JP6062729B2 - 粘膜適用組成物 - Google Patents
粘膜適用組成物 Download PDFInfo
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- JP6062729B2 JP6062729B2 JP2012265842A JP2012265842A JP6062729B2 JP 6062729 B2 JP6062729 B2 JP 6062729B2 JP 2012265842 A JP2012265842 A JP 2012265842A JP 2012265842 A JP2012265842 A JP 2012265842A JP 6062729 B2 JP6062729 B2 JP 6062729B2
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- 239000000203 mixture Substances 0.000 title claims description 175
- 210000004877 mucosa Anatomy 0.000 claims description 81
- -1 fatty acid ester Chemical class 0.000 claims description 56
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims description 42
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 29
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 23
- 239000002202 Polyethylene glycol Substances 0.000 claims description 23
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 23
- 239000000194 fatty acid Substances 0.000 claims description 23
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- 238000000034 method Methods 0.000 claims description 23
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- 229940012356 eye drops Drugs 0.000 description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 18
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- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 6
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- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 4
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
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- 238000007796 conventional method Methods 0.000 description 3
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- 229920001992 poloxamer 407 Polymers 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 150000005846 sugar alcohols Chemical class 0.000 description 3
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010013774 Dry eye Diseases 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
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- 206010020565 Hyperaemia Diseases 0.000 description 2
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- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- DJDFFEBSKJCGHC-UHFFFAOYSA-N Naphazoline Chemical compound Cl.C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 DJDFFEBSKJCGHC-UHFFFAOYSA-N 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 229960002684 aminocaproic acid Drugs 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- 229960001950 benzethonium chloride Drugs 0.000 description 2
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
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- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
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- 239000012459 cleaning agent Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
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- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- YKZPPPNXRZHVGX-PXYKVGKMSA-L dipotassium;(2s)-2-aminobutanedioate;hydron;hydrate Chemical compound [H+].[H+].O.[K+].[K+].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O YKZPPPNXRZHVGX-PXYKVGKMSA-L 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 150000003949 imides Chemical group 0.000 description 2
- 229960001983 magnesium aspartate Drugs 0.000 description 2
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 description 2
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
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- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
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- 239000004328 sodium tetraborate Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
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- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
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- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 description 1
- MMINFSMURORWKH-UHFFFAOYSA-N 3,6-dioxabicyclo[6.2.2]dodeca-1(10),8,11-triene-2,7-dione Chemical group O=C1OCCOC(=O)C2=CC=C1C=C2 MMINFSMURORWKH-UHFFFAOYSA-N 0.000 description 1
- XDVOLDOITVSJGL-UHFFFAOYSA-N 3,7-dihydroxy-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound O1B(O)OB2OB(O)OB1O2 XDVOLDOITVSJGL-UHFFFAOYSA-N 0.000 description 1
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- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 description 1
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
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- WXKPPMQZRGORPB-UHFFFAOYSA-M sodium;2-hydroxypropane-1,2,3-tricarboxylic acid;acetate Chemical compound [Na+].CC([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O WXKPPMQZRGORPB-UHFFFAOYSA-M 0.000 description 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000011232 storage material Substances 0.000 description 1
- 229960005404 sulfamethoxazole Drugs 0.000 description 1
- 229940021790 tetrahydrozoline hydrochloride Drugs 0.000 description 1
- BJORNXNYWNIWEY-UHFFFAOYSA-N tetrahydrozoline hydrochloride Chemical compound Cl.N1CCN=C1C1C2=CC=CC=C2CCC1 BJORNXNYWNIWEY-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- WYXIGTJNYDDFFH-UHFFFAOYSA-Q triazanium;borate Chemical compound [NH4+].[NH4+].[NH4+].[O-]B([O-])[O-] WYXIGTJNYDDFFH-UHFFFAOYSA-Q 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Description
項1-1.(A)クロロブタノール、(B)モノステアリン酸ポリエチレングリコール、及び(C)ポリオキシエチレンソルビタン脂肪酸エステルを含有する、粘膜適用組成物。
項1-2.(B)成分が、酸化エチレンの平均付加モル数が2〜80モルのステアリン酸ポリオキシルである、項1-1に記載の粘膜適用組成物。
項1-3.(C)成分が、モノオレイン酸ポリオキシエチレン(20)ソルビタンである、項1-1又は項1-2に記載の粘膜適用組成物。
項1-4.粘膜適用組成物の総量を基準として、(A)成分の含有量が、0.01〜1w/v%である、項1-1乃至1-3のいずれかに記載の粘膜適用組成物。
項1-5.粘膜適用組成物の総量を基準として、(B)成分の含有量が、総量で0.01〜2.5w/v%である、項1-1乃至1-4のいずれかに記載の粘膜適用組成物。
項1-6.(A)成分の総含有量1質量部に対して、(B)成分の含有比率が、総含有量で0.01〜250質量部である、項1-1乃至1-5のいずれかに記載の粘膜適用組成物。
項1-7.(B)成分の総含有量1質量部に対して、(C)成分の含有比率が、総含有量で0.004〜100質量部である、項1-1乃至1-6のいずれかに記載の粘膜適用組成物。
項1-8. 更に、(D)緩衝剤を含有する、項1-1乃至1-7のいずれかに記載の粘膜適用組成物。
項1-9.粘膜適用組成物の総量を基準として、(D)成分の含有量が、総量で0.1〜5w/v%である、項1-8に記載の粘膜適用組成物。
項1-10.更に、(B)成分及び(C)成分以外の界面活性剤(E)を含有する、項1-1乃至1-9のいずれかに記載の粘膜適用組成物。
項1-11.(D)成分が、ホウ酸、リン酸、クエン酸及びそれらの塩からなる群より選択される少なくとも一種である、項1-10に記載の粘膜適用組成物。
項1-12.粘膜適用組成物の総量を基準として、(E)成分の含有量が、総量で0.1〜5w/v%である、項1-10又は1-11に記載の粘膜適用組成物。
項1-13.点眼剤である項1-1乃至1-12のいずれかに記載の粘膜適用組成物。
項1-14.洗眼剤である項1-1乃至1-12のいずれかに記載の粘膜適用組成物。
項1-15.コンタクトレンズ装着液である項1-1乃至1-12のいずれかに記載の粘膜適用組成物。
項1-16.コンタクトレンズケア用剤である項1-1乃至1-12のいずれかに記載の粘膜適用組成物。
項1-17.点鼻剤である項1-1乃至1-12のいずれかに記載の粘膜適用組成物。
項2-1.(A)クロロブタノール、(B)モノステアリン酸ポリエチレングリコール、及び(C)ポリオキシエチレンソルビタン脂肪酸エステルを、粘膜適用組成物に含有させることにより、該粘膜適用組成物における保存効力を増強する方法。
項2-2.(A)クロロブタノールを含有する粘膜適用組成物に、(B)モノステアリン酸ポリエチレングリコール及び(C)ポリオキシエチレンソルビタン脂肪酸エステルを含有させることにより、該粘膜適用組成物における保存効力を増強する方法。
項3-1.粘膜適用組成物の製造のための、(A)クロロブタノール、(B)モノステアリン酸ポリエチレングリコール、及び(C)ポリオキシエチレンソルビタン脂肪酸エステルの使用。
項3-2.粘膜適用組成物が、上記項1-1乃至1-17のいずれかに記載の組成物である、項3-1に記載の使用。
項4-1.粘膜適用組成物としての、(A)クロロブタノール、(B)モノステアリン酸ポリエチレングリコール、及び(C)ポリオキシエチレンソルビタン脂肪酸エステルを含む組成物の使用。
項4-2.組成物が、上記項1-1乃至1-17のいずれかに記載の組成物である、項4-1に記載の使用。
項5-1.粘膜適用組成物としての使用のための、(A)クロロブタノール、(B)モノステアリン酸ポリエチレングリコール、及び(C)ポリオキシエチレンソルビタン脂肪酸エステルを含む組成物。
項5-2.上記項1-1乃至1-17のいずれかに記載されたものである、項5-1に記載の組成物。
項6-1.水と、(A)クロロブタノールと、(B)モノステアリン酸ポリエチレングリコールと、(C)ポリオキシエチレンソルビタン脂肪酸エステルとを混合する工程を含む、粘膜適用組成物の製造方法。
項6-2.粘膜適用組成物が、上記項1-1乃至1-17のいずれかに記載の組成物である、項6-1に記載の製造方法。
本発明の粘膜適用組成物は、(A)クロロブタノール、(B)モノステアリン酸ポリエチレングリコール、及び(C)ポリオキシエチレンソルビタン脂肪酸エステルを含有する。
本明細書において配合割合の単位「%」は、「w/v%」を意味し、「g/100mL」と同義である。
(1)クロロブタノール
本発明の粘膜適用組成物は、クロロブタノール((A)成分)を含有する。
本発明の粘膜適用組成物は、モノステアリン酸ポリエチレングリコール((B)成分)を含有する。モノステアリン酸ポリエチレングリコールは、ステアリン酸マクロゴール、ステアリン酸ポリエチレングリコール又はステアリン酸ポリオキシルとも称される公知の化合物であり、酸化エチレンの平均付加モル数が異なるいくつかの種類が知られている。
(B)成分の含有量が、総量で0.0001〜10w/v%、好ましくは0.0005〜5w/v%、より好ましくは0.001〜4w/v%、さらに好ましくは0.005〜3w/v%、特に好ましくは0.01〜2.5w/v%である。
本発明の粘膜適用組成物は、ポリオキシエチレンソルビタン脂肪酸エステル((C)成分)を含有する。
本発明の粘膜適用組成物は、(A)〜(C)成分の他に、更に緩衝剤((D)成分)を含有することが好ましい。これにより、本発明の効果をより一層向上させることができる。
本発明の粘膜適用組成物は、更に、(B)成分及び(C)成分以外の界面活性剤((E)成分)を含有することが好ましい。これにより、本発明の効果をより一層向上させることができる。
本発明の粘膜適用組成物は、本発明の効果が奏される限り、上記成分の他に、種々の薬理活性成分及び/又は生理活性成分を単独又は適宜組み合わせて適当量含有してもよい。このような成分は特に制限されず、具体的には、眼科用薬及び/又は点鼻薬において用いられる成分としては、次のような成分が挙げられる。
本発明の粘膜適用組成物のpHについては、医薬上、薬理学的に(製薬上)又は生理学的に許容される範囲内であれば特に限定されるものではない。本発明の粘膜適用組成物のpHの一例として、4.0〜9.5、好ましくは4.5〜9.0、更に好ましくは5.0〜8.5となる範囲が挙げられる。
本発明の粘膜適用組成物の具体例として、眼科用組成物、耳鼻科用組成物、口腔用組成物等が挙げられ、特に眼科用組成物、耳鼻科用組成物が好ましい。眼科用組成物としては、点眼剤(点眼液又は点眼薬ともいう)[但し、点眼剤には人工涙液を含む。また、点眼剤にはコンタクトレンズ装用中に点眼可能な点眼剤を含む]、洗眼剤(洗眼液又は洗眼薬ともいう)[但し、洗眼剤にはコンタクトレンズ装用中に洗眼可能な洗眼剤を含む]、コンタクトレンズ装着液、コンタクトレンズケア用品(コンタクトレンズ消毒剤、コンタクトレンズ用保存剤、コンタクトレンズ用洗浄剤、コンタクトレンズ用洗浄保存剤、コンタクトレンズ用消毒・保存・洗浄剤(コンタクトレンズ用マルチパーパスソリューション))等が挙げられ、耳鼻科用組成物としては、点鼻剤(点鼻液又は点鼻薬ともいう)、鼻洗浄液等が挙げられる。中でも、医薬品として特に高い保存効力が求められる組成物として、点眼剤、洗眼剤、点鼻剤が好ましい。
前述したように、本発明の粘膜適用組成物では、(A)成分、(B)成分及び(C)成分を含有させることによって、粘膜適用組成物において保存効力を増強させることができる。
下記表1〜表3に示す粘膜適用組成物を、常法に従い調製した。そして、以下の方法で、実施例1〜4及び比較例1〜13の粘膜適用組成物の保存効力試験を実施した。
表4−1〜表4−6に記載の処方で、常法により点眼剤(製剤例1〜9)、点鼻剤(10及び11)を調製する。
Claims (3)
- (A)クロロブタノール、(B)モノステアリン酸ポリエチレングリコール、及び(C)ポリオキシエチレンソルビタン脂肪酸エステルを含有する粘膜適用組成物。
- 更に、緩衝剤を含有する、請求項1に記載の粘膜適用組成物。
- (A)クロロブタノール、(B)モノステアリン酸ポリエチレングリコール、及び(C)ポリオキシエチレンソルビタン脂肪酸エステルを含有させることにより、該粘膜適用組成物における保存効力を増強する方法。
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