JP6062962B2 - 置換ピリミジン化合物およびｓｙｋ阻害剤としてのそれらの使用 - Google Patents

置換ピリミジン化合物およびｓｙｋ阻害剤としてのそれらの使用 Download PDF

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JP6062962B2
JP6062962B2 JP2014553451A JP2014553451A JP6062962B2 JP 6062962 B2 JP6062962 B2 JP 6062962B2 JP 2014553451 A JP2014553451 A JP 2014553451A JP 2014553451 A JP2014553451 A JP 2014553451A JP 6062962 B2 JP6062962 B2 JP 6062962B2
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methyl
ylamino
pyrazol
pyrimidin
indol
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JP2015504093A (ja
JP2015504093A5 (enExample
Inventor
チョイ，ジャン−シク
ファン，ヘ−ジュン
イ，エンホ
イ，ジェキュ
ソン，ホ−ジュン
ウォン キム，セ
ウォン キム，セ
キム，ジュン−ホ
ソン コ，ジョン
ソン コ，ジョン
イ，テ−イム
チョイ，ヤン−グン
ハン，イ−ファン
イ，ジェソン
ヨン イ，イン
ヨン イ，イン
シク ジョン，ドン
シク ジョン，ドン
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Oscotec Inc
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Oscotec Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2014553451A 2012-01-20 2013-01-18 置換ピリミジン化合物およびｓｙｋ阻害剤としてのそれらの使用 Active JP6062962B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261588793P 2012-01-20 2012-01-20
US61/588,793 2012-01-20
PCT/US2013/022135 WO2013109882A1 (en) 2012-01-20 2013-01-18 Substituted pyrimidine compounds and their use as syk inhibitors

Publications (3)

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JP2015504093A JP2015504093A (ja) 2015-02-05
JP2015504093A5 JP2015504093A5 (enExample) 2016-03-10
JP6062962B2 true JP6062962B2 (ja) 2017-01-18

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JP2014553451A Active JP6062962B2 (ja) 2012-01-20 2013-01-18 置換ピリミジン化合物およびｓｙｋ阻害剤としてのそれらの使用

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Country Link
US (1) US8871778B2 (enExample)
EP (1) EP2804861B1 (enExample)
JP (1) JP6062962B2 (enExample)
KR (1) KR101944914B1 (enExample)
CN (1) CN104203943B (enExample)
AU (1) AU2013209586B2 (enExample)
CA (1) CA2863517C (enExample)
ES (1) ES2668479T3 (enExample)
NZ (1) NZ627113A (enExample)
PL (1) PL2804861T3 (enExample)
WO (1) WO2013109882A1 (enExample)
ZA (1) ZA201406038B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201602566XA (en) * 2013-10-21 2016-05-30 Genosco Substituted pyrimidine compounds and their use as syk inhibitors
CN103969445B (zh) * 2014-05-08 2015-09-30 中南大学 亚铁血红素—二氧化锰复合物的制备及其用于检测人IgG的方法
EP3929190B1 (en) 2014-10-13 2024-12-25 Yuhan Corporation Compounds and compositions for modulating egfr mutant kinase activities
CA2978823C (en) 2014-12-29 2023-10-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
WO2018228475A1 (zh) 2017-06-14 2018-12-20 正大天晴药业集团股份有限公司 Syk抑制剂及其使用方法
DK3658547T3 (da) * 2017-07-28 2023-10-16 Yuhan Corp Fremgangsmåde til fremstilling af n-(5-(4-(4-formyl-3-phenyl-1h-pyrazol-1-yl)pyrimidin-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamid
JP7109013B2 (ja) 2019-03-19 2022-07-29 ボロノイ インコーポレイテッド ヘテロアリール誘導体、ヘテロアリール誘導体の生成方法、およびヘテロアリール誘導体を有効成分として含む医薬組成物
US12157730B2 (en) 2019-03-19 2024-12-03 Voronoi Inc. Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
KR20210152312A (ko) * 2020-06-08 2021-12-15 주식회사 종근당 카나비노이드 수용체 (cb1 수용체) 길항제로서의 4-(4,5-디하이드로-1h-피라졸-1-닐)피리미딘 화합물 및 이를 포함하는 약제학적 조성물
US20240285621A1 (en) * 2020-09-23 2024-08-29 Nerviano Medical Sciences S.R.L. Pyrazolyl-pyrimidine derivatives as kinase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516231A (ja) * 1996-08-09 2000-12-05 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 免疫調節物質としての４―置換β―カルボリン
JP2006524688A (ja) * 2003-03-25 2006-11-02 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼのインヒビターとして有用なチアゾール
TW201016676A (en) * 2008-10-03 2010-05-01 Astrazeneca Ab Heterocyclic derivatives and methods of use thereof
CA2780892C (en) * 2009-11-13 2017-02-14 Genosco Kinase inhibitors
EP2668177B1 (en) * 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Substituted pyridinyl-pyrimidines and their use as medicaments

Also Published As

Publication number Publication date
ES2668479T3 (es) 2018-05-18
CA2863517C (en) 2019-11-05
US20130274242A1 (en) 2013-10-17
CN104203943A (zh) 2014-12-10
KR20140135954A (ko) 2014-11-27
EP2804861A1 (en) 2014-11-26
CN104203943B (zh) 2017-12-29
WO2013109882A1 (en) 2013-07-25
JP2015504093A (ja) 2015-02-05
AU2013209586B2 (en) 2017-08-17
ZA201406038B (en) 2015-12-23
CA2863517A1 (en) 2013-07-25
EP2804861A4 (en) 2015-07-22
KR101944914B1 (ko) 2019-02-07
EP2804861B1 (en) 2018-02-28
NZ627113A (en) 2016-07-29
AU2013209586A1 (en) 2014-07-24
PL2804861T3 (pl) 2018-08-31
US8871778B2 (en) 2014-10-28
HK1205106A1 (en) 2015-12-11

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