JP5950557B2 - Liquid detergent composition - Google Patents

Description

  The present invention relates to a liquid detergent composition. More specifically, (a) an alkaline agent and (b) a compound having a carboxyl group and an amino group at 1: 1 can be used to lower the pH of the stock solution without lowering the alkalinity. The present invention relates to a liquid detergent composition capable of stably blending an enzyme that is easily deactivated in an alkaline environment for a long period of time and also capable of stably blending an active ingredient including a disinfectant, a surfactant, a chelating agent, a dye, and a fragrance. .

  “Alkaline agent” used in the present invention refers to a compound that raises the pH of the liquid detergent composition to the alkaline side, and “alkalinity” means that the alkaline pH is maintained when the liquid detergent composition is diluted. The index which showed the capability to perform by KOH weight% is shown.

  In recent years, there has been a demand for cleaners with higher cleaning power in order to improve convenience for consumers. The higher the alkalinity that is an index of the cleaning power, the liquidity is maintained on the alkaline side even when dirt is loaded, and the dissolution / dispersion of contaminants is promoted. However, in order to increase the alkalinity, it is general that the pH of the composition is higher than that of a practical solution, and in order to obtain an alkalinity effective for detergency, the pH of the stock solution is required to be at least 10 or more. It is. Under such a high alkaline environment, the enzyme blended as an active ingredient is deactivated, the disinfectant loses the bactericidal power, and the surfactant and the dye are denatured to cause deterioration of the appearance. Therefore, it has been strongly desired to provide a liquid detergent composition capable of stably incorporating an active ingredient even under a high alkaline environment.

  The “practical liquid” used in the present invention refers to a liquid obtained by diluting the liquid detergent composition to the actual use concentration.

  On the other hand, in order to improve enzyme stability in an alkaline environment, Patent Document 1 discloses a blending system using (meth) acrylic acid / (meth) acrylic acid ester copolymer and polyethylene glycol, which is set. Since the pH is 10 or more, there is a concern about inactivating enzymes that are susceptible to alkali such as lipase, cellulase, and amylase. Patent Document 2 discloses a compounding system of a copper phthalocyanine blue dye and an azo yellow dye for a combination of amine oxides, alkanolamines and alkali metal hydroxides. There is no denying the typical color change.

Patent 3876945 JP 2008-266552 A

  From the above, in order to obtain high detergency with the conventional technique, it is necessary to increase the alkalinity of the practical liquid, and for that purpose, it is necessary to raise the pH of the liquid detergent composition more than the practical liquid. As a result, the stability of the active ingredients of enzymes, disinfectants, surfactants, chelating agents, dyes, and fragrances that are susceptible to pH increase is lost, and high detergency and performance due to the active ingredients are achieved in the liquid detergent composition. It was difficult to achieve both.

  The present inventors combine (a) an alkali agent with (b) a compound having a carboxyl group and an amino group in a ratio of 1: 1, so that (a) the pH is lower than that of the alkali agent single composition, Finding that the alkalinity can be maintained, and making the performance of at least one active ingredient out of the cleaning power and the enzyme, disinfectant, surfactant, chelating agent, dye, and fragrance in the liquid detergent composition I got the means that can. That is, (a) 2 to 20% by weight of an alkali agent, (b) 0.1 to 20% by weight of a compound having a carboxyl group and an amino group in a ratio of 1: 1, and (c) 0.0001 to 40% by weight of an active ingredient % Is a liquid detergent composition.

  According to the present invention, by using together (a) an alkali agent and (b) a compound having a carboxyl group and an amino group at a ratio of 1: 1, the pH of the stock solution can be lowered without lowering the alkalinity. A liquid detergent composition capable of stably blending an enzyme that is easily inactivated in an alkaline environment for a long period of time and also capable of stably blending an active ingredient including a disinfectant, a surfactant, a chelating agent, a dye, and a fragrance Can be provided.

<(A) Alkaline agent>
Examples of the alkali agent used in the present invention include carbonates and bicarbonates as inorganic salts, and monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA), and tris (hydroxymethyl) amino as alkanolamines. Methane is mentioned.

  The blending amount of the alkaline agent is 2 to 20% by weight, preferably 2 to 15% by weight. These may be used alone or in combination. When the amount is 2% by weight or more, the alkalinity of 1% necessary for detergency can be obtained. When the alkali agent is carbonate and bicarbonate, when the total amount exceeds 15% by weight, it becomes difficult to dissolve. When the alkali agent is alkanolamine, if it exceeds 20% by weight, the unpleasant odor becomes strong. Therefore, the compounding quantity as an alkali agent is limited to 20 weight% or less.

<(B) Compound having a carboxyl group and an amino group at 1: 1>
The compound having a carboxyl group and an amino group of 1: 1 used in the present invention is selected from neutral amino acids and peptides, and these may be used alone or in combination.

  The “neutral amino acid” used in the present invention is an amino acid having an isoelectric point in the range of 5 to 7, and is glycine, serine, threonine, cysteine, asparagine, glutamine, tyrosine, alanine, valine, leucine, isoleucine, Examples include methionine, tryptophan, phenylalanine, and proline. Examples of the peptide include glycylglycine.

  As the particularly preferred component (b) in the present invention, glycine, alanine, methionine, and proline are preferred from the viewpoint of solubility.

  The blending amount of the component (b) is 0.1 to 20% by weight, preferably 0.5 to 20% by weight. Making the pH of the liquid detergent composition closer to neutral is effective for the stability of the active ingredient. However, even if it is added in an amount of 20% by weight or more with respect to the addition range of the alkaline agent, the effect of lowering the pH cannot be obtained, so the blending amount of the component (b) is limited to 20% by weight or less. Moreover, in order to keep in the range of pH 6-10, the mixing | blending of 0.1 weight% or more is required at least.

<(C) Active ingredient>
In the present invention, (c) the active ingredient is
(I) an enzyme or
(Ii) a surfactant or
(Iii) an enzyme and a surfactant or
(Iv) In addition, one of disinfectant, chelating agent, pigment, and fragrance, or
(V) Among the active ingredients described in the above (i), (ii) and (iv), at least two kinds can be blended in the liquid detergent composition.

  The enzyme used in the present invention is not limited as long as it is an enzyme used for washing, and in particular, protease, lipase, amylase, cellulase, and pectinase. Specific examples include Alkalase, Esperase, Sabinase, Everase, Recanase, Genencore's Purefect, Properase, and Protex, which are proteases from Novo Nordisk. Examples of the lipase include lipolase and lipex from Novo Nordisk, and examples of the amylase include Duramil, Stinzyme, Termamyl and Genencor Puraster from Novo Nordisk. Cellulases are exemplified by Novonordisk's Cellzyme, Carezyme and Genencor's Puradax. These may be used alone or in combination of two or more.

  The disinfectant used in the present invention is not limited as long as it is used for the purpose of disinfection or sterilization. As biguanidine compounds, chlorhexidine gluconate, polyhexamethylene biguanide hydrochloride, quaternary ammonium salts as benzalkonium chloride, didecyldimethylammonium chloride, benzethonium chloride, glycine as amphoteric surfactants, alkyldiaminoethylglycine hydrochloride, sodium Examples include alkyldiaminoethylglycine. These may be used alone or in combination of two or more.

  As the surfactant used in the present invention, polyethylene glycol type nonionic surfactant higher alcohol ethylene oxide, alkylphenol ethylene oxide, fatty acid ethylene oxide, polyhydric alcohol fatty acid ester ethylene oxide, higher alkylamine ethylene Oxide, fatty acid amide ethylene oxide, polypropylene glycol ethylene oxide, polyhydric alcohol type nonionic surfactant glycerin and pentaerythritol fatty acid ester, sorbitol and sorbitan fatty acid ester, sucrose fatty acid ester, alkyl polyglucoside, Biosurfactant sophorolipid, rhamnolipid, surfactin, mannosyl erythritol lipid, arthrofactin, Fatty acid alkanolamides. Examples of the carboxylic acid anionic surfactant include soap, polyoxyethylene alkyl ether carboxylate, and alkyl hydroxy ether carboxylate. Examples of the sulfonate anionic surfactant include alkylbenzene sulfonate and oil-soluble alkylbenzene. Examples of the sulfonate, alpha olefin sulfate, sulfate ester anionic surfactant include higher alcohol sulfate, higher alkyl ether sulfate, sulfated oil, sulfated fatty acid ester and sulfated fatty acid, and sulfated olefin. It is done. Examples of amphoteric surfactants include amino acid type amphoteric surfactants and betaine type amphoteric surfactants. These may be used alone or in combination of two or more.

  Examples of the chelating agent used in the present invention include orthophosphoric acid, pyrophosphoric acid, and tripolyphosphoric acid as phosphoric acid compounds. As aminopolyacetic acid, nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA), hydroxyethylenediaminetriacetic acid ( HEDTA), diethylenetriaminopentaacetic acid (DTPA), triethylenetetraaminehexaacetic acid (TTHA), hydroxyethyliminodiacetic acid (HIMDA), 1,3-propanediaminetetraacetic acid (1,3-PDTA), dihydroxyethylglycine ( DHEG), methylglycine diacetate (MGDA), glutamate diacetate (GLDA), aspartate diacetate (ASDA), β-alanine diacetate (ADA), serine diacetate (SDA) and their metal salts. These may be used alone or in combination of two or more.

  Although the fragrance | flavor used by this invention will not be limited if it is used in order to give a fragrance, Especially the following are mentioned. Examples of hydrocarbons include aliphatic hydrocarbons, terpene hydrocarbons, and aromatic hydrocarbons. Examples of alcohols include aliphatic alcohols, terpene alcohols, aromatic alcohols, and ethers include aliphatic ethers and aromatics. Ether. Also, oxides, aldehydes, ketones, acetals, phenols, phenol ethers, aliphatic amides, aliphatic lactones, esters, nitromusks, nitriles, amines, pyridines, quinolines, quinols and indoles Also mentioned. Examples of natural fragrances include animal fragrances and vegetable fragrances, and these may be used alone or in combination of two or more.

  The dye used in the present invention is not limited as long as it is used for the purpose of coloring. Organic dyes include nitro dyes, azo dyes, nitroso dyes, triphenylmethane dyes, xanthene dyes, quinoline dyes, anthraquinone dyes, indigo dyes, and inorganic dyes such as ferrocyanides, sulfides, metal oxides, and silicic acids Examples of salts, phosphates, and natural dyes include carotenoid dyes, flavonoid dyes, flavin dyes, quinone dyes, porphyrin dyes, diketone compounds, betacyanidine dyes, and fluorescent dyes. These may be used alone or in combination of two or more.

  The compounding amount of the active ingredient is 0.0001 to 40% by weight, preferably 0.0005 to 40% by weight. The amount of the enzyme is 0.01 to 20% by weight, preferably 0.1 to 20% by weight. In order to obtain detergency as an enzyme, a blending amount of 0.01% by weight or more is necessary. When used as a cleaning agent for medical equipment, a high detergency is required to quickly remove blood and body fluids. In some products, 20% by weight of the enzyme is blended in the product, and when blended as a liquid detergent composition for medical devices, 20% by weight is necessary to obtain a high detergency. The compounding amount of the surfactant is 1 to 20% by weight, preferably 5 to 20% by weight. If the cleaning action, recontamination prevention action, permeation action, and dispersion action are required as a surfactant, 1% by weight or more is necessary. However, if it exceeds 20% by weight, low temperature stability and nonionic interface are required. Since there is concern about deterioration of the appearance due to the cloud point of the activator, it is limited to 20% by weight or less. The blending amount of the pigment is 0.0001 to 0.5% by weight, preferably 0.0005 to 0.1% by weight. If the purpose is to color the liquid detergent composition itself, 0.0001% by weight or more is necessary, and for the purpose of safety in use, the practical liquid is a diluted liquid detergent composition. In order to visually check by coloring, 0.5% by weight is necessary if the liquid detergent composition is colored. In addition, disinfectants, chelating agents, and fragrances can be blended in the present invention within a range that does not hinder the performance and appearance of the liquid detergent composition, with the blending amount according to the purpose of use. It is. When at least one of disinfectant, dye, chelating agent, and fragrance is blended, the blending amount of the enzyme and / or surfactant can be reduced. The compounding amount as an active ingredient is 0.0001 to 40% by weight, preferably 0.0005 to 40% by weight.

  In the present invention, by adding boric acid or borate, the pH can be increased and the alkalinity can be further increased as compared with the component (b) alone. Thereby, a higher detergency can be obtained while maintaining the stability of the active ingredient. Boric acid or borate may be used alone or in combination of two or more.

  Examples of the borate used in the present invention include sodium borate, potassium borate, sodium tetraborate, and potassium potassium borate.

  The blending amount of boric acid or borate is 0.1 to 10% by weight, preferably 0.5 to 6% by weight. In order to increase the alkalinity, 0.1% by weight or more is necessary, and when it exceeds 10% by weight, dissolution becomes difficult.

  The liquid cleaning composition of the present invention can optionally contain the following components as long as the effects of the present invention are not hindered. As an enzyme stabilizer, calcium chloride, as a hydrotrope, toluene sulfonate, xylene sulfonate, lower alcohol, polyhydric alcohol, as rust inhibitor, benzotriazole, silicate, as pH adjuster Can contain caustic potassium, caustic soda, hydrochloric acid, and sulfuric acid as required.

  In order to mix | blend an active ingredient stably, pH of this invention is 6-10, Preferably it is 7-9.5. When the pH of the liquid detergent composition is close to neutral, the active ingredient can be stably blended. And pH (8-10) required in order to obtain sufficient detergency at the time of use (for example, aqueous solution which diluted liquid detergent composition 100 times) is. As a range satisfying the stability of the active ingredient in the liquid detergent composition and the alkaline pH required at the time of use, the pH of the liquid detergent composition is from 6 to 10, more preferably from 7 to 9.5, and at the time of use. The pH is 8-10.

  The alkalinity necessary in the present invention is 1% or more, preferably 1.5%. If it is 1% or more, it is possible to obtain a cleaning power of ◯ or higher in the cleaning power evaluation described in the examples below.

  The present invention is for general household use or business use, and more specific uses are for vegetables and tableware, for clothing, for automatic dishwashers, for kitchens, for housing and furniture, for medical instruments, for jewelry, For vehicles.

  The following examples further illustrate the present invention in detail but are not to be construed to limit the scope thereof.

  The measurement methods and evaluation items performed in the following examples are as follows.

≪pH measurement method≫
It measured using the pH meter. The pH of various liquid detergent compositions was measured as the stock solution pH, and diluted 100 times with water as the diluted pH.

≪Measurement method of alkalinity≫
Exactly 1 g of various liquid detergent compositions were collected and 80 ml of distilled water was added. 0.1 mol / L hydrochloric acid was added dropwise until the pH was lower than 8. The alkalinity was calculated as KOH wt%.

≪Detergent evaluation method (immediately after preparation of liquid detergent composition) ≫
100 microliters of model dirt described in ISO / TS 15883-5 is applied to a stainless steel test piece (SUS304) (50 mm × 30 mm × 0.8 mm (L × W × T)) to a size of 20 mm × 20 mm. Thereafter, a sample left for 2 hours at room temperature was used as a contamination model test piece, and immersed in a liquid detergent composition immediately after preparation diluted to 1% at 40 ° C. for 20 minutes and 30 minutes. After immersion, the contamination residue was visually confirmed and evaluated based on the following criteria.
◎: When contaminants are removed within 20 minutes ○; When contaminants are removed within 30 minutes ×: When contaminants remain after 30 minutes

≪Enzyme stability evaluation≫
The enzyme activity after storing various liquid detergent compositions at 30 ° C. and 35 ° C. was examined, and the relative value to the enzyme activity before storage was calculated as stability (%) to evaluate the enzyme stability. The protease was measured by the Follin-Lowry method using casein as a substrate, the lipase was measured by a method using paranitrophenylvaleric acid as a substrate, the amylase was measured by starch, and the cellulase was measured by the dinitrosalicylic acid method using carboxymethylcellulose as a substrate.

<< Examples 1-4, Comparative Examples 1 and 2 >>
(A) Carbonate and bicarbonate are used as components, (b) components glycine, alanine, methionine and proline are mixed, and (c) components of protease, amylase, lipase, cellulase, and biosurfactant are mixed. Acid type sophorolipid was blended to prepare a liquid detergent composition as shown in Table 1 below. About the obtained liquid detergent composition, pH measurement, alkalinity measurement, the cleaning power immediately after preparation, and enzyme stability were evaluated. Further, as Comparative Example 1, a component not containing the component (b) was prepared, and as a Comparative Example 2, a component adjusted to the pH when the component (b) was blended with 35% hydrochloric acid without preparing the component (b) was prepared and carried out. Measurements and evaluations similar to those in Examples 1 to 4 were performed.

  As is apparent from Table 1, by using the component (b) together with the component (a), the alkalinity contributing to the detergency is not lowered from the stock solution pH 10.1 of Comparative Example 1, and Examples 1 to 4 Thus, the pH could be lowered to 9.0. The alkalinity of each of Examples 1 to 4 and Comparative Example 1 was 1.5%, and good results were obtained in the detergency evaluation immediately after preparation. On the other hand, in Comparative Example 2 in which the pH was lowered with 35% hydrochloric acid, the alkalinity decreased to 0.3%, and the detergency immediately after preparation was inferior to Examples 1-4 and Comparative Example 1. In addition, with respect to any enzyme stability of protease, amylase, lipase, and cellulase, Examples 1 to 4 are equivalent to Comparative Example 2 in which the stock solution pH was lowered with 35% hydrochloric acid, and the liquid detergent composition was used for a long time. Even when left untreated, it is expected that amylase-degrading starch, lipase-degrading activity, and cellulase-degrading activity can be obtained. On the other hand, in Comparative Example 1, the enzyme activity greatly decreased when left at 35 ° C. for 1 week, so that the enzyme was deactivated when left for a long period of time, as in Examples 1 to 4 and Comparative Example 2. Enzymatic activity cannot be obtained, and detergency due to enzymatic activity cannot be expected. Therefore, for Comparative Example 1, the detergency evaluation after being left at 35 ° C. for 1 week is expected to be x.

  From these results, by using the component (b) together with the component (a), it is possible to lower the pH without lowering the alkalinity that contributes to the detergency. Therefore, high detergency and long-term stability of the enzyme are achieved. It was confirmed that both were compatible.

<< Reference Examples 5-7, Comparative Examples 3-5 >>
The types of component (a) and component (c) were changed, and glycine was used as component (b) to prepare liquid detergent compositions shown in Table 2. As the component (a), an alkanolamine type is used, and as the component (c), a higher alcohol ethylene oxide type as a nonionic surfactant, a higher alkyl ether sulfate, an alpha olefin sulfate, and a protease as an anionic surfactant Amylase, lipase and cellulase were used. About the obtained liquid detergent composition, pH measurement, alkalinity measurement, the cleaning power immediately after preparation, and enzyme stability were evaluated. As a comparative example, a liquid detergent composition not containing the component (b) was prepared, and the same measurements and evaluations as in Reference Examples 5 to 7 were performed.

As apparent from Table 2, the pH of the stock solution could be lowered without lowering the alkalinity by adding the component (b) in any alkaline agent. In Comparative Examples 3 to 5, the pH of the stock solution was different depending on the type of alkaline agent, but all were pH 10 or higher. However, by adding the component (b) in Reference Examples 5 to 7, the stock solution pH of each Comparative Example can be lowered to 9.0, which is much larger than that of Comparative Examples as in Examples 1 to 4. A significant improvement in enzyme stability was confirmed.

In addition, in Reference Examples 5 to 7 using not only the above-mentioned acid type sophorolipid but also a polyoxyalkylene alkyl ether of a nonionic surfactant, a higher alkyl ether sulfate of an anionic surfactant, and an alpha olefin sulfate, Compared with Examples 3-5, it was confirmed that the enzyme stability was greatly improved. Therefore, regardless of the type of the surfactant, by adding the component (b), the stock solution compared to the case where the component (b) is not added. Because the pH is lowered, the stability of the enzyme can be improved, and even when stored for a long period of time, it can be expected that a detergency due to the enzyme activity can be obtained.

  From the above, it was confirmed that the stability of the enzyme can be improved by adding the component (b) and lowering the pH of the stock solution without lowering the alkalinity, regardless of the type of alkaline agent or surfactant. The alkali agents and surfactants described in 1) can be used in the present invention.

<< Reference Example 8 and Example 9, Comparative Examples 6-9 >>
(C) Liquid detergent composition as shown in Table 3 and Table 4 below using protease, amylase, lipase, cellulase, alkylpolyglucoside, sodium alpha olefin sulfate, acid type sophorolipid, blue No. 1 as component (c) Was prepared. About the obtained liquid detergent composition, in addition to evaluation of pH measurement, alkalinity measurement, detergency immediately after preparation and enzyme stability, reference example 8 was evaluated for appearance stability, and example 9 was evaluated for dye stability. went. In addition, as comparative examples, those not containing the component (b), those not containing the component (b) and adjusting the pH when the component (b) was blended with 35% hydrochloric acid were prepared, and Reference Example 8 and Measurements and evaluations similar to those in Example 9 were performed.

≪Appearance stability evaluation≫
100 g of various liquid detergent compositions were prepared, the appearance was visually confirmed, and evaluation was performed based on the following criteria.
○: Uniform and transparent ×: White turbidity or separation during preparation

≪Dye stability evaluation≫
100 g of various liquid detergent compositions were prepared and stored at 50 ° C. for 1 week, the color change was visually confirmed and evaluated based on the following criteria.
○: Same as before storage ×: Discoloration or fading from before storage

Table 3 As is apparent, (a) by a combination of component and component (b), since it was possible to lower the stock solution pH without lowering the alkalinity, in Reference Example 8, in addition to the enzyme stability, high It was confirmed that the alkylpolyglucoside that is easily denatured at pH can be stably blended in the liquid detergent composition. On the other hand, in Comparative Example 6 containing no component (b), in addition to the decrease in enzyme stability, the alkylpolyglucoside was denatured, and the liquid detergent composition became cloudy during preparation. In Comparative Example 7 in which the stock solution pH was lowered with 35% hydrochloric acid, the alkylpolyglucoside could be stably blended, but the alkalinity dropped to 0.1%, and an expected detergency was obtained even immediately after preparation. I couldn't.

  Further, as apparent from Table 4, since the stock solution pH could be lowered without lowering the alkalinity by using the components (a) and (b) in combination, in Example 9, in addition to the enzyme stability, It was confirmed that Blue No. 1 did not fade and remained in the same state as before being stored at 50 ° C. On the other hand, in Comparative Example 8 which does not contain the component (b), in addition to the decrease in enzyme stability, blue No. 1 fading occurred in the dye stability evaluation. In Comparative Example 9 where the pH of the stock solution was lowered with 35% hydrochloric acid, the fading of Blue No. 1 did not occur, but the alkalinity decreased to 0.3%, and an expected detergency cannot be obtained even immediately after preparation. It was.

  From the above, by using the components (a) and (b) together, in addition to the stability of the enzyme, the alkylpolyglucoside and blue No. 1 that are denatured at a high pH can be adjusted to the stock solution pH without reducing the alkalinity. Therefore, it was confirmed that the liquid detergent composition can be stably blended. Therefore, in addition to enzyme stability, it can be easily assumed that surfactants and pigments that are easily denatured by high pH can be stably incorporated into the liquid detergent composition of the present invention, and even higher pH. It can also be expected that disinfectants, chelating agents, and fragrances that are modified by the above can also be stably incorporated into the liquid detergent composition of the present invention.

  For this reason, it is apparent that the present invention can be used in a stable manner in addition to the above-mentioned surfactants and pigments, as well as effective components such as disinfectants, chelating agents, and perfumes that are easily affected in an alkaline environment.

Example 10
Using boric acid which is one of the boron compounds, boric acid was added to Example 1, and the pH lowered by boric acid was adjusted with caustic potassium to pH 9.0, as shown in Table 5 below. Example 10 was prepared and evaluated for pH measurement, alkalinity measurement, detergency immediately after preparation, and enzyme stability.

  As is apparent from Table 5, in Example 10 in which boric acid was added to adjust the pH to 9.0 in addition to the component (b), the alkalinity increased from 1.5% in Example 1 to 3.2%. Went up. Due to the increase in alkalinity, the detergency immediately after the preparation was greatly improved as compared with Example 1. Boric acid is also an enzyme stabilizer, and since it has a pKa of 9.2, it is also known as an alkaline and buffering compound. Therefore, it is considered that the buffering action and synergistic effect of the component (b) were brought about and high alkalinity was obtained.

  The liquid detergent composition of the present invention has industrial applicability in that it has high alkalinity and excellent detergency even when the pH during use is not strongly alkaline. For example, the present invention is considered to be less irritating and less corrosive to metals even when exposed to the human body while having alkalinity and detergency equivalent to conventional high pH products. And is expected to be superior to conventional products in terms of safety. Moreover, when handling the thing which is easy to influence with respect to high pH, such as a lacquer ware, wool, and silk, it is thought that a high detergency is acquired without damaging a raw material. As described above, the present invention is useful and industrially applicable even in a field where conventional products are hindered by high pH.

Claims (8)

(A) at least one alkaline agent selected from the group consisting of carbonates, bicarbonates, and alkanolamines;
A liquid detergent composition comprising (b) a neutral amino acid, and (c) an enzyme and a surfactant,
Ri enzymes and surfactants lipase and acid type sophorolipid der each of the above (c), the liquid detergent composition, wherein the pH is 6-10 der Rukoto of the composition at 25 ° C.. Furthermore, the liquid cleaning composition of Claim 1 containing at least 1 sort (s) selected from the group which consists of a disinfectant, a chelating agent, a pigment | dye, and a fragrance | flavor. The liquid detergent composition according to claim 1 or 2, further comprising at least one selected from the group consisting of protease, amylase, cellulase, and pectinase as the enzyme described in (c). The liquid detergent composition according to any one of claims 1 to 3, wherein the amount of the neutral amino acid (b) is 0.1 to 20% by weight. (A) The blending amount of the alkali agent is 2 to 20% by weight, (c) the blending amounts of the enzyme and the surfactant are 0.01 to 20% by weight and 1 to 20% by weight, respectively. The liquid cleaning composition in any one of Claims 1-4. Furthermore, at least 1 sort (s) selected from the group which consists of boric acid and a borate is contained, The liquid cleaning composition in any one of Claims 1-5 characterized by the above-mentioned. The liquid detergent composition according to claim 6, wherein the total amount of boric acid or borate is 0.1 to 10% by weight. The liquid detergent composition according to any one of claims 1 to 7, wherein the pH of the aqueous solution diluted 100 times is 8 to 10.