JP6046058B2 - 可逆的なイオン及び分子検出又は移動用ナノポアデバイス - Google Patents

可逆的なイオン及び分子検出又は移動用ナノポアデバイス Download PDF

Info

Publication number
JP6046058B2
JP6046058B2 JP2013556907A JP2013556907A JP6046058B2 JP 6046058 B2 JP6046058 B2 JP 6046058B2 JP 2013556907 A JP2013556907 A JP 2013556907A JP 2013556907 A JP2013556907 A JP 2013556907A JP 6046058 B2 JP6046058 B2 JP 6046058B2
Authority
JP
Japan
Prior art keywords
nanopipette
nanopore
current
polymer
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013556907A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014508300A5 (enExample
JP2014508300A (ja
Inventor
ポウルマンド ナダル
ポウルマンド ナダル
ビロズニー ボアズ
ビロズニー ボアズ
アクティス パオロ
アクティス パオロ
アダム セガール アール
アダム セガール アール
シンガラム バクタン
シンガラム バクタン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Los Angeles UCLA
Original Assignee
University of California San Diego UCSD
University of California Los Angeles UCLA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD, University of California Los Angeles UCLA filed Critical University of California San Diego UCSD
Publication of JP2014508300A publication Critical patent/JP2014508300A/ja
Publication of JP2014508300A5 publication Critical patent/JP2014508300A5/ja
Application granted granted Critical
Publication of JP6046058B2 publication Critical patent/JP6046058B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4166—Systems measuring a particular property of an electrolyte
    • G01N27/4167—Systems measuring a particular property of an electrolyte pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/49—Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
    • G01Q60/44—SICM [Scanning Ion-Conductance Microscopy] or apparatus therefor, e.g. SICM probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0896—Nanoscaled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Electrochemistry (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2013556907A 2011-03-04 2012-03-02 可逆的なイオン及び分子検出又は移動用ナノポアデバイス Expired - Fee Related JP6046058B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449379P 2011-03-04 2011-03-04
US61/449,379 2011-03-04
PCT/US2012/027531 WO2012122029A2 (en) 2011-03-04 2012-03-02 Nanopore device for reversible ion and molecule sensing or migration

Publications (3)

Publication Number Publication Date
JP2014508300A JP2014508300A (ja) 2014-04-03
JP2014508300A5 JP2014508300A5 (enExample) 2016-06-30
JP6046058B2 true JP6046058B2 (ja) 2016-12-14

Family

ID=46752618

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013556907A Expired - Fee Related JP6046058B2 (ja) 2011-03-04 2012-03-02 可逆的なイオン及び分子検出又は移動用ナノポアデバイス

Country Status (6)

Country Link
US (4) US8980073B2 (enExample)
EP (1) EP2681542B1 (enExample)
JP (1) JP6046058B2 (enExample)
KR (1) KR101923241B1 (enExample)
CN (2) CN103502804B (enExample)
WO (1) WO2012122029A2 (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2276812B1 (en) 2008-04-30 2016-06-29 Wright Advanced Asphalt Systems System and method for pre-treatment of rubber-modified asphalt cement, and emulsions thereof
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
CN102216382B (zh) 2008-09-24 2014-06-18 莱特高级沥青系统公司 高生产量制备橡胶改性的沥青膏的系统和方法
JP5998148B2 (ja) 2010-11-16 2016-09-28 ナブシス ２．０ エルエルシー ハイブリダイズされたプローブの相対位置を検出することによる生体分子のシークエンシングのための方法
US11274341B2 (en) 2011-02-11 2022-03-15 NABsys, 2.0 LLC Assay methods using DNA binding proteins
WO2012122029A2 (en) 2011-03-04 2012-09-13 The Regents Of The University Of California Nanopore device for reversible ion and molecule sensing or migration
US10006879B2 (en) 2011-04-12 2018-06-26 Electronic Biosciences, Inc. Site specific chemically modified nanopore devices
WO2013192178A1 (en) * 2012-06-18 2013-12-27 Electronic Biosciences Inc. Cell-free assay device and methods of use
US9810688B2 (en) * 2013-03-15 2017-11-07 Robert Bosch Gmbh Smart glass slide for microarrays
US9874538B2 (en) 2012-07-06 2018-01-23 Robert Bosch Gmbh Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
US9910008B2 (en) 2012-07-06 2018-03-06 Robert Bosch Gmbh Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
US9021864B2 (en) * 2012-08-21 2015-05-05 International Business Machines Corporation Sensing biomolecules using scanning probe with twin-nanopore to detect a change in the magnitude of the current through the second nanopore
RU2510017C1 (ru) * 2012-10-25 2014-03-20 Федеральное государственное бюджетное учреждение высшего профессионального образования "Национальный исследовательский Томский политехнический университет" Способ определения аскорбата кальция в биологически активных добавках методом вольтамперометрии
US9914966B1 (en) * 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
US9791453B2 (en) 2012-12-26 2017-10-17 International Business Machines Corporation Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels
WO2014113557A1 (en) 2013-01-18 2014-07-24 Nabsys, Inc. Enhanced probe binding
JP6453300B2 (ja) 2013-03-14 2019-01-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞内分析のためのナノピペット装置および方法
US9753009B2 (en) 2013-04-17 2017-09-05 Revalesio Corporation Methods and apparatus for trapping and size resolution of nanoparticles and nanobubbles
JP2016519773A (ja) * 2013-04-17 2016-07-07 リバルシオ コーポレイション 円錐体のナノ細孔におけるナノバブル及びナノ粒子動態の制御
WO2014189960A1 (en) * 2013-05-22 2014-11-27 University Of Notre Dame Du Lac Method and apparatus for a nanopipette biosensor
US20150037787A1 (en) * 2013-07-31 2015-02-05 International Business Machines Corporation Polynucleotide configuration for reliable electrical and optical sensing
US10597702B2 (en) * 2013-08-26 2020-03-24 Ontera Inc. Molecule detection using boronic acid substituted probes
US9303310B2 (en) 2013-10-15 2016-04-05 International Business Machines Corporation Nanofluidic sensor comprising spatially separated functional sensing components
US10024851B2 (en) 2013-10-15 2018-07-17 International Business Machines Corporation Use of disulfide bonds to form a reversible and reusable coating for nanofluidic devices
US9255321B2 (en) 2013-10-15 2016-02-09 Globalfoundries Inc. Directed surface functionalization on selected surface areas of topographical features with nanometer resolution
WO2015061371A1 (en) * 2013-10-21 2015-04-30 Northeastern University Compositions and methods for measurement of analytes
EP3105572B1 (en) 2014-02-13 2019-04-10 Robert Bosch GmbH Capacitive bubble detection
WO2015130874A1 (en) * 2014-02-26 2015-09-03 University Of Central Florida Research Foundation, Inc. Capillary ionic transistor
US10335781B2 (en) 2014-05-16 2019-07-02 Konkuk University Industrial Cooperation Corp Nanopipette provided with membrane containing saturated ion-sensitive material, method for preparing same, and ion measuring apparatus comprising same
DE102014007519A1 (de) * 2014-05-22 2015-11-26 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zur Bestimmung des zentralen systolischen Blutdrucks
US9921181B2 (en) 2014-06-26 2018-03-20 International Business Machines Corporation Detection of translocation events using graphene-based nanopore assemblies
JP6401588B2 (ja) * 2014-11-28 2018-10-10 株式会社アドバンテスト 電流測定装置および塩基配列解析装置、測定用チップ
CN107407657A (zh) * 2015-02-25 2017-11-28 加利福尼亚大学董事会 单个细胞胞内纳米ph探针
GB201508003D0 (en) * 2015-05-11 2015-06-24 Oxford Nanopore Tech Ltd Apparatus and methods for measuring an electrical current
GB201510322D0 (en) * 2015-06-12 2015-07-29 Imp Innovations Ltd Apparatus and method
US11867660B2 (en) 2015-07-06 2024-01-09 Robert Bosch Gmbh Electronic control of the pH of a solution close to an electrode surface
US10379080B2 (en) 2015-07-06 2019-08-13 Robert Bosch Gmbh Electronic control of the pH of a solution close to an electrode surfaces
US10011549B2 (en) 2015-07-06 2018-07-03 Robert Bosch Gmbh Electrochemically active agents for pH modulation in biological buffers
EP3472340B1 (en) 2016-06-15 2023-08-16 Eastman Chemical Company Physical vapor deposited biosensor components
KR102547061B1 (ko) 2016-09-16 2023-06-22 이스트만 케미칼 컴파니 물리적 증착에 의해 제조된 바이오센서 전극
WO2018052711A1 (en) 2016-09-16 2018-03-22 Eastman Chemical Company Biosensor electrodes prepared by physical vapor deposition
CN107884329B (zh) * 2016-09-29 2020-03-10 中国科学院化学研究所 检测单颗粒的方法和装置
US11559817B2 (en) 2017-05-17 2023-01-24 University Of Cincinnati Using electrokinetic forces to manipulate suspended particles
CA3178751C (en) * 2017-06-20 2025-11-18 Illumina, Inc. NANOPORE SEQUENCERS
US11881549B2 (en) 2017-06-22 2024-01-23 Eastman Chemical Company Physical vapor deposited electrode for electrochemical sensors
CN107356580B (zh) * 2017-06-27 2020-04-03 南京大学 一种基于单分散纳米片层的纳米单孔及其制备方法和应用
CN107505379B (zh) * 2017-08-16 2019-06-11 中国科学院植物研究所 一种毛细管电泳分离小麦醇溶蛋白的方法
US11325987B2 (en) 2017-10-11 2022-05-10 Arizona Board Of Regents On Behalf Of Arizona State University Solid state nanopores aided by machine learning for identification and quantification of heparins and glycosaminoglycans
CN107991374B (zh) * 2017-11-30 2019-12-10 江苏省农业科学院 基于CS-Zn NPs传感器检测肉品中肌动蛋白的方法
US12196750B2 (en) * 2018-02-12 2025-01-14 The Regents Of The University Of California Methods for simultaneous detection of analytes and apparatuses for practicing same
CN108919844A (zh) * 2018-05-15 2018-11-30 电子科技大学 一种化学反应速率实时溶液浓度自动控制系统
KR102086107B1 (ko) * 2018-05-31 2020-03-06 건국대학교 산학협력단 포화된 이온감지물질을 포함하는 막을 구비하는 나노피펫
KR102086414B1 (ko) * 2018-05-31 2020-03-09 건국대학교 산학협력단 포화된 이온감지물질을 포함하는 막을 구비하는 나노피펫의 제조방법
JP6989183B2 (ja) * 2018-08-09 2022-01-05 ビービービー インコーポレイテッド 磁性ナノ粒子を用いるバイオセンサー、これを用いる検出装置及び検出方法
US11181501B2 (en) 2018-09-11 2021-11-23 City University Of Hong Kong Method and an apparatus for determining a presence or an amount of a polyamine or its derivative in a sample
WO2020092464A1 (en) 2018-10-30 2020-05-07 The Research Foundation For The State University Of New York Compositions and methods for removal of negatively charged impurities using metal-cellulose fiber composite
EP3835755A4 (en) * 2019-03-12 2022-05-04 Tohoku University Endotoxin detection device and endotoxin detection method
US20200326325A1 (en) 2019-04-12 2020-10-15 Lisa Diamond Nanosensor chip with compound nanopores
CN110132921B (zh) * 2019-05-16 2021-09-14 中国科学院重庆绿色智能技术研究院 一种基于针尖纳米孔单分子检测技术的实时监控酶切反应的方法
CN110132947B (zh) * 2019-06-14 2021-09-28 福州大学 一种锥形微米孔表面电荷密度调控电致化学发光信号的方法
CN110606463A (zh) * 2019-07-24 2019-12-24 西北工业大学 制备基于固态纳米孔的对温度和pH双重响应的纳米流体二极管的方法
WO2021133339A2 (en) * 2019-12-26 2021-07-01 Ege Universitesi Carbohydrate polymer-based sensor and method for developing this sensor
US20230236147A1 (en) * 2020-05-27 2023-07-27 Jose Maria Piccinini Sensors and systems based on field-effect transistors, methods of preparation and devices for their operation
CN112851821B (zh) * 2021-01-12 2022-07-05 山东省科学院生物研究所 一种融合酶及所述融合酶在纸基生物传感器中的应用
CN112746289B (zh) * 2021-01-21 2021-11-09 合肥工业大学 一种烷基硼酸酯类化合物的合成方法
US11994484B2 (en) * 2021-03-25 2024-05-28 The Regents Of The University Of California Apparatus and method for single cell discrimination
JP2024540851A (ja) * 2021-10-09 2024-11-06 ナンジン、ユニバーシティ 反応性不均一ナノ細孔による単一分子同定
CN114166911B (zh) * 2021-11-17 2023-12-12 大连民族大学 基于微流控的海洋金属离子检测系统及电化学传感器的涂料的制备方法
CN114965646B (zh) * 2022-05-20 2023-08-29 复旦大学 基于超组装策略得到的mc/aao/ms纳米通道膜在离子存储与释放的应用
CN116223589B (zh) * 2023-02-22 2025-11-21 海南大学 基于盐差转换的盐溶液pH检测装置及方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4384075A (en) 1981-12-11 1983-05-17 Owens-Corning Fiberglas Corporation Cationic alkenyl azabenzene and rubber modified asphalts
ZA889546B (en) * 1987-12-24 1990-08-29 Igen Inc Chemical sensors employing catalytic antibodies
US5447617A (en) * 1994-01-25 1995-09-05 Beckman Instruments, Inc. Coated capillary columns and electrophoretic separation methods for their use
ES2312490T3 (es) * 2000-12-11 2009-03-01 President And Fellows Of Harvard College Dispositivo que contiene manosensores para detectar un analito y su metodo de fabricacion.
EP1397675B1 (en) * 2001-06-14 2011-05-25 Ionscope Ltd. The production of molecular arrays
JP2005535283A (ja) * 2001-11-13 2005-11-24 ルビコン ゲノミクス インコーポレイテッド ランダムフラグメント化により生成されたｄｎａ分子を用いたｄｎａ増幅および配列決定
DE10244914A1 (de) 2002-09-25 2004-05-06 Gesellschaft für Schwerionenforschung mbH Nanovorrichtung für einen geladenen Teilchenfluß und Verfahren zu deren Herstellung
US20050260119A1 (en) 2003-09-09 2005-11-24 Sunkara Mahendra K Carbon nanopipettes methods of making and applications
US7955738B2 (en) * 2004-03-05 2011-06-07 Honeywell International, Inc. Polymer ionic electrolytes
JP4558382B2 (ja) * 2004-06-04 2010-10-06 ジーエルサイエンス株式会社 アフィニティクロマトグラフィ用デバイス及びその製法
WO2006000064A2 (en) 2004-06-28 2006-01-05 Interuniversitair Microelektronica Centrum Vzw Device for controlling the flow of charged carriers through a nanopore in a mebmrane and method for the fabrication of such a device
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
US8083926B2 (en) 2006-04-19 2011-12-27 Chen Ellen T Nanopore structured electrochemical biosensors
US7849581B2 (en) * 2006-05-05 2010-12-14 University Of Utah Research Foundation Nanopore electrode, nanopore membrane, methods of preparation and surface modification, and use thereof
US7777505B2 (en) * 2006-05-05 2010-08-17 University Of Utah Research Foundation Nanopore platforms for ion channel recordings and single molecule detection and analysis
EP2105735B1 (en) * 2006-12-26 2014-11-26 Sekisui Chemical Co., Ltd. STABLE HEMOGLOBIN A1c MEASUREMENT METHOD AND ELECTROPHORESIS APPARATUS
US20110136255A1 (en) 2007-11-30 2011-06-09 Nir Dotan Composition and method for prediction of complicated disease course in crohn's disease
US8940142B2 (en) * 2008-05-05 2015-01-27 The Regents Of The University Of California Functionalized nanopipette biosensor
WO2012122029A2 (en) * 2011-03-04 2012-09-13 The Regents Of The University Of California Nanopore device for reversible ion and molecule sensing or migration

Also Published As

Publication number Publication date
US20120222958A1 (en) 2012-09-06
US11243188B2 (en) 2022-02-08
EP2681542A2 (en) 2014-01-08
WO2012122029A3 (en) 2012-11-22
US10345260B2 (en) 2019-07-09
US8980073B2 (en) 2015-03-17
US20150177189A1 (en) 2015-06-25
US11709148B2 (en) 2023-07-25
WO2012122029A2 (en) 2012-09-13
CN103502804A (zh) 2014-01-08
US20220229014A1 (en) 2022-07-21
EP2681542B1 (en) 2019-12-18
KR101923241B1 (ko) 2018-11-28
US20190369047A1 (en) 2019-12-05
CN103502804B (zh) 2015-07-22
KR20140015428A (ko) 2014-02-06
JP2014508300A (ja) 2014-04-03
CN105044170B (zh) 2019-06-07
CN105044170A (zh) 2015-11-11
EP2681542A4 (en) 2014-09-24

Similar Documents

Publication Publication Date Title
JP6046058B2 (ja) 可逆的なイオン及び分子検出又は移動用ナノポアデバイス
US12455276B2 (en) Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
Eggenberger et al. Surface coatings for solid-state nanopores
de la Escosura-Muñiz et al. Nanochannels for diagnostic of thrombin-related diseases in human blood
Barfidokht et al. Approaches toward allowing electroanalytical devices to be used in biological fluids
Hasanzadeh et al. Electrochemical nanobiosensing in whole blood: Recent advances
Zhang et al. Solid-state nanopore/nanochannel sensors with enhanced selectivity through pore-in modification
Vilozny et al. Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette
Wang et al. Chronopotentiometric nanopore sensor based on a stimulus-responsive molecularly imprinted polymer for label-free dual-biomarker detection
Ahmed et al. Iontronic sensing based on confined ion transport
Hussein et al. Silver nanoneedle probes enable sustained DC current, single-channel resistive pulse nanopore sensing
Lu et al. Recent advances in the modification and characterization of solid‐state nanopores
Pourmand et al. Nanopore device for reversible ion and molecule sensing or migration
Lee et al. Surface modification of solid-state nanopore by plasma-polymerized chemical vapor deposition of poly (ethylene glycol) for stable device operation
Zhang Biomimetic Nanochannel-Based Sensing Device for Efficient Detection of Various Intended Analytes
Yamada et al. Artificial cell membrane system for odorant sensor: development of solution exchange driven by superabsorbent polymer for repeatable detection
Reddy Membrane technologies for sensing and biosensing
Onofri Electrochemical sensing strategies for the detection of interactions between biological macromolecules
Tiwari Multimode Analysis of Nanoscale Biomolecular Interactions

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150302

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150302

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20151224

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160209

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20160509

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20161025

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20161116

R150 Certificate of patent or registration of utility model

Ref document number: 6046058

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees