JP6054379B2 - キナーゼをモジュレートするための組成物および方法 - Google Patents

キナーゼをモジュレートするための組成物および方法 Download PDF

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JP6054379B2
JP6054379B2 JP2014514164A JP2014514164A JP6054379B2 JP 6054379 B2 JP6054379 B2 JP 6054379B2 JP 2014514164 A JP2014514164 A JP 2014514164A JP 2014514164 A JP2014514164 A JP 2014514164A JP 6054379 B2 JP6054379 B2 JP 6054379B2
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branched
linear
cancer
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JP2014520108A (ja
JP2014520108A5 (fr
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ベッカー、オーレン・エム．
ブロッチ、イタイ
ベン—ゼーブ・エフラット
ベン―ゼーブ・エフラット
シトリット、アリーナ
ヤコバン、アビハイ
ガザル、シャロン
ベハル、ベレド
コンソン、アレクサンダー
シュッズ、ニリ
ミリラシュビリ、シマ
ゴラン、ガリ
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Clevexel Pharma
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Clevexel Pharma
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
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    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014514164A 2011-06-07 2012-06-07 キナーゼをモジュレートするための組成物および方法 Active JP6054379B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161520256P 2011-06-07 2011-06-07
US61/520,256 2011-06-07
US201161562700P 2011-11-22 2011-11-22
US61/562,700 2011-11-22
US201261640139P 2012-04-30 2012-04-30
US61/640,139 2012-04-30
PCT/IB2012/001987 WO2012172438A2 (fr) 2011-06-07 2012-06-07 Compositions et procédé de modulation d'une kinase

Publications (3)

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JP2014520108A JP2014520108A (ja) 2014-08-21
JP2014520108A5 JP2014520108A5 (fr) 2015-06-11
JP6054379B2 true JP6054379B2 (ja) 2016-12-27

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US (1) US8937065B2 (fr)
EP (1) EP2718290B1 (fr)
JP (1) JP6054379B2 (fr)
CN (1) CN103717593B (fr)
AU (1) AU2012270029B2 (fr)
BR (1) BR112013031121B1 (fr)
CA (1) CA2837268C (fr)
DK (1) DK2718290T3 (fr)
ES (1) ES2585244T3 (fr)
HK (1) HK1191324A1 (fr)
HR (1) HRP20160879T1 (fr)
HU (1) HUE028097T2 (fr)
IL (1) IL229692A (fr)
MX (1) MX355415B (fr)
PL (1) PL2718290T3 (fr)
PT (1) PT2718290T (fr)
WO (1) WO2012172438A2 (fr)
ZA (1) ZA201309042B (fr)

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EP2877598A1 (fr) 2012-07-24 2015-06-03 Pharmacyclics, Inc. Mutations associées à la résistance à des inhibiteurs de la tyrosine kinase de bruton (btk)
WO2017097215A1 (fr) * 2015-12-07 2017-06-15 杭州雷索药业有限公司 Inhibiteur de la voie wnt doté d'une structure urées
KR102214225B1 (ko) * 2015-12-07 2021-02-10 쑤저우 시노벤트 파마슈티칼즈 씨오., 엘티디. 5원 헤테로시클릭 아미드계 wnt 경로 억제제
WO2021146903A1 (fr) * 2020-01-21 2021-07-29 苏州信诺维医药科技股份有限公司 Forme cristalline d'un composé contenant de l'azote
EP4346827A1 (fr) * 2021-05-26 2024-04-10 Emory University Inhibiteurs de jak pour la gestion d'états chez des patients atteints du syndrome de down ou d'une autre trisomie
AU2022354321A1 (en) * 2021-09-29 2024-04-04 Repare Therapeutics Inc. N-(5-substituted-[(1,3,4-thiadiazolyl) or (thiazolyl)])(substituted)carboxamide compounds and use thereof for inhibiting human polymerase theta

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ES2585244T3 (es) 2016-10-04
IL229692A0 (en) 2014-01-30
WO2012172438A2 (fr) 2012-12-20
US8937065B2 (en) 2015-01-20
WO2012172438A3 (fr) 2013-03-28
JP2014520108A (ja) 2014-08-21
HRP20160879T1 (hr) 2016-09-23
CN103717593A (zh) 2014-04-09
CN103717593B (zh) 2016-07-06
BR112013031121A2 (pt) 2019-04-09
US20120316148A1 (en) 2012-12-13
PT2718290T (pt) 2016-07-14
MX355415B (es) 2018-04-18
EP2718290A2 (fr) 2014-04-16
CA2837268C (fr) 2020-05-12
DK2718290T3 (en) 2016-08-15
AU2012270029B2 (en) 2017-08-10
WO2012172438A9 (fr) 2013-02-07
BR112013031121B1 (pt) 2022-03-29
ZA201309042B (en) 2014-08-27
AU2012270029A1 (en) 2012-12-20
HUE028097T2 (en) 2016-11-28
CA2837268A1 (fr) 2012-12-20
MX2013014433A (es) 2014-02-27
HK1191324A1 (zh) 2014-07-25
EP2718290B1 (fr) 2016-05-04
AU2012270029A8 (en) 2014-01-30
IL229692A (en) 2017-04-30

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