JP6054379B2 - キナーゼをモジュレートするための組成物および方法 - Google Patents

キナーゼをモジュレートするための組成物および方法 Download PDF

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JP6054379B2
JP6054379B2 JP2014514164A JP2014514164A JP6054379B2 JP 6054379 B2 JP6054379 B2 JP 6054379B2 JP 2014514164 A JP2014514164 A JP 2014514164A JP 2014514164 A JP2014514164 A JP 2014514164A JP 6054379 B2 JP6054379 B2 JP 6054379B2
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ベッカー、オーレン・エム．
ブロッチ、イタイ
ベン—ゼーブ・エフラット
ベン―ゼーブ・エフラット
シトリット、アリーナ
ヤコバン、アビハイ
ガザル、シャロン
ベハル、ベレド
コンソン、アレクサンダー
シュッズ、ニリ
ミリラシュビリ、シマ
ゴラン、ガリ
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Clevexel Pharma
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014514164A 2011-06-07 2012-06-07 キナーゼをモジュレートするための組成物および方法 Active JP6054379B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161520256P 2011-06-07 2011-06-07
US61/520,256 2011-06-07
US201161562700P 2011-11-22 2011-11-22
US61/562,700 2011-11-22
US201261640139P 2012-04-30 2012-04-30
US61/640,139 2012-04-30
PCT/IB2012/001987 WO2012172438A2 (en) 2011-06-07 2012-06-07 Compositions and methods for modulating a kinase

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JP2014520108A JP2014520108A (ja) 2014-08-21
JP2014520108A5 JP2014520108A5 (cg-RX-API-DMAC7.html) 2015-06-11
JP6054379B2 true JP6054379B2 (ja) 2016-12-27

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KR102214225B1 (ko) * 2015-12-07 2021-02-10 쑤저우 시노벤트 파마슈티칼즈 씨오., 엘티디. 5원 헤테로시클릭 아미드계 wnt 경로 억제제
CA3099753A1 (en) 2018-05-29 2019-12-05 Omeros Corporation Masp-2 inhibitors and methods of use
AU2020356575A1 (en) 2019-09-27 2022-04-14 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
MX2022006750A (es) 2019-12-04 2022-06-14 Omeros Corp Inhibidores de masp-2 y metodos de uso.
WO2021146903A1 (zh) * 2020-01-21 2021-07-29 苏州信诺维医药科技股份有限公司 一种含氮化合物的晶型
EP4149548A4 (en) 2020-05-13 2024-05-08 Disc Medicine, Inc. ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS
AU2022280871A1 (en) * 2021-05-26 2023-12-07 Emory University Jak inhibitors for managing conditions in patients with down's syndrome or other trisomy
EP4408841A4 (en) * 2021-09-29 2025-08-20 Repare Therapeutics Inc N-([(L,3,4-THIADIAZOLYL) OR (THIAZOLYL)]-5-SUBSTITUTED)CARBOXAMIDE COMPOUNDS (SUBSTITUTED) AND THEIR USE FOR INHIBITING HUMAN THETA POLYMERASE
CN120344522A (zh) * 2022-09-29 2025-07-18 修复治疗公司 N-(5-取代的-[(1,3,4-噻二唑基)或(1,3-噻唑基)](取代的)甲酰胺化合物、药物组合物以及制备酰胺化合物的方法及其用途
EP4620949A1 (en) * 2024-03-18 2025-09-24 Eberhard Karls Universität Tübingen (Medizinische Fakultät) Ackr3 modulators for cardiovascular or antiplatelet therapy

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WO2012172438A9 (en) 2013-02-07
IL229692A0 (en) 2014-01-30
AU2012270029A8 (en) 2014-01-30
HRP20160879T1 (hr) 2016-09-23
MX2013014433A (es) 2014-02-27
CA2837268C (en) 2020-05-12
CN103717593A (zh) 2014-04-09
US20120316148A1 (en) 2012-12-13
IL229692A (en) 2017-04-30
DK2718290T3 (en) 2016-08-15
AU2012270029A1 (en) 2012-12-20
PL2718290T3 (pl) 2016-11-30
PT2718290T (pt) 2016-07-14
JP2014520108A (ja) 2014-08-21
AU2012270029B2 (en) 2017-08-10
HK1191324A1 (zh) 2014-07-25
WO2012172438A2 (en) 2012-12-20
EP2718290A2 (en) 2014-04-16
CN103717593B (zh) 2016-07-06
ZA201309042B (en) 2014-08-27
BR112013031121B1 (pt) 2022-03-29
CA2837268A1 (en) 2012-12-20
BR112013031121A2 (pt) 2019-04-09
US8937065B2 (en) 2015-01-20
WO2012172438A3 (en) 2013-03-28
MX355415B (es) 2018-04-18

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