JP5944836B2 - 高分子薬物送達結合体ならびにその製造および使用方法 - Google Patents

高分子薬物送達結合体ならびにその製造および使用方法 Download PDF

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JP5944836B2
JP5944836B2 JP2012557145A JP2012557145A JP5944836B2 JP 5944836 B2 JP5944836 B2 JP 5944836B2 JP 2012557145 A JP2012557145 A JP 2012557145A JP 2012557145 A JP2012557145 A JP 2012557145A JP 5944836 B2 JP5944836 B2 JP 5944836B2
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conjugate
polymer
hpma
kda
mmol
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JP2013522205A (ja
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パン，ファイホン
コペッコヴァ，パヴラ
ヤン，ジュアン
コペチェック，ジンドリッチ
ルオ，クイ
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ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012557145A 2010-03-08 2011-03-07 高分子薬物送達結合体ならびにその製造および使用方法 Active JP5944836B2 (ja)

Applications Claiming Priority (3)

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US31145910P 2010-03-08 2010-03-08
US61/311,459 2010-03-08
PCT/US2011/027337 WO2011112482A2 (en) 2010-03-08 2011-03-07 Polymeric drug delivery conjugates and methods of making and using thereof

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JP2013522205A JP2013522205A (ja) 2013-06-13
JP5944836B2 true JP5944836B2 (ja) 2016-07-05

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US (1) US9289510B2 (de)
EP (1) EP2544701B1 (de)
JP (1) JP5944836B2 (de)
WO (1) WO2011112482A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011112482A2 (en) * 2010-03-08 2011-09-15 University Of Utah Research Foundation Polymeric drug delivery conjugates and methods of making and using thereof
WO2012021512A2 (en) 2010-08-10 2012-02-16 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
PL3358356T3 (pl) * 2013-09-17 2021-03-08 bioMérieux Roztwór do oddzielania witaminy d od jej białka wiążącego, powiązany sposób wykrywania i zestaw
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
AU2015233084B2 (en) * 2014-02-21 2020-12-17 Anokion Sa Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
JP6607189B2 (ja) * 2014-09-02 2019-11-20 東亞合成株式会社 周期的に官能基を備えるビニル系重合体及びその製造方法
EP3267975A4 (de) 2015-03-09 2018-08-08 The Regents of the University of California Polymer-arzneimittel-konjugate zur kombinationstherapie gegen krebs
WO2017019559A1 (en) * 2015-07-24 2017-02-02 University Of Utah Research Foundation Hpma-drug conjugates for the treatment of acute myeloid leukemia
EA201891235A1 (ru) 2015-11-25 2018-12-28 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Составы лекарственных средств для лечения злокачественной опухоли
EP3525808A4 (de) * 2016-10-14 2020-06-24 University of Utah Research Foundation Antikörper-polymer-wirkstoffkonjugate
JP6835529B2 (ja) * 2016-10-21 2021-02-24 株式会社日本触媒 チオール基含有イオン性高分子化合物及びその製造方法
CN106581690B (zh) * 2016-12-23 2019-05-28 四川大学 肿瘤微环境刺激可降解的两亲性嵌段hpma聚合物给药系统及其制备方法
CN106880848B (zh) * 2017-02-14 2019-09-06 四川大学 可生物降解的多聚HPMA-Gd磁共振成像探针及其制备方法
EP3638296A1 (de) 2017-06-16 2020-04-22 The University Of Chicago Zusammensetzungen und verfahren zur herbeiführung einer immuntoleranz
JP2022552841A (ja) * 2019-10-18 2022-12-20 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション ポリマー薬物送達コンジュゲートならびにそれを作製および使用する方法
CN114621393A (zh) * 2022-03-17 2022-06-14 华侨大学 一种n-（2-羟基）丙基甲基丙烯酰胺和n-甲基丙烯酰甘氨酰甘氨酸的共聚物及其应用

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US4074039A (en) 1970-03-26 1978-02-14 Ceskoslovenska Akademie Ved Hydrophilic N,N-diethyl acrylamide copolymers
CS159937B1 (de) 1972-02-29 1975-02-28
CS173846B1 (de) 1974-04-23 1977-03-31
CS173849B1 (de) 1974-04-25 1977-03-31
GB8500209D0 (en) 1985-01-04 1985-02-13 Ceskoslovenska Akademie Ved Synthetic polymeric drugs
US5258453A (en) 1992-01-21 1993-11-02 University Of Utah Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
US7179487B1 (en) 1998-06-19 2007-02-20 University Of Utah Research Foundation Hydrogels of water soluble polymers crosslinked by protein domains
US7098032B2 (en) 2001-01-02 2006-08-29 Mirus Bio Corporation Compositions and methods for drug delivery using pH sensitive molecules
WO2004062588A2 (en) * 2003-01-06 2004-07-29 University Of Utah Water-soluble polymeric bone-targeting drug delivery system
US20040228831A1 (en) * 2003-05-15 2004-11-18 Belinka Benjamin A. Polymeric conjugates for tissue activated drug delivery
US20070287680A1 (en) * 2004-05-10 2007-12-13 University Of Utah Research Foundation Combined Active and Passive Targeting of Biologically Active Agents
WO2007003054A1 (en) * 2005-07-06 2007-01-11 Shoichet Molly S Method of biomolecule immobilization on polymers using click-type chemistry
CN101420984B (zh) * 2006-02-21 2013-01-02 尼克塔治疗公司 嵌段可降解聚合物及由其制备的轭合物
US20090171455A1 (en) * 2007-12-31 2009-07-02 Boston Scientific Scimed, Inc. Biodegradable polymers
CN102105157B (zh) 2008-05-22 2015-09-30 特拉维夫大学拉莫特有限公司 聚合物、抗血管生成剂和靶向部分的缀合物及其在制备用于治疗骨相关血管生成状况的药物中的用途
KR20150058554A (ko) * 2009-10-13 2015-05-28 렉산 파마슈티컬스, 인코포레이티드 항암제의 전달을 위한 폴리머 시스템
WO2011112482A2 (en) * 2010-03-08 2011-09-15 University Of Utah Research Foundation Polymeric drug delivery conjugates and methods of making and using thereof

Also Published As

Publication number Publication date
US20130156722A1 (en) 2013-06-20
US9289510B2 (en) 2016-03-22
WO2011112482A3 (en) 2011-12-08
WO2011112482A2 (en) 2011-09-15
EP2544701B1 (de) 2019-08-14
EP2544701A4 (de) 2016-03-02
JP2013522205A (ja) 2013-06-13
EP2544701A2 (de) 2013-01-16

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