JP6008161B2 - Sleep improver - Google Patents
Sleep improver Download PDFInfo
- Publication number
- JP6008161B2 JP6008161B2 JP2011071367A JP2011071367A JP6008161B2 JP 6008161 B2 JP6008161 B2 JP 6008161B2 JP 2011071367 A JP2011071367 A JP 2011071367A JP 2011071367 A JP2011071367 A JP 2011071367A JP 6008161 B2 JP6008161 B2 JP 6008161B2
- Authority
- JP
- Japan
- Prior art keywords
- sleep
- seed
- improving agent
- cucurbita
- pumpkin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Landscapes
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Description
本発明は、新規な睡眠改善剤に関し、さらに詳しくはカボチャ属(Cucurbita)種子抽出物を有効成分とする新規な睡眠改善剤に関する。 The present invention relates to a novel sleep-improving agent, and more specifically to a novel sleep-improving agent containing a pumpkin (Cucurbita) seed extract as an active ingredient.
人生の約3分の1は「眠り」に占められており、睡眠は、ヒトにとって重要な行為である。しかし、最近、生活リズムの乱れ、ストレス、運動不足等により睡眠不足、不眠等の症状を訴えるヒトが増加している。このような睡眠の質の低下は、昼間の集中力の低下、自律神経失調症等の生活の質(QOL)の低下の原因ともなり、眠りの質を改善することは重要な課題となっている。 About one third of life is occupied by "sleeping", and sleep is an important act for humans. However, recently, an increasing number of people complain of symptoms such as lack of sleep and insomnia due to disturbance of life rhythm, stress, lack of exercise and the like. Such a decrease in sleep quality causes a decrease in daytime concentration and a decrease in quality of life (QOL) such as autonomic insufficiency, and improving sleep quality is an important issue. Yes.
睡眠の質の低下は、一般に、寝つきが悪い入眠障害、夜中に何度も目が覚める熟眠障害、朝早くに目が覚めてしまう早期覚醒、よく眠った感じがしない熟眠不全などに分類される。薬物を用いた治療法としては、ベンゾジアゼピン系の睡眠薬や、抗ヒスタミン系の睡眠補助薬などが用いられているが、これらの薬剤には精神症状や筋弛緩作用などの副作用があり、服用に対する不安などの課題もある。また、医薬品であるため簡便に入手することができず、必ずしも睡眠の質の低下に対する十分な解決策とはなっていない。 Deterioration of sleep quality is generally categorized into sleep disturbances that cause poor sleep, deep sleep disorders that wake up many times in the night, early awakening that wakes up early in the morning, and insomnia that does not feel well asleep. . Benzodiazepine sleeping pills and antihistamine sleeping aids are used as drug treatments, but these drugs have side effects such as psychiatric symptoms and muscle relaxation, and anxiety about taking them. There are also issues such as. Moreover, since it is a pharmaceutical, it cannot be obtained easily and is not necessarily a sufficient solution for the deterioration of sleep quality.
そこで、食品由来の機能性成分を有効成分として含有する睡眠改善剤が望まれている。これまでに、テアニンを含有する睡眠促進用組成物(特許文献1)、グリシンを含有する熟眠障害改善剤(特許文献2)、オルニチンを含有する寝つきまたは寝起き改善用経口剤(特許文献3)、γ−アミノ酪酸を有効成分として含有する睡眠の質改善用組成物(特許文献4)、アルギニンを含有する睡眠誘導剤あるいはストレス性不眠症改善剤(特許文献5)、グルタチオンを含有する睡眠誘導剤(特許文献6)、納豆菌などバシラス・サブチルス(Bacillus subtilis)に属する微生物の菌体破砕物を有効成分とする睡眠改善組成物(特許文献7)、カゼイン加水分解物およびミネラルを含有することを特徴とする睡眠改善用組成物(特許文献8)、セサミン類を有効成分として含有する睡眠障害改善剤(特許文献9)などが報告されている。 Therefore, a sleep improving agent containing a functional ingredient derived from food as an active ingredient is desired. So far, a composition for promoting sleep containing theanine (Patent Document 1), a deep sleep disorder improving agent containing glycine (Patent Document 2), an oral preparation for improving sleep or wakefulness containing ornithine (Patent Document 3), Sleep quality improving composition containing γ-aminobutyric acid as an active ingredient (Patent Document 4), sleep inducing agent containing arginine or stress insomnia improving agent (Patent Document 5), sleep inducing agent containing glutathione (Patent Document 6), a sleep improvement composition (Patent Document 7) containing a microbial cell disruption product of microorganisms belonging to Bacillus subtilis, such as natto, as an active ingredient, a casein hydrolyzate, and a mineral The composition for sleep improvement (Patent Document 8), the sleep disorder improving agent (Patent Document 9) containing sesamin as an active ingredient Have been reported.
カボチャ(南瓜)はアメリカ大陸が原産であり、瓜(ウリ)科、南瓜属(Cucurbita)に分類され、Cucurbita maxima(カボチャの西洋種)、Cucurbita moscha(カボチャの東洋種)、Cucurbita pepo(カボチャのペポ種、ペポカボチャ)が知られている。 The pumpkin (nanban) is native to the American continent, and is classified into the cucurbitaceae family, the genus Cucurbita, Cucurbita maxima (Western pumpkin species), Cucurbita moscha (Oriental species of pumpkins), Cucurbita pepo (pumpkins) Pepo species, Pepo Pumpkin) are known.
ペポカボチャはオーストリア、ハンガリー等で栽培され、主として種子を採取し、油の製造に供される。種子油は不飽和脂肪酸含量が高く、食用油としてその栄養学的価値が高い。油を採取した後の画分は安全性の高い食品としてスナック菓子、シリアル、パン、ソーセージ等に添加され、また飼料添加物、医薬品原料としても利用されている。 Pepo pumpkins are cultivated in Austria, Hungary, etc., mainly collecting seeds for oil production. Seed oil has a high unsaturated fatty acid content and has high nutritional value as an edible oil. The fraction after the oil is collected is added as a highly safe food to snacks, cereals, breads, sausages, etc., and also used as feed additives and pharmaceutical raw materials.
ペポカボチャ種子の生化学的、薬理学的作用としては、前立腺肥大抑制作用、利尿作用、駆虫作用、蛋白質生合成に対する作用、血液凝固・線溶系に対する作用、膀胱機能に対する作用等が知られているが(非特許文献1)、睡眠改善作用については明らかにされていなかった。 The biochemical and pharmacological effects of peppo pumpkin seeds are known to include prostate hypertrophy suppression, diuretic action, anthelmintic action, action on protein biosynthesis, action on blood coagulation / fibrinolytic system, action on bladder function, etc. (Non-Patent Document 1), the sleep improving action has not been clarified.
睡眠薬や睡眠導入薬を服用するほどではないが、眠りが浅い、寝覚めがすっきりしない、寝つきがよくない等の睡眠に関する不満を有する人達にとって、睡眠薬や睡眠導入薬を服用することには抵抗がある。また、これら薬剤の持つ精神症状や筋弛緩作用などの副作用に対する不安が少なからず存在している。そのため、睡眠に関する不満を有する人達に対して、彼らの睡眠満足度を高める要望は潜在的に存在する。 Although it is not enough to take sleeping pills or sleep-inducing drugs, people who have sleep dissatisfaction, such as light sleep, lack of awakening, and poor sleep, are reluctant to take sleeping pills and sleep-inducing drugs . In addition, there are many anxieties about side effects such as psychiatric symptoms and muscle relaxant action of these drugs. Therefore, there is a potential demand for people who have dissatisfaction with sleep to increase their sleep satisfaction.
本発明は、睡眠薬や睡眠導入薬を服用するほどではないが、眠りが浅い、寝覚めがすっきりしない、寝つきがよくない等の睡眠に関する不満を有する人達に対して、日常的に簡便に摂取することが可能で、かつ効果的に睡眠の質を改善することが可能な睡眠改善剤を提供することにある。 Although the present invention is not so much as to take sleeping pills or sleep-inducing drugs, it can be easily taken on a daily basis for people who have sleep dissatisfaction, such as light sleep, poor awakening, and poor sleep. An object of the present invention is to provide a sleep-improving agent capable of effectively improving sleep quality.
本発明者らは、上記課題を解決すべく鋭意探索した結果、手軽に入手でき、かつ長期に渡り安全に服用できるカボチャ属(Cucurbita)種子の、水又は30(v/v)%以下のエタノール溶液抽出物に顕著な睡眠改善作用があることを見出し、さらに、手軽にカボチャ属(Cucurbita)種子抽出物を摂取できる形態を検討した結果、ティーバッグの形態が最も適しているとの知見も得られ、本発明を完成するに至った。 As a result of diligent search to solve the above-mentioned problems, the present inventors have obtained water or 30 (v / v)% or less ethanol of a pumpkin (Cucurbita) seed that can be easily obtained and can be safely taken for a long time. As a result of finding out that the extract of the solution has a remarkable sleep-improving effect, and further examining the form in which the Cucurbita seed extract can be ingested easily, the knowledge that the form of the tea bag is most suitable was also obtained. The present invention has been completed.
すなわち、本発明はカボチャ属(Cucurbita)種子の水又は30(v/v)%以下のエタノール溶液抽出物を含有することを特徴とする睡眠改善剤を提供するものである。 That is, this invention provides the sleep improving agent characterized by containing the water of a pumpkin (Cucurbita) seed | species, or the ethanol solution extract of 30 (v / v)% or less.
また、本発明は袋内にカボチャ属(Cucurbita)種子が収納され、水又は30(v/v)%以下のエタノール溶液に浸漬することにより内容物から有効成分を袋外に溶出させるティーバッグの形態の睡眠改善剤を提供するものである。 In addition, the present invention is a tea bag in which pumpkin seeds are stored in a bag and the active ingredient is eluted from the contents by immersing in water or an ethanol solution of 30 (v / v) or less. A form of sleep improving agent is provided.
本発明の睡眠改善剤は、カボチャ種子の水又は30(v/v)%以下のエタノール溶液抽出物を有効成分として含有することにより、眠りが浅い、寝覚めがすっきりしない、寝つきがよくない、といった睡眠に関する不満を解消し、眠りの質を改善することができる。 The sleep-improving agent of the present invention contains water of pumpkin seeds or an ethanol solution extract of 30 (v / v)% or less as an active ingredient, so that sleep is shallow, sleep is not refreshed, and sleep is not good. It can eliminate sleep dissatisfaction and improve sleep quality.
また、本発明の睡眠改善剤は、カボチャ種子粉末をティーバッグに封入することにより、手軽にカボチャ種子抽出物を得ることができる。 Moreover, the sleep improvement agent of this invention can obtain a pumpkin seed extract easily by enclosing a pumpkin seed powder in a tea bag.
さらに、カボチャ種子は古くから食品として摂取されており、安全性に優れることから、本発明の睡眠改善剤は、その形態に関わらず長期摂取が可能である。 Furthermore, since pumpkin seeds have been ingested as food for a long time and are excellent in safety, the sleep-improving agent of the present invention can be ingested for a long time regardless of its form.
本発明の睡眠改善剤は、カボチャ属(Cucurbita)種子の水又は30(v/v)%以下のエタノール溶液抽出物を含有するものである。 The sleep-improving agent of the present invention contains water of a pumpkin (Cucurbita) seed or an ethanol solution extract of 30 (v / v) or less.
本発明の実施形態において「睡眠改善」とは、自然の睡眠導入の促進(入眠促進)、熟眠感の向上など、睡眠全般の質が向上することをいい、睡眠薬や睡眠導入薬を服用するほどではないが、眠りが浅い、寝覚めがすっきりしない、寝つきがよくない等の睡眠に関する不満を有する人達に対して、彼らの睡眠満足度を高めることを意味する。 In the embodiment of the present invention, “sleep improvement” refers to improvement of the quality of sleep in general, such as promotion of natural sleep induction (promoting sleep), improvement of a feeling of deep sleep, etc. However, it means increasing the level of sleep satisfaction for those who have sleep dissatisfaction, such as light sleep, poor awakening, and poor sleep.
前記カボチャ属(Cucurbita)種子は、ウリ科(Cucurbitaceae)、カボチャ属に分類される植物の果実中の種子を用いる。カボチャ属(Cucurbita)種子としては、その品種に限定されることはないが、睡眠改善剤としての効果を考慮すれば、ペポカボチャ(Cucurbita pepo)又は西洋カボチャ(Cucurbita maxima)の種子であることが好ましい。 As the seed of the genus Cucurbita, a seed in the fruit of a plant classified as Cucurbitaceae or genus Pumpkin is used. The seed of the genus Cucurbita (Cucurbita) is not limited to its variety, but in view of the effect as a sleep improving agent, it is preferably a seed of pepo pumpkin (Cucurbita pepo) or western pumpkin (Cucurbita maxima). .
前記カボチャ属(Cucurbita)種子はそのまま用いてもよいが、カボチャ属(Cucurbita)種子の酸化に対する保存安定性と抽出の容易さを考慮した場合、カボチャ属(Cucurbita)種子から油を採取した後の脂肪含量の低い脱脂カボチャ種子を使用することが好ましい。具体的には、油を取り除いた後の脂肪含量を種子重量の約10重量%以下とすることが好ましく、さらに好ましくは脂肪含量を約1重量%以下に取り除いたカボチャ属(Cucurbita)種子である。 The Cucurbita seed may be used as it is. However, in consideration of the storage stability against the oxidation of the Cucurbita seed and the ease of extraction, after the oil is collected from the Cucurbita seed. It is preferred to use defatted pumpkin seeds with a low fat content. Specifically, it is preferable that the fat content after removing the oil is about 10% by weight or less of the seed weight, and more preferable is a Cucurbita seed from which the fat content is removed to about 1% by weight or less. .
また、カボチャ属(Cucurbita)種子の抽出物を得るためには、種子の形状には限定されない。例えば外皮の薄いカボチャ属(Cucurbita)種子ではそのまま抽出に供してもよく、外皮の厚いものでは二つ割以上に割ったものを使用することもできる。また、カボチャ属(Cucurbita)種子の搾油後に残った搾り粕を使用することもでき、さらにそれを粉砕処理したカボチャ属(Cucurbita)種子粉末を使用することもできる。 Moreover, in order to obtain the extract of a pumpkin (Cucurbita) seed, it is not limited to the shape of a seed. For example, pumpkin seeds with a thin outer skin may be subjected to extraction as they are, and those with a thick outer skin can be used by dividing into 20% or more. Moreover, the squeezed rice cake which remained after the oil extraction of the pumpkin (Cucurbita) seed | species can also be used, and also the pumpkin seed | species (Cucurbita) seed powder which grind | pulverized it can also be used.
カボチャ属(Cucurbita)種子中に含まれる油脂の酸化安定性を考慮するとなるべく粒子は粗いほうがよいが、有効成分の抽出効率を考慮すると、ある程度粒子が細かいほうが望ましい。具体的には、粉砕粒度において500μm以下の粒子の占める割合が 50重量%以上であることが好ましい。 The particles should be as coarse as possible considering the oxidative stability of the fats and oils contained in the seeds of the genus Cucurbita, but it is desirable that the particles be fine to some extent when considering the extraction efficiency of the active ingredient. Specifically, the proportion of particles of 500 μm or less in the pulverized particle size is preferably 50% by weight or more.
本実施例において使用されるカボチャ属(Cucurbita)種子は、殺菌処理が施されたものであることが好ましい。殺菌処理により、グラム陰性病原菌(例えばサルモネラ菌)を実質的に滅菌することができるため、睡眠改善剤としての安全性を高めることができる。 The pumpkin (Cucurbita) seeds used in this example are preferably those that have been sterilized. The sterilization treatment can substantially sterilize Gram-negative pathogenic bacteria (eg, Salmonella), so that safety as a sleep improving agent can be enhanced.
具体的には、例えば、カボチャ属(Cucurbita)種子、脱脂カボチャ種子又はカボチャ種子粉末を、過熱水蒸気殺菌装置により110℃の過熱水蒸気の中を数秒間くぐらせることで殺菌処理を行うことができる。また、マイクロウェーブ殺菌機を用いて殺菌処理をすることもできる。 Specifically, for example, a sterilization treatment can be performed by passing a pumpkin seed, a defatted pumpkin seed or a pumpkin seed powder through superheated steam at 110 ° C. for several seconds with a superheated steam sterilizer. Moreover, it can also sterilize using a microwave sterilizer.
本発明の睡眠改善剤は水又はアルコール抽出で得られるため、液体のまま利用することもできるが、乾燥処理を行い、乾燥粉末とすれば保存性もよく、加工食品にも添加しやすい。乾燥する方法には制限はないが、例えば、噴霧乾燥法、ドラム乾燥、凍結乾燥法等を挙げることができる。また、必要に応じて、乾燥する前に、濃縮、ろ過、粉末化基材の添加等、いわゆるエキス粉末の製造で一般に行われている工程を加えることもできる。 Since the sleep-improving agent of the present invention is obtained by extraction with water or alcohol, it can be used as it is, but if it is dried and made into a dry powder, it has good storage stability and can be easily added to processed foods. Although there is no restriction | limiting in the method of drying, For example, a spray-drying method, drum drying, a freeze-drying method etc. can be mentioned. Moreover, before drying, the process generally performed by manufacture of what is called an extract powder, such as concentration, filtration, and addition of a powdered base material, can also be added before drying as needed.
本実施形態の睡眠改善剤の成人1日服用量は、固形分換算で50mg〜1000mgが望ましく、100mg〜500mgがより好ましい。また、いつ服用しても問題はないが、夕食後から就寝直前までに服用することが推奨される。 The daily dose for adults of the sleep improving agent of this embodiment is desirably 50 mg to 1000 mg, more preferably 100 mg to 500 mg, in terms of solid content. Although there is no problem when taking it, it is recommended to take it after dinner until just before going to bed.
本実施形態の睡眠改善剤は、公知の製剤化方法、特に経口摂取に適した製剤化技術を使用して製剤化することができる。製剤としては、錠剤被覆錠剤、カプセル剤、顆粒剤、細粒剤、散剤、乳剤、シロップ剤等を挙げることができる。 The sleep-improving agent of the present embodiment can be formulated using a known formulation method, particularly a formulation technique suitable for oral intake. Examples of the preparation include tablet-coated tablets, capsules, granules, fine granules, powders, emulsions, syrups and the like.
例えば、経口剤の剤形が、錠剤、顆粒剤、散剤等の場合には、糖類、デンプン、タンパク質、植物末等の賦形剤;結晶セルロース、カルメロースナトリウム、カルメロースカルシウム、炭酸カルシウム、炭酸水素ナトリウム、アルギン酸ナトリウム等の崩壊剤;ステアリン酸マグネシウム、タルク、水素添加植物油、マクロゴール、シリコン油等の滑沢剤;ポリビニールアルコール、ヒドロキシプロピルセルロース、メチルセルロース、エチルセルロース、カルメロース、ゼラチン、デンプンのり液等の結合剤;脂肪酸エステル等の界面活性剤;グリセリン等の可塑剤等を添加して、製剤化することができる。 For example, when the oral dosage form is tablets, granules, powders, etc., excipients such as sugars, starches, proteins, plant powders; crystalline cellulose, carmellose sodium, carmellose calcium, calcium carbonate, carbonic acid Disintegrants such as sodium hydrogen and sodium alginate; lubricants such as magnesium stearate, talc, hydrogenated vegetable oil, macrogol, silicone oil; polyvinyl alcohol, hydroxypropylcellulose, methylcellulose, ethylcellulose, carmellose, gelatin, starch paste It can be formulated by adding a binder such as a fatty acid ester, a plasticizer such as glycerin, and the like.
経口剤の剤形がシロップ剤等の液体調製物である場合は、水;ショ糖、ソルビトール、果糖等の糖類;フレーバー類などを添加して、製剤化することができる。 When the oral dosage form is a liquid preparation such as a syrup, it can be formulated by adding water; sugars such as sucrose, sorbitol and fructose; flavors and the like.
カボチャ種子抽出物は様々な加工食品に添加し、摂取せしめることができる。添加する加工食品に制限はなく、原料の由来や形態はいずれでもよい。例えば、クッキー、せんべい、錠菓、ゼリー、グミ、ガム、チョコレート、シリアル等の菓子類;アイスクリーム、プリン、ゼリー、ババロア等のデザート類;スポーツ飲料、栄養ドリンク、野菜や果汁飲料等の飲料類;スープ等の液状食品;ココア、抹茶粉末、ふりかけ等の粉末食品類;ドレッシング、マヨネーズ等の油脂含有食品等が挙げられるが、これら以外でもよい。 Pumpkin seed extract can be added to various processed foods and consumed. There is no restriction | limiting in the processed food to add, Any may be sufficient as the origin and form of a raw material. For example, confectionery such as cookies, rice crackers, tablet confectionery, jelly, gummi, gum, chocolate, cereal, etc .; desserts such as ice cream, pudding, jelly, bavaroa; beverages such as sports drinks, energy drinks, vegetables and fruit juice drinks Liquid foods such as soup; powdered foods such as cocoa, matcha powder, and sprinkles; and fat-containing foods such as dressing and mayonnaise.
また、本実施形態の睡眠改善剤の効果を減じない、すなわち、本実施形態の睡眠改善剤との配合により好ましくない相互作用を生じない限り、必要に応じて、ビタミンA、カロチン類、ビタミンB群、ビタミンC、ビタミンD群、ビタミンE、ビタミンK群、ビタミンP、ナイアシン、ニコチン酸、パントテン酸、ビオチン、イノシトール、コリン、葉酸等のビタミン類;カルシウム、カリウム、マグネシウム、ナトリウム、銅、鉄、マンガン、亜鉛、セレン等のミネラル類;糖質、タンパク質、脂質、食物繊維等の栄養成分;香料;色素などを混合することができる。これらはいずれも飲食品に一般的に用いられるものが使用できる。 Moreover, as long as it does not reduce the effect of the sleep improving agent of the present embodiment, that is, an undesirable interaction is not caused by blending with the sleep improving agent of the present embodiment, vitamin A, carotenes, vitamin B may be used as necessary. Group, vitamin C, vitamin D group, vitamin E, vitamin K group, vitamin P, niacin, nicotinic acid, pantothenic acid, biotin, inositol, choline, folic acid and other vitamins; calcium, potassium, magnesium, sodium, copper, iron , Manganese, zinc, selenium and other minerals; carbohydrates, proteins, lipids, dietary fiber and other nutritional ingredients; flavors; pigments and the like. Any of those commonly used for food and drink can be used.
さらに、本実施形態の睡眠改善剤は、嗜好性および機能性を高める目的で、カボチャ属(Cucurbita)種子以外の植物の葉、茎、根、花、果実、種子からなる群から選ばれる1種または2種以上の素材を含有することができる。 Furthermore, the sleep-improving agent of the present embodiment is one kind selected from the group consisting of leaves, stems, roots, flowers, fruits, and seeds of plants other than pumpkin (Cucurbita) seeds for the purpose of enhancing palatability and functionality. Or 2 or more types of raw materials can be contained.
具体的には、例えば、ハト麦、烏龍茶、ハブ茶、サンザシ、麦芽、甜茶、アマドコロ、ギムネマシルベスタ、ベニバナ、ダイダイ、緑茶、玄米、ウーロン茶、昆布、よもぎ、霊芝、クコ、熊笹、柿の葉、シイタケ、ミカンの皮、決明子(えびす草種子)、浜茶、モロヘイヤ、杜仲葉、甘草、びわ葉、バンカ、高麗人参、ルイボス、あまちゃづる、すぎな、ほうじ茶、プーアル茶、金花茶、緑茶抽出物、くちなしの実、生姜、ナツメ、薄荷、月見草、グァバ葉、バナバ葉、カワラケツメイ、エビスグサ、モロヘイヤ、オオバコ、ヨモギ、クコ葉、クワ葉、イチョウ、スイカズラ、カキドオシ、マテ葉、ウラジロガシ、シソ、ゴマ、アーティーチョーク、エキナセア、エルダーフラワー、オレガノ、オレンジピール、オレンジブロッサム、カモミール、カルダモン、クローブ、クワンソウ、ゲンノショウコ、コンフリー、サフラワー、サマーセイボリー、シジュウム、シナモン、ジャスミン、ジュニパーベリー、ステビア、セージ、セルピルム、セントジョーンズ、ターメリック、タイム、タンポポ、ネトル、ハイビスカス、バジル、パッションフラワー、バニラビーンズ、バレリアン、ヒソップ、フィーバーフュー、フェンネル、ホップ、マージョラム、マリーゴールド、マロウ、ペパーミント、メドウスイート、ヤロウ、ユーカリ、ラフマ、ラベンダー、リコリス、リンデン、レモングラス、レモンバーベナ、レモンバーム、レモンピール、ローズ、ローズヒップ、ローズマリー、ワイルドストロベリー等の一種以上を組み合わせることができる。 Specifically, for example, pigeons, oolong tea, hub tea, hawthorn, malt, strawberry tea, amadokoroko, gymnema sylvestre, safflower, daidai, green tea, brown rice, oolong tea, kelp, wormwood, ganoderma, wolfberry, bear cocoon, bamboo leaf , Shiitake mushroom peel, citrus peel (Ebisu grass seeds), beach tea, morohaya, chunakaba, licorice, loquat leaf, banca, ginseng, rooibos, messy, too much, hojicha, puer tea, gold flower tea, green tea Extract, beakless fruit, ginger, jujube, light load, evening primrose, guava leaf, banaba leaf, arabesque, shrimp, moroheiya, plantain, mugwort, wolfberry leaf, mulberry leaf, ginkgo, honeysuckle, oyster, mate leaf, vulgaris, perilla, Sesame, artichoke, echinacea, elderflower, oregano, orange peel, orange blossom, chamomile Lemon, Cardamom, Cloves, Gwansow, Gen's pepper, Comfrey, Saflower, Summer savory, Sisium, Cinnamon, Jasmine, Juniper berry, Stevia, Sage, Serpyrum, St. John's, Turmeric, Thyme, Dandelion, Nettle, Hibiscus, Basil, Passion Flower, Vanilla Beans, Valerian, Hyssop, Fever Fue, Fennel, Hop, Marjoram, Marigold, Mallow, Peppermint, Meadow Sweet, Yarrow, Eucalyptus, Ruffa, Lavender, Licorice, Linden, Lemongrass, Lemon Verbena, Lemon Balm, Lemon Peel , Rose, Rosehip, Rosemary, Wild Strawberry etc. can be combined.
本発明はまた、袋内にカボチャ属(Cucurbita)種子が収納され、水又は30(v/v)%以下のエタノール溶液に浸漬することにより内容物から有効成分を袋外に溶出させるティーバッグの形態の睡眠改善剤を提供するものである。 The present invention also relates to a tea bag in which pumpkin seeds are contained in a bag and the active ingredient is eluted from the contents by immersing in water or an ethanol solution of 30 (v / v)% or less. A form of sleep improving agent is provided.
すなわち、不織布袋又はメッシュ袋等の袋内にカボチャ種子を収納し、水又は30(v/v)%以下のエタノール溶液に浸漬することにより、睡眠の改善に有効な成分を袋外に溶出させるものである。ティーバッグの形態であれば、睡眠改善効果を有するカボチャ属抽出物を簡単に得ることができ、お茶やアルコール飲料と同様にそのまま飲料として服用することができる。 That is, pumpkin seeds are stored in a bag such as a non-woven bag or a mesh bag, and immersed in water or an ethanol solution of 30 (v / v)% or less to elute ingredients effective for improving sleep out of the bag. Is. If it is the form of a tea bag, the pumpkin genus extract which has a sleep improvement effect can be obtained easily, and can be taken as it is as a drink like tea and alcoholic beverages.
本実施形態におけるティーバッグの形態の睡眠改善剤は、ティーバッグの形態とするほか、必要に応じて先述した睡眠改善剤について記載した事項を適宜適用することができる。 The sleep improving agent in the form of a tea bag in the present embodiment is not limited to the form of a tea bag, and the items described above regarding the sleeping improving agent can be appropriately applied as necessary.
また、本実施形態のティーバッグの形態の睡眠改善剤の効果を減じない、すなわち、本実施形態のティーバッグの形態の睡眠改善剤との配合により好ましくない相互作用を生じない限り、必要に応じて、上述したビタミン類、ミネラル類、糖質等の栄養成分、香料、色素などを混合することができる。 Moreover, as long as it does not reduce the effect of the sleep improving agent in the form of the tea bag of the present embodiment, that is, as long as an undesirable interaction is not caused by the combination with the sleep improving agent in the form of the tea bag of the present embodiment, as necessary. In addition, nutrients such as vitamins, minerals, and sugars, fragrances, and pigments described above can be mixed.
さらに、本実施形態のティーバッグの形態の睡眠改善剤は、嗜好性および機能性を高める目的で、上述したカボチャ属(Cucurbita)種子以外の植物の葉、茎、根、花、果実、種子からなる群から選ばれる1種または2種以上の素材を含有することができる。 Furthermore, the sleep improving agent in the form of the tea bag of the present embodiment is from the leaves, stems, roots, flowers, fruits and seeds of plants other than the above-mentioned Cucurbita seeds for the purpose of enhancing palatability and functionality. One or two or more materials selected from the group can be contained.
以下に実施例を挙げて本発明をさらに具体的に説明するが、本発明はそれらの限定されるものではない。 EXAMPLES The present invention will be described more specifically with reference to examples below, but the present invention is not limited thereto.
1.睡眠改善剤の調製
(1)ペポカボチャ種子
ペポカボチャ種子の脱脂粉末100gに脱イオン水1kgを加え、3時間撹拌した。その後、ろ過を行うことにより不溶物を除去し、全量が400gになるまでろ過液を濃縮した。次いでその濃縮物を凍結乾燥することにより、ペポカボチャ種子由来の睡眠改善剤11.8gを得た。
1. Preparation of sleep improving agent (1) Pepo pumpkin seeds 1 kg of deionized water was added to 100 g of defatted powder of peppo pumpkin seeds and stirred for 3 hours. Thereafter, the insoluble matter was removed by filtration, and the filtrate was concentrated until the total amount reached 400 g. Subsequently, the concentrate was freeze-dried to obtain 11.8 g of a sleep improving agent derived from peppo pumpkin seeds.
(2)西洋カボチャ種子
西洋カボチャ種子の脱脂粉末100gに30(v/v)%エタノール溶液1kgを加え、一晩撹拌した。その後、ろ過を行うことにより不溶物を除去し、全量が400gになるまで濃縮した。次いでその濃縮物を噴霧乾燥することにより、西洋カボチャ種子由来の睡眠改善剤7.4gを得た。
(2) Western pumpkin seeds 1 kg of 30 (v / v)% ethanol solution was added to 100 g of defatted powder of western pumpkin seeds and stirred overnight. Thereafter, filtration was performed to remove insoluble matters, and the mixture was concentrated until the total amount became 400 g. Subsequently, the concentrate was spray-dried to obtain 7.4 g of a sleep improving agent derived from western pumpkin seeds.
(3)ペポカボチャ種子ティーバッグ1
ペポカボチャ種子の脱脂粉末5gをピラミッド型の不織布製ティーバッグに充填した。飲用方法は、このティーバッグをカップに入れ、180mlの熱湯を注ぎ5分程度抽出してから飲用することを標準とした。
(3) Pepo Pumpkin Seed Tea Bag 1
5 g of pepo pumpkin seed defatted powder was filled into a pyramid-type non-woven tea bag. The standard drinking method was to put this tea bag in a cup, pour 180 ml of hot water and extract it for about 5 minutes before drinking.
(4)ペポカボチャ種子ティーバッグ2
ペポカボチャ種子の脱脂粉末4gとクワンソウ葉乾燥物1gをピラミッド型の不織布製ティーバッグに充填した。飲用方法は、このティーバッグをカップに入れ、180mlの熱湯を注ぎ5分程度抽出してから飲用することを標準とした。
(4) Pepo Pumpkin Seed Tea Bag 2
4 g of pepo pumpkin seed defatted powder and 1 g of dried Kwanso leaves were filled into a pyramid-type non-woven tea bag. The standard drinking method was to put this tea bag in a cup, pour 180 ml of hot water and extract it for about 5 minutes before drinking.
(5)ペポカボチャ種子ティーバッグ3
ペポカボチャ種子の脱脂粉末3gとラフマ葉乾燥物2gをピラミッド型の不織布製ティーバッグに充填した。飲用方法は、このティーバッグをカップに入れ、180mlの熱湯を注ぎ5分程度抽出してから飲用することを標準とした。
(5) Pepo Pumpkin Seed Tea Bag 3
Pyramid-type non-woven tea bags were filled with 3 g of pepo pumpkin seed defatted powder and 2 g of dried luffa leaves. The standard drinking method was to put this tea bag in a cup, pour 180 ml of hot water and extract it for about 5 minutes before drinking.
2.睡眠改善確認試験1
(1)試験方法
睡眠薬や睡眠導入薬を飲むほどではないが、睡眠に不満のある被験者25名を選び、以下の要領で睡眠改善確認試験を行った。すなわち、最初の1週間(試験前期間)は、対照期間として白湯180mlを、就寝1時間前から就寝前に飲用してもらった。その後3週間(試験期間)にわたって、上記1(3)で調製したティーバッグ形態の睡眠改善剤を服用した。服用方法は、上記1(3)で調製したティーバッグ形態の睡眠改善剤をカップに入れ、180mlの熱湯を注ぎ5分程度抽出し、就寝1時間前から就寝前に飲用してもらった。
2. Sleep improvement confirmation test 1
(1) Test method 25 subjects who were not enough to take sleeping pills or sleep-inducing drugs, but were unhappy with sleep, and conducted a sleep improvement confirmation test in the following manner. That is, in the first week (pre-test period), 180 ml of white hot water was drunk from 1 hour before bedtime to bedtime as a control period. Thereafter, over a period of 3 weeks (test period), the sleep improving agent in the form of a tea bag prepared in the above 1 (3) was taken. The taking method was that the tea bag-type sleep-improving agent prepared in 1 (3) above was put in a cup, 180 ml of hot water was poured and extracted for about 5 minutes, and was drunk from 1 hour before bedtime to bedtime.
(2)睡眠改善に関する評価
試験開始から試験終了日までの全4週間にわたり、被験者に日誌記載を依頼した。日誌には、白湯又は睡眠改善剤を飲んだ時刻、就寝・起床時間、普段の生活と異なる点(運動量や飲酒について)、補足メモ(体調や副作用について)を記載させた。睡眠改善に関する評価は、試験期間前と比較したときの試験期間中の睡眠の改善度合いを、「2」:著明改善、「1」:少し改善、「0」:不変、「−1」:悪化、の4段階で評価してもらった。
(2) Evaluation on sleep improvement Over 4 weeks from the start of the test to the end of the test, the subjects were asked to write a diary. The diary included the time of drinking white hot water or sleep-improving agent, bedtime / wake-up time, points different from normal life (about exercise amount and drinking), and supplementary notes (about physical condition and side effects). The evaluation regarding sleep improvement is the degree of improvement in sleep during the test period when compared with before the test period: “2”: marked improvement, “1”: slight improvement, “0”: unchanged, “−1”: We had you evaluate in four stages of deterioration.
(3)データ集計および統計解析
摂取期間の3週間について、1週間ごとに4段階の評価数値の平均値を算出し、スコア化した。試験期間前のスコアを0とし、それぞれとの統計解析を行った。
(3) Data aggregation and statistical analysis For the three weeks of the intake period, the average value of the four evaluation values was calculated for each week and scored. The score before the test period was set to 0, and statistical analysis with each was performed.
スコアについてはKruskal Wallis H-testを行い、有意差が認められたときにはDunnett’s testにてpost−hoc test(多重比較検定)を行った。 As for the score, Kruskal Wallis H-test was performed. When a significant difference was observed, a post-hoc test (multiple comparison test) was performed at Dunnett's test.
睡眠満足度の変化について、試験期間中の睡眠満足度スコアの平均値を表1に示す。睡眠満足度は睡眠改善剤の摂取期間1週目から有意に改善し(P<0.01)、試験が後半になるにつれて改善度合いも大きくなった。その結果、ペポカボチャ種子ティーバッグには、顕著な有意差をもって睡眠改善効果があることが認められた。 Table 1 shows the average value of sleep satisfaction scores during the test period with respect to changes in sleep satisfaction. The degree of sleep satisfaction improved significantly from the first week of taking the sleep improving agent (P <0.01), and the degree of improvement increased as the test progressed to the second half. As a result, it was confirmed that the Pepo Pumpkin Seed Tea Bag has a sleep improvement effect with a significant difference.
3.睡眠改善確認試験2
睡眠改善確認試験1と同様にして、ペポカボチャ種子抽出物の睡眠改善効果を確認した。被験者にはペポカボチャ種子ティーバッグの代わりに、前記1(1)で調製したペポカボチャ種子由来の睡眠改善剤を0.5g含有する錠剤を製造し、就寝1時間前から就寝前に飲用してもらった。試験期間前の白湯の飲用は行わなかった。それ以外は睡眠改善確認試験1と全く同様に行った。
3. Sleep improvement confirmation test 2
In the same manner as sleep improvement confirmation test 1, the sleep improvement effect of the peppo pumpkin seed extract was confirmed. The subject produced a tablet containing 0.5 g of the sleep improving agent derived from the peppo pumpkin seed prepared in 1 (1) above instead of the peppo pumpkin seed tea bag, and was taken from 1 hour before bedtime to bedtime. . Drinking white water before the test period was not performed. Other than that was carried out in exactly the same way as sleep improvement confirmation test 1.
睡眠満足度の変化について、被験者25名の試験期間中の睡眠満足度スコアの平均値を表2に示す。睡眠改善確認試験1と同様に、睡眠満足度は摂取期間1週目から有意に改善し(P<0.01)、試験が後半になるにつれて改善度合いも大きくなった。これにより、ペポカボチャ種子由来の睡眠改善剤にも、睡眠改善効果があることが確認された。 Table 2 shows the average value of sleep satisfaction scores during the test period of 25 subjects with respect to changes in sleep satisfaction. Similar to Sleep Improvement Confirmation Test 1, sleep satisfaction improved significantly from the first week of the intake period (P <0.01), and the degree of improvement increased as the test progressed to the second half. Thereby, it was confirmed that the sleep improvement agent derived from a peppo pumpkin seed also has a sleep improvement effect.
4.睡眠改善確認試験3
睡眠改善確認試験1と同様にして、西洋カボチャ種子抽出物の睡眠改善効果を確認した。被験者にはペポカボチャ種子ティーバッグの代わりに、前記1(2)で調製した西洋カボチャ種子由来の睡眠改善剤を0.1g含有する錠剤を製造し、就寝1時間前から就寝前に飲用してもらった。試験期間前の白湯の飲用は行わなかった。それ以外は睡眠改善確認試験1と全く同様に行った。
4). Sleep improvement confirmation test 3
The sleep improvement effect of the western pumpkin seed extract was confirmed in the same manner as sleep improvement confirmation test 1. In place of the peppo pumpkin seed tea bag, the subject manufactured a tablet containing 0.1 g of the sleep improving agent derived from the western pumpkin seed prepared in 1 (2) and had it taken from 1 hour before bedtime to bedtime. It was. Drinking white water before the test period was not performed. Other than that was carried out in exactly the same way as sleep improvement confirmation test 1.
睡眠満足度の変化について、被験者25名の試験期間中の睡眠満足度スコアの平均値を表3に示す。睡眠改善確認試験1と同様に、睡眠満足度は摂取期間2週目から有意に改善し(P<0.01)、試験が後半になるにつれて改善度合いも大きくなった。これにより、西洋カボチャ種子由来の睡眠改善剤にも、睡眠改善効果があることが確認された。 Table 3 shows the average value of sleep satisfaction scores during the test period of 25 subjects with respect to changes in sleep satisfaction. Similar to Sleep Improvement Confirmation Test 1, sleep satisfaction improved significantly from the 2nd week of the intake period (P <0.01), and the degree of improvement increased as the test progressed to the second half. Thereby, it was confirmed that the sleep improvement agent derived from a western pumpkin seed also has a sleep improvement effect.
5.睡眠改善確認試験4
睡眠改善確認試験1と同様にして、上記1(4)で調製したティーバッグ形態の睡眠改善剤を服用した。服用方法、評価方法、統計解析は睡眠改善確認試験1と全く同様に行った。
5. Sleep improvement confirmation test 4
In the same manner as sleep improvement confirmation test 1, the tea bag form sleep improving agent prepared in 1 (4) above was taken. The dosing method, the evaluation method, and the statistical analysis were performed in exactly the same manner as the sleep improvement confirmation test 1.
睡眠満足度の変化について、被験者25名の試験期間中の睡眠満足度スコアの平均値を表4に示す。睡眠改善確認試験1と同様に、睡眠満足度は摂取期間2週目から有意に改善し(P<0.01)、試験が後半になるにつれて改善度合いも大きくなった。これにより、ペポカボチャ種子にクワンソウをさらに含有させることで、睡眠改善効果がさらに向上することが確認された。 Table 4 shows the average value of sleep satisfaction scores during the test period of 25 subjects with respect to changes in sleep satisfaction. Similar to Sleep Improvement Confirmation Test 1, sleep satisfaction improved significantly from the 2nd week of the intake period (P <0.01), and the degree of improvement increased as the test progressed to the second half. Thereby, it was confirmed that the sleep improvement effect is further improved by further adding kuwanso to the peppo pumpkin seeds.
6.睡眠改善確認試験5
睡眠改善確認試験1と同様にして、上記1(5)で調製したティーバッグ形態の睡眠改善剤を服用した。服用方法、評価方法、統計解析は睡眠改善確認試験1と全く同様に行った。
6). Sleep improvement confirmation test 5
In the same manner as sleep improvement confirmation test 1, the sleep improving agent in the form of a tea bag prepared in 1 (5) above was taken. The dosing method, the evaluation method, and the statistical analysis were performed in exactly the same manner as the sleep improvement confirmation test 1.
睡眠満足度の変化について、被験者25名の試験期間中の睡眠満足度スコアの平均値を表5に示す。睡眠改善確認試験1と同様に、睡眠満足度は摂取期間2週目から有意に改善し(P<0.01)、試験が後半になるにつれて改善度合いも大きくなった。これにより、ペポカボチャ種子にラフマをさらに含有させることで、睡眠改善効果がさらに向上することが確認された。 Table 5 shows the average value of sleep satisfaction scores during the test period of 25 subjects with respect to changes in sleep satisfaction. Similar to Sleep Improvement Confirmation Test 1, sleep satisfaction improved significantly from the 2nd week of the intake period (P <0.01), and the degree of improvement increased as the test progressed to the second half. Thereby, it was confirmed that the sleep improvement effect is further improved by further adding rafuma to the peppo pumpkin seeds.
睡眠改善確認試験4、5の結果から、ペポカボチャ種子にカボチャ属(Cucurbita)種子以外の植物の葉、茎、根、花、果実、種子からなる群から選ばれる1種または2種以上の素材をさらに含有させることで、睡眠改善効果がさらに向上することが立証された。 From the results of sleep improvement confirmation tests 4 and 5, one or more materials selected from the group consisting of leaves, stems, roots, flowers, fruits, and seeds other than pumpkin seeds are added to the peppo pumpkin seeds. Furthermore, it was proved that the sleep improvement effect was further improved by the inclusion.
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WO2023113278A1 (en) * | 2021-12-15 | 2023-06-22 | 아주대학교산학협력단 | Anti-stress composition comprising natural extract mixture, and use thereof |
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JP7337363B2 (en) * | 2019-02-28 | 2023-09-04 | 株式会社ウェルナス | Oral composition for improving sleep |
CN114404576A (en) * | 2022-03-31 | 2022-04-29 | 深圳德荫堂生物科技有限公司 | Medicine for soothing nerves and aiding sleep and production method thereof |
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LAPS | Cancellation because of no payment of annual fees |