JP6002691B2 - 組織因子経路阻害剤に対するアプタマーおよび出血障害治療薬としてのそれらの使用 - Google Patents

組織因子経路阻害剤に対するアプタマーおよび出血障害治療薬としてのそれらの使用 Download PDF

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JP6002691B2
JP6002691B2 JP2013553643A JP2013553643A JP6002691B2 JP 6002691 B2 JP6002691 B2 JP 6002691B2 JP 2013553643 A JP2013553643 A JP 2013553643A JP 2013553643 A JP2013553643 A JP 2013553643A JP 6002691 B2 JP6002691 B2 JP 6002691B2
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tfpi
aptamer
amino acids
ome
seq
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JP2014507147A (ja
JP2014507147A5 (enExample
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ロバート シャウブ，
ロバート シャウブ，
キャスリーン マクギネス，
キャスリーン マクギネス，
ジェニファー ネルソン，
ジェニファー ネルソン，
ライアン ゲンガ，
ライアン ゲンガ，
エミリー ウォーターズ，
エミリー ウォーターズ，
ジェフリー クルス，
ジェフリー クルス，
ジョン ディーナー，
ジョン ディーナー，
Original Assignee
バクスアルタ ゲーエムベーハー
バクスアルタ ゲーエムベーハー
バクスアルタ インコーポレイテッド
バクスアルタ インコーポレイテッド
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Priority claimed from US13/026,165 external-priority patent/US8598327B2/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Organic Chemistry (AREA)
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  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
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  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013553643A 2011-02-11 2012-02-13 組織因子経路阻害剤に対するアプタマーおよび出血障害治療薬としてのそれらの使用 Active JP6002691B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/026,165 2011-02-11
US13/026,165 US8598327B2 (en) 2009-08-18 2011-02-11 Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
PCT/US2012/024916 WO2012109675A1 (en) 2011-02-11 2012-02-13 Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics

Publications (3)

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JP2014507147A JP2014507147A (ja) 2014-03-27
JP2014507147A5 JP2014507147A5 (enExample) 2015-04-09
JP6002691B2 true JP6002691B2 (ja) 2016-10-05

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JP2013553643A Active JP6002691B2 (ja) 2011-02-11 2012-02-13 組織因子経路阻害剤に対するアプタマーおよび出血障害治療薬としてのそれらの使用

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EP (1) EP2673364A1 (enExample)
JP (1) JP6002691B2 (enExample)
AU (1) AU2012214148A1 (enExample)
CA (1) CA2827160A1 (enExample)
WO (1) WO2012109675A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101745394B1 (ko) † 2008-12-22 2017-06-09 노보 노르디스크 에이/에스 조직 인자 경로 억제자에 대한 항체
SG183443A1 (en) 2010-03-01 2012-09-27 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
WO2013142153A2 (en) * 2012-03-22 2013-09-26 Baxter International Inc. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
CN111411164B (zh) * 2020-05-26 2022-11-01 中国检验检疫科学研究院 利用数字pcr检测番茄溃疡病菌的方法及其使用的成套试剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
AU738513B2 (en) 1997-02-28 2001-09-20 University Of Iowa Research Foundation, The Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders
US6426334B1 (en) 1997-04-30 2002-07-30 Hybridon, Inc. Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
EP1872786A1 (en) 1997-09-05 2008-01-02 The Regents of the University of California Use of immunostimulatory oligonucleotides for preventing or reducing antigen-stimulated, granulocyte-mediated inflammation
US6514948B1 (en) 1999-07-02 2003-02-04 The Regents Of The University Of California Method for enhancing an immune response
US20080161425A1 (en) * 2005-07-29 2008-07-03 Universiteit Van Maastricht Regulation of Tissue Factor Activity by Protein S and Tissue Factor Pathway Inhibitor
JP5739816B2 (ja) * 2008-12-19 2015-06-24 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Ｔｆｐｉインヒビターおよび使用法
FR2942232B1 (fr) * 2009-02-19 2015-03-13 Lfb Biotechnologies Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre
WO2011022427A1 (en) * 2009-08-18 2011-02-24 Archemix Corp. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics

Also Published As

Publication number Publication date
WO2012109675A1 (en) 2012-08-16
CA2827160A1 (en) 2012-08-16
JP2014507147A (ja) 2014-03-27
AU2012214148A1 (en) 2013-08-29
EP2673364A1 (en) 2013-12-18

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