JP5961622B2 - 癌治療のための、エモジンと併用する強心配糖体アナログ - Google Patents
癌治療のための、エモジンと併用する強心配糖体アナログ Download PDFInfo
- Publication number
- JP5961622B2 JP5961622B2 JP2013538290A JP2013538290A JP5961622B2 JP 5961622 B2 JP5961622 B2 JP 5961622B2 JP 2013538290 A JP2013538290 A JP 2013538290A JP 2013538290 A JP2013538290 A JP 2013538290A JP 5961622 B2 JP5961622 B2 JP 5961622B2
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- Prior art keywords
- emodin
- digoxin
- cells
- cancer
- combinations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000010282 Emodin Substances 0.000 title claims description 78
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
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- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41343010P | 2010-11-13 | 2010-11-13 | |
| US61/413,430 | 2010-11-13 | ||
| US13/018,435 | 2011-02-01 | ||
| US13/018,435 US8541382B2 (en) | 2010-11-13 | 2011-02-01 | Cardiac glycoside analogs in combination with emodin for cancer therapy |
| PCT/IB2011/003078 WO2012063134A2 (en) | 2010-11-13 | 2011-11-13 | Cardiac glycoside analogs in combination with emodin for cancer therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506233A JP2014506233A (ja) | 2014-03-13 |
| JP2014506233A5 JP2014506233A5 (enExample) | 2015-01-08 |
| JP5961622B2 true JP5961622B2 (ja) | 2016-08-02 |
Family
ID=46048345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538290A Expired - Fee Related JP5961622B2 (ja) | 2010-11-13 | 2011-11-13 | 癌治療のための、エモジンと併用する強心配糖体アナログ |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US8541382B2 (enExample) |
| EP (1) | EP2637671A4 (enExample) |
| JP (1) | JP5961622B2 (enExample) |
| WO (1) | WO2012063134A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US20170049835A1 (en) | 2015-07-29 | 2017-02-23 | Sirbal Ltd. | Herbal Combinations For Treating Scalp Conditions |
| US9561245B2 (en) | 2012-09-06 | 2017-02-07 | The Board Of Regents Of The University Of Texas System | Combination treatments for melanoma |
| US20140080772A1 (en) * | 2012-09-06 | 2014-03-20 | The Board Of Regents Of The University Of Texas System | Treatments for melanoma |
| US9572828B2 (en) * | 2013-07-18 | 2017-02-21 | The Board Of Regents Of The University Of Texas System | Treatment for melanoma |
| EP3586858A1 (en) | 2015-10-01 | 2020-01-01 | Photodynamic Inc. | Novel polygonum cuspidatum extracts and their use as photodynamic inactivating agents |
| US9795570B2 (en) * | 2016-03-17 | 2017-10-24 | University Of South Carolina | Modulation of macrophage phenotype by emodin |
| US20240076666A1 (en) * | 2021-02-12 | 2024-03-07 | The Regents Of The University Of California | Immunomodulators Targeting MORC3 for Interferon Induction |
| JP2023086330A (ja) * | 2021-12-10 | 2023-06-22 | 株式会社アミノエース | がん細胞の増殖抑制用組成物 |
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| US2068027A (en) * | 1935-05-09 | 1937-01-19 | Rare Chemicals Inc | Process of making glucosides from digitalis purpurea |
| US5872103A (en) | 1986-11-26 | 1999-02-16 | Belletti; Dino A. | Prevention of mammary tumors by treatment with cardiac glycosides |
| JPH06321795A (ja) | 1993-05-07 | 1994-11-22 | Kuga Takaaki | アトピー性皮膚炎等の皮膚疾患治療薬 |
| US6326356B1 (en) | 1996-10-18 | 2001-12-04 | Board Of Regents, The University Of Texas System | Suppression of neu overexpression using a mini-E1A gene |
| WO1997027848A1 (en) * | 1996-01-31 | 1997-08-07 | Board Of Regents, The University Of Texas System | SENSITIZATION OF HER2/neu OVER-EXPRESSING CANCER CELLS TO CHEMOTHERAPEUTIC DRUGS |
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2011
- 2011-02-01 US US13/018,435 patent/US8541382B2/en not_active Expired - Fee Related
- 2011-11-13 WO PCT/IB2011/003078 patent/WO2012063134A2/en not_active Ceased
- 2011-11-13 JP JP2013538290A patent/JP5961622B2/ja not_active Expired - Fee Related
- 2011-11-13 EP EP11839034.3A patent/EP2637671A4/en not_active Withdrawn
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- 2013-09-23 US US14/034,423 patent/US20140206631A1/en not_active Abandoned
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|---|---|
| WO2012063134A2 (en) | 2012-05-18 |
| US8541382B2 (en) | 2013-09-24 |
| US20140206631A1 (en) | 2014-07-24 |
| EP2637671A2 (en) | 2013-09-18 |
| WO2012063134A3 (en) | 2013-12-05 |
| US20120122807A1 (en) | 2012-05-17 |
| JP2014506233A (ja) | 2014-03-13 |
| EP2637671A4 (en) | 2015-01-07 |
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