JP6029670B2 - アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 - Google Patents

アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 Download PDF

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JP6029670B2
JP6029670B2 JP2014532014A JP2014532014A JP6029670B2 JP 6029670 B2 JP6029670 B2 JP 6029670B2 JP 2014532014 A JP2014532014 A JP 2014532014A JP 2014532014 A JP2014532014 A JP 2014532014A JP 6029670 B2 JP6029670 B2 JP 6029670B2
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acetaminophen
compound
conjugate
individual
administration
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JP2014530204A (ja
JP2014530204A5 (enExample
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キース アール． ブレー，
キース アール． ブレー，
ベルンド ジャンデレイト，
ベルンド ジャンデレイト，
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アコーダ セラピューティクス、インク．
アコーダ セラピューティクス、インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C07C329/06—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2014532014A 2011-09-22 2012-09-21 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 Expired - Fee Related JP6029670B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161538075P 2011-09-22 2011-09-22
US61/538,075 2011-09-22
PCT/US2012/056625 WO2013044064A1 (en) 2011-09-22 2012-09-21 Acetaminophen conjugates, compositions and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016204398A Division JP2017019859A (ja) 2011-09-22 2016-10-18 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法

Publications (3)

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JP2014530204A JP2014530204A (ja) 2014-11-17
JP2014530204A5 JP2014530204A5 (enExample) 2015-11-12
JP6029670B2 true JP6029670B2 (ja) 2016-11-24

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JP2014532014A Expired - Fee Related JP6029670B2 (ja) 2011-09-22 2012-09-21 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法
JP2016204398A Withdrawn JP2017019859A (ja) 2011-09-22 2016-10-18 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法
JP2018067394A Withdrawn JP2018131447A (ja) 2011-09-22 2018-03-30 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法
JP2020081769A Withdrawn JP2020122010A (ja) 2011-09-22 2020-05-07 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2016204398A Withdrawn JP2017019859A (ja) 2011-09-22 2016-10-18 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法
JP2018067394A Withdrawn JP2018131447A (ja) 2011-09-22 2018-03-30 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法
JP2020081769A Withdrawn JP2020122010A (ja) 2011-09-22 2020-05-07 アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法

Country Status (7)

Country Link
US (1) US9024055B2 (enExample)
EP (1) EP2758133A4 (enExample)
JP (4) JP6029670B2 (enExample)
AU (1) AU2012312136B2 (enExample)
CA (1) CA2849731C (enExample)
HK (1) HK1200392A1 (enExample)
WO (1) WO2013044064A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101698028B1 (ko) 2008-05-20 2017-01-26 노이로제스엑스, 인코포레이티드 수용성 아세트아미노펜 유사체
CN102149282B (zh) 2008-05-20 2014-12-17 纽罗吉斯克斯公司 碳酸酯前药及其使用方法
JP7156154B2 (ja) * 2019-04-18 2022-10-19 株式会社島津製作所 培地処理システム及び培地処理方法
US20220313630A1 (en) * 2019-06-04 2022-10-06 Lennham Pharmaceuticals, Inc. Deuterated forms of acetaminophen and uses thereof
CN113248596B (zh) * 2021-04-15 2022-12-16 华南农业大学 一种可同时检测对乙酰氨基酚和非那西丁的人工抗原、抗体及其制备方法和应用
CN116239486B (zh) * 2023-03-16 2025-07-08 梯尔希（南京）药物研发有限公司 一种对乙酰氨基酚杂质的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444043A1 (fr) 1978-12-15 1980-07-11 Bottu Nouveau derive du paracetamol, son procede de preparation et son utilisation en therapeutique
CA2317008C (en) 1997-12-31 2009-01-20 The University Of Kansas Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
JP2010511717A (ja) 2006-12-05 2010-04-15 ニューロジェシックス， インコーポレイテッド プロドラッグおよびその作成ならびに使用方法
KR101698028B1 (ko) 2008-05-20 2017-01-26 노이로제스엑스, 인코포레이티드 수용성 아세트아미노펜 유사체
CN102149282B (zh) 2008-05-20 2014-12-17 纽罗吉斯克斯公司 碳酸酯前药及其使用方法
US20110263545A1 (en) 2008-05-20 2011-10-27 Naweed Muhammad Hepatoprotectant acetaminophen mutual prodrugs
US8569466B2 (en) * 2008-09-10 2013-10-29 Nnochiri Ekwuribe Aromatic carboxylic acid derivatives for treatment and prophylaxis of gastrointestinal diseases including colon cancers
AU2010224866C1 (en) * 2009-03-16 2015-01-15 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders

Also Published As

Publication number Publication date
JP2017019859A (ja) 2017-01-26
EP2758133A1 (en) 2014-07-30
US20140243407A1 (en) 2014-08-28
WO2013044064A1 (en) 2013-03-28
AU2012312136B2 (en) 2017-06-29
JP2014530204A (ja) 2014-11-17
AU2012312136A1 (en) 2014-04-17
CA2849731C (en) 2020-01-14
HK1200392A1 (en) 2015-08-07
JP2018131447A (ja) 2018-08-23
JP2020122010A (ja) 2020-08-13
US9024055B2 (en) 2015-05-05
CA2849731A1 (en) 2013-03-28
EP2758133A4 (en) 2015-05-27

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