JP5923027B2 - Apparatus for producing purified water for medical use and operation method thereof - Google Patents

Description

  The present invention relates to a device for producing medical purified water such as artificial dialysis water and a method for operating the same.

2. Description of the Related Art Conventionally, a purified water production apparatus combining an activated carbon apparatus, a membrane separation apparatus, an EDI apparatus, and the like, and a purified water production method using the same are known.
And when manufacturing purified water using these purified water manufacturing apparatuses, it becomes important to sterilize the inside of an apparatus from a hygiene viewpoint.

  Patent Document 1 describes an invention in which purified water heated to 80 ° C. or higher is circulated in a device for sterilization (paragraph 0042). And it is described about the apparatus after sterilization using raw material water, and cooling water is discharged | emitted out of the system (paragraph number 0043).

  Patent Document 2 describes a method of heat sterilizing the apparatus by circulating purified water heated in the same manner as Patent Document 1, and a cooling method (temperature lowering step) is a method of naturally cooling a circulation line. And a method of forced cooling to room temperature by flowing raw water (paragraph number 0048).

Patent Document 3 describes a method for producing purified water in a state where raw water itself is heated to 50 to 90 ° C. by a first heat exchanger as shown in FIG.
FIG. 2 shows an apparatus in which a second heat exchanger is installed in front of the purified water tank (between the EDI apparatus and the purified water tank). In the apparatus of FIG. 2, the temperature of the purified water discharged from the EDI apparatus is lowered by the second heat exchanger and then stored in the purified water tank, and the temperature is raised by passing the raw water through the second heat exchanger. It is described that it is sent to the raw water tank in the state of being allowed to go.

JP 2010-433 A JP 2011-147911 A JP 2010-269235 A

In the methods of the inventions of Patent Documents 1 and 2, the inside of the apparatus sterilized with hot water at 80 ° C. or higher is cooled with raw material water at room temperature. There is a fear.
Moreover, when it cools naturally by invention of patent document 2, it will take a long time to return to room temperature, and productivity will fall remarkably.
In the invention of Patent Document 3, since water that is constantly heated circulates in the apparatus, there is a risk of giving a thermal burden to the membrane and the resin, and the temperature of the purified water in the purified water tank is high. When used for medical purified water, there is a possibility that it cannot be used in an emergency.
In order to avoid a sudden temperature drop when cooling the inside of the apparatus with raw water at room temperature, a method of cooling while supplying the raw water intermittently has been conventionally performed. However, this method requires complicated adjustment and setting of intermittent water supply starting and stopping, and in addition, a sudden drop in water temperature during intermittent water supply is unavoidable.

  The present invention can heat and sterilize the inside of a device without producing a rapid temperature change in heating and cooling for heat sterilization of the device when producing purified water for medical use with a device for producing medical purified water. In addition, an object of the present invention is to provide a device for producing purified medical water capable of cooling the inside of the device after heat sterilization by an easy operation and an operation method thereof.

As a means for solving the problems, the present invention
An adsorption device (3) with activated carbon;
Reverse osmosis membrane treatment equipment (hereinafter referred to as “RO equipment”) (5),
RO water tank (6) provided with heating means (6a) for storing treated water (hereinafter referred to as “RO water”) treated by the RO device (5);
It has a heat exchanger (8) that is connected to the RO water tank (6) and has means for cooling with raw water,
The raw water supply source and the activated carbon device (3) are connected by the raw water supply line (11, 12, 13),
Activated carbon device (3) and RO device (5) are connected by pretreatment water line (14),
RO device (5) and RO water tank (6) are connected by RO water line (17),
RO water tank (6) and intake section are connected by intake line (18),
RO water tank (6) and heat exchanger (8) are connected to RO water tank (6) to heat exchanger (8) with an incoming water line (18, 21) and from heat exchanger (8) to RO water tank ( 6) A device for producing purified water for medical use connected to a water discharge line (22) to 6)
It has a circulation line that circulates hot water or cooling water when the production of medical purified water stops.
The circulation line is a combination of a first circulation line and a second circulation line;
The first circulation line is a circulation line that returns from the RO water tank (6) to the RO water tank (6) through the incoming water line (18, 21), the heat exchanger (8), the outgoing water line (22),
The second circulation line from the RO water tank (6), the intake line (18), the line (23), the raw water supply line (13), the activated carbon device (3), the pretreatment water line (14), the RO device (5 ), An apparatus for producing purified water for medical use, which is a circulation line that returns to the RO water tank (6) through the RO water line (17), and an operation method thereof.

According to the device for producing purified water for medical use and the operation method using the same according to the present invention, it is possible to periodically sterilize the place where the chlorine in the production device is removed and the bacteria are likely to propagate. Safety against the risk of contamination is enhanced, and it is easy to achieve a high level of cleaning in the apparatus, particularly in the production of water for artificial dialysis.
Furthermore, since thermal effects such as expansion and contraction of equipment and piping in the manufacturing equipment due to rapid temperature changes during hot water sterilization and cooling are reduced, manufacturing equipment (especially membranes and resins) compared to conventional technologies Safe and stable operation can be continued for a long period of time without causing damage to the pipes or poor connection of pipe joints.
Further, the cooling operation does not require complicated operations such as starting and stopping of intermittent water supply when directly supplying / cooling raw water into the apparatus, and enables a simple and smooth cooling operation.

Explanatory drawing of the manufacture flow of the medical purified water of this invention. Explanatory drawing of the manufacture flow of the medical purified water of this invention which is other embodiment. The figure which shows a temperature change when the manufacturing method of the medical purified water of Example 1 is implemented.

(1) Manufacturing apparatus for medical purified water of FIG. 1 and its operation method <Operation for manufacturing medical purified water>
The raw water (tap water or groundwater) is sent to the prefilter 1 by the first raw water line 11 and is removed if there is a large foreign matter.
The water treated by the prefilter 1 is sent to the water softening device 2 through the second raw water line 12, and the amount of hardness component is reduced.
The water treated by the water softening device 2 is sent to the adsorption device (activated carbon device) 3 by activated carbon through the third raw water line 13, and the amount of chlorine in the raw water is reduced.
From the raw water source to the activated carbon device 3, the raw water pump 61 is driven to supply water. Note that the prefilter 1 and the water softening device 2 may not be installed depending on the quality of the raw water. Further, when used for producing purified water for artificial dialysis, a heater or a heat exchanger for raising the water temperature in the cold season may be provided in front of the prefilter 1.

The water treated by the activated carbon device 3 is sent to the reverse osmosis membrane treatment device (RO device) 5 through the pretreatment water line 14. An RO device pump 62 is installed in the pretreatment water line 14.
A line heater 4 as auxiliary heating means can be installed in the pretreatment water line 14.

As the RO device 5, a known device can be used. For example, a device model VCR40 series, VCR80 series, NER40 series, NER80 series, SHR series, etc. sold by Daisen Membrane Systems Co., Ltd. can be used. it can.
However, it is necessary to use a heat resistant RO membrane module using a heat resistant material such as a membrane material or an adhesive member.
The RO device 5 having a treatment capacity (treatment water production capacity) of 30 to 5000 L / hr can be used, but is not limited to the above range, and is appropriately selected according to the supply amount of purified water. can do.

The treated water (RO water) treated by the RO device 5 is sent to the RO water tank 6 through the RO water line 17 and stored.
In the RO water tank 6, a heater 6a is installed as a main heating means, and the RO water can be heated by the heater 6a.
Further, a thermometer is attached in the RO water tank 6 so that the water temperature in the tank can be monitored from the outside.
Furthermore, in order to equalize the water temperature in the tank, a stirring device can be attached if necessary.
Part of the concentrated water generated in the RO device 5 is discharged from the concentrated water line 16a, and the remainder is returned to the pretreatment water line 14 by driving the concentrated water circulation pump 64.

The water storage capacity of the RO water tank 6 can be set to 100 to 3000 L, for example. The RO water tank 6 is made of metal such as stainless steel.
The shape of the RO water tank 6 is not particularly limited, but from the viewpoint of facilitating the flow of the liquid by preventing the liquid from remaining in the tank, the RO water tank 6 preferably has a conical structure with a conical bottom or a quadrangular pyramid. .

  The RO water tank 6 has a vent hole with an air filter for preventing contamination of germs and the like from the outside atmosphere, and an ultraviolet lamp can be attached to the inside for the purpose of sterilization, if necessary. .

  It is preferable to install a water level meter in the RO water tank 6 so that the operation of the RO device 5 can be started or stopped according to the water level. For example, the upper limit value and the lower limit value of the water level in the RO water tank 6 are determined in advance, and when the upper limit value is reached, the operation of the RO device 5 is stopped, and conversely, when the lower limit value is reached, the RO device 5 Start driving.

The RO water in the RO water tank 6 is sent to the ultrafiltration membrane device (UF device) 7 through the first intake line 18 to remove endotoxin, bacteria, and the like.
A water intake pump (UF device pump) 63 is installed in the first water intake line 18.

The purified water treated by the UF device 7 is sent to the artificial dialysate preparation device 50 via the second water intake line 19 and the third water intake line 20 branched from the second water intake line 19.
The second water intake line 19 is further connected to the RO water tank 6, and the purified water that has not been taken is returned to the RO water tank 6.

The apparatus for producing purified water for medical use according to the present invention has a circulation line comprising a combination of a first circulation line and a second circulation line for circulating hot water or cooling water when the production operation of purified medical water is stopped. doing.
The first circulation line is a circulation line that returns from the RO water tank 6 to the RO water tank 6 through the incoming water line 21 (including the partial intake line 18), the heat exchanger 8, and the outlet water line 22.
The heat exchanger 8 is connected to the first raw water line 11 and the line 24 so that raw water as a cooling medium can be supplied into the heat exchanger 8.
The heat exchanger 8 has a raw water drain line 25 used for cooling.
Immediately after the start of the cooling operation after the hot water sterilization, since the heat exchange water is at a high temperature, a storage pot equipped with a thermometer is provided in the drain line 25, and the raw water until the water temperature in the storage pot drops to a predetermined temperature. It is desirable to drain after mixing and cooling.
Since the drainage (raw water) from the drainage line 25 is tap water or groundwater, it can be used for other purposes.
The second circulation line passes from the RO water tank 6 to the RO water tank 6 through the intake water line 18, the line 23, the raw water supply line 13, the activated carbon device 3, the pretreatment water line 14, the RO device 5, and the RO water line 17. It is a return circulation line.

<Sterilization and cooling operation>
When the purified water production operation by the production apparatus shown in FIG. 1 is continuously performed, the purified water production operation is periodically stopped and the sterilization and cooling operations are performed.

The sterilization operation is performed according to the following procedure.
The RO water in the RO water tank 6 is heated by the heater 6a with the purified water production operation stopped.
The temperature of the RO water before heating is preferably room temperature or adjusted to 20 to 30 ° C., and is heated to 70 ° C. or higher (preferably about 70 to 100 ° C.) by heating with the heater 6a. The temperature is raised little by little at 1 to 5 ° C./min, preferably 0.5 to 4 ° C./min.
The said heating temperature is not restrict | limited to the said range, According to RO membrane module to be used, it can select and change suitably.

The pump 63 is driven to circulate in the first circulation line while heating and raising the temperature of the RO water in the RO water tank 6 at the above temperature increase rate.
In parallel with the circulation operation of the first circulation line, the circulation operation of the second circulation line is performed.
Further, the pressurizing pump 62 of the RO device is stopped, but the concentrated water circulation pump 64 is operated to pass water through the concentrated water line 16b.

Thus, the circulation operation by the two circulation lines of the first circulation line and the second circulation line is performed in parallel.
By the circulation operation of the first circulation line, the RO water in the RO water tank 6 is heated without temperature unevenness, and the RO water can be circulated to the second circulation line while gradually heating and raising the temperature.
For this reason, compared with the case where hot water is circulated from the beginning, the thermal load on the devices in the second circulation line (particularly activated carbon, separation membranes, pipe joints, valves) can be reduced, and finally In order to circulate the hot water heated up to about 80-90 degreeC, sufficient hot water sterilization is also implemented.
In addition, the second circulation line has a long flow path, and the temperature of the hot water drops due to heat radiation from the pipes and devices. Therefore, the temperature of the hot water as the sterilizing medium can be lowered by heating with the line heater 4 as necessary. It is desirable to prevent it. By providing the line heater 4, more precise heating rate and heating temperature can be easily controlled.
In the sterilization operation, in order to perform sufficient sterilization and suppress the thermal influence on the activated carbon and the separation membrane, the temperature of the hot water passed through the RO device 5 becomes about 80 to 90 ° C., It is preferred to stop after circulating for at least 10 minutes.

  The sterilization operation using hot water is not limited to the circulation line described above, but also includes a RO water tank 6, a first water intake line 18, a UF device 7, a second water intake line 19, and a RO water tank 6. Including the circulation line). The hot water sterilization operation of the circulation line including the UF device 7 may be performed simultaneously with the sterilization operation of the circulation line and device including the RO device 5 or separately.

After the hot water sterilization operation for the circulation line is completed, a cooling operation for cooling the circulation line is performed before restarting the production of medical purified water.
The cooling operation is performed according to the following procedure.
After completion of the hot water sterilization operation, heating in the RO water tank 6 and heating of the line heater 4 are stopped, then the on-off valve 73 is opened, and raw water is supplied as a cooling medium to the heat exchanger 8 through the line 24.
And RO water is cooled, implementing the circulating operation of a 1st circulation line. The cooling rate at this time can be adjusted by adjusting the flow rate of the flow rate adjusting valve 72.
The water temperature in the RO water tank 6 is gradually lowered by the circulation operation of the first circulation line, and finally it is lowered to about 20 to 30 ° C. The temperature lowering rate is preferably adjusted at 0.1 to 5 ° C./min, more preferably 0.5 to 4 ° C./min.

While reducing the temperature of the RO water in the RO water tank 6 by the circulation operation of the first circulation line described above, the circulation operation of the second circulation line is performed in parallel therewith.
At this time, the pressurization pump 62 of the RO device is stopped, but the concentrated water circulation pump 64 is operated to pass water through the concentrated water line 16b.

In this manner, the circulation operation of the first circulation line and the second circulation line is carried out in parallel to cool.
Since the RO water is circulated in the second circulation line while gradually decreasing the temperature of the RO water in this way, compared with the case where cold water (water at room temperature) is circulated from the beginning, the device in the second circulation line (particularly activated carbon). And thermal effects such as shrinkage due to a rapid temperature drop of the separation membrane, pipe joint, and valves) are reduced. Further, the cooling operation does not require complicated operations such as starting and stopping of intermittent water supply when directly supplying / cooling raw water into the apparatus, and enables a simple and smooth cooling operation.
When the sterilization operation is performed on the circulation line including the UF device 7, the same cooling operation is performed. The cooling operation of the circulation line including the UF device 7 may be performed simultaneously with the cooling operation of the circulation line including the RO device 5 and the device, or may be performed separately.
It is desirable that the sterilization operation and the cooling operation with hot water be performed continuously without interruption.
In addition, after the hot water sterilization is finished, the medical purified water is manufactured and operated. Even at night and holidays when the artificial dialysis treatment is finished, the circulation of the circulation line including the first circulation line, the second circulation line, and the UF device 7 is performed. In order to prevent the growth of bacteria, it is preferable to continue the operation (RO water circulation operation).

(2) Manufacturing apparatus for medical purified water of FIG. 2 and its operating method The manufacturing apparatus of FIG. 2 is that the EDI apparatus 9 and the EDI water tank 10 are further added, and the line is changed accordingly. It is different from the manufacturing equipment.

  The RO water in the RO water tank 6 is sent to the EDI device 9 through the second RO water line 31. In the second RO water line 31, a liquid feed pump 65 to the EDI device 9 is installed. In the apparatus of FIG. 2, a line corresponding to the RO water line 17 of FIG.

The EDI apparatus 9 includes an ion exchange chamber (desalination chamber) in the center, two concentration chambers on both outer sides of the desalination chamber, and electrode chambers (positive and negative electrode chambers) on the outer sides of the concentration chamber. It is a known device having deionized water (EDI-treated water) by deionization treatment in an ion exchange chamber.
As the EDI apparatus 9, for example, JP 2007-252396 A, JP 2007-237062 A, JP 11-244853 A, JP 2001-239270 A, JP 2001-353498 A, JP In addition to the one described in Japanese Patent Application Publication No. 2004-74109, a commercially available EDI apparatus, EDI system series, trade name MOLSEP (registered trademark) (sold by Daisen Membrane Systems Co., Ltd.), and those used in the examples are used. be able to.
However, it is necessary to use heat-resistant members such as ion exchange resins, ion exchange membranes, and adhesives.

The operating conditions of the EDI device 9 are
The amount of liquid supplied from the RO water line 31 is preferably 50 to 4500 L / hr,
The amount of EDI treated water (demineralized water amount) is preferably 30 to 4000 L / hr,
The concentrated water flow rate is preferably 5% to 40% of the supply liquid amount,
The applied voltage is preferably 30 to 1000 V, the applied current is preferably 0.2 to 6 A, and the applied current density is preferably 0.05 to 4 A / dm ² .

The EDI water processed by the EDI device 9 is sent to the EDI water tank 10 and stored therein.
A heating means can be installed in the EDI water tank 10 as necessary.
The concentrated water generated in the EDI apparatus 10 is discharged from the concentrated water line 33.
The EDI water tank 10 and the RO water tank 6 may be communicated with each other through a communication pipe 34 having an on-off valve.

  The water storage capacity of the RO water tank 6 and the EDI water tank 10 can be set to, for example, 100 to 3000 L, respectively. The RO water tank 6 and the EDI water tank 10 are made of metal such as stainless steel.

  The shapes of the RO water tank 6 and the EDI water tank 10 are not particularly limited. From the viewpoint of preventing the liquid from remaining in the tank and smoothing the flow of the liquid, the bottom portion is a cone or a quadrangular pyramid. The thing of a shape structure is preferable.

  The EDI water tank 10 has a vent hole with an air filter for preventing contamination of germs and the like from the external atmosphere, and an ultraviolet lamp can be attached to the inside for the purpose of sterilization, if necessary. .

The EDI water in the EDI water tank 10 is sent to the UF device 7 through the first intake line 18 to remove endotoxin and bacteria.
A water intake pump (UF device pump) 63 is installed in the first water intake line 18.

The purified water treated by the UF device 7 is sent to the artificial dialysate preparation device 50 via the second water intake line 19 and the third water intake line 20 branched from the second water intake line 19.
The second water intake line 19 is further connected to the RO water tank 6, and the purified water that has not been taken is returned to the RO water tank 6.

The apparatus for producing purified water for medical use according to the present invention has a circulation line composed of a combination of a first circulation line and a third circulation line for circulating hot water or cooling water when the operation for producing purified medical water is stopped. doing.
The first circulation line is a circulation line that returns from the RO water tank 6 to the RO water tank 6 through the incoming water line 21 (partly includes the second RO water line 31), the heat exchanger 8, and the outgoing water line 22.
The heat exchanger 8 is connected to the first raw water line 11 and the line 24 so that raw water as a cooling medium can be supplied into the heat exchanger 8.
The heat exchanger 8 has a raw water drain line 25 used for cooling.
Immediately after the start of the cooling operation after the hot water sterilization, since the heat exchange water is at a high temperature, a storage pot equipped with a thermometer is provided in the drain line 25, and the raw water and the water are kept until the water temperature in the storage pot drops to a predetermined temperature. Drain after mixing and cooling.
Since the drainage (raw water) from the drainage line 25 is tap water or groundwater, it can be used for other purposes.
The third circulation line starts from the EDI water tank 10, the intake line 18, the line 23, the raw water supply line 13, the activated carbon device 3, the pretreatment water line 14, the RO device 5, the first RO water line 17, the RO water tank 6, 2 is a circulation line that returns to the EDI water tank 10 through the ERO water line 31, the EDI device 9, and the EDI water line 32.

<Sterilization and cooling operation>
When the purified water production operation by the production apparatus shown in FIG. 2 is continued, the purified water production operation is periodically stopped and the sterilization and cooling operations are performed.

The sterilization operation is performed according to the following procedure.
The RO water in the RO water tank 6 is heated by the heater 6a with the purified water production operation stopped.
The temperature of the RO water before heating is adjusted to 20 to 30 ° C., and is heated to 70 ° C. or higher (preferably about 70 to 100 ° C.) by heating with the heater 6a, preferably 0.1 to 5 ° C./min. More preferably, the temperature is raised little by little at 0.5 to 4 ° C./min.
The heating temperature is not limited to the above range, and can be appropriately selected and changed according to the RO membrane module or EDI apparatus to be used.

While heating and raising the temperature of the RO water in the RO water tank 6 at the above-described rate of temperature rise, the pump 65 is driven to circulate in the first circulation line.
In parallel with the circulation operation of the first circulation line, the circulation operation of the third circulation line is performed.
Further, the pressurizing pump 62 of the RO device is stopped, but the concentrated water circulation pump 64 is operated to pass water through the concentrated water line 16b.
Further, the EDI supply pump 65 is operated at a lower pressure (0.1 MPa at the EDI inlet pressure) than in normal EDI operation, and supplies heated RO water to the EDI device 9.
Further, in the above heating operation, the open / close valve provided in the communication pipe 34 connecting the EDI water tank 10 and the RO water tank 6 is opened to allow the water in both tanks to communicate with each other, thereby heating the EDI water tank 10. In addition, the water levels of both tanks associated with the circulation operation can be maintained in a balanced and appropriate level.

  The sterilization operation using hot water is not limited to the above-described circulation line, but also the EDI water tank 10, the first intake line 18, the UF device 7, the second intake line 19, the RO water tank 6, the second RO water line 31, and the EDI device. 9. It can implement also with respect to the circulation line (circulation line containing UF apparatus 7) which returns to the EDI water tank 10 via the EDI water line 32. FIG. The hot water sterilization operation of the circulation line including the UF device 7 may be performed simultaneously with the sterilization operation of the circulation line and device including the RO device 5 or separately.

In this way, the operation of the first circulation line and the operation of the third circulation line are performed.
The RO water in the RO water tank 6 is heated without temperature unevenness by the circulation operation of the first circulation line, and the circulation operation to the third circulation line is performed while heating and heating the RO water little by little.
For this reason, compared with the case where hot water is circulated from the beginning, the thermal load on the devices (particularly activated carbon, separation membranes, piping joints, valves) in the third circulation line can be reduced. In order to circulate the hot water heated up to about 70-90 degreeC, sufficient hot water sterilization is also implemented.
In addition, the third circulation line has a long flow path, and the temperature of the hot water drops due to heat radiation from the pipes and devices. Therefore, the temperature of the hot water as the sterilizing medium can be lowered by heating with the line heater 4 as necessary. It is desirable to prevent it. By providing the line heater 4, more precise heating rate and heating temperature can be easily controlled.
In the sterilization operation, in order to perform sufficient sterilization and suppress the thermal influence on the activated carbon and the separation membrane, the temperature of the hot water passed through the RO device 5 becomes about 70 to 90 ° C, When the temperature of hot water is 70 to 80 ° C., it is preferably circulated for at least 30 minutes. When the temperature of hot water is 80 to 90 ° C., it is preferably circulated for at least 10 minutes.

The cooling operation is performed according to the following procedure.
After completion of the hot water sterilization operation, heating in the RO water tank 6 and heating of the line heater 4 are stopped, then the on-off valve 73 is opened, and raw water is supplied as a cooling medium to the heat exchanger 8 through the line 24.
And RO water is cooled, implementing the circulating operation of a 1st circulation line. The cooling rate at this time can be adjusted by adjusting the flow rate of the flow rate adjusting valve 72.
The water temperature in the RO water tank 6 is gradually lowered by the circulation operation of the first circulation line, and finally it is lowered to about 20 to 30 ° C. The temperature lowering rate is preferably adjusted at 0.1 to 5 ° C./min, more preferably 0.5 to 4 ° C./min.

While the temperature of the RO water in the RO water tank 6 is lowered by the circulation operation of the first circulation line, the circulation operation of the third circulation line is performed in parallel therewith.
At this time, the pressurization pump 62 of the RO device is stopped, but the concentrated water circulation pump 64 is operated to pass water through the concentrated water line 16b.

In this way, the circulation operation of the first circulation line and the third circulation line is carried out in parallel to cool.
Since the RO water is circulated in the third circulation line while gradually decreasing the temperature of the RO water, compared with the case where cold water (water at room temperature) is circulated from the beginning, the device in the third circulation line (particularly activated carbon). And thermal effects such as shrinkage due to a rapid temperature drop of the separation membrane, pipe joint, and valves) are reduced. Further, the cooling operation does not require complicated operations such as starting and stopping of intermittent water supply when directly supplying / cooling raw water into the apparatus, and enables a simple and smooth cooling operation.
When the sterilization operation is performed on the circulation line including the UF device 7, the same cooling operation is performed. The cooling operation of the circulation line including the UF device 7 may be performed simultaneously with the cooling operation of the circulation line including the RO device 5 and the device, or may be performed separately.
It is desirable that the sterilization operation and the cooling operation with hot water be performed continuously without interruption.
In addition, the medical purified water is manufactured after the hot water sterilization is completed. Even at night and holidays when the artificial dialysis treatment is completed, the circulation of the circulation line including the first circulation line, the third circulation line, and the UF device 7 is performed. It is preferable to continue the operation (circulation operation of RO water and / or EDI water) (combination of sterilization operation and cooling operation) in order to prevent the growth of bacteria.

Example 1
Using the production apparatus shown in FIG. 1, the production operation of purified water for medical use was performed.
The specifications of each device are as follows.

Activated carbon device 3: Duracoal MAC750SH manufactured by Daisen Membrane Systems Co., Ltd.
RO device 5: RO membrane module; SV08-GP-DRA heat resistant type manufactured by Daisen Membrane Systems Co., Ltd. RO water tank 6: SUS316, 280L
UF device 7: UF membrane module; FS10FC-FUST653 manufactured by Daisen Membrane Systems Co., Ltd.
RO water tank electric heater 6a: 20kw
Line heater 4: 10 kW
Heat exchanger 8: 70000 kcal
RO water production volume: 1000L / hr

The apparatus of FIG. 1 was used to stop the production of purified water for medical use, and then the sterilization and cooling operations were performed.
The heating of the RO water tank heater 6a and the heating of the line heater 4 were started, and the circulation operation by the two circulation lines of the first circulation line and the second circulation line was performed in parallel.
Heating by the heater 6a and the line heater 4 is controlled so that the temperature rising rate at the outlet of the RO module 5 in the second circulation line is 0.5 to 2.5 ° C./min. The water in the water tank 6 was heated for about 60 minutes until it became hot water of 80 ° C to 85 ° C.
Thereafter, the circulation operation was continued for 30 minutes while maintaining the hot water temperature of 80 to 85 ° C., and the heat sterilization operation was performed.

After completion of the hot water sterilization operation, the cooling operation was continued.
In order to perform the cooling operation, the heating of the RO water tank heater 6 a and the heating of the line heater 4 were stopped, then the on-off valve 73 was opened, and raw water was supplied as a cooling medium to the heat exchanger 8 through the line 24.
The two circulation lines of the first circulation line and the second circulation line continued the circulation operation in parallel as in the case of the sterilization operation.
Cooling by the heat exchanger 8 is controlled so that the temperature drop rate at the outlet of the RO module 5 in the second circulation line is 1.0 to 3.0 ° C./min, while hot water of 80 to 85 ° C. is 20 ° C. It cooled over about 30 minutes until it became -30 degreeC.

FIG. 3 shows temporal temperature changes in the RO module outlet water and the RO water tank water in the heating process, the hot water sterilization operation process, and the cooling operation process.
As can be seen from FIG. 3, no rapid temperature change was observed in any process during heating, sterilization, or cooling, and slow heating and cooling could be performed.

Next, the sterilization operation and the cooling operation with hot water were also performed on the circulation line including the UF device 7.
In the hot water sterilization operation for the circulation line including the UF device 7, the heating of the RO water tank heater 6 a is started and the open / close valve 74 is opened, the first intake line 18, the UF device 7, the second intake line 19, and the RO water. Circulation operation was performed on the circulation line composed of the tank 6. At this time, the circulation operation of the first circulation line was also performed in parallel.
During the heating operation, the heater 6a controls the temperature increase rate from 0.5 to 2.5 ° C./min until the water in the 20-30 ° C. RO water tank 6 reaches 80 ° C. to 85 ° C. Warmed over a minute.
Next, the hot water sterilization operation was carried out by continuing the circulation operation for 30 minutes while maintaining the hot water temperature of 80 to 85 ° C.
Further, raw water was supplied to the heat exchanger 8 to perform a cooling operation. The temperature lowering rate was controlled to be 1.0 to 3.0 ° C./min.

The above sterilization operation and cooling operation were performed once a week while performing purified water production operation, and the purified water production operation was performed continuously for 6 months.
During this operation period, the permeated water of the RO membrane module and the water in the RO water tank were sampled to measure the number of viable bacteria. The viable cell count was obtained by collecting 50 ml of sample water and using the membrane filter method. The results are shown in Table 1.

As can be seen from the results in Table 1, the hot water sterilization of the present invention could maintain a good sterilizing effect continuously.
During the 6-month operation, there were no troubles such as water leakage due to poor connection of piping, performance degradation or damage to the RO device or UF device.

Example 2
An operation for producing purified water for medical use was carried out using the production apparatus shown in FIG.
The specifications of each device are as follows.

Activated carbon device 3: Duracoal MAC750SH manufactured by Daisen Membrane Systems Co., Ltd.
RO device 5: RO membrane module; SV08-GP-DRA heat resistant type manufactured by Daisen Membrane Systems Co., Ltd. EDI device 9: XL-500-S heat resistant type manufactured by Daisen Membrane Systems Co., Ltd. RO water tank 6: SUS316 250L
EDI water tank 10: SUS316, 250L
UF device 7: UF membrane module; FS10FC-FUST653 manufactured by Daisen Membrane Systems Co., Ltd.
RO water tank electric heater 6a: 20kw
Line heater 4: 10 kW
Heat exchanger 8: 70000 kcal
RO water production volume: 1000L / hr

The apparatus of FIG. 2 was used to stop the production of purified water for medical use and then sterilization and cooling operations were performed.
The heating of the RO water tank heater 6a and the heating of the line heater 4 were started, and the circulation operation by the two circulation lines of the first circulation line and the third circulation line was performed in parallel.
Heating by the heater 6a and the line heater 4 is controlled so that the temperature rising rate at the RO module outlet of the third circulation line is 0.5 to 2.5 ° C./minute, and the RO water tank of 20 to 30 ° C. It heated for about 60 minutes until the water in 10 became hot water of 80 to 85 degreeC.
Thereafter, the circulation operation was continued for 30 minutes while maintaining the hot water temperature of 80 to 85 ° C., and the heat sterilization operation was performed.

After completion of the hot water sterilization operation, the cooling operation was continued.
In order to perform the cooling operation, the heating of the RO water tank heater 6 a and the heating of the line heater 4 were stopped, then the on-off valve 73 was opened, and raw water was supplied as a cooling medium to the heat exchanger 8 through the line 24.
The two circulation lines of the first circulation line and the third circulation line continued the circulation operation in parallel as in the case of the sterilization operation.
Cooling by the heat exchanger 8 is controlled so that the temperature drop rate at the RO module outlet of the second circulation line is 1.0 to 3.0 ° C./min, while 80 to 85 ° C. hot water is 20 ° C. to 30 ° C. It cooled over about 30 minutes until it became ° C.

The purified water production operation was performed while the above-described sterilization operation and cooling operation were performed once a week.
1) After the hot water sterilization is carried out once, the purified water production operation is continued for one week, immediately before the next hot water sterilization, and 2) 30 minutes after the end of the hot water sterilization,
The viable cell count was measured by sampling the permeated water of the RO membrane module, the EDI inlet water (corresponding to the water in the RO tank), and the EDI-treated demineralized water.
Viable count was performed by collecting 100 ml of sample water and using the membrane filter method. The results are shown in Table 2.

  From the results in Table 2, it was clear that a sufficiently good sterilizing effect could be maintained by hot water sterilization in the apparatus.

DESCRIPTION OF SYMBOLS 1 Prefilter 2 Water softening device 3 Activated carbon device 4 Line heater 5 RO device 6 RO water tank 7 UF device 8 Heat exchanger 9 EDI device 10 EDI water tank

Claims (9)

An adsorption device using activated carbon (hereinafter referred to as “activated carbon device”) (3),
Reverse osmosis membrane treatment equipment (hereinafter referred to as “RO equipment”) (5),
RO water tank (6) provided with heating means (6a) for storing treated water (hereinafter referred to as “RO water”) treated by the RO device (5);
It has a heat exchanger (8) that is connected to the RO water tank (6) and has means for cooling with raw water,
The raw water supply source and the activated carbon device (3) are connected by the raw water supply line (11, 12, 13),
Activated carbon device (3) and RO device (5) are connected by pretreatment water line (14),
RO device (5) and RO water tank (6) are connected by RO water line (17),
RO water tank (6) and intake section are connected by intake line (18),
RO water tank (6) and heat exchanger (8) are connected to RO water tank (6) to heat exchanger (8) with an incoming water line (18, 21) and from heat exchanger (8) to RO water tank ( 6) A device for producing purified water for medical use connected to a water discharge line (22) to 6)
It has a circulation line that circulates hot water or cooling water when the production of medical purified water stops.
The circulation line is a combination of a first circulation line and a second circulation line;
The first circulation line is a circulation line that returns from the RO water tank (6) to the RO water tank (6) through the incoming water line (18, 21), the heat exchanger (8), the outgoing water line (22),
The second circulation line from the RO water tank (6), the intake line (18), the line (23), the raw water supply line (13), the activated carbon device (3), the pretreatment water line (14), the RO device (5 ), A device for producing purified water for medical use, which is a circulation line that returns to the RO water tank (6) through the RO water line (17).   The ultrafiltration membrane device (7) is further provided in the intake line, and the ultrafiltration membrane device (7) and the RO water tank (6) are connected by the intake line (18). Medical purified water production equipment. An activated carbon adsorption device (hereinafter referred to as “activated carbon device”) (3),
Reverse osmosis membrane treatment equipment (hereinafter referred to as “RO equipment”) (5),
RO water tank (6) provided with heating means (6a) for storing treated water (hereinafter referred to as “RO water”) treated by the RO device (5);
It has a heat exchanger (8) that is connected to the RO water tank (6) and has means for cooling with raw water,
The raw water supply source and the activated carbon device (3) are connected by the raw water supply line (11, 12, 13),
Activated carbon device (3) and RO device (5) are connected by pretreatment water line (14),
RO device (5) and RO water tank (6) are connected by RO water line (17),
RO water tank (6) and intake section are connected by intake line (18),
RO water tank (6) and heat exchanger (8) are connected to RO water tank (6) through heat input line (21, 31) and from heat exchanger (8) to RO water tank ( Connected at the water discharge line (22) to 6)
In addition, an electric regenerative deionization device (hereinafter referred to as “EDI device”) (9) is provided,
The RO water tank (6) and the EDI device (9) are connected by the second RO water line (31),
An EDI water tank (10) for storing the EDI device (9) and treated water (hereinafter referred to as "EDI water") treated by the EDI device (9) is connected by an EDI water line (32),
An apparatus for producing purified water for medical use , wherein an EDI water tank (10) is connected to an intake line (18) ,
It has a circulation line that circulates hot water or cooling water when the production of medical purified water stops.
The circulation line is a combination of a first circulation line and a third circulation line;
The first circulation line is a circulation line that returns from the RO water tank (6) to the RO water tank (6) through the incoming water line ( 21 , 31 ), the heat exchanger (8), the outgoing water line (22),
The third circulation line is from the EDI water tank (10), the intake line (18), the line (23), the raw water supply line (13), the activated carbon device (3), the pretreatment water line (14), the RO device (5 ), 1st RO water line (17), RO water tank (6), 2nd RO water line (31), EDI device (9), circulation line returning to EDI water tank (10) through EDI water line (32) in it, medical Ryoyo purified water manufacturing apparatus.   The ultrafiltration membrane device (7) is further provided in the intake line, and the ultrafiltration membrane device (7) and the EDI water tank (10) are connected by the intake line (18). Medical purified water production equipment. The apparatus for producing purified water for medical use according to any one of claims 1 to 4, further comprising a water softening device (2) provided between the raw water source and the adsorption device (3) using activated carbon . And manufacturing method Tsu der medical purified water by the manufacturing apparatus of the medical purified water according to claim 1,
The method for producing purified water for medical use includes operation for sterilization and cooling in a state where production of purified water for medical use is stopped,
The sterilization operation is
An operation of heating the RO water in the RO water tank by a heating means and circulating it to the first circulation line while raising the temperature at 0.1 to 5 ° C./min;
Including the operation of circulating the RO water to the second circulation line in parallel with the operation of circulating to the first circulation line;
The cooling operation is
After stopping heating by the heating means, an operation for lowering the temperature at 0.1 to 5 ° C./min while circulating the RO water to the first circulation line;
The manufacturing method of the purified water for medical treatment by the manufacturing apparatus for purified water for medical treatment including the driving | operation which circulates the said RO water to a 2nd circulation line in parallel with the driving | operation circulated to a 1st circulation line. And manufacturing method Tsu der medical purified water by the manufacturing apparatus of the medical purified water according to claim 3,
The method for producing purified water for medical use includes operation for sterilization and cooling in a state where production of purified water for medical use is stopped,
The sterilization operation is
An operation of circulating the RO water to the first circulation line while heating the RO water in the RO water tank by a heating means and raising the temperature at 0.1 to 5 ° C./min;
Including the operation of circulating the RO water to the third circulation line in parallel with the operation of circulating to the first circulation line;
The cooling operation is
After stopping heating by the heating means, an operation for lowering the temperature at 0.1 to 5 ° C./min while circulating the RO water to the first circulation line;
The manufacturing method of the purified water for medical treatment by the manufacturing apparatus for purified water for medical treatment which includes the operation | movement made to circulate to a 3rd circulation line in parallel with the driving | operation circulated to a 1st circulation line. After stopping the production run of the medical purified water, then until resuming production run medical purified water, carried out continuously circulating operation of the first circulation line and the second circulation line, according to claim 6 A method for producing medical purified water using the medical purified water manufacturing apparatus described above. 8. The circulation operation of the first circulation line and the third circulation line is continuously performed until the production operation of medical purified water is restarted after the production operation of medical purified water is stopped. A method for producing purified water for medical use by a device for producing purified medical water .

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