JP5936707B2 - インターフェロンおよびアンドログラホリドを用いた多発性硬化症のための併用療法 - Google Patents

インターフェロンおよびアンドログラホリドを用いた多発性硬化症のための併用療法 Download PDF

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JP5936707B2
JP5936707B2 JP2014548825A JP2014548825A JP5936707B2 JP 5936707 B2 JP5936707 B2 JP 5936707B2 JP 2014548825 A JP2014548825 A JP 2014548825A JP 2014548825 A JP2014548825 A JP 2014548825A JP 5936707 B2 JP5936707 B2 JP 5936707B2
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group
formula
combination
andrographolide
compound
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JP2015500880A5 (enExample
JP2015500880A (ja
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オロスコ， フアン エレ． ハンク
オロスコ， フアン エレ． ハンク
ラファエル ブルゴス，
ラファエル ブルゴス，
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イノバイオサイエンス， エルエルシー
イノバイオサイエンス， エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014548825A 2011-12-21 2012-12-19 インターフェロンおよびアンドログラホリドを用いた多発性硬化症のための併用療法 Active JP5936707B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161578650P 2011-12-21 2011-12-21
US61/578,650 2011-12-21
PCT/US2012/070568 WO2013096423A1 (en) 2011-12-21 2012-12-19 Combination therapy with interferon and andrographolides for multiple sclerosis

Publications (3)

Publication Number Publication Date
JP2015500880A JP2015500880A (ja) 2015-01-08
JP2015500880A5 JP2015500880A5 (enExample) 2016-02-18
JP5936707B2 true JP5936707B2 (ja) 2016-06-22

Family

ID=48669439

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014548825A Active JP5936707B2 (ja) 2011-12-21 2012-12-19 インターフェロンおよびアンドログラホリドを用いた多発性硬化症のための併用療法

Country Status (10)

Country Link
US (1) US9060994B2 (enExample)
EP (1) EP2670406B1 (enExample)
JP (1) JP5936707B2 (enExample)
AU (1) AU2012359081B2 (enExample)
BR (1) BR112014015178A2 (enExample)
CA (1) CA2853779C (enExample)
CL (1) CL2014001663A1 (enExample)
ES (1) ES2554459T3 (enExample)
RU (1) RU2014113967A (enExample)
WO (1) WO2013096423A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3468553B1 (en) * 2016-06-08 2023-05-24 InnoBioscience, LLC Andrographolide treats progressive forms of multiple sclerosis
US11318153B2 (en) 2018-06-25 2022-05-03 Bialpha International Sdn. Bhd. Method of using Neoandrographolide for lowering blood sugar, lowering blood lipid, improving liver function and improving renal function
CN109824655B (zh) * 2019-04-08 2021-09-24 沈阳药科大学 穿心莲内酯化合物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1043027A1 (en) * 1999-04-08 2000-10-11 Applied Research Systems ARS Holding N.V. Treatment of multiple sclerosis with a combination of Interferon and Growth hormone
US6410590B1 (en) 2000-02-03 2002-06-25 Dr. Reddy's Research Foundation Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them
US20050181033A1 (en) 2000-06-29 2005-08-18 Dekker John P.Iii Method for delivering interferons to the intradermal compartment
WO2003025541A2 (en) * 2001-09-18 2003-03-27 Chiron Corporation Methods for treating multiple sclerosis
CA2555296A1 (en) 2004-02-03 2005-08-18 Universidad Austral De Chile Composition of labdane diterpenes extracted from andrographis paniculata, useful for the treatment of autoimmune diseases, and alzheimer disease by activation of ppr-gamma receptors
US20050220764A1 (en) 2004-04-01 2005-10-06 Schering Aktiengesellschaft Higher-doses of interferon-beta for treatment of multiple sclerosis
US20080108641A1 (en) * 2006-02-08 2008-05-08 Ajami Alfred M Compounds for treating inflammatory disorders, demyelinating disdorders and cancers
CA2765463C (en) * 2009-06-22 2018-10-09 Moise A. Khayrallah Methods for treating or preventing fatigue

Also Published As

Publication number Publication date
EP2670406A4 (en) 2014-05-28
US20140301981A1 (en) 2014-10-09
CL2014001663A1 (es) 2015-02-27
WO2013096423A1 (en) 2013-06-27
EP2670406A1 (en) 2013-12-11
CA2853779C (en) 2016-04-26
AU2012359081B2 (en) 2015-09-17
NZ625051A (en) 2016-07-29
AU2012359081A1 (en) 2014-06-05
BR112014015178A2 (pt) 2017-06-13
CA2853779A1 (en) 2013-06-27
EP2670406B1 (en) 2015-09-02
ES2554459T3 (es) 2015-12-21
RU2014113967A (ru) 2016-02-10
US9060994B2 (en) 2015-06-23
JP2015500880A (ja) 2015-01-08

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