JP6007417B2 - 新規glp−1受容体安定剤および調節剤 - Google Patents
新規glp−1受容体安定剤および調節剤 Download PDFInfo
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- JP6007417B2 JP6007417B2 JP2014513706A JP2014513706A JP6007417B2 JP 6007417 B2 JP6007417 B2 JP 6007417B2 JP 2014513706 A JP2014513706 A JP 2014513706A JP 2014513706 A JP2014513706 A JP 2014513706A JP 6007417 B2 JP6007417 B2 JP 6007417B2
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- 0 CC**(I(C)=C1)=**=C1C(N(CC(O)=O)Cc(cc1)ccc1-c1c[o]c(-c2cc(CC3CC3)ccc2)n1)=O Chemical compound CC**(I(C)=C1)=**=C1C(N(CC(O)=O)Cc(cc1)ccc1-c1c[o]c(-c2cc(CC3CC3)ccc2)n1)=O 0.000 description 22
- HXAKXGYHLSQZAT-UHFFFAOYSA-N N#Cc(cc1)ccc1-c1c[o]c(-c(cc2)ccc2Br)n1 Chemical compound N#Cc(cc1)ccc1-c1c[o]c(-c(cc2)ccc2Br)n1 HXAKXGYHLSQZAT-UHFFFAOYSA-N 0.000 description 3
- VTOPCOHGNVVQDI-UHFFFAOYSA-N CC(C)(C)OC(CN(Cc(cc1)ccc1O)C(c(cc1)ccc1NC(Cc(cc1)c(C(F)(F)F)cc1OC)=O)=O)=O Chemical compound CC(C)(C)OC(CN(Cc(cc1)ccc1O)C(c(cc1)ccc1NC(Cc(cc1)c(C(F)(F)F)cc1OC)=O)=O)=O VTOPCOHGNVVQDI-UHFFFAOYSA-N 0.000 description 2
- MWEPEELWZJPSNQ-UHFFFAOYSA-N CCCCCCCOc1ccc(Cc2nc3cc(C=O)ccc3[nH]2)cc1 Chemical compound CCCCCCCOc1ccc(Cc2nc3cc(C=O)ccc3[nH]2)cc1 MWEPEELWZJPSNQ-UHFFFAOYSA-N 0.000 description 2
- LJANCPRIUMHGJE-UHFFFAOYSA-N N#Cc(cc1)ccc1C(CBr)=O Chemical compound N#Cc(cc1)ccc1C(CBr)=O LJANCPRIUMHGJE-UHFFFAOYSA-N 0.000 description 2
- NEGDYSVDTFPAIV-UHFFFAOYSA-N O=Cc(cc1)ccc1-c1c[o]c(-c(cc2)ccc2Br)n1 Chemical compound O=Cc(cc1)ccc1-c1c[o]c(-c(cc2)ccc2Br)n1 NEGDYSVDTFPAIV-UHFFFAOYSA-N 0.000 description 2
- URWNWBSDMSXHAX-UHFFFAOYSA-N CC(C)(C)OC(CN(Cc(cc1)ccc1OC(c(cc1)ccc1Br)=O)C(c(cc1)ccc1NC(Cc(cc1)c(C(F)(F)F)cc1OC)=O)=O)=O Chemical compound CC(C)(C)OC(CN(Cc(cc1)ccc1OC(c(cc1)ccc1Br)=O)C(c(cc1)ccc1NC(Cc(cc1)c(C(F)(F)F)cc1OC)=O)=O)=O URWNWBSDMSXHAX-UHFFFAOYSA-N 0.000 description 1
- MILMOOGFNFCVHV-UHFFFAOYSA-N CC(C)(C)OC(CNCc(cc1)ccc1-c1c[o]c(-c(cc2)ccc2Br)n1)=O Chemical compound CC(C)(C)OC(CNCc(cc1)ccc1-c1c[o]c(-c(cc2)ccc2Br)n1)=O MILMOOGFNFCVHV-UHFFFAOYSA-N 0.000 description 1
- GEPSGAZCRVXGNT-UHFFFAOYSA-N CC(C)(C)OC(CNCc(cc1)ccc1O)=O Chemical compound CC(C)(C)OC(CNCc(cc1)ccc1O)=O GEPSGAZCRVXGNT-UHFFFAOYSA-N 0.000 description 1
- XEKQTBWHYNJMDX-UHFFFAOYSA-N CC(C)(C)OC(N(CC(OC)=O)Cc(cc1)ccc1C#N)=O Chemical compound CC(C)(C)OC(N(CC(OC)=O)Cc(cc1)ccc1C#N)=O XEKQTBWHYNJMDX-UHFFFAOYSA-N 0.000 description 1
- KZFCZWLGLRKNEF-UHFFFAOYSA-N CCCCCCCOC1C=CC(C(Oc2ccc(CN(CC(OC(C)(C)C)=O)C(c(cc3)ccc3N=O)=O)cc2)=O)=CC1 Chemical compound CCCCCCCOC1C=CC(C(Oc2ccc(CN(CC(OC(C)(C)C)=O)C(c(cc3)ccc3N=O)=O)cc2)=O)=CC1 KZFCZWLGLRKNEF-UHFFFAOYSA-N 0.000 description 1
- ZRVIYEJYXIDATJ-UHFFFAOYSA-N CCCCCCCOc(cc1)ccc1C(O)=O Chemical compound CCCCCCCOc(cc1)ccc1C(O)=O ZRVIYEJYXIDATJ-UHFFFAOYSA-N 0.000 description 1
- BFEZVZBCRXRFGE-UHFFFAOYSA-N CCCCCCCOc(cc1)ccc1C(Oc1cc(OC)c(C=O)cc1)=O Chemical compound CCCCCCCOc(cc1)ccc1C(Oc1cc(OC)c(C=O)cc1)=O BFEZVZBCRXRFGE-UHFFFAOYSA-N 0.000 description 1
- FMMBAJKHOCXKOD-UHFFFAOYSA-N CCCCCCCOc(cc1)ccc1C(Oc1ccc(CN(CC(O)=O)C(c(cc2)ccc2C(NCc(cc2)c(C(F)(F)F)cc2OC)=O)=O)cc1)=O Chemical compound CCCCCCCOc(cc1)ccc1C(Oc1ccc(CN(CC(O)=O)C(c(cc2)ccc2C(NCc(cc2)c(C(F)(F)F)cc2OC)=O)=O)cc1)=O FMMBAJKHOCXKOD-UHFFFAOYSA-N 0.000 description 1
- DCLGSZZBKUHDBD-UHFFFAOYSA-N CCCCCCCOc(cc1)ccc1C(Oc1ccc(CN(CC(OC(C)(C)C)=O)C(c(cc2)ccc2NC(Cc(c(C(F)(F)F)c2)ccc2OC)=O)=O)cc1)=O Chemical compound CCCCCCCOc(cc1)ccc1C(Oc1ccc(CN(CC(OC(C)(C)C)=O)C(c(cc2)ccc2NC(Cc(c(C(F)(F)F)c2)ccc2OC)=O)=O)cc1)=O DCLGSZZBKUHDBD-UHFFFAOYSA-N 0.000 description 1
- SPGNHSLAANOJAG-UHFFFAOYSA-N CCCCCCCOc(cc1)ccc1C(Oc1ccc(CNC(c(cc2)ccc2[N+]([O-])=O)=O)cc1)=O Chemical compound CCCCCCCOc(cc1)ccc1C(Oc1ccc(CNC(c(cc2)ccc2[N+]([O-])=O)=O)cc1)=O SPGNHSLAANOJAG-UHFFFAOYSA-N 0.000 description 1
- QSMIUSCWMLKLJN-UHFFFAOYSA-N CCCCCCCOc1ccc(Cc2nc(cc(cc3)C#N)c3[nH]2)cc1 Chemical compound CCCCCCCOc1ccc(Cc2nc(cc(cc3)C#N)c3[nH]2)cc1 QSMIUSCWMLKLJN-UHFFFAOYSA-N 0.000 description 1
- USZYIQAPOTUNKJ-UHFFFAOYSA-N CCCCCCCOc1ccc(Cc2nc3cc(CNCC(OC(C)(C)C)=O)ccc3[nH]2)cc1 Chemical compound CCCCCCCOc1ccc(Cc2nc3cc(CNCC(OC(C)(C)C)=O)ccc3[nH]2)cc1 USZYIQAPOTUNKJ-UHFFFAOYSA-N 0.000 description 1
- DTQACBOISKRHJE-UHFFFAOYSA-N CCOC(CNCc(cc1)ccc1-c1c[o]c(-c2ccc(C)cc2)n1)=O Chemical compound CCOC(CNCc(cc1)ccc1-c1c[o]c(-c2ccc(C)cc2)n1)=O DTQACBOISKRHJE-UHFFFAOYSA-N 0.000 description 1
- JGDNLNGUBKTITA-UHFFFAOYSA-N COC(CNCc(cc1)ccc1C#N)=O Chemical compound COC(CNCc(cc1)ccc1C#N)=O JGDNLNGUBKTITA-UHFFFAOYSA-N 0.000 description 1
- VZYRHZBUKHZBAN-UHFFFAOYSA-N COc1cc(C(F)(F)F)c(CC(Nc(cc2)ccc2C(N(CC(O)=O)Cc(cc2)ccc2OC(c(cc2)ccc2-c(cc2)ccc2Cl)=O)=O)=O)cc1 Chemical compound COc1cc(C(F)(F)F)c(CC(Nc(cc2)ccc2C(N(CC(O)=O)Cc(cc2)ccc2OC(c(cc2)ccc2-c(cc2)ccc2Cl)=O)=O)=O)cc1 VZYRHZBUKHZBAN-UHFFFAOYSA-N 0.000 description 1
- VQUUGQJCPMMHRT-UHFFFAOYSA-N Cc(cc1)ccc1-c(cc1)ccc1C(Oc1ccc(CN(CC(O)=O)C(c(cc2)ccc2NC(Cc(cc2)c(C(F)(F)F)cc2OC)=O)=O)cc1)=O Chemical compound Cc(cc1)ccc1-c(cc1)ccc1C(Oc1ccc(CN(CC(O)=O)C(c(cc2)ccc2NC(Cc(cc2)c(C(F)(F)F)cc2OC)=O)=O)cc1)=O VQUUGQJCPMMHRT-UHFFFAOYSA-N 0.000 description 1
- RQJDUEKERVZLLU-UHFFFAOYSA-N NCc(cc1)ccc1O Chemical compound NCc(cc1)ccc1O RQJDUEKERVZLLU-UHFFFAOYSA-N 0.000 description 1
- SMEAMQXMRKHVEX-UHFFFAOYSA-N OCc(cc1)ccc1-c1c[o]c(-c(cc2)ccc2Br)n1 Chemical compound OCc(cc1)ccc1-c1c[o]c(-c(cc2)ccc2Br)n1 SMEAMQXMRKHVEX-UHFFFAOYSA-N 0.000 description 1
Classifications
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| RU2634896C2 (ru) | 2011-12-12 | 2017-11-08 | Селджин Интернэшнл Ii Сарл | Новые модуляторы рецептора glp-1 |
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| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| JP6864675B2 (ja) * | 2015-10-02 | 2021-04-28 | シンジェンタ パーティシペーションズ アーゲー | 殺微生物オキサジアゾール誘導体 |
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| EP2713722B1 (en) | 2017-03-15 |
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| US20140336185A1 (en) | 2014-11-13 |
| US20160310471A1 (en) | 2016-10-27 |
| JP2016128509A (ja) | 2016-07-14 |
| US9278910B2 (en) | 2016-03-08 |
| DK2713722T3 (en) | 2017-07-03 |
| US9700543B2 (en) | 2017-07-11 |
| EP2713722A4 (en) | 2014-11-26 |
| PT2713722T (pt) | 2017-06-27 |
| WO2012166951A9 (en) | 2013-02-21 |
| JP2014527027A (ja) | 2014-10-09 |
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