOP20190275A1 (ar) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج اضطراب إسهال خِلقي
CA3128973A1 (en) 2019-03-04 2020-09-10 Bhaskar Bhattacharyya Data compression and communication using machine learning
JP2023538186A (ja) * 2020-06-19 2023-09-07 ナポ ファーマシューティカルズ インク． 化学療法誘発性下痢を治療するための方法及び組成物
WO2022115481A1 (en) * 2020-11-24 2022-06-02 Napo Pharmaceuticals, Inc. Methods and compositions for treating post-acute infection gastrointestinal disorders

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211944A (en) 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
EP0935417B1 (en) * 1996-10-16 2009-05-06 Napo Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
WO2000047062A2 (en) * 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
US20040071793A1 (en) 2002-10-05 2004-04-15 Bobrowski Paul J. Oral rehydration methods and compositions
US20080025966A1 (en) * 2004-01-30 2008-01-31 Currie Mark G Methods And Compositions For The Treatment Of Gastrointestinal disorders
CA2667449A1 (en) * 2005-06-22 2007-01-04 University Of Massachusetts Hiv-1 protease inhibitors, and methods of making and using them
JP2009524585A (ja) 2005-12-15 2009-07-02 バイエル・ヘルスケア・アクチェンゲゼルシャフト ウイルス感染を処置するためのジアリールウレア
JP2009535419A (ja) 2006-05-01 2009-10-01 ナポ ファーマシューティカルズ インク． 便秘型過敏性腸症候群の治療方法
US8852649B2 (en) 2006-05-01 2014-10-07 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer
US20070254050A1 (en) * 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
WO2010021681A2 (en) 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
EA023814B1 (ru) 2009-08-26 2016-07-29 Гленмарк Фармасьютикалс Лтд. Способ получения полимерных композиций на основе проантоцианидина для фармацевтических форм
AU2010303577B2 (en) 2009-10-06 2015-10-22 Napo Pharmaceuticals, Inc. Methods of treating diseases with proanthocyanidin oligomers such as crofelemer
US20110087530A1 (en) 2009-10-09 2011-04-14 Visa U.S.A. Inc. Systems and Methods to Provide Loyalty Programs
BR112013010774A2 (pt) 2010-10-31 2017-03-21 Napo Pharmaceuticals Inc "usos de crofelemer no tratamento de diarreia associada ao hiv"
BR112013018688B1 (pt) 2011-01-27 2021-08-24 Napo Pharmaceuticals, Inc Método de produção de uma composição polimérica de proantocianidina
RU2014124981A (ru) 2011-12-22 2016-02-10 Гленмарк Фармасьютикалс Лимитед Неэнтеросолюбильная фармацевтическая композиция, содержащая крофелемер
US20140163096A1 (en) 2012-12-07 2014-06-12 Pam Golden Methods and compositions for treating hiv-associated diarrhea

Also Published As

Publication number Publication date
JP6310971B2 (ja) 2018-04-11
CA2816416C (en) 2020-02-11
AU2011320155A1 (en) 2013-05-09
RU2597746C2 (ru) 2016-09-20
MX348184B (es) 2017-06-02
CN103370101A (zh) 2013-10-23
BR112013010774A2 (pt) 2017-03-21
JP2017019806A (ja) 2017-01-26
ZA201303136B (en) 2016-01-27
EP2632550B1 (en) 2017-05-03
PE20140036A1 (es) 2014-01-31
CN107595836A (zh) 2018-01-19
PL2632550T3 (pl) 2017-10-31
PH12013500857A1 (en) 2018-01-17
US20120107370A1 (en) 2012-05-03
US9585868B2 (en) 2017-03-07
HUE035393T2 (en) 2018-05-02
CA2816416A1 (en) 2012-05-03
AU2011320155B2 (en) 2016-02-25
WO2012058664A1 (en) 2012-05-03
US20120184605A1 (en) 2012-07-19
US8962680B2 (en) 2015-02-24
EP2632550A4 (en) 2014-04-23
MX2013004873A (es) 2013-08-21
PT2632550T (pt) 2017-08-02
EP2632550A1 (en) 2013-09-04
US20150190367A1 (en) 2015-07-09
ES2635435T3 (es) 2017-10-03
ECSP13012650A (es) 2013-10-31
DK2632550T3 (en) 2017-08-07
RU2013123794A (ru) 2014-12-10
US20140294903A1 (en) 2014-10-02
HK1249036A1 (zh) 2018-10-26
JP2013540826A (ja) 2013-11-07

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