JP6058529B2 - 血友病ａにおけるインヒビターの発達と関連する遺伝因子 - Google Patents

血友病ａにおけるインヒビターの発達と関連する遺伝因子 Download PDF

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JP6058529B2
JP6058529B2 JP2013505490A JP2013505490A JP6058529B2 JP 6058529 B2 JP6058529 B2 JP 6058529B2 JP 2013505490 A JP2013505490 A JP 2013505490A JP 2013505490 A JP2013505490 A JP 2013505490A JP 6058529 B2 JP6058529 B2 JP 6058529B2
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individual
factor viii
risk
antibody against
another embodiment
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JP2013529071A5 (cg-RX-API-DMAC10.html
JP2013529071A (ja
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エリック ベルントルプ，
エリック ベルントルプ，
ヤン アステルマルク，
ヤン アステルマルク，
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013505490A 2010-04-21 2011-04-21 血友病ａにおけるインヒビターの発達と関連する遺伝因子 Active JP6058529B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32660210P 2010-04-21 2010-04-21
US61/326,602 2010-04-21
PCT/EP2011/056471 WO2011131774A1 (en) 2010-04-21 2011-04-21 Genetic factors associated with inhibitor development in hemophilia a

Related Child Applications (1)

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JP2015183020A Division JP6189904B2 (ja) 2010-04-21 2015-09-16 血友病ａにおけるインヒビターの発達と関連する遺伝因子

Publications (3)

Publication Number Publication Date
JP2013529071A JP2013529071A (ja) 2013-07-18
JP2013529071A5 JP2013529071A5 (cg-RX-API-DMAC10.html) 2014-06-05
JP6058529B2 true JP6058529B2 (ja) 2017-01-11

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ID=43983253

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2013505490A Active JP6058529B2 (ja) 2010-04-21 2011-04-21 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2015183020A Active JP6189904B2 (ja) 2010-04-21 2015-09-16 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2017151073A Active JP6568162B2 (ja) 2010-04-21 2017-08-03 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2019142337A Withdrawn JP2019180421A (ja) 2010-04-21 2019-08-01 血友病ａにおけるインヒビターの発達と関連する遺伝因子

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JP2015183020A Active JP6189904B2 (ja) 2010-04-21 2015-09-16 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2017151073A Active JP6568162B2 (ja) 2010-04-21 2017-08-03 血友病ａにおけるインヒビターの発達と関連する遺伝因子
JP2019142337A Withdrawn JP2019180421A (ja) 2010-04-21 2019-08-01 血友病ａにおけるインヒビターの発達と関連する遺伝因子

Country Status (7)

Country Link
US (3) US9637789B2 (cg-RX-API-DMAC10.html)
EP (2) EP2730663B1 (cg-RX-API-DMAC10.html)
JP (4) JP6058529B2 (cg-RX-API-DMAC10.html)
AU (1) AU2011244228B2 (cg-RX-API-DMAC10.html)
CA (2) CA2796561C (cg-RX-API-DMAC10.html)
ES (1) ES2949953T3 (cg-RX-API-DMAC10.html)
WO (1) WO2011131774A1 (cg-RX-API-DMAC10.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2771999A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor vii compositions and methods of making and using same
US9637789B2 (en) * 2010-04-21 2017-05-02 Jan Astermark and Erik Berntorp Genetic factors associated with inhibitor development in hemophilia A
WO2013123457A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
CN111548418A (zh) 2012-02-15 2020-08-18 比奥贝拉蒂治疗公司 因子viii组合物及其制备和使用方法
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
EA201691111A1 (ru) 2014-01-10 2017-01-30 Байоджен Ма Инк. Химерные белки фактора viii и их применение
UA126016C2 (uk) 2015-08-03 2022-08-03 Біовератів Терапеутікс Інк. Злитий білок фактора іх
KR101774996B1 (ko) * 2016-06-23 2017-09-19 주식회사 녹십자지놈 혈우병 치료제의 효능 예측 마커 및 이의 용도
KR20190090827A (ko) 2016-12-02 2019-08-02 바이오버라티브 테라퓨틱스 인크. 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법
KR102914074B1 (ko) 2018-05-18 2026-01-16 바이오버라티브 테라퓨틱스 인크. A형 혈우병의 치료 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
EP0728218B1 (en) 1993-11-12 2008-01-02 PHRI Properties, Inc. Hybridization probes for nucleic acid detection, universal stems, methods and kits
JP3439221B2 (ja) 1995-12-18 2003-08-25 ワシントン ユニヴァーシティ 蛍光共鳴エネルギー移動を利用する核酸分析方法
WO2008059009A2 (en) 2006-11-16 2008-05-22 Crucell Holland B.V. Factor v mutants for hemostasis in hemophilia
US9637789B2 (en) * 2010-04-21 2017-05-02 Jan Astermark and Erik Berntorp Genetic factors associated with inhibitor development in hemophilia A

Also Published As

Publication number Publication date
US20110312519A1 (en) 2011-12-22
JP2019180421A (ja) 2019-10-24
JP2013529071A (ja) 2013-07-18
AU2011244228B2 (en) 2015-07-30
EP2730663A2 (en) 2014-05-14
US9644239B2 (en) 2017-05-09
CA3050896A1 (en) 2011-10-27
JP6189904B2 (ja) 2017-08-30
ES2949953T3 (es) 2023-10-04
WO2011131774A1 (en) 2011-10-27
JP6568162B2 (ja) 2019-08-28
CA2796561C (en) 2019-09-17
US20180016635A1 (en) 2018-01-18
EP2730663B1 (en) 2023-03-22
US20120065077A1 (en) 2012-03-15
CA3050896C (en) 2023-01-24
EP2561090A1 (en) 2013-02-27
JP2015226551A (ja) 2015-12-17
CA2796561A1 (en) 2011-10-27
AU2011244228A1 (en) 2012-11-08
US9637789B2 (en) 2017-05-02
JP2017200491A (ja) 2017-11-09
EP2730663A3 (en) 2014-09-10

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