JP6011528B2 - ペプチドの製造方法 - Google Patents

ペプチドの製造方法 Download PDF

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Publication number
JP6011528B2
JP6011528B2 JP2013518159A JP2013518159A JP6011528B2 JP 6011528 B2 JP6011528 B2 JP 6011528B2 JP 2013518159 A JP2013518159 A JP 2013518159A JP 2013518159 A JP2013518159 A JP 2013518159A JP 6011528 B2 JP6011528 B2 JP 6011528B2
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Japan
Prior art keywords
group
protected
peptide
formula
amino acid
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Active
Application number
JP2013518159A
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English (en)
Japanese (ja)
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JPWO2012165545A1 (ja
Inventor
高橋　大輔
大輔 高橋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
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Ajinomoto Co Inc
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Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of JPWO2012165545A1 publication Critical patent/JPWO2012165545A1/ja
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Publication of JP6011528B2 publication Critical patent/JP6011528B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2013518159A 2011-05-31 2012-05-31 ペプチドの製造方法 Active JP6011528B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011122943 2011-05-31
JP2011122943 2011-05-31
PCT/JP2012/064073 WO2012165545A1 (fr) 2011-05-31 2012-05-31 Procédé pour produire un peptide

Publications (2)

Publication Number Publication Date
JPWO2012165545A1 JPWO2012165545A1 (ja) 2015-02-23
JP6011528B2 true JP6011528B2 (ja) 2016-10-19

Family

ID=47259397

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013518159A Active JP6011528B2 (ja) 2011-05-31 2012-05-31 ペプチドの製造方法

Country Status (4)

Country Link
US (1) US9353148B2 (fr)
EP (1) EP2716649A1 (fr)
JP (1) JP6011528B2 (fr)
WO (1) WO2012165545A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5768712B2 (ja) 2009-03-30 2015-08-26 味の素株式会社 ジフェニルメタン化合物
JP6733554B2 (ja) * 2015-01-21 2020-08-05 味の素株式会社 沈殿促進剤およびそれを用いる沈殿化方法
ES2924473T3 (es) 2015-12-21 2022-10-07 Univ Texas Tech System Sistema y procedimiento de síntesis de péptidos GAP en fase de solución
CA3078393A1 (fr) * 2017-10-03 2019-04-11 Nissan Chemical Corporation Procede de production de compose peptidique
WO2020159837A1 (fr) 2019-02-01 2020-08-06 Gap Peptides Llc Stratégie de synthèse pour groupe de protection gap
CN114206901B (zh) * 2019-08-30 2024-02-20 日产化学株式会社 肽化合物的制造方法
JP7459121B2 (ja) * 2019-09-12 2024-04-01 富士フイルム株式会社 ペプチド化合物の製造方法、保護基形成用試薬、及び、ヒドラジン誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000044493A (ja) * 1998-07-27 2000-02-15 Asahi Chem Ind Co Ltd 化合物ライブラリー合成用保護基
WO2003062266A2 (fr) * 2002-01-22 2003-07-31 Intrabiotics Pharmaceuticals, Inc. Procede de synthese hybride destine a des peptides antimicrobiens
WO2006104166A1 (fr) 2005-03-29 2006-10-05 National University Corporation, Tokyo University Of Agriculture And Technology Support pour separation par cristallisation et procede pour separer un compose
CN101277921B (zh) 2005-09-20 2013-05-22 Jitsubo株式会社 分离用载体、化合物的分离方法以及利用其的肽合成方法
DK2003104T3 (en) 2006-03-24 2015-08-10 Jitsubo Co Ltd Reagents for organic synthesis and method for organic synthesis reaction with the reagent
KR20100080812A (ko) * 2007-09-25 2010-07-12 트라이머리스, 인코퍼레이티드 치료용 항-ｈｉｖ 펩티드의 합성 방법
WO2010104169A1 (fr) * 2009-03-12 2010-09-16 味の素株式会社 Composé fluorène
JP5768712B2 (ja) 2009-03-30 2015-08-26 味の素株式会社 ジフェニルメタン化合物
US8859732B2 (en) 2009-12-25 2014-10-14 Ajinomoto Co., Inc. Benzylic compound
DK2612845T3 (da) 2010-08-30 2020-11-02 Ajinomoto Kk Aromatisk forbindelse som indeholder specifik forgrening

Also Published As

Publication number Publication date
EP2716649A1 (fr) 2014-04-09
US9353148B2 (en) 2016-05-31
US20140080999A1 (en) 2014-03-20
JPWO2012165545A1 (ja) 2015-02-23
WO2012165545A1 (fr) 2012-12-06

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