JP6043627B2 - アルブミン非含有ボツリヌス毒素製剤 - Google Patents

アルブミン非含有ボツリヌス毒素製剤 Download PDF

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Publication number
JP6043627B2
JP6043627B2 JP2012517802A JP2012517802A JP6043627B2 JP 6043627 B2 JP6043627 B2 JP 6043627B2 JP 2012517802 A JP2012517802 A JP 2012517802A JP 2012517802 A JP2012517802 A JP 2012517802A JP 6043627 B2 JP6043627 B2 JP 6043627B2
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Prior art keywords
botulinum toxin
liquid composition
positively charged
gly
lyophilizate
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Expired - Fee Related
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JP2012517802A
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Japanese (ja)
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JP2012531442A (ja
JP2012531442A5 (https=
Inventor
スチュアート エイ． トンプソン
スチュアート エイ． トンプソン
カーチス エル． リュエッグ
カーチス エル． リュエッグ
ジェイコブ エム． ウォー
ジェイコブ エム． ウォー
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Revance Therapeuticals Inc
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Revance Therapeuticals Inc
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
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    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
JP2012517802A 2009-06-25 2010-06-25 アルブミン非含有ボツリヌス毒素製剤 Expired - Fee Related JP6043627B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22043309P 2009-06-25 2009-06-25
US61/220,433 2009-06-25
PCT/US2010/040104 WO2010151840A2 (en) 2009-06-25 2010-06-25 Albumin-free botulinum toxin formulations

Publications (3)

Publication Number Publication Date
JP2012531442A JP2012531442A (ja) 2012-12-10
JP2012531442A5 JP2012531442A5 (https=) 2013-08-08
JP6043627B2 true JP6043627B2 (ja) 2016-12-14

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JP2012517802A Expired - Fee Related JP6043627B2 (ja) 2009-06-25 2010-06-25 アルブミン非含有ボツリヌス毒素製剤

Country Status (13)

Country Link
US (6) US20120107361A1 (https=)
EP (1) EP2445521A4 (https=)
JP (1) JP6043627B2 (https=)
KR (5) KR102192618B1 (https=)
CN (1) CN102869373B (https=)
AU (1) AU2010265888A1 (https=)
BR (1) BRPI1015938A2 (https=)
CA (1) CA2766521C (https=)
CO (1) CO6491076A2 (https=)
IL (2) IL268980B (https=)
MX (3) MX344583B (https=)
SG (1) SG177357A1 (https=)
WO (1) WO2010151840A2 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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JP2007527431A (ja) 2004-03-03 2007-09-27 ルバンス セラピュティックス 局所的診断及び治療用の輸送のための組成物及び方法
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
EP2266599B1 (en) * 2004-07-26 2014-04-16 Merz Pharma GmbH & Co. KGaA Therapeutic composition with a botulinum neurotoxin
ZA200707352B (en) 2005-03-03 2009-04-29 Revance Therapeutics Inc Compositions and methods for topical application and transdermal delivery of botulinum toxins
US8168206B1 (en) * 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
HUE037595T2 (hu) 2008-12-31 2018-09-28 Revance Therapeutics Inc Injektálható botulinum toxin készítmények
IL268980B (en) * 2009-06-25 2022-09-01 Revance Therapeutics Inc Albumin-free botulinum toxin formulations
SI2490986T1 (sl) * 2009-10-21 2018-12-31 Revance Therapeutics, Inc. Metode in sistemi za prečiščenje nekompleksiranega nevrotoksina botulina
LT2661276T (lt) * 2011-01-07 2017-12-11 Revance Therapeutics, Inc. Paviršinio naudojimo kompozicija, apimanti botulino toksiną ir dažą
US20130251770A1 (en) 2012-03-22 2013-09-26 Revance Therapeutics, Inc. Method of Treatment of Wrinkles Using Topical Chemodenervating Agents
US20140242110A1 (en) * 2013-02-28 2014-08-28 Dt Scimed, Llc Dose, localization, and formulation of botulinum toxins in skin and muscle
RU2662968C2 (ru) * 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
US9480731B2 (en) 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
US9943576B2 (en) * 2014-04-30 2018-04-17 Allergan, Inc. Formulations of biologics for intravesical instillation
EP3590500B1 (en) 2014-12-23 2025-06-25 Merz Pharma GmbH & Co. KGaA Botulinum toxin prefilled container
US10406290B2 (en) 2015-02-03 2019-09-10 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled plastic syringe
EP3368071B1 (en) * 2015-10-29 2022-01-26 ReVance Therapeutics, Inc. Injectable botulinum toxin formulations and methods of use thereof having long duration of therapeutic or cosmetic effect
WO2018038585A1 (ko) * 2016-08-26 2018-03-01 주식회사 에이비바이오 보툴리눔 독소 및 안정화제를 포함하는 액상 제형 및 이의 제조방법
WO2018038301A1 (en) 2016-08-26 2018-03-01 Hugel Inc. Stabilized liquid formulation of botulinum toxin and preparation method thereof
KR102480965B1 (ko) 2016-09-13 2022-12-26 알레간 인코포레이티드 안정화된 비단백질 클로스트리듐 독소 조성물
MX2019005833A (es) * 2016-11-21 2019-10-30 Eirion Therapeutics Inc Administracion transdermica de agentes grandes.
KR101744900B1 (ko) * 2017-01-20 2017-06-08 주식회사 대웅 보툴리눔 독소를 포함하는 안정한 액상 조성물
EP3624819A4 (en) * 2017-05-18 2021-03-24 Revance Therapeutics, Inc. Methods of treatment for cervical dystonia
US11400136B2 (en) 2017-06-19 2022-08-02 President And Fellows Of Harvard College Methods and compositions for treating a microbial infection
CA3068292A1 (en) * 2017-06-26 2019-01-03 Bonti, Inc. Clostridial neurotoxin formulations and use
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