JP6025861B2 - カバジタキセルの結晶形およびこれを調製するための方法 - Google Patents

カバジタキセルの結晶形およびこれを調製するための方法 Download PDF

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JP6025861B2
JP6025861B2 JP2014546702A JP2014546702A JP6025861B2 JP 6025861 B2 JP6025861 B2 JP 6025861B2 JP 2014546702 A JP2014546702 A JP 2014546702A JP 2014546702 A JP2014546702 A JP 2014546702A JP 6025861 B2 JP6025861 B2 JP 6025861B2
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hydroxy
ethyl acetate
phenylpropionate
benzoyloxy
acetoxy
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JP2015500331A (ja
JP2015500331A5 (enExample
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ディディエ，エリック
トレモードゥ，ニコラ
ザスク，リオネル
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アベンティス・ファーマ・ソシエテ・アノニム
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014546702A 2011-12-13 2012-12-11 カバジタキセルの結晶形およびこれを調製するための方法 Active JP6025861B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11306644 2011-12-13
EP11306644.3 2011-12-13
PCT/IB2012/057170 WO2013088335A1 (en) 2011-12-13 2012-12-11 Crystalline form of cabazitaxel and process for preparing the same

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JP2015500331A JP2015500331A (ja) 2015-01-05
JP2015500331A5 JP2015500331A5 (enExample) 2015-12-03
JP6025861B2 true JP6025861B2 (ja) 2016-11-16

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JP2014546702A Active JP6025861B2 (ja) 2011-12-13 2012-12-11 カバジタキセルの結晶形およびこれを調製するための方法

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US (2) US9309210B2 (enExample)
EP (1) EP2791122B1 (enExample)
JP (1) JP6025861B2 (enExample)
TW (1) TWI572594B (enExample)
WO (1) WO2013088335A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2926551A1 (fr) 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
TWI526437B (zh) * 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
WO2013088335A1 (en) * 2011-12-13 2013-06-20 Aventis Pharma S.A. Crystalline form of cabazitaxel and process for preparing the same
WO2013134534A2 (en) * 2012-03-08 2013-09-12 Plus Chemicals S.A. Solid state forms of cabazitaxel and processes for preparation thereof
CN102746258B (zh) * 2012-07-25 2015-02-04 重庆泰濠制药有限公司 卡巴他赛的结晶形式及其制备方法
US20150315164A1 (en) * 2012-12-31 2015-11-05 Shilpa Medicare Limited Process for preparing amorphous cabazitaxel
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
WO2015000165A1 (zh) * 2013-07-04 2015-01-08 北京新天宇科技开发有限公司 二甲氧基多西紫杉醇一丙酮化物的稳定转化物及其结晶形式、以及它们的制备方法
EP2865674A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
EP2865675A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
WO2015087228A1 (en) * 2013-12-10 2015-06-18 Mylan Laboratories Ltd. Process for the preparation of cabazitaxel and its solvates
JP2019501953A (ja) 2016-01-15 2019-01-24 珠海貝海生物技術有限公司Ｚｈｕｈａｉ Ｂｅｉｈａｉ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． カバジタキセル及びヒト血清アルブミンを含む組成物及び製剤
CN112055588B (zh) 2018-04-20 2023-09-08 珠海贝海生物技术有限公司 卡巴他赛的制剂和组合物
CN113429369B (zh) * 2021-07-23 2022-12-02 无锡紫杉药业有限公司 一种高效的卡巴他赛纯化方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847170A (en) 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6346543B1 (en) 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
FR2859996B1 (fr) 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR2926551A1 (fr) 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
JP5566466B2 (ja) * 2009-10-29 2014-08-06 アバンテイス・フアルマ・エス・アー カバジタキセルの新規の抗腫瘍的使用
TWI526437B (zh) 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
PL2785701T3 (pl) * 2011-11-28 2019-08-30 Fresenius Kabi Oncology Limited Krystaliczna postać kabazytakselu i sposób jej otrzymywania
WO2013088335A1 (en) * 2011-12-13 2013-06-20 Aventis Pharma S.A. Crystalline form of cabazitaxel and process for preparing the same

Also Published As

Publication number Publication date
JP2015500331A (ja) 2015-01-05
US9309210B2 (en) 2016-04-12
US20160318888A1 (en) 2016-11-03
US20140343133A1 (en) 2014-11-20
WO2013088335A1 (en) 2013-06-20
EP2791122B1 (en) 2019-01-23
EP2791122A1 (en) 2014-10-22
TWI572594B (zh) 2017-03-01
TW201329056A (zh) 2013-07-16

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