HK1200392A1 - Acetaminophen conjugates, compositions and methods of use thereof - Google Patents

Acetaminophen conjugates, compositions and methods of use thereof Download PDF

Info

Publication number
HK1200392A1
HK1200392A1 HK15101054.4A HK15101054A HK1200392A1 HK 1200392 A1 HK1200392 A1 HK 1200392A1 HK 15101054 A HK15101054 A HK 15101054A HK 1200392 A1 HK1200392 A1 HK 1200392A1
Authority
HK
Hong Kong
Prior art keywords
conjugates
acetaminophen
methods
compositions
compared
Prior art date
Application number
HK15101054.4A
Other languages
English (en)
Chinese (zh)
Inventor
Keith R. Bley
Bernd Jandeleit
Original Assignee
Acorda Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acorda Therapeutics, Inc. filed Critical Acorda Therapeutics, Inc.
Publication of HK1200392A1 publication Critical patent/HK1200392A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C07C329/06—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15101054.4A 2011-09-22 2012-09-21 Acetaminophen conjugates, compositions and methods of use thereof HK1200392A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161538075P 2011-09-22 2011-09-22
US61/538,075 2011-09-22
PCT/US2012/056625 WO2013044064A1 (en) 2011-09-22 2012-09-21 Acetaminophen conjugates, compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1200392A1 true HK1200392A1 (en) 2015-08-07

Family

ID=47914904

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101054.4A HK1200392A1 (en) 2011-09-22 2012-09-21 Acetaminophen conjugates, compositions and methods of use thereof

Country Status (7)

Country Link
US (1) US9024055B2 (enExample)
EP (1) EP2758133A4 (enExample)
JP (4) JP6029670B2 (enExample)
AU (1) AU2012312136B2 (enExample)
CA (1) CA2849731C (enExample)
HK (1) HK1200392A1 (enExample)
WO (1) WO2013044064A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105254662A (zh) 2008-05-20 2016-01-20 阿索尔达治疗公司 水溶性对乙酰氨基酚类似物
CA2724881C (en) 2008-05-20 2016-09-27 Neurogesx, Inc. Carbonate prodrugs and methods of using the same
JP7156154B2 (ja) * 2019-04-18 2022-10-19 株式会社島津製作所 培地処理システム及び培地処理方法
US20220313630A1 (en) * 2019-06-04 2022-10-06 Lennham Pharmaceuticals, Inc. Deuterated forms of acetaminophen and uses thereof
CN113248596B (zh) * 2021-04-15 2022-12-16 华南农业大学 一种可同时检测对乙酰氨基酚和非那西丁的人工抗原、抗体及其制备方法和应用
CN116239486B (zh) * 2023-03-16 2025-07-08 梯尔希（南京）药物研发有限公司 一种对乙酰氨基酚杂质的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444043A1 (fr) 1978-12-15 1980-07-11 Bottu Nouveau derive du paracetamol, son procede de preparation et son utilisation en therapeutique
CA2317008C (en) 1997-12-31 2009-01-20 The University Of Kansas Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
WO2008070149A2 (en) 2006-12-05 2008-06-12 Neurogesx, Inc. Prodrugs and methods of making and using the same
WO2009143299A1 (en) 2008-05-20 2009-11-26 Neurogesx, Inc. Hepatoprotectant acetaminophen mutual prodrugs
CN105254662A (zh) 2008-05-20 2016-01-20 阿索尔达治疗公司 水溶性对乙酰氨基酚类似物
CA2724881C (en) 2008-05-20 2016-09-27 Neurogesx, Inc. Carbonate prodrugs and methods of using the same
US8569466B2 (en) * 2008-09-10 2013-10-29 Nnochiri Ekwuribe Aromatic carboxylic acid derivatives for treatment and prophylaxis of gastrointestinal diseases including colon cancers
EP2408443A1 (en) * 2009-03-16 2012-01-25 Genmedica Therapeutics SL Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders

Also Published As

Publication number Publication date
JP2018131447A (ja) 2018-08-23
JP6029670B2 (ja) 2016-11-24
CA2849731A1 (en) 2013-03-28
EP2758133A1 (en) 2014-07-30
US9024055B2 (en) 2015-05-05
JP2017019859A (ja) 2017-01-26
JP2020122010A (ja) 2020-08-13
WO2013044064A1 (en) 2013-03-28
US20140243407A1 (en) 2014-08-28
JP2014530204A (ja) 2014-11-17
AU2012312136A1 (en) 2014-04-17
AU2012312136B2 (en) 2017-06-29
CA2849731C (en) 2020-01-14
EP2758133A4 (en) 2015-05-27

Similar Documents

Publication Publication Date Title
WO2010063700A3 (en) Novel pyrazole-4 -n-alkoxycarboxamides as microbiocides
WO2009024342A3 (en) Novel microbiocides
WO2008101682A3 (en) Iminipyridine derivatives and their uses as microbiocides
WO2009087098A3 (en) Quinoline derivatives and their use as fungicides
NZ588884A (en) Cross-linkers and their uses
EP4218802A3 (en) Conjugates for targeted cell surface editing
WO2008110355A8 (en) Quinoline derivatives as fungicides
WO2012135025A3 (en) Conjugated lipomers and uses thereof
WO2010077740A3 (en) Novel antiviral compounds, compositions, and methods of use
MX2010003156A (es) Derivados de aril amida substituida con tetrazol y usos de los mismos.
MX2010003155A (es) Derivados de ciclopropil aril amida y uso de los mismos.
WO2011088027A8 (en) Compounds and methods
WO2009019015A8 (en) Novel herbicides
WO2008151828A3 (en) Novel microbiocides
WO2007021937A3 (en) Unsaturated heterocyclic derivatives
WO2008028688A3 (en) Compounds and methods for 18f labeled agents
WO2009007535A3 (fr) Derives de 7 -alkynyl-1.8-naphthyrid0nes, leur preparation et leur application en therapeutique
HK1248069A1 (zh) 去乙酰氧基微管溶素h及其类似物
HK1200392A1 (en) Acetaminophen conjugates, compositions and methods of use thereof
WO2012075117A3 (en) Small molecule-polymer conjugates and methods of making same
WO2009127718A3 (en) Novel microbiocides
WO2009007115A8 (en) Tropane derivatives useful as pesticides
HK1214128A1 (zh) 癌症的治療
EP2129672A4 (en) ESTER AND CARBAMATE AZAADAMANTANE DERIVATIVES AND METHODS OF USE
TN2011000355A1 (en) Novel microbiocides