JP6038122B2 - 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 - Google Patents
機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 Download PDFInfo
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- JP6038122B2 JP6038122B2 JP2014506434A JP2014506434A JP6038122B2 JP 6038122 B2 JP6038122 B2 JP 6038122B2 JP 2014506434 A JP2014506434 A JP 2014506434A JP 2014506434 A JP2014506434 A JP 2014506434A JP 6038122 B2 JP6038122 B2 JP 6038122B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
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- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
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- Life Sciences & Earth Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477958P | 2011-04-21 | 2011-04-21 | |
| US61/477,958 | 2011-04-21 | ||
| PCT/US2012/032100 WO2012145169A2 (en) | 2011-04-21 | 2012-04-04 | Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016212546A Division JP6353007B2 (ja) | 2011-04-21 | 2016-10-31 | 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014512382A JP2014512382A (ja) | 2014-05-22 |
| JP2014512382A5 JP2014512382A5 (https=) | 2015-05-21 |
| JP6038122B2 true JP6038122B2 (ja) | 2016-12-07 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506434A Active JP6038122B2 (ja) | 2011-04-21 | 2012-04-04 | 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 |
| JP2016212546A Active JP6353007B2 (ja) | 2011-04-21 | 2016-10-31 | 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 |
| JP2018109290A Active JP6960883B2 (ja) | 2011-04-21 | 2018-06-07 | 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016212546A Active JP6353007B2 (ja) | 2011-04-21 | 2016-10-31 | 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 |
| JP2018109290A Active JP6960883B2 (ja) | 2011-04-21 | 2018-06-07 | 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9272055B2 (https=) |
| EP (2) | EP3345545B1 (https=) |
| JP (3) | JP6038122B2 (https=) |
| KR (1) | KR20140012732A (https=) |
| CN (2) | CN106729771A (https=) |
| AU (3) | AU2012245861A1 (https=) |
| CA (2) | CA3058702C (https=) |
| ES (1) | ES2667894T3 (https=) |
| WO (1) | WO2012145169A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103157414B (zh) * | 2013-03-28 | 2014-10-01 | 天津理工大学 | 一种聚缩水甘油表面接枝的铁磁纳米粒子的制备方法 |
| WO2019028062A1 (en) * | 2017-07-31 | 2019-02-07 | Washington University | PIRFENIDONE DERIVATIVES FOR MODULATION OF B-LYMPHOCYTE ACTIVITY AND PROTECTION OF ORGANS |
| JP7450812B2 (ja) | 2021-05-18 | 2024-03-15 | 三菱電機株式会社 | 生体情報検出装置および生体情報検出装置の作動方法 |
| DE102023003949A1 (de) | 2023-09-30 | 2025-04-03 | Carola Kryschi | Eisensulfid-Nanopartikel als Enzym-mimetische Nanokatalysatoren (nanoXcats) |
Family Cites Families (31)
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| DE3343530A1 (de) | 1983-12-01 | 1985-06-13 | Max Planck Gesellschaft | Arzneimittel mit verbesserter penetration der gewebsmembran |
| US5017566A (en) | 1987-12-30 | 1991-05-21 | University Of Florida | Redox systems for brain-targeted drug delivery |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| CA2025907A1 (en) | 1989-09-21 | 1991-03-22 | Franklin D. Collins | Method of transporting compositions across the blood brain barrier |
| US5411730A (en) | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| JPH11510837A (ja) | 1995-07-28 | 1999-09-21 | フォーカル,インコーポレイテッド | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
| US7964598B2 (en) | 1995-10-17 | 2011-06-21 | The J. David Gladstone Institutes | ApoE4 domain interaction inhibitors and methods of use thereof |
| CA2340394A1 (en) * | 1998-08-20 | 2000-03-02 | Jorge R. Barrio | Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles |
| US6767635B1 (en) | 1999-09-14 | 2004-07-27 | Biomedical Apherese Systeme Gmbh | Magnetic nanoparticles having biochemical activity, method for the production thereof and their use |
| US6548264B1 (en) | 2000-05-17 | 2003-04-15 | University Of Florida | Coated nanoparticles |
| US6534039B2 (en) | 2000-07-21 | 2003-03-18 | James F. Hainfeld | Extended organic cobalt and nickel magnetic complexes |
| US7270800B2 (en) * | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| US6714138B1 (en) | 2000-09-29 | 2004-03-30 | Aps Technology, Inc. | Method and apparatus for transmitting information to the surface from a drill string down hole in a well |
| WO2002028441A2 (en) | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| US6821504B2 (en) | 2001-05-23 | 2004-11-23 | New York University | Detection of alzheimer's amyloid by magnetic resonance imaging |
| GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
| KR100754596B1 (ko) | 2001-09-21 | 2007-09-05 | 미쯔비시 웰 파마 가부시키가이샤 | 3-치환-4-피리미돈 유도체 |
| EP1547996A4 (en) * | 2002-08-30 | 2006-08-02 | Bf Res Inst Inc | DIAGNOSTIC PROBES AND REMEDIES FOR DISEASES IN WHICH PRION PROTEIN IS ACCUMULATED, AND ANIMAL FEVERING FOR PRION PROTEIN |
| CN1312479C (zh) * | 2003-08-08 | 2007-04-25 | 清华大学 | 一种纳米荧光磁粒及其制备方法 |
| EP1789046A2 (en) * | 2004-08-16 | 2007-05-30 | Queen Mary University of London | Peripheral benzodiazepine receptor independent superoxide generation |
| SG194363A1 (en) * | 2004-12-17 | 2013-11-29 | Univ Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| ATE507250T1 (de) * | 2005-02-10 | 2011-05-15 | Qiagen Gmbh | Probenlyse und beschichtung einer reaktionsoberfläche |
| KR101306641B1 (ko) | 2005-03-21 | 2013-09-12 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 작용화된 자성 나노입자 및 이의 사용방법 |
| TW200736252A (en) | 2006-01-27 | 2007-10-01 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| HRP20120135T1 (hr) * | 2006-03-30 | 2012-03-31 | The Trustees Of The University Of Pennsylvania | Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova |
| US7737183B2 (en) * | 2006-10-17 | 2010-06-15 | The Regents Of The University Of California | β-amyloid and neurofibrillary tangle imaging agents |
| FR2913886B1 (fr) * | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| CN101544584B (zh) * | 2008-03-26 | 2013-09-25 | 中国医学科学院放射医学研究所 | 阿尔茨海默病显像剂前体物的制备方法 |
| US8445021B2 (en) * | 2008-04-04 | 2013-05-21 | The Regents Of The University Of California | Functionalized magnetic nanoparticles and methods of use thereof |
| CA2731738A1 (en) | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
| RS55674B1 (sr) * | 2008-12-31 | 2017-06-30 | Avid Radiopharmaceuticals Inc | Sinteza 18f-radio obeleženih stirilpiridina od tozilat prekursora i njihovih stabilnih farmaceutskih kompozicija |
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| CA3058702C (en) | 2023-11-07 |
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| EP3345545B1 (en) | 2021-10-20 |
| JP2018154646A (ja) | 2018-10-04 |
| CN106729771A (zh) | 2017-05-31 |
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| US20160184461A1 (en) | 2016-06-30 |
| KR20140012732A (ko) | 2014-02-03 |
| JP6960883B2 (ja) | 2021-11-05 |
| CA3058702A1 (en) | 2012-10-26 |
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