JP5995714B2 - Packing bag for patch - Google Patents

Description

  The present invention relates to a packaging bag for a patch, and more specifically, it can safely seal and package an adhesive sheet-like patch containing a transdermal drug such as an analgesic anti-inflammatory agent and manufacture a laminate used for the packaging bag. The present invention relates to a packaging bag for adhesive patches that can reduce the amount of organic solvent discharged during the process, and further improves the opening of the packaging bag when the packaged contents are taken out.

  Conventionally, as a packaging bag for sealing and packaging an adhesive sheet-like patch containing a transdermal penetrating agent such as an analgesic anti-inflammatory agent, for example, a base material layer, a barrier layer, a sealant layer (usually a polyolefin resin layer) Etc., a packaging bag produced by heat-sealing a laminated body obtained by laminating each of them via an adhesive layer has been used. However, if the contents to be packed contain a highly permeable component, the component may penetrate into the sealant layer during long-term storage and attack the adhesive layer between the barrier layer and the sealant layer. In the case of remarkable damage, the sealant layer peeled off (delamination) and the packaging bag was damaged.

As a method of laminating the sealant layer on the barrier layer, generally, an anchor coat layer is provided as an adhesive layer on the barrier layer surface, and a resin of the sealant layer is extruded and laminated thereon, or the barrier layer surface in advance. A method of laminating and laminating a film of a sealant layer formed into a film shape by a dry lamination method using an adhesive for dry lamination such as a two-component curable polyurethane adhesive as an adhesive layer is employed.
And as an anchor coat agent (henceforth AC agent) used for the said anchor coat layer, organic titanium system AC agent, isocyanate system AC agent (urethane system), polyethyleneimine system AC agent, polybutadiene system AC agent, etc. AC agents are commercially available and used, but in any case where the contents contain highly permeable medicinal ingredients, the resistance is insufficient, and as a test for promoting the preservability of a packaging bag in which the contents are hermetically sealed, for example, When the storage test was conducted at 60 ° C. for about 2 weeks, there was a problem that the sealant layer peeled off from the barrier layer.
Similarly, when the sealant layer is bonded to the barrier layer by the dry lamination method, there is a problem that the adhesive for the dry laminate is insufficient and the sealant layer is peeled off from the barrier layer by the storage test.
Moreover, the AC agent and the adhesive for dry laminating, except for some of them, use an organic solvent for the coating solution. there were.

As a means for solving such a problem, in the method of extruding and coating a resin of a sealant layer on the barrier layer, an anchor coat layer is not provided on the barrier layer surface, an aluminum foil is used as the barrier layer, and aluminum is used. A method of using an ethylene-methacrylic acid random copolymer (EMAA resin), which is said to exhibit excellent adhesion to a metal such as a foil, as a sealant layer resin, and directly extruding and coating the aluminum foil surface As a result of producing the laminate with the laminate and producing a packaging bag with the laminate, the sealant layer is sealed even when the contents containing the medicinal component having a strong permeability are sealed in the packaging bag and the storage test is performed. Was able to produce a packaging bag that did not peel from the barrier layer.
However, even with this packaging bag, peeling of the sealant layer due to the storage test (delamination) could be prevented, but the laminate strength itself of the sealant layer with respect to the barrier layer was not always sufficient, and therefore tearing when opening the packaging bag In other words, there is a problem that the cutting property, i.e., the hand cutting property is not good.

In order to completely solve the above-mentioned problems, as a result of various studies on AC agents used for laminating a sealant layer to the barrier layer by extrusion coating, etc., as a result of research on unsaturated carboxylic acids or their anhydrides, An aqueous dispersion in which a polyolefin copolymer resin containing 0.01 to 5% by mass is dispersed so that its number average particle size is as small as 1 μm or less, and the aqueous dispersion contains a nonvolatile aqueous auxiliary agent By applying an aqueous dispersion formed so as not to contain an AC agent so that the thickness upon drying is 0.1 to 2 μm, the coating surface of the barrier layer is a metal foil such as an aluminum foil or biaxial Even a plastic film such as stretched polyethylene terephthalate adheres well to the surface, and is laminated on it as a sealant layer with an extrusion coat, etc. A packaging bag made by using a laminate produced by using this AC agent, with a polyolefin resin layer adhered well, is a pressure-sensitive adhesive sheet-like adhesive containing a medicinal component having a strong permeability as described above. The present invention has been completed by finding that the sealant layer does not peel off even when the above-mentioned storage test is carried out after the medicine is sealed and packaged, and that the hand tearability at the time of opening is good.

In addition, there is no prior art document relating to a packaging bag that can be sealed and packaged with the content containing a medicinal component having a strong penetrability as described above, and can be safely stored for a long time. There is a material and an outer bag for a cataplasm using the same, in which a vapor-deposited surface of a sealant film, on which aluminum is vapor-deposited, is laminated via an adhesive on the back surface of a printing substrate mainly composed of a paper layer. In addition, it is also described that a non-stretched polypropylene film is used as the sealant film, and that an outer bag for a poultice is produced using the outer packaging material (see Patent Document 1).
However, this Patent Document 1 does not provide any reference to the present invention regarding the storability when the outer bag is sealed and packaged with a poultice and stored for a long period of time.
There is a patent document relating to an aqueous dispersion of a polyolefin resin having a structure used for the AC agent and a method for producing the same, and a coating composition and an adhesive composition containing the aqueous dispersion are also described. It is also described that the coating film is excellent in water resistance (see Patent Document 2).
However, the coating film of the polyolefin resin aqueous dispersion described in Patent Document 2 is excellent in resistance to transdermal penetrating agents such as an analgesic anti-inflammatory agent, and in the production of a laminate used for a packaging bag, By using this aqueous dispersion as an AC agent at the time of sealing, the contents containing the medicinal ingredients having strong penetrability as described above are hermetically packaged, and even if the storage test as described above is performed, excellent resistance to withstand it It is not described at all that a packaging bag having can be manufactured.

JP 2002-166495 A (pages 2 to 3) Japanese Patent No. 3699935 (pages 1 to 15)

  The present invention has been made in order to solve the above-described problems, and the problem is that the adhesive sheet-like patch containing a transdermal penetrant such as an analgesic anti-inflammatory agent is hermetically packaged. A packaging bag formed by heat-sealing the body, and after the contents are sealed and packaged, as a preservative acceleration test, the sealant layer or the like is peeled off even if a storage test is performed at 60 ° C. for 2 weeks. There is no lamination), it has excellent content resistance and content preservability, is easy to open when opening the bag, that is, easy to cut, and discharges organic solvents when producing laminates. The present invention is to provide a packaging bag for a patch, which is excellent in performance and suitability for use, which can be reduced in amount, and has little adverse effect on the environment.

The above problems can be solved by the following present invention.
That is, the present invention is a packaging bag for sealing and packaging an adhesive sheet-like patch containing a transdermal penetrating agent such as a pain relieving anti-inflammatory agent, and the packaging bag includes at least a base material layer, an adhesive layer, a barrier A layered product obtained by laminating a layer, an anchor coat layer, and a polyolefin-based resin layer in this order is formed by heat-sealing, and the anchor coat layer of the layered product contains an unsaturated carboxylic acid or its anhydride in an amount of 0.01. An aqueous dispersion in which a polyolefin copolymer resin containing ˜5% by mass is dispersed so that its number average particle diameter is 1 μm or less, and the aqueous dispersion substantially contains a non-volatile aqueous agent. An aqueous dispersion formed in such a manner is applied to the surface of the barrier layer so that the thickness when dried is 0.1 to 2 μm, and dried by heating. The polyolefin resin layer is formed of the anchor coating. It is made of a packaging bag for a patch, which is formed by a method of extruding and coating a polyolefin resin on the surface of a layer or a method of extruding and laminating a polyolefin resin film using a similar polyolefin resin.

  Further, the present invention provides the adhesive packaging bag, wherein the barrier layer is an aluminum foil or a deposited film obtained by depositing aluminum, aluminum oxide or silicon oxide on a base film.

  The present invention also provides the packaging bag for a patch, wherein the base material layer is paper or a biaxially stretched polyethylene terephthalate film.

  Moreover, this invention consists of a packaging bag for patches, wherein an easy-opening means is provided at the opening position of the packaging bag for patches.

Furthermore, the present invention is a packaging bag for sealing and packaging an adhesive sheet-like patch containing a transdermal penetrating drug such as a pain relieving anti-inflammatory agent, the packaging bag comprising at least a base material layer, an adhesive layer, and a barrier layer The laminate formed by laminating the anchor coat layer and the polyolefin resin layer in this order is heat-sealed, and a printing layer is provided on the outer surface side or inner surface side of the base material layer,
The anchor coat layer is an aqueous dispersion in which a polyolefin copolymer resin containing 0.01 to 5% by mass of an unsaturated carboxylic acid or an anhydride thereof is dispersed so that the number average particle size thereof is 1 μm or less. In addition, an aqueous dispersion formed so that the aqueous dispersion does not substantially contain a non-volatile aqueous additive is applied to the barrier layer surface so that the thickness upon drying is 0.1 to 2 μm. Formed by heating and drying,
The polyolefin resin layer is formed by a method of extruding and coating a polyolefin resin on the surface of the anchor coat layer or a method of extruding and laminating a polyolefin resin film using a similar polyolefin resin. It is a packaging bag for patch.

  The easy-opening means includes a cut line by printing, a display instructing opening by letters, symbols, etc., as well as notches, half-cut lines, and a plurality of square-shaped pushes that narrow in the cutting direction ( It is particularly effective when the base material layer is paper), and any of these may be used alone, but for example, a cut line by printing, a notch and a half cut line, It is more preferable to use a combination of a plurality of them.

According to the present invention, since the patch packaging bag is configured as described above, the following effects can be obtained.
(1) Since the laminate forming the packaging bag for a patch is formed by laminating at least the base material layer, the adhesive layer, the barrier layer, the anchor coat layer, and the polyolefin resin layer in this order, it is necessary for the packaging bag. Almost all performance can be imparted. In other words, the base material layer provides the necessary strength, rigidity, and printability, and the barrier layer reliably blocks the penetration of water vapor and other gases from the outside to the outside, thereby preserving the content. Can increase the sex. Moreover, since a polyolefin-type resin layer can be used for the sealant layer of a packaging bag, the outstanding heat-seal property and content resistance property can be provided.
(2) Since the anchor coat layer provided on the barrier layer surface when the polyolefin resin layer of the sealant layer is laminated on the barrier layer is configured as described above, the anchor coat layer lamination surface of the barrier layer is a metal such as an aluminum foil. Even if it is a foil or a plastic film surface such as a vapor deposition film, it is possible to form a uniform anchor coat layer that adheres well and has no defects such as pinholes. Also, when laminating the polyolefin resin layer of the sealant layer on the anchor coat layer, the polyolefin resin is extrusion coated or the polyolefin resin film is extruded and laminated using the same polyolefin resin. Since they are laminated, the sealant layer is firmly heat bonded to the anchor coat layer surface, and the laminate strength of the sealant layer becomes excellent.
Therefore, an adhesive sheet-like patch containing a transdermal drug such as an analgesic anti-inflammatory agent is hermetically sealed in the packaging bag of the present invention, and a storage test such as 60 ° C. for 2 weeks is performed. However, it can be set as the packaging bag for adhesive patches in which the sealant layer does not peel (delaminate).
(3) Further, since the anchor coat layer is formed of the aqueous dispersion of polyolefin copolymer resin as described above, the anchor coat layer has a good resistance to a transdermal drug such as an analgesic anti-inflammatory agent and is laminated. The amount of organic solvent discharged during body production can also be reduced, and adverse effects on the environment can be reduced.

  According to the present invention, in the configuration of the patch packaging bag, the barrier layer is an aluminum foil or a vapor deposition film obtained by vapor-depositing aluminum, aluminum oxide, or silicon oxide on a base film. Therefore, the gas barrier property of the adhesive packaging bag can be further improved, and at the same time, the permeation of the medicinal components in the contents can be further reduced, and the storage stability of the contents can be further improved. .

  According to the present invention, since the base material layer is a paper or a biaxially oriented polyethylene terephthalate film in the configuration of the patch packaging bag, the rigidity, mechanical strength, and printing of the patch packaging bag are further provided. The aptitude, hand cutting ability, etc. can be made even better.

  According to the present invention, since the easy-opening means is provided at the opening position of the packaging bag for patch, the packaging bag can be more easily removed when taking out the contents sealed and packaged in the packaging bag. The contents can be taken out after opening.

It is a schematic cross section which shows the structure of one Example of the laminated body used for the packaging bag for adhesive patches of this invention. It is a schematic plan view which shows the structure of one Example of the packaging bag for adhesive patches of this invention. However, the packaging bags are shown with the contents sealed and packaged. It is a schematic plan view which shows the structure of another Example of the packaging bag for adhesive patches of this invention. However, the packaging bags are shown with the contents sealed and packaged. It is the sectional view on the AA line of FIG. 2, FIG.

  The packaging bag for patch of the present invention is characterized by the structure of the laminated body used for the production of the packaging bag. For example, the laminated body having the structure shown in FIG. Can do. Therefore, the form of the bag itself is not particularly limited. For example, a three-side seal type or four-side seal type bag, a flat bag such as a pillow type bag, a self-standing bag such as a standing pouch, or a gusset bag. Any type of bag may be used.

Hereinafter, the present invention will be specifically described with reference to the drawings.
FIG. 1 is a schematic cross-sectional view showing the configuration of an embodiment of a laminate used for the packaging bag for a patch of the present invention.
FIG. 2 is a schematic plan view showing the configuration of an embodiment of the packaging bag for patch of the present invention. However, the packaging bags are shown with the contents sealed and packaged.
FIG. 3 is a schematic plan view showing the configuration of another embodiment of the packaging bag for patch of the present invention. However, the packaging bags are shown with the contents sealed and packaged.
FIG. 4 is a cross-sectional view taken along line AA in FIGS. 2 and 3.
Moreover, this invention is not limited to these drawings, unless the summary is exceeded.

The laminated body 20 shown in FIG. 1 is configured by laminating a base material layer 1, an adhesive layer 2, a barrier layer 3, an anchor coat layer 4, and a polyolefin resin layer 5 in this order from the top.
When the patch packaging bag of the present invention is produced using the laminate 20, the polyolefin resin layer 5 is used as a sealant layer, and the polyolefin resin layer 5 is directed to the inner surface side of the bag. Then, the laminated body 20 is disposed and heat sealed to form a bag.

In the configuration of the laminate 20 shown in FIG. 1, a uniaxial or biaxially stretched plastic film or the like can be used as the base material layer 1 in addition to paper.
As the paper, for example, high-quality paper, art paper, coated paper, pure white roll paper, single gloss bleached kraft paper, special bifurcated kraft paper, bleached kraft paper, synthetic paper, and the like can be used.
Examples of the uniaxial or biaxially stretched plastic film include uniaxial or biaxially stretched polyester film such as polyethylene terephthalate polyethylene naphthalate, and uniaxial or biaxial stretch of polyamide such as nylon 6, nylon 66, MXD6 (polymetaxylylene adipamide). Polyamide films, uniaxial or biaxially oriented polypropylene films, and the like can be used.
These papers or uniaxially or biaxially stretched plastic films can be used alone or in a laminate.

  Further, as the barrier layer 3, in addition to a metal foil such as an aluminum foil, a metal film such as aluminum or an inorganic oxide such as aluminum oxide or silicon oxide is vapor-deposited on a base film such as a biaxially stretched polyethylene terephthalate film. A film, a saponified ethylene / vinyl acetate copolymer film, a polyacrylonitrile film, or the like can be used. When using the said vapor deposition film, the range of 150-2000 mm is suitable for the thickness of a vapor deposition layer, and the range of 200-1000 mm is still more preferable.

The adhesive layer 2 between the base material layer 1 and the barrier layer 3 differs depending on the method of adhering the base material layer 1 and the barrier layer 3, and the adhesive strength can be increased by adhering them together by the dry lamination method. However, in this case, for example, a two-component curable polyurethane adhesive for dry lamination can be used as the adhesive layer 2.
Further, the base material layer 1 and the barrier layer 3 can be bonded together by an extrusion laminating method. In this case, as the adhesive layer 2, a polyolefin-based heat adhesive resin, for example, low density polyethylene, ethylene- A simple substance such as a methacrylic acid copolymer, an ethylene-acrylic acid copolymer, or an ionomer, or a resin blended with an adhesion improver such as a hard resin can be used.

  In the structure of the laminate 20 shown in FIG. 1, the anchor coat layer 4 is composed of a polyolefin copolymer resin containing 0.01 to 5% by mass of an unsaturated carboxylic acid or an anhydride thereof as described above. Is an aqueous dispersion dispersed so as to be 1 μm or less, and the aqueous dispersion formed so that the aqueous dispersion does not substantially contain a non-volatile aqueous agent is used as the barrier layer 3. It is formed by applying and heating and drying so that the thickness upon drying is 0.1 to 2 μm.

Next, the polyolefin resin layer 5 serving as a sealant layer is, for example, low density polyethylene, medium density polyethylene, high density polyethylene, linear low density polyethylene, polypropylene, ethylene-propylene copolymer, ionomer, ethylene-methacrylic acid. Polyolefin resins such as copolymers and ethylene-acrylic acid copolymers can be used.
The polyolefin resin layer 5 is formed by extruding and coating the polyolefin resin on the surface of the anchor coat layer 4 or extruding and laminating a polyolefin resin film using a similar polyolefin resin (so-called sandwich lamination). Can be formed by a method.

FIG. 2 is a schematic plan view showing the configuration of one embodiment of the packaging bag for patch of the present invention, and shows the shape of the packaging bag after the contents are sealed and packaged.
A patch packaging bag 100 shown in FIG. 2 is formed into a four-sided seal type bag using the laminate 20 having the configuration shown in FIG. 1, and the side edges on both sides and the edge on the bottom are side parts. Heat seal with the seal portions 6a, 6b and the bottom seal portion 7 to produce a bag with an opening at the top, and a sheet-like patch 30 (a stack of a plurality of sheets) is filled as a content from the opening at the top, Next, the upper opening is heat sealed with the upper seal portion 8 and sealed.
In making the patch packaging bag 100, the laminated body 20 on both sides is preliminarily placed as an easy-opening means on the lower side of the upper seal portion 8 serving as the opening position of the bag, as shown in the drawing direction. A plurality of laterally C-shaped bracing portions 9 having narrow ends are arranged and provided, and a notch 10 is provided at the end of the cut start side.
In this case, it is more preferable to use paper as the base material layer 1 of the laminate 20 in order to effectively obtain the easy-opening property by the muscle pushing portion 9.
By providing the streaks 9 as described above on the paper of the base material layer 1, the three-dimensional structure due to the entanglement of the pulp fibers in the paper layer of the part is crushed, and the entanglement of the pulp fibers is partially broken and broken apart. Therefore, the resistance to tearing is reduced.
Accordingly, the shape of the muscle pushing portion is not limited to a shape in which a plurality of laterally-shaped bracing-like muscle pushing portions 9 that are narrowed in the cutting direction as shown in the figure are arranged, linear shape, broken line shape, or the horizontal orientation Any shape can be provided as long as the tearing direction can be stabilized, such as a shape in which straight or broken lines are added to the center of the C-shaped array.

FIG. 3 is a schematic plan view showing the configuration of another embodiment of the packaging bag for adhesive patches of the present invention. In this case as well, the shape of the packaging bag after the contents are hermetically sealed is shown.
The patch packaging bag 200 shown in FIG. 3 is formed into a four-side seal type bag using the laminate 20 having the structure shown in FIG. 1 as in the case of the patch packaging bag 100 shown in FIG. The side edges on both sides and the edge of the bottom are heat sealed with the side seals 6a, 6b and the bottom seal 7 to produce a bag with an open top, and the contents from the top opening The sheet-like patch 30 (a plurality of stacked sheets) is filled, and then the upper opening is heat-sealed by the upper seal portion 8 and sealed.
只, the patch packaging bag 200 shown in FIG. 3 is different from the patch packaging bag 100 shown in FIG. 2 in that the muscle pushing portion 9 and the notch 10 provided as easy-opening means at the opening position of the bag. Among them, the muscle pushing portion 9 is changed to the half-cut line 11 and provided on the surface of the laminated body 20 on both sides, and further, the bag is resealed on the inner surface of the laminated body 20 at the lower position of the half-cut line 11. It is the point which set it as the structure attached by heat-bonding the chuck | zipper tape 12 for providing this.

In the figure, the half-cut line 11 is shown in a configuration in which five half-cut lines are provided in parallel. However, only one central half-cut line may be provided, and one half-cut line is provided on each side of the central half-cut line. Alternatively, each of the two half-cut lines may be provided in parallel, and may be provided in an arbitrary shape such as a structure in which half-cut lines that obliquely intersect with the plurality of parallel half-cut lines are added.
As a method of providing the half-cut line 11, a method using laser light irradiation can be adopted in addition to a mechanical method using a rotary or platen type blade. In particular, when the surface of the bag, that is, the base material layer of the laminate 20 is a plastic film such as a biaxially stretched polyethylene terephthalate film, the method using laser light irradiation is simple, and the depth of the half cut line 11 The half-cut line 11 having a depth that is easy to adjust and stable can be provided.

  Next, FIG. 4 is a cross-sectional view taken along line AA in FIGS. 2 and 3, and both cross-sectional views taken along line AA of the packaging bags 100 and 200 for patch shown in FIGS. 2 and 3 are shown in FIG. 4. It becomes the structure shown. That is, in FIG. 4, the sheet-like patch 30 as the contents is surrounded by the laminates 20 and 20 at the top and bottom, and the left and right edge portions of the laminates 20 and 20 are the side seal portions 6a and 6b. It is the structure heat-sealed and sealed.

  Hereinafter, the present invention will be described more specifically with reference to Examples and Comparative Examples.

As a laminate used for the packaging bag for a patch, the laminate 20 having the configuration shown in FIG. 1 is used by using a biaxially stretched polyethylene terephthalate film (hereinafter referred to as a PET film) having a thickness of 12 μm as the base layer 1. A printing surface of the base material layer 1 is printed using a PET film having a thickness of 12 μm, which is printed with a gravure printing on the back surface, and a barrier layer 3 is provided with a silicon oxide vapor deposition film having a thickness of 500 mm on one surface. And a PET film surface of the barrier layer 3 as an adhesive layer 2 between them and dry using a two-component curable polyurethane adhesive for dry lamination so that the coating amount upon drying is 2.5 g / m ^2. Both are bonded together by a lamination method, and then anhydrous maleic acid is used as an AC agent used for the anchor coat layer (hereinafter referred to as AC layer) 4 on the silicon oxide vapor deposition surface of the barrier layer 3. Using an aqueous dispersion of polyolefin copolymer resin containing 2% by mass of acid (number average particle diameter of dispersed resin 0.6 μm, no emulsifier used) so that the dry thickness is 0.5 μm. Then, the AC layer 4 was formed by heating and drying, and a low-density polyethylene (hereinafter referred to as LDPE) was extruded onto the polyolefin resin layer 5 by extrusion coating at a temperature of 295 ° C. to a thickness of 30 μm.
(Configuration of the laminate)
PET film (thickness 12 μm), printing layer / adhesive layer for dry lamination (coating amount 2.5 g / m ² ) / PET film (thickness 12 μm), silicon oxide vapor deposition film (thickness 500 mm) / AC layer (thickness 0. 5μm) / LDPE layer (thickness 30μm)
Using the laminate produced as described above, a rectangular bag with outer dimensions of 170 mm in length and 130 mm in width and a four-sided seal type packaging bag was prepared with a seal width of 6 mm on each side and bottom edge. A packaging bag having an upper portion opened by heat sealing was prepared, and the packaging bag for patch of Example 1 was obtained.
The packaging bag is sealed by heat-sealing the edge of the opening with the upper seal after filling the sheet-like patch as the contents from the upper opening. With the position as the lower side of the upper seal part, three half-cut lines parallel to the opening position of the upper seal part are provided along the planned position of the upper seal part by laser light irradiation during bag making as an easy-opening means at the opening position. A notch was provided at the end of the half-cut line.

In the configuration of the packaging bag for adhesive patch of Example 1, a PET film having a thickness of 12 μm provided with a silicon oxide vapor deposition film used for the barrier layer 3 in the configuration of the laminate used for the packaging bag has a thickness of A patch packaging bag of Example 2 was produced in the same manner as in Example 1 except that a laminate was produced in place of 7 μm aluminum foil (hereinafter referred to as AL foil).
(Configuration of the laminate)
PET film (thickness 12 μm), printing layer / adhesive layer for dry lamination (application amount 2.5 g / m ² ) / AL foil (thickness 7 μm) / AC layer (thickness 0.5 μm) / LDPE layer (thickness 30 μm)

A laminate 20 having the structure shown in FIG. 1 is used as a laminate for an adhesive packaging bag, and a base material layer 1 is made of high-quality paper with a basis weight of 209.3 g / m ² and its surface is subjected to gravure printing. In addition, on the surface of the bag, a horizontal C-shaped streak whose tip is narrowed in the cutting direction using a mold as an easy-opening means at a position corresponding to the opening position when the bag is formed. A plurality of pressing portions 9 (see FIG. 2) are arranged, and an AL foil having a thickness of 7 μm is used for the barrier layer 3, and the AL foil is opposed to the back surface of the fine paper, and between them, Using LDPE as the adhesive layer 2, the fine paper and the AL foil are bonded together by an extrusion laminating method by extruding it to a thickness of 15 μm at an extrusion temperature of 295 ° C., and then bonding the AC foil on the AL foil surface. As an AC agent used in No. 4, maleic anhydride Using an aqueous dispersion of a polyolefin copolymer resin containing 2% by mass of acid (number average particle diameter of dispersed resin 0.6 μm, no emulsifier used), the coating thickness is 0.5 μm when dried. An AC layer 4 was formed by heating and drying, and a polyolefin resin layer 5 was further formed thereon by applying LDPE at an extrusion temperature of 295 ° C. to a thickness of 30 μm.
(Configuration of the laminate)
Printing layer / quality paper (rice basis weight 209.3 g / m ² ) / LDPE layer (thickness 15 μm) / AL foil (thickness 7 μm) / AC layer (thickness 0.5 μm) / LDPE layer (thickness 30 μm)
Using the laminate produced as described above, a rectangular bag with outer dimensions of 170 mm in length and 130 mm in width and a four-sided seal type packaging bag was prepared with a seal width of 6 mm on each side and bottom edge. A packaging bag having an upper opening was prepared by heat sealing. In this case, as the easy-opening means of the bag, a plurality of laterally shaped C-shaped bracing portions 9 whose tips narrow in the cutting direction are arranged on the high-quality paper of the base material layer 1 as described above. However, after making the bag, a notch was provided at the end of the c-shaped muscle pushing portion on the cut-off start side to obtain the packaging bag for patch of Example 3.

[Comparative Example 1]
In the configuration of the packaging bag for patch of Example 1, among the configurations of the laminate used for the packaging bag, the AC layer 4 formed on the vapor deposition film surface of the PET film provided with the vapor deposition film of silicon oxide of the barrier layer 3 Example 1 with the exception of using an isocyanate-based AC agent (a type dissolved and diluted with an organic solvent), which was applied and heat-dried so that the thickness during drying was 0.3 μm. In the same manner, a patch packaging bag of Comparative Example 1 was produced.
(Configuration of the laminate)
PET film (thickness 12 μm), printing layer / adhesive layer for dry lamination (coating amount 2.5 g / m ² ) / PET film (thickness 12 μm), silicon oxide vapor-deposited film (thickness 500 mm) / AC with isocyanate AC agent Layer (thickness 0.3 μm) / LDPE layer (thickness 30 μm)

[Comparative Example 2]
In the configuration of the packaging bag for adhesive patch of Example 2, the AC layer provided on the AL foil surface of the barrier layer 3 was removed from the configuration of the laminate used for the packaging bag, and the LDPE used for the polyolefin resin layer 5 was further removed. A comparative example was formed in the same manner as in Example 2 except that the copolymer was changed to an ethylene-methacrylic acid random copolymer (hereinafter referred to as EMAA resin) and directly extruded onto the AL foil surface to a thickness of 30 μm and laminated. A packaging bag for patch 2 was prepared.
(Configuration of the laminate)
PET film (thickness 12 μm) / printing layer / adhesive layer for dry lamination (application amount 2.5 g / m ² ) / AL foil (thickness 7 μm) / EMAA resin layer (thickness 30 μm)

[Evaluation of packaging bag for patch]
The following tests were performed on the packaging bags for adhesive patches of Examples 1 to 3 and Comparative Examples 1 and 2 prepared as described above in order to evaluate the content resistance and the tearability at the time of opening.

(1) Test for resistance to contents After filling each packaging bag with 5 sheets of a patch containing an analgesic anti-inflammatory agent (glycol salicylate, 1-menthol or the like as a main component) as contents from the opening, The packaging bodies of Examples 1 to 3 and Comparative Examples 1 and 2 in which the opening was heat sealed and the contents were hermetically packaged were prepared.
Each package is subjected to a storage test at 60 ° C. for 2 weeks, and then each package is cut open to delaminate the laminate, particularly whether or not the sealant layer is delaminated, and laminate the sealant layer. The strength was examined.
The laminate strength of the sealant layer was measured using a tensile test apparatus (Tensilon) at a tensile speed of 100 mm / min and a sample width of 15 mm.
(Test results)
-Example 1: No peeling of sealant layer, laminating strength 4.7 N / 15 mm width-Example 2: No peeling of sealant layer, laminating strength 4.5 N / 15 mm width-Example 3: No peeling of sealant layer, laminating Strength 4.6 N / 15 mm width Comparative Example 1: There was peeling of the sealant layer, and the laminate strength could not be measured.
Comparative Example 2: No peeling of sealant layer, laminate strength 3.4 N / 15 mm width

(2) Hand cutting test For each packaging bag after the content storage test, starting from a notch provided at the end of the opening position of the packaging bag, a half-cut line or a C-shaped push Tear the packaging bag by hand along the arrangement of the parts, and check the tear line for large bends, and check for tear line disturbances, such as elongation breaks of the sealant layer due to peeling of the sealant layer at the torn ends. It was.
(Test results)
-Example 1: There is no big bending in a tear line, and there is no disorder of the tear line by the elongation fracture of the sealant layer, and the hand cutting property is good.
-Example 2: There is no big bending in a tear line, and there is no disorder of the tear line due to elongation fracture of the sealant layer, and the hand cutting property is good.
Example 3: The bending of the tear line is within the range of the C-shaped struts, and the tear line is not disturbed by the elongation break of the sealant layer, and the hand cutting property is good.
-Comparative example 1: Peeling of the sealant layer has occurred and the hand cutting property is poor.
Comparative Example 2: The sealant layer was not peeled by the storage test, but the laminate strength was weak, so the tear line was disturbed such as elongation break due to peeling of the sealant layer, and the hand cutting property was poor.

  As is clear from the above test results, the packaging bags for adhesive patches of Examples 1, 2, and 3 were good in both the content resistance by the preservation test of the contents and the hand tearability at the time of opening. On the other hand, among the packaging bags for adhesive patches of Comparative Examples 1 and 2, the adhesive packaging bag of Comparative Example 1 is inferior in content resistance due to peeling of the sealant layer in the storage test. The medicinal packaging bag did not peel off the sealant layer in the above storage test, but the laminate strength of the sealant layer was as weak as 3.4 N / 15 mm width, which was unfavorable due to poor hand cutting at the time of opening.

  The packaging bag for patch of the present invention can be suitably used as a packaging bag for sealing and packaging an adhesive sheet-like patch containing a transdermal penetrating drug such as an analgesic anti-inflammatory agent. There are no particular restrictions on the contents and applications as long as the performance can be used effectively.

DESCRIPTION OF SYMBOLS 1 Base material layer 2 Adhesive layer 3 Barrier layer 4 Anchor coat layer 5 Polyolefin-type resin layer 6a, 6b Side seal part 7 Bottom seal part 8 Upper seal part 9 Muscle push part 10 Notch 11 Half cut line 12 Chuck tape 20 Laminate 30 Sheet-like patch 100, 200 Packing bag for patch

Claims (3)

A packaging bag for sealing and packaging an adhesive sheet-like patch containing a transdermal penetrating drug, the packaging bag being resistant to at least a base layer, an adhesive layer, a barrier layer, and a transdermal penetrating drug An anchor coat layer having a polyolefin resin layer is laminated in this order, and the base material layer is a packaging bag formed by a laminate having a printed layer on the outer surface side or the inner surface side thereof,
The barrier layer is an aluminum foil or a deposited film obtained by depositing aluminum, aluminum oxide, or silicon oxide on a base film,
The anchor coat layer disposed on the barrier layer surface is a polyolefin copolymer resin containing 0.01 to 5% by mass of an unsaturated carboxylic acid or anhydride thereof (however, a (meth) acrylic acid ester component is added to the polyolefin copolymer component). except if it contains.) is by aqueous dispersion having a number-average particle diameter thereof is substantially free of dispersed and non-volatile aqueous aid so that 1μm or less, the dry thickness of 0.1 2 μm layer,
In addition, the polyolefin resin layer that becomes the sealant layer is an extruded polyolefin resin layer disposed on the anchor coat layer surface ,
Further, the laminate strength of the sealant layer is 4.5 to 4.7 N / 15 mm width after hermetically wrapping an analgesic / anti-inflammatory agent as a content and stored at 60 ° C. for 2 weeks, Medicinal packaging bag.   The packaging bag for patches according to claim 1, wherein the base material layer is paper or a biaxially stretched polyethylene terephthalate film.   The packaging bag for patches according to claim 1 or 2, further comprising an easy-opening means at an opening position of the packaging bag for patches.

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