JP5956928B2 - 哺乳類のステロイドの代謝物質 - Google Patents
哺乳類のステロイドの代謝物質 Download PDFInfo
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- JP5956928B2 JP5956928B2 JP2012538889A JP2012538889A JP5956928B2 JP 5956928 B2 JP5956928 B2 JP 5956928B2 JP 2012538889 A JP2012538889 A JP 2012538889A JP 2012538889 A JP2012538889 A JP 2012538889A JP 5956928 B2 JP5956928 B2 JP 5956928B2
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (3)
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| US26126209P | 2009-11-13 | 2009-11-13 | |
| US61/261,262 | 2009-11-13 | ||
| PCT/US2010/055996 WO2011059969A2 (en) | 2009-11-13 | 2010-11-09 | Mammalian metabolites of steroids |
Publications (3)
| Publication Number | Publication Date |
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| JP2013510856A JP2013510856A (ja) | 2013-03-28 |
| JP2013510856A5 JP2013510856A5 (enExample) | 2013-12-26 |
| JP5956928B2 true JP5956928B2 (ja) | 2016-07-27 |
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| JP2012538889A Expired - Fee Related JP5956928B2 (ja) | 2009-11-13 | 2010-11-09 | 哺乳類のステロイドの代謝物質 |
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| BR (1) | BR112012012167A2 (enExample) |
| CA (1) | CA2780365A1 (enExample) |
| WO (1) | WO2011059969A2 (enExample) |
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| US20100048524A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| EP2393827B1 (en) | 2009-02-05 | 2015-10-07 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| PE20121048A1 (es) | 2009-06-26 | 2012-08-25 | Novartis Ag | Derivados de imidazolidin-2-ona 1,3-disustituida como inhibidores de cyp17 |
| MX359399B (es) | 2011-04-28 | 2018-09-27 | Novartis Ag | Inhibidores de 17alfa-hidroxilasa/c17-20-liasa. |
| CA2904170A1 (en) * | 2013-03-14 | 2014-09-25 | University Of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
| KR20160058774A (ko) | 2013-08-12 | 2016-05-25 | 토카이 파마슈티컬, 아이엔씨. | 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커 |
| WO2016054472A1 (en) | 2014-10-02 | 2016-04-07 | University Of Maryland, Baltimore | Methods of treating pancreatic cancer |
| WO2016119742A1 (zh) * | 2015-01-29 | 2016-08-04 | 苏州晶云药物科技有限公司 | (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法 |
| WO2017140183A1 (zh) * | 2016-02-19 | 2017-08-24 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的甾体类化合物及其应用 |
| CN111454315B (zh) * | 2020-04-15 | 2022-12-09 | 宁波第二激素厂 | 一种雄甾-16-烯-3β-醇的合成方法 |
| CN116621902B (zh) * | 2022-05-18 | 2026-03-27 | 湖南科益新生物医药有限公司 | 17-苯并咪唑基-10α-甲基-甾体衍生物及其制备方法、用途和药物组合物 |
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| US3480621A (en) * | 1967-01-17 | 1969-11-25 | Phytogen Prod Inc | Steroid ketal |
| ES2138618T3 (es) * | 1992-03-31 | 2000-01-16 | Btg Int Ltd | Esteroides 17-sustituidos utiles en el tratamiento del cancer. |
| DE4232681C2 (de) * | 1992-09-29 | 1994-11-24 | Sigma Tau Ind Farmaceuti | 17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung |
| JP5130453B2 (ja) * | 2005-03-02 | 2013-01-30 | ユニバーシティ オブ メリーランド，ボルティモア | 新規なｃ−１７−ヘテロアリールステロイドｃｙｐ１７阻害剤／抗アンドロゲン：合成、インビトロ生物活性、薬物動態および抗腫瘍活性 |
| GB2470873A (en) * | 2008-03-12 | 2010-12-08 | Univ Maryland | Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer |
| WO2009120565A2 (en) * | 2008-03-25 | 2009-10-01 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| WO2010091299A2 (en) * | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel combination cancer therapies |
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2010
- 2010-11-09 AU AU2010319697A patent/AU2010319697B2/en not_active Ceased
- 2010-11-09 US US13/508,726 patent/US20120282331A1/en not_active Abandoned
- 2010-11-09 EP EP10830591A patent/EP2499151A4/en not_active Withdrawn
- 2010-11-09 CA CA2780365A patent/CA2780365A1/en not_active Abandoned
- 2010-11-09 JP JP2012538889A patent/JP5956928B2/ja not_active Expired - Fee Related
- 2010-11-09 BR BR112012012167A patent/BR112012012167A2/pt not_active IP Right Cessation
- 2010-11-09 WO PCT/US2010/055996 patent/WO2011059969A2/en not_active Ceased
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2010319697A1 (en) | 2012-06-07 |
| WO2011059969A2 (en) | 2011-05-19 |
| EP2499151A2 (en) | 2012-09-19 |
| JP2013510856A (ja) | 2013-03-28 |
| US20170008920A1 (en) | 2017-01-12 |
| CN102822190A (zh) | 2012-12-12 |
| WO2011059969A3 (en) | 2011-09-22 |
| BR112012012167A2 (pt) | 2017-10-03 |
| EP2499151A4 (en) | 2013-03-20 |
| AU2010319697B2 (en) | 2016-05-19 |
| CA2780365A1 (en) | 2011-05-19 |
| US20120282331A1 (en) | 2012-11-08 |
| CN102822190B (zh) | 2016-03-30 |
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