CA2827160A1 - Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics - Google Patents
Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics Download PDFInfo
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- CA2827160A1 CA2827160A1 CA2827160A CA2827160A CA2827160A1 CA 2827160 A1 CA2827160 A1 CA 2827160A1 CA 2827160 A CA2827160 A CA 2827160A CA 2827160 A CA2827160 A CA 2827160A CA 2827160 A1 CA2827160 A1 CA 2827160A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/026,165 | 2011-02-11 | ||
| US13/026,165 US8598327B2 (en) | 2009-08-18 | 2011-02-11 | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| PCT/US2012/024916 WO2012109675A1 (en) | 2011-02-11 | 2012-02-13 | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2827160A1 true CA2827160A1 (en) | 2012-08-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2827160A Abandoned CA2827160A1 (en) | 2011-02-11 | 2012-02-13 | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
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|---|---|
| EP (1) | EP2673364A1 (enExample) |
| JP (1) | JP6002691B2 (enExample) |
| AU (1) | AU2012214148A1 (enExample) |
| CA (1) | CA2827160A1 (enExample) |
| WO (1) | WO2012109675A1 (enExample) |
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| KR101745394B1 (ko) † | 2008-12-22 | 2017-06-09 | 노보 노르디스크 에이/에스 | 조직 인자 경로 억제자에 대한 항체 |
| SG183443A1 (en) | 2010-03-01 | 2012-09-27 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| WO2013142153A2 (en) * | 2012-03-22 | 2013-09-26 | Baxter International Inc. | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| CN111411164B (zh) * | 2020-05-26 | 2022-11-01 | 中国检验检疫科学研究院 | 利用数字pcr检测番茄溃疡病菌的方法及其使用的成套试剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AU738513B2 (en) | 1997-02-28 | 2001-09-20 | University Of Iowa Research Foundation, The | Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| EP1872786A1 (en) | 1997-09-05 | 2008-01-02 | The Regents of the University of California | Use of immunostimulatory oligonucleotides for preventing or reducing antigen-stimulated, granulocyte-mediated inflammation |
| US6514948B1 (en) | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
| US20080161425A1 (en) * | 2005-07-29 | 2008-07-03 | Universiteit Van Maastricht | Regulation of Tissue Factor Activity by Protein S and Tissue Factor Pathway Inhibitor |
| JP5739816B2 (ja) * | 2008-12-19 | 2015-06-24 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | Ｔｆｐｉインヒビターおよび使用法 |
| FR2942232B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre |
| WO2011022427A1 (en) * | 2009-08-18 | 2011-02-24 | Archemix Corp. | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
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2012
- 2012-02-13 EP EP12706378.2A patent/EP2673364A1/en not_active Withdrawn
- 2012-02-13 AU AU2012214148A patent/AU2012214148A1/en not_active Abandoned
- 2012-02-13 CA CA2827160A patent/CA2827160A1/en not_active Abandoned
- 2012-02-13 JP JP2013553643A patent/JP6002691B2/ja active Active
- 2012-02-13 WO PCT/US2012/024916 patent/WO2012109675A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012109675A1 (en) | 2012-08-16 |
| JP2014507147A (ja) | 2014-03-27 |
| AU2012214148A1 (en) | 2013-08-29 |
| JP6002691B2 (ja) | 2016-10-05 |
| EP2673364A1 (en) | 2013-12-18 |
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