JP6047393B2 - Automatic analyzer with reagent storage and reagent storage - Google Patents
Automatic analyzer with reagent storage and reagent storage Download PDFInfo
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Description
本発明は、血液等の生体試料の成分を自動的に分析する自動分析装置において複数の試薬を保管する試薬保管庫、および、試薬保管庫を有する自動分析装置に関する。
The present invention relates to a reagent storage for storing a plurality of reagents in an automatic analyzer that automatically analyzes components of a biological sample such as blood, and an automatic analyzer having a reagent storage.
臨床検査における生化学分析や免疫分析等の化学分析を、自動で実行する分析装置が知られている。これらの自動分析装置には、分析で使用する試薬が変性して分析データが悪化しないよう、試薬がおさめられた試薬ボトルを冷却保管する機構を有した試薬保管庫を有しているものが多い。試薬の保冷方式は、主に下記に示す２種類の方式が存在する。 2. Description of the Related Art Analyzing apparatuses that automatically perform chemical analysis such as biochemical analysis and immunological analysis in clinical tests are known. Many of these automatic analyzers have a reagent storage with a mechanism for cooling and storing reagent bottles containing reagents so that the analysis data does not deteriorate due to denaturation of the reagents used in the analysis. . There are mainly two types of reagent cooling methods as shown below.
（冷却方式１）試薬保管庫の壁面内に冷却媒体を流通させ、壁面を介して試薬保管庫内の空気を冷却する方式。 (Cooling method 1) A method of circulating a cooling medium in the wall surface of the reagent storage and cooling the air in the reagent storage through the wall surface.
（冷却方式２）冷却装置によって冷却した空気を、ファンなどの循環装置を用いて試薬保管庫内部に循環させる方式（特許文献１，２）。
(Cooling method 2) A method in which air cooled by a cooling device is circulated inside a reagent storage using a circulation device such as a fan (Patent Documents 1 and 2).
前述した２種類の保冷方式のうち、前者の保管庫の壁面内に冷却媒体を流通させる保冷方式は、試薬ボトルの冷却効率が高くない。そのため、前者の場合、冷却装置の大型化を伴い、自動分析装置の大型化と製造コストの上昇が懸念される。 Of the two types of cooling systems described above, the cooling system in which the cooling medium is circulated in the wall surface of the former storage is not high in cooling efficiency of the reagent bottles. Therefore, in the former case, the size of the automatic analyzer is increased and the manufacturing cost is increased with the increase in size of the cooling device.
一方、後者の冷却空気を循環させる保冷方式は、前者の方式よりも試薬ボトルの冷却効率が優れている。しかし、同保冷方式の保管庫内に収納された試薬ボトルの吸引口に前記冷却空気が流入すると、試薬ボトル内の試薬が蒸発し、試薬が劣化する可能性がある。そのため、従来装置では、試薬吸引口を小型化し、同吸引口に冷却空気が流入することを防ぐことで対応している。 On the other hand, the cooling method of circulating the latter cooling air is superior to the former method in cooling the reagent bottle. However, if the cooling air flows into the suction port of the reagent bottle housed in the cold storage storage, the reagent in the reagent bottle may evaporate and the reagent may deteriorate. For this reason, in the conventional apparatus, the reagent suction port is reduced in size and the cooling air is prevented from flowing into the suction port.
ここで試薬ボトルは、試薬ボトル上面に設けられた試薬吸引口を開口した状態で試薬保管庫内に設置されることが多い。試薬ボトル内の試薬は、試薬分注機構に備えられた試薬分注ノズルによって、試薬吸引口を通じて吸引される。試薬分注ノズルが試薬ボトル内の試薬液面まで下降して試薬を吸引し、試薬吸引後に試薬ノズルが上昇し、所定の位置に試薬を吐出する。しかし、吸引口が小型化された前記試薬ボトルの場合、試薬吸引時に試薬分注ノズル先端に付着した試薬が、小型化された吸引口に付着する可能性がある。このような試薬ボトルに対して再度、試薬分注ノズルが試薬吸引動作を実施すると、吸引口に付着した試薬によって試薬分注ノズルが広範囲に汚れ、試薬ボトル間の試薬コンタミネーションが発生する可能性がある。 Here, the reagent bottle is often installed in the reagent storage with the reagent suction port provided on the upper surface of the reagent bottle opened. The reagent in the reagent bottle is sucked through the reagent suction port by the reagent dispensing nozzle provided in the reagent dispensing mechanism. The reagent dispensing nozzle descends to the reagent liquid level in the reagent bottle and sucks the reagent. After the reagent is sucked, the reagent nozzle rises and discharges the reagent to a predetermined position. However, in the case of the reagent bottle with the suction port reduced in size, there is a possibility that the reagent attached to the tip of the reagent dispensing nozzle at the time of reagent aspiration adheres to the reduced suction port. If the reagent dispensing nozzle performs the reagent aspirating operation again on such a reagent bottle, the reagent dispensing nozzle may be extensively contaminated by the reagent adhering to the suction port, and reagent contamination between the reagent bottles may occur. There is.
また、試薬コンタミネーションを回避するためには、試薬分注ノズルを広範囲に洗浄する必要があり、洗浄時間に長時間を要することになる。このことは自動分析装置の処理能力向上に悪影響を及ぼす可能性がある。 Further, in order to avoid reagent contamination, it is necessary to clean the reagent dispensing nozzle in a wide range, and a long cleaning time is required. This may adversely affect the processing capacity of the automatic analyzer.
上記の問題点に対して、例えば特許文献１では、試薬ボトルを設置するための複数の小区画を持った試薬保持ラックの材料と形状を工夫し、試薬ボトル吸引口が存在する空間と冷却空気が循環する空間を分割し、試薬ボトル吸引口に冷却空気が流入するのを防ぐ試薬保管庫が提案されている。しかしながら、特許文献１に記載の技術において、試薬ボトルは熱伝導性の材料が用いられた試薬保持ラックを経て冷却されるため、冷却効率がそれほど高くないという問題がある。 For example, in Patent Document 1, the material and shape of the reagent holding rack having a plurality of small sections for installing the reagent bottles are devised to solve the above problems, and the space where the reagent bottle suction port exists and the cooling air A reagent storage has been proposed that divides the space in which the air circulates and prevents cooling air from flowing into the reagent bottle suction port. However, in the technique described in Patent Document 1, since the reagent bottle is cooled through a reagent holding rack using a heat conductive material, there is a problem that the cooling efficiency is not so high.
特許文献２には、試薬ボトルを設置するための複数の小区画を持った試薬保持ラックと、試薬保管庫の内側の周壁形状を工夫し、試薬ボトルの吸引口に冷却空気が流入するのを防ぐ試薬保管庫が提案されている。しかしながら、特許文献２の試薬保持ラック内に試薬ボトルが設置されない小区画が存在する場合、その小区画を介して試薬ボトルの吸引口まで冷却空気が流入することとなり、試薬の蒸発・劣化を回避できない。 In Patent Document 2, a reagent holding rack having a plurality of small sections for installing reagent bottles and a peripheral wall shape inside the reagent storage are devised so that cooling air flows into the suction port of the reagent bottle. Preventing reagent storage has been proposed. However, when there is a small section in the reagent holding rack of Patent Document 2 where no reagent bottle is installed, cooling air flows into the reagent bottle suction port through the small section, thereby avoiding evaporation and deterioration of the reagent. Can not.
本発明の目的は、冷却効率のよい空冷方式の保冷方式の採用により、自動分析装置の小型化と低コスト化を行うことと、前記保冷方式を採用した自動分析装置の処理能力の向上を可能とする自動分析装置とその試薬保管庫を提供することにある。
The object of the present invention is to reduce the size and cost of an automatic analyzer by adopting an air-cooled cooling system with good cooling efficiency, and to improve the processing capacity of an automatic analyzer that employs the cooling system. It is to provide an automatic analyzer and its reagent storage.
上記に鑑みた本願発明の特徴は以下の通りである。 The features of the present invention in view of the above are as follows.
すなわち、分析に使用する試薬を収納し、吸引口を有する試薬ボトルを保持する試薬ラックと、前記試薬保管庫内部に温調した気体を循環させる循環装置と、前記試薬ラックの上部を開閉可能に覆う試薬保管庫蓋と、を備えた試薬保管庫であって、前記試薬ラックは、前記試薬ボトルを１つずつ設置し、かつ、当該試薬ボトルの少なくとも五面を覆う壁を有する複数の小区画と、前記試薬ボトルを前記小区画内に挿入するための小区画開口部と、前記試薬ボトルを温調するための温調空気が前記試薬ボトルの壁面に接触するよう、前記小区画の壁に設けられた温調用開口部と、を備え、前記試薬保管庫蓋は、前記小区画開口部を閉鎖することで、前記試薬ボトルの開口部に温調空気が流入することを防ぐことを特徴としている。
That is, a reagent rack for storing a reagent used for analysis and holding a reagent bottle having a suction port, a circulation device for circulating a temperature-controlled gas inside the reagent storage, and an upper part of the reagent rack can be opened and closed. A reagent storage comprising: a reagent storage lid that covers the plurality of small compartments each having the reagent bottle installed and having a wall covering at least five sides of the reagent bottle And a small compartment opening for inserting the reagent bottle into the small compartment and a wall of the small compartment so that temperature-controlled air for regulating the temperature of the reagent bottle contacts the wall surface of the reagent bottle. A temperature control opening provided, and the reagent storage lid prevents temperature control air from flowing into the opening of the reagent bottle by closing the small compartment opening. Yes.
本発明の試薬保管庫では、冷却効率に優れた保冷方式を採用することによって冷却装置の小型化と低コスト化が可能になる。また、前記保冷方式において、自動分析装置の処理能力向上が可能となる。
In the reagent storage of the present invention, it is possible to reduce the size and cost of the cooling device by adopting a cooling system with excellent cooling efficiency. Further, in the cold insulation system, the processing capacity of the automatic analyzer can be improved.
本発明の実施例を、図面に基づいて説明する。 Embodiments of the present invention will be described with reference to the drawings.
まず、図１を用いて自動分析装置の構成を説明する。図１は自動分析装置の全体構成を示した図である。 First, the configuration of the automatic analyzer will be described with reference to FIG. FIG. 1 is a diagram showing the overall configuration of the automatic analyzer.
図１において、自動分析装置は、試料と試薬を反応させる反応容器１と、該反応容器を環状に配列した反応ディスク２と、採血管など生体試料を収納した試料収納容器３と、分析で使用する試薬を安定的に保存するために、試薬が収納された試薬ボトル４を冷却保管する試薬保管庫５を持つ。なお、図１では二つの試薬保管庫５を備えているが、試薬保管庫の数は本発明においては特に限定するものではない。 In FIG. 1, an automatic analyzer is used for analysis in a reaction container 1 for reacting a sample and a reagent, a reaction disk 2 in which the reaction containers are arranged in an annular shape, a sample storage container 3 for storing a biological sample such as a blood collection tube. In order to stably store the reagent to be stored, a reagent storage 5 is provided for storing the reagent bottle 4 in which the reagent is stored. Although two reagent storages 5 are provided in FIG. 1, the number of reagent storages is not particularly limited in the present invention.
試料分注機構６は、試料収納容器３から所定量の試料を吸引し、反応容器１に吐出する。試薬分注機構７は、試薬ボトル４から所定量の試薬を吸引し、前記の反応容器１に吐出する。この反応容器１内の試料と試薬は撹拌機構８により撹拌混合される。反応容器内の混合液は、反応ディスク外周に設置した分光光度計９により吸光度を測定し、測定結果から生体試料内の各成分を算出する。分析が終了した反応容器は、反応容器洗浄機構１０により洗浄され、再度分析に利用される。 The sample dispensing mechanism 6 sucks a predetermined amount of sample from the sample storage container 3 and discharges it to the reaction container 1. The reagent dispensing mechanism 7 sucks a predetermined amount of reagent from the reagent bottle 4 and discharges it to the reaction container 1. The sample and the reagent in the reaction vessel 1 are stirred and mixed by the stirring mechanism 8. The mixed solution in the reaction vessel is measured for absorbance with a spectrophotometer 9 installed on the outer periphery of the reaction disk, and each component in the biological sample is calculated from the measurement result. The reaction vessel that has been analyzed is washed by the reaction vessel washing mechanism 10 and used again for analysis.
次に、図２と図３を用いて前記自動分析装置における試薬保管庫の構成を説明する。 Next, the configuration of the reagent storage in the automatic analyzer will be described with reference to FIGS.
図２は試薬保管庫５を真上から見た図である。図３は図２の試薬保管庫５におけるＡ−Ａ線矢視断面図である。 FIG. 2 is a view of the reagent storage 5 as viewed from directly above. 3 is a cross-sectional view taken along line AA in the reagent storage 5 of FIG.
試薬保管庫は、試薬ボトル４を設置するための小区画１１が複数個設けられた試薬保持ラック１２と、この試薬保持ラック１２を収納する略筒形状に形成された周壁を有する試薬ジャケット１３と、試薬ジャケット１３上部開口を覆う開閉可能な試薬保管庫フタ１４、試薬ラック１２を回転駆動させる駆動部１７を持つ。本実施例では、試薬ラックは円周上に複数の試薬ボトル４を保持可能となるよう、複数の小区画が形成されている構成である。一つの小区画には一つの試薬ボトルを挿入可能である。 The reagent storage has a reagent holding rack 12 provided with a plurality of small compartments 11 for installing the reagent bottles 4, and a reagent jacket 13 having a substantially cylindrical wall for accommodating the reagent holding rack 12. The reagent jacket 13 has an openable / closable reagent storage lid 14 that covers the upper opening of the reagent jacket 13, and a drive unit 17 that rotationally drives the reagent rack 12. In this embodiment, the reagent rack has a configuration in which a plurality of small sections are formed so that a plurality of reagent bottles 4 can be held on the circumference. One reagent bottle can be inserted into one small compartment.
各試薬ボトルはボトル上面に試薬の吸引を行うための試薬吸引口１５を有しており、各試薬ボトルは前記吸引口が開口された状態で各小区画内に挿入される。試薬保管庫フタ１４の所定の位置には試薬吸引孔１６が備えられており、試薬吸引時には駆動部１７が試薬保持ラック１２を回転させて、任意の試薬ボトル４の試薬吸引口１５を前記吸引孔に移動させる。 Each reagent bottle has a reagent suction port 15 for aspirating the reagent on the upper surface of the bottle, and each reagent bottle is inserted into each small section with the suction port opened. A reagent suction hole 16 is provided at a predetermined position of the reagent storage lid 14, and when the reagent is sucked, the driving unit 17 rotates the reagent holding rack 12 to suck the reagent suction port 15 of any reagent bottle 4. Move to hole.
前記吸引孔に移動された試薬ボトル４内の試薬は試薬分注ノズルを用い、試薬吸引口１５を通じて吸引される。試薬ジャケット１３と試薬保管庫フタ１４により形成される試薬保管庫内部１８の空気は、冷却装置１９により冷却され、循環装置２０により試薬保管庫内部１８を循環して試薬ボトル４を冷却する。そのため、試薬ラック１４の外側には冷却空気が循環するためのスペースが設けられている。 The reagent in the reagent bottle 4 moved to the suction hole is sucked through the reagent suction port 15 using a reagent dispensing nozzle. The air inside the reagent storage 18 formed by the reagent jacket 13 and the reagent storage lid 14 is cooled by the cooling device 19, and circulates inside the reagent storage 18 by the circulation device 20 to cool the reagent bottle 4. Therefore, a space for circulating cooling air is provided outside the reagent rack 14.
次に、図４と図５を用いて前記試薬保管庫の内部構成を説明する。 Next, the internal configuration of the reagent storage will be described with reference to FIGS.
図４は図３における試薬保持ラック１２が備える小区画１１の拡大図である。図５は前記小区画１１を斜めから見た図である。 FIG. 4 is an enlarged view of the small section 11 provided in the reagent holding rack 12 in FIG. FIG. 5 is a view of the small section 11 as viewed obliquely.
試薬ボトルは小区画１１の上面に設けられた挿入用開口部２１を通じて、小区画１１内に挿入される。各小区画１１の側面および底面は、挿入される試薬ボトル側面および底面と極めて近接するように構成されている。また、各小区画１１において、小区画１１内に挿入された試薬ボトル４の試薬吸引口１５よりも下部に冷却用開口部２２が設けられている。例えば、図４のように直方体の容器本体の上面に試薬吸引口１５が設けられているような試薬ボトル形状の場合、冷却用開口部２２は、側方から見た試薬ボトル４の肩よりも下方に位置している必要がある。図４の場合においては、冷却用開口部２２として、小区画１１の側面に一つ、底面に三つ開口部が設けられている。 The reagent bottle is inserted into the small section 11 through the insertion opening 21 provided on the upper surface of the small section 11. The side surface and the bottom surface of each small section 11 are configured to be very close to the side surface and the bottom surface of the reagent bottle to be inserted. In each small section 11, a cooling opening 22 is provided below the reagent suction port 15 of the reagent bottle 4 inserted in the small section 11. For example, in the case of the reagent bottle shape in which the reagent suction port 15 is provided on the upper surface of the rectangular parallelepiped container body as shown in FIG. 4, the cooling opening 22 is more than the shoulder of the reagent bottle 4 seen from the side. Must be located below. In the case of FIG. 4, the cooling opening 22 is provided with one opening on the side surface of the small section 11 and three openings on the bottom surface.
小区画に挿入される試薬ボトル４は、前記冷却用開口部を介して、試薬保管庫内を循環する冷却空気が直接あたる構造となっており、冷却空気による効率的な冷却を行うことができる。 The reagent bottle 4 inserted into the small compartment has a structure in which the cooling air circulating in the reagent storage is directly applied through the cooling opening, and can be efficiently cooled by the cooling air. .
また、試薬ボトル４が各小区画１１内に挿入されると、冷却用開口部２２は試薬ボトル４自身の外壁によって塞がれる。そのため、冷却空気は小区画１１の外部を循環するのみであり、冷却空気が小区画内部に入り込むことはない。 Further, when the reagent bottle 4 is inserted into each of the small sections 11, the cooling opening 22 is blocked by the outer wall of the reagent bottle 4 itself. Therefore, the cooling air only circulates outside the small section 11, and the cooling air does not enter the small section.
試薬ボトル４が小区画１１内に挿入されない場合には、冷却用開口部２２を介して冷却空気が空いている小区画１１内に入り込む。しかしこの場合でも、試薬保管庫フタ１４を閉めることで、小区画１１の試薬ボトル挿入用開口部２１が塞がれるように構成されているので、空いている小区画１１内に入り込んだ冷却空気は、試薬容器が挿入されている他の小区画１１に流入することはない。なお、このため、小区画１１の挿入用開口部２１は、試薬保持ラック１２の回転駆動を邪魔せず、かつ、試薬保管庫フタ１４と冷却空気が流入しない程度の隙間２３を形成するように構成されている。 When the reagent bottle 4 is not inserted into the small compartment 11, the cooling air enters the empty small compartment 11 through the cooling opening 22. However, even in this case, since the reagent bottle insertion opening 21 of the small section 11 is closed by closing the reagent storage lid 14, the cooling air that has entered the vacant small section 11 is formed. Does not flow into the other small compartment 11 in which the reagent container is inserted. For this reason, the insertion opening 21 of the small section 11 does not interfere with the rotational drive of the reagent holding rack 12 and forms a gap 23 that does not allow cooling air to flow into the reagent storage lid 14. It is configured.
このように試薬ラック１２、小区画１１、試薬保管庫フタ１４を構成することにより、試薬ボトル４は冷却空気により冷却保管されるが、小区間内の試薬ボトル吸引口１５には冷却空気が流入することはない。そのため、試薬ボトル内の試薬の蒸発や劣化を防ぐことができる。
By configuring the reagent rack 12, the small section 11, and the reagent storage lid 14 in this way, the reagent bottle 4 is cooled and stored by cooling air, but the cooling air flows into the reagent bottle suction port 15 in the small section. Never do. Therefore, evaporation and deterioration of the reagent in the reagent bottle can be prevented.
以下、図６及び図７及び図８を用いて本実施例の第２実施例に係る自動分析装置の試薬保管庫を説明する。 Hereinafter, the reagent storage of the automatic analyzer according to the second embodiment of the present embodiment will be described with reference to FIGS. 6, 7, and 8.
図６は試薬保管庫を斜めから見た図である。図７は試薬保管庫の断面図である。 FIG. 6 is a view of the reagent storage when viewed from an oblique direction. FIG. 7 is a cross-sectional view of the reagent storage.
試薬保管庫は、試薬ボトル４を設置するための小区画１１が設けられた試薬保持引き出し２４と、前記試薬保持引き出しを収納する角筒形状の試薬保管筒体２５を持つ。試薬保管筒体内部の空気は、冷却装置１９により冷却され、循環装置２０により空間内部を循環する。 The reagent storage has a reagent holding drawer 24 provided with a small section 11 for installing the reagent bottle 4 and a rectangular cylindrical reagent storage cylinder 25 for storing the reagent holding drawer. The air inside the reagent storage cylinder is cooled by the cooling device 19 and circulated in the space by the circulation device 20.
試薬ボトルは、前記小区画に設けられた試薬ボトル挿入用開口部２１を通じて小区画内に挿入される。本実施例では、試薬ボトル挿入用開口部２１の面積は試薬ボトルも大きい。そのため、オペレータが試薬ボトルの側面をつかんだ状態で、試薬ボトルを、試薬ボトル挿入用開口部２１を介して小区画１１内に挿入および取り出ししやすくしている。 The reagent bottle is inserted into the small compartment through the reagent bottle insertion opening 21 provided in the small compartment. In this embodiment, the reagent bottle insertion opening 21 has a large area for the reagent bottle. Therefore, the reagent bottle can be easily inserted into and removed from the small section 11 through the reagent bottle insertion opening 21 while the operator grasps the side surface of the reagent bottle.
また、試薬ボトル４の四方の側面は小区画１１内の壁面２７と極めて近接している。挿入された試薬ボトルは、前記小区画内の壁面２７もしくは底面に設けられた冷却用開口部２２を通じて、試薬保管庫２５内を循環する冷却空気が直接噴きつけられるため、効率的な冷却が可能となる。なお、本実施例においても実施例１と同様に、冷却用開口部２２からの空気が小区画内部に入り込まないよう、冷却用開口部２２は試薬ボトルの開口部よりも下方（試薬ボトルの肩よりも下）に設けられている。 Further, the four side surfaces of the reagent bottle 4 are extremely close to the wall surface 27 in the small section 11. The inserted reagent bottle can be efficiently cooled because the cooling air circulating in the reagent storage 25 is directly sprayed through the cooling opening 22 provided on the wall surface 27 or the bottom surface in the small compartment. It becomes. In this embodiment, similarly to the first embodiment, the cooling opening 22 is located below the opening of the reagent bottle (the shoulder of the reagent bottle) so that the air from the cooling opening 22 does not enter the small compartment. Below).
小区画１１内に挿入された試薬ボトルの開口部は、試薬保持引き出し２４が試薬保管庫２５に収納されることで、試薬保管庫内壁面２７と、小区画１１、および試薬ボトル自体の外壁によって、冷却空気の流入を制限した保存状態となる。このとき、試薬保管筒体内の小区画開口部２６と接する試薬保管庫内壁面２７と、小区画の試薬ボトル挿入用開口部２１の上面との間はわずかな隙間２３のみが存在し、ほぼ近接している状態である。このとき、挿入された試薬ボトル４上面にある試薬吸引口１５には保管庫内を循環する冷却空気が流入せず、同試薬ボトル内の試薬が蒸発し、試薬が劣化するのを防ぐことができる。 The opening of the reagent bottle inserted into the small section 11 is formed by the reagent holding drawer 24 being housed in the reagent storage 25, so that the reagent storage inner wall 27, the small section 11, and the outer wall of the reagent bottle itself In this state, the cooling air flow is limited. At this time, there is only a slight gap 23 between the reagent storage inner wall surface 27 in contact with the small compartment opening 26 in the reagent storage cylinder and the upper surface of the reagent bottle insertion opening 21 in the small compartment, and it is almost close. It is in a state of being. At this time, it is possible to prevent the cooling air circulating in the storage from flowing into the reagent suction port 15 on the upper surface of the inserted reagent bottle 4 and preventing the reagent in the reagent bottle from evaporating and deteriorating. it can.
上記保管庫は、試薬分注機構を備えており、配置された任意の試薬ボトル内部から試薬を吸引できるように構成されている。なお、小区画１１を駆動させることなく、試薬分注機構が全ての小区画１１にアクセス可能となるように構成している場合には、隙間２３を備えず、小区画１１と試薬保管庫内壁面２３が密閉する様に構成しても良い。 The storage is provided with a reagent dispensing mechanism, and is configured so that the reagent can be sucked from the inside of any of the arranged reagent bottles. When the reagent dispensing mechanism is configured to be accessible to all the small compartments 11 without driving the small compartments 11, the gaps 23 are not provided, and the small compartments 11 and the reagent storage compartment are not provided. You may comprise so that the wall surface 23 may seal.
なお、上記二つの実施例では、試薬容器を冷却する機構について説明したが、本発明では当該用途に限定されるものではない。すなわち、試薬を加温する場合であっても同様の構成をすることで試薬の蒸発および劣化を防止した試薬保管庫を提供することが可能となる。 In the above two embodiments, the mechanism for cooling the reagent container has been described. However, the present invention is not limited to this application. That is, even when the reagent is heated, it is possible to provide a reagent storage that prevents the reagent from evaporating and deteriorating by adopting the same configuration.
また、試薬に限定されず、複数の試料容器を空気により温調しながら保管する試料保管庫に適用することも可能である。この場合は、試料容器を１つずつ保持する小区画を有し、当該小区画の適切な位置に温調用の開口部を備え、この温調用開口部を介して試料容器を温調する構成となる。
Moreover, it is not limited to a reagent, It is also possible to apply to the sample storage store | warehouse | chamber in which several sample containers are stored, adjusting temperature with air. In this case, there is a small section for holding the sample containers one by one, a temperature adjustment opening is provided at an appropriate position of the small section, and the temperature of the sample container is adjusted via the temperature adjustment opening. Become.
１ 反応容器
２ 反応ディスク
３ 試料収納容器
４ 試薬ボトル
５ 試薬保管庫
６ 試料分注機構
７ 試薬分注機構
８ 撹拌機構
９ 分光光度計
１０ 反応容器洗浄機構
１１ 小区画
１２ 試薬保持ラック
１３ 試薬ジャケット
１４ 試薬保管庫フタ
１５ 試薬吸引口
１６ 試薬吸引孔
１７ 駆動部
１８ 試薬保管庫内部
１９ 冷却装置
２０ 循環装置
２１ 挿入用開口部
２２ 冷却用開口部
２３ 隙間
２４ 試薬保持引き出し
２５ 角筒形状試薬保管庫
２６ 小区画開口部と接する試薬保管庫壁面
２７ 小区画内壁面
DESCRIPTION OF SYMBOLS 1 Reaction container 2 Reaction disk 3 Sample storage container 4 Reagent bottle 5 Reagent storage 6 Sample dispensing mechanism 7 Reagent dispensing mechanism 8 Stirring mechanism 9 Spectrophotometer 10 Reaction container washing mechanism 11 Subdivision 12 Reagent holding rack 13 Reagent jacket 14 Reagent storage lid 15 Reagent suction port 16 Reagent suction hole 17 Drive unit 18 Inside reagent storage 19 Cooling device 20 Circulating device 21 Opening opening 22 Cooling opening 23 Clearance 24 Reagent holding drawer 25 Square tube shaped reagent storage 26 Reagent storage wall in contact with the small compartment opening 27 Inside wall of the small compartment
Claims (5)
前記試薬ラックを内部に収容し、上部に開口を有する試薬ジャケットと、
前記試薬ジャケットの開口を開閉可能に覆う試薬保管庫蓋と、
前記試薬ジャケット内の空間に温調気体を循環させる循環装置と、を備えた試薬保管庫であって、
前記試薬ラックは、
側面および底面を壁によって囲まれた領域内に前記試薬ボトルを１つずつ収容可能であって、かつ前記試薬ボトルを挿入するための開口部を上方に有する小区画を有し、
前記小区画はさらに、前記試薬ボトルを温調するための温調気体が前記試薬ボトルの壁面に接触するよう、前記壁の一部に温調用開口部を有し、
前記試薬保管庫蓋が前記小区画開口部を閉鎖し、かつ前記温調用開口部が前記小区画内に収容された試薬ボトルの吸引口よりも下方に設けられていることで、前記試薬ボトルの開口部に温調気体が流入することを防ぐことを特徴とする試薬保管庫。
A reagent rack for storing reagents used for analysis and holding reagent bottles having suction ports;
A reagent jacket containing the reagent rack therein and having an opening at the top;
A reagent storage lid that covers the opening of the reagent jacket so as to be openable and closable;
A reagent storage comprising a circulation device that circulates a temperature-controlled gas in a space in the reagent jacket ,
The reagent rack is
The reagent bottles can be accommodated one by one in a region surrounded by walls on the side surface and the bottom surface , and has a small section having an opening upward for inserting the reagent bottle,
The small compartment Furthermore, as the temperature control gas for temperature control of the reagent bottle is in contact with the wall surface of the reagent bottle has a temperature control opening in a part of the wall,
The reagent container lid closes the cubicle opening and the than the suction port of the contained reagent bottle to the temperature adjustment opening the small compartment that is provided below, the reagent bottle A reagent storage characterized by preventing temperature-controlled gas from flowing into the opening.
前記小区画の外部であって当該試薬ジャケット内の空間に温調気体が循環する領域を有することを特徴とする試薬保管庫。
In the reagent storage according to claim 1,
A reagent storage, characterized in that it has a region outside the small compartment and in which the temperature-controlled gas circulates in a space inside the reagent jacket .
前記開口部の外形は、少なくとも一部で挿入される試薬ボトルの外形よりも大きいことを特徴とする試薬保管庫。
In the reagent storage according to claim 1,
The reagent storage, wherein the outer shape of the opening is larger than the outer shape of a reagent bottle inserted at least in part.
前記試薬保管庫内の試薬ボトルから試薬を吸引する試薬吸引機構と、
前記試薬吸引機構により吸引された試薬を用いてサンプルの分析を行う分析機構と、
を備えたことを特徴とする自動分析装置。
Reagent storage in any one of Claims 1-3 ,
A reagent suction mechanism for sucking a reagent from a reagent bottle in the reagent storage;
An analysis mechanism for analyzing a sample using the reagent sucked by the reagent suction mechanism;
An automatic analyzer characterized by comprising:
前記試薬保管庫蓋は、前記試薬吸引機構による試薬の吸引を行う位置に試薬吸引口を有し、
前記試薬吸引口の下方に、前記試薬保管庫内に保管された任意の試薬ボトルを収容した小区画を移動させるよう、前記試薬ラックを駆動する駆動機構を備えたことを特徴とする自動分析装置。 The automatic analyzer according to claim 4 ,
The reagent storage lid has a reagent suction port at a position where the reagent is sucked by the reagent suction mechanism,
An automatic analyzer comprising a drive mechanism for driving the reagent rack so as to move a small section containing an arbitrary reagent bottle stored in the reagent storage below the reagent suction port. .
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| JP7100985B2 (en) * | 2018-01-25 | 2022-07-14 | シスメックス株式会社 | Method of circulating air in the sample measuring device and reagent storage |
| JP6959875B2 (en) | 2018-01-25 | 2021-11-05 | シスメックス株式会社 | Specimen measuring device, reagent container and sample measuring method |
| JP7140545B2 (en) * | 2018-05-17 | 2022-09-21 | キヤノンメディカルシステムズ株式会社 | Reagent storage and automatic analyzer |
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