JP6050242B2 - ピリドニルグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびその治療的使用 - Google Patents

ピリドニルグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびその治療的使用 Download PDF

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JP6050242B2
JP6050242B2 JP2013543340A JP2013543340A JP6050242B2 JP 6050242 B2 JP6050242 B2 JP 6050242B2 JP 2013543340 A JP2013543340 A JP 2013543340A JP 2013543340 A JP2013543340 A JP 2013543340A JP 6050242 B2 JP6050242 B2 JP 6050242B2
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JP2014505032A5 (enExample
JP2014505032A (ja
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ゲイリー・ディ・グリック
アレクサンダー・アール・ハード
マシュー・エヌ・マットソン
クラーク・ビー・テイラー
チャド・エイ・バンフイス
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Lycera Corp
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
JP2013543340A 2010-12-08 2011-12-08 ピリドニルグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびその治療的使用 Expired - Fee Related JP6050242B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42093410P 2010-12-08 2010-12-08
US61/420,934 2010-12-08
PCT/US2011/063945 WO2012078869A1 (en) 2010-12-08 2011-12-08 Pyridonyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof

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JP2014505032A JP2014505032A (ja) 2014-02-27
JP2014505032A5 JP2014505032A5 (enExample) 2015-01-29
JP6050242B2 true JP6050242B2 (ja) 2016-12-21

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US (2) US9000014B2 (enExample)
EP (1) EP2648710B1 (enExample)
JP (1) JP6050242B2 (enExample)
CN (1) CN103458886B (enExample)
AU (1) AU2011338304B2 (enExample)
CA (1) CA2820044A1 (enExample)
ES (1) ES2591156T3 (enExample)
IL (1) IL226790A (enExample)
MX (1) MX2013006398A (enExample)
WO (1) WO2012078869A1 (enExample)

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US9169199B2 (en) 2010-12-08 2015-10-27 Lycera Corporation Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
CA2820044A1 (en) 2010-12-08 2012-06-14 Lycera Corporation Pyridonyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
HRP20171280T1 (hr) 2010-12-08 2018-01-12 Lycera Corporation Pirazolilgvanidinski inhibitori f1f0-atpaze i njihova upotreba u terapiji
WO2013185045A1 (en) 2012-06-08 2013-12-12 Lycera Corporation Indazole guanidine f1f0-atpase inhibitors and therapeutic uses thereof
US9580391B2 (en) 2012-06-08 2017-02-28 Lycera Corporation Saturated acyl guanidine for inhibition of F1F0-ATPase
WO2013185048A2 (en) 2012-06-08 2013-12-12 Lycera Corporation Heterocyclic guanidine f1f0-atpase inhibitors and therapeutic uses thereof
WO2015089152A1 (en) 2013-12-10 2015-06-18 Lycera Corporation N-substituted pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
CA2931851A1 (en) 2013-12-10 2015-06-18 Lycera Corporation Trifluoromethyl pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
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CA2820044A1 (en) 2012-06-14
WO2012078869A1 (en) 2012-06-14
ES2591156T3 (es) 2016-11-25
AU2011338304B2 (en) 2016-10-27
JP2014505032A (ja) 2014-02-27
CN103458886B (zh) 2016-06-08
EP2648710B1 (en) 2016-06-15
US9000014B2 (en) 2015-04-07
MX2013006398A (es) 2013-12-02
US9370507B2 (en) 2016-06-21
US20150335625A1 (en) 2015-11-26
CN103458886A (zh) 2013-12-18
AU2011338304A1 (en) 2013-07-11

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