JP5916946B2 - モノクローナルＩｇＡ抗体の製造方法 - Google Patents

モノクローナルＩｇＡ抗体の製造方法 Download PDF

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JP5916946B2
JP5916946B2 JP2015505472A JP2015505472A JP5916946B2 JP 5916946 B2 JP5916946 B2 JP 5916946B2 JP 2015505472 A JP2015505472 A JP 2015505472A JP 2015505472 A JP2015505472 A JP 2015505472A JP 5916946 B2 JP5916946 B2 JP 5916946B2
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amino acid
acid sequence
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iga antibody
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JPWO2014142084A1 (ja
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礼子 新蔵
礼子 新蔵
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EDUCATIONAL CORP KANSAI BUNRI SOUGOUGAKUEN
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015505472A 2013-03-11 2014-03-10 モノクローナルＩｇＡ抗体の製造方法 Expired - Fee Related JP5916946B2 (ja)

Applications Claiming Priority (5)

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JP2013048365 2013-03-11
JP2013048365 2013-03-11
JP2013167120 2013-08-09
JP2013167120 2013-08-09
PCT/JP2014/056216 WO2014142084A1 (ja) 2013-03-11 2014-03-10 モノクローナルＩｇＡ抗体の製造方法

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US (2) US9765151B2 (enExample)
EP (1) EP2995679A4 (enExample)
JP (2) JP5916946B2 (enExample)
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WO (1) WO2014142084A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016183153A (ja) * 2013-03-11 2016-10-20 学校法人関西文理総合学園 モノクローナルＩｇＡ抗体の製造方法

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WO2014144292A2 (en) 2013-03-15 2014-09-18 Sanofi Pasteur Biologics , Llc Antibodies against clostridium difficile toxins and methods of using the same
JP7031662B2 (ja) * 2017-03-28 2022-03-08 味の素株式会社 腸内環境改善用食品
CN110891583B (zh) * 2017-07-18 2023-06-06 学校法人庆应义塾 针对Th1细胞诱导性细菌的抗菌组合物
EP3683303A4 (en) * 2017-09-15 2021-05-05 BGI Shenzhen MEGAMONAS FUNIFORMIS AND ITS APPLICATIONS
JP2021530237A (ja) 2018-07-17 2021-11-11 ウーマブス ビオメド エセアー Ｃａｍｐｙｌｏｂａｃｔｅｒの種に対する抗体
WO2020113579A1 (zh) * 2018-12-07 2020-06-11 深圳华大生命科学研究院 单形巨单胞菌在预防和/或治疗代谢性疾病中的用途
WO2022011264A2 (en) * 2020-07-10 2022-01-13 The Wistar Institute Of Anatomy And Biology Dna antibody constructs for use against rotavirus
CN113122507B (zh) * 2021-04-27 2023-03-24 江南大学 一种快速检测铜绿假单胞菌的双抗体夹心elisa方法
AU2022269411A1 (en) * 2021-05-04 2023-12-21 Immunorizon Ltd. Anti-nkg2d antibodies and uses thereof
JP7425452B2 (ja) * 2021-07-01 2024-01-31 国立大学法人 東京大学 クロストリジウム・ディフィシル菌に結合する抗体
EP4364755A4 (en) * 2021-07-02 2026-02-18 Univ Tokyo COMPOSITION CONTAINING A MONOCLONAL ANTIBODY TO SUPPRESS CLOSTRIDIUM DIFFICILE BACTERIA
CN118043074A (zh) 2021-09-30 2024-05-14 伊加尔株式会社 含有单克隆抗体的组合物
TWI795150B (zh) * 2021-12-28 2023-03-01 林知儀 以生物污泥製成農業用劑的方法
EP4574840A1 (en) 2022-08-15 2025-06-25 The University of Tokyo Method for producing immunoglobulin or multimer immunoglobulin using filamentous fungus
CN120826417A (zh) 2023-03-03 2025-10-21 国立大学法人东京大学 免疫球蛋白
WO2024237217A1 (ja) * 2023-05-12 2024-11-21 国立大学法人 東京大学 クロストリジオイデス・ディフィシル菌に結合する抗体
CN117467016B (zh) * 2023-12-27 2024-03-12 北京索莱宝科技有限公司 人IgA的抗体、抗体组合及其应用
WO2025220732A1 (ja) * 2024-04-17 2025-10-23 国立研究開発法人国立循環器病研究センター 肺高血圧症の予防又は治療薬

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CN1381567A (zh) * 2001-04-18 2002-11-27 上海博德基因开发有限公司 一种多肽——丝氨酸羟甲基转移酶－10.56和编码这种多肽的多核苷酸

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KR20180058863A (ko) * 2005-11-30 2018-06-01 애브비 인코포레이티드 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도
US8669353B2 (en) * 2008-05-15 2014-03-11 W. Health L.P. Process for producing milk fractions rich in secretory immunoglobulins
WO2014142084A1 (ja) * 2013-03-11 2014-09-18 学校法人関西文理総合学園 モノクローナルＩｇＡ抗体の製造方法

Patent Citations (1)

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CN1381567A (zh) * 2001-04-18 2002-11-27 上海博德基因开发有限公司 一种多肽——丝氨酸羟甲基转移酶－10.56和编码这种多肽的多核苷酸

Non-Patent Citations (8)

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Title
JPN6014022545; 新蔵礼子: '腸内フローラ制御に有効な腸管ＩｇＡ抗体の分離' ヤクルト・バイオサイエンス研究財団年報 Ｎｏ．２０, 20130131, ｐｐ．５０-５７ *
JPN6014048534; Ｍｏｒｇａｎ　ＣＬ．　ｅｔ　ａｌ．: 'Ｃｏｏｒｄｉｎａｔｉｏｎ　ｏｆ　ｔｈｅ　ｃｅｌｌ-ｓｐｅｃｉｆｉｃ　ｄｉｓｔｒｉｂｕｔｉｏｎ　ｏｆ　ｔｈｅ　ｆｏｕｒ　ｓｕｂｕｎｉｔｓ　ｏｆ　ｇｌｙｃｉｎｅ　ｄｅｃａｒｂｏｘｙｌａｓｅ　ａｎｄ　ｏｆ' Ｐｌａｎｔａ Ｖｏｌ．１９０, 1993, ｐｐ．４６８-４７３ *
JPN6014048538; Ｓｔｒｏｎｇ　ＷＢ．　ｅｔ　ａｌ．: 'Ｐｕｒｉｆｉｃａｔｉｏｎ　ａｎｄ　ｐｒｏｐｅｒｔｉｅｓ　ｏｆ　ｓｅｒｉｎｅ　ｈｙｄｒｏｘｙｍｅｔｈｙｌｔｒａｎｓｆｅｒａｓｅ　ａｎｄ　Ｃ１-ｔｅｔｒａｈｙｄｒｏｆｏｌａｔｅ　ｓｙｎｔｈａｓｅ　ｆｒｏｍ' Ｊ　Ｂｉｏｌ　Ｃｈｅｍ． Ｖｏｌ．２６５，　Ｎｏ．２１, 1990, ｐｐ．１２１４９-１２１５５ *
JPN6014048541; Ｚｅｎｇ　ＧＪ．　ｅｔ　ａｌ．: 'Ｄｉｆｆｅｒｅｎｔｉａｌ　ｐｒｏｔｅｏｍｉｃ　ａｎａｌｙｓｉｓ　ｄｕｒｉｎｇ　ｔｈｅ　ｖｅｇｅｔａｔｉｖｅ　ｐｈａｓｅ　ｃｈａｎｇｅ　ａｎｄ　ｔｈｅ　ｆｌｏｒａｌ　ｔｒａｎｓｉｔｉｏｎ　ｉｎ　Ｍａｌｕ' Ｄｅｖ　Ｇｒｏｗｔｈ　Ｄｉｆｆｅｒ． Ｖｏｌ．５２，　Ｎｏ．７, 2010, ｐｐ．６３５-６４４ *
JPN6014048545; Ｇｉａｍｍａｒｉｏｌｉ　ＡＭ．　ｅｔ　ａｌ．: 'Ｐｒｏｄｕｃｔｉｏｎ　ａｎｄ　ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ　ｏｆ　ｍｕｒｉｎｅ　ＩｇＡ　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｉｅｓ　ｔｏ　ｔｈｅ　ｓｕｒｆａｃｅ　ａｎｔｉｇｅｎｓ　ｏｆ　ｒｈｅｓｕ' Ｖｉｒｏｌｏｇｙ Ｖｏｌ．２２５，　Ｎｏ．１, 1996, ｐｐ．９７-１１０ *
JPN6014048548; Ｔａｎｉｋａｗａ　Ｔ．　ｅｔ　ａｌ．: 'Ｐｒｏｄｕｃｔｉｏｎ　ａｎｄ　ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ　ｏｆ　ＩｇＡ　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ａｇａｉｎｓｔ　ｏｖａｌｂｕｍｉｎ．' Ｈｙｂｒｉｄｏｍａ　（Ｌａｒｃｈｍｔ） Ｖｏｌ．２６，　Ｎｏ．５, 2007, ｐｐ．３２８-３３２ *
JPN6014048551; Ｉｍａｉ　Ｙ．　ｅｔ　ａｌ．: 'Ｐｒｏｄｕｃｔｉｏｎ　ｏｆ　ＩｇＡ　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ａｇａｉｎｓｔ　Ｓｈｉｇａ　ｔｏｘｉｎ　ｂｉｎｄｉｎｇ　ｓｕｂｕｎｉｔｓ　ｅｍｐｌｏｙｉｎｇ　ｎａｓａｌ-ａｓｓｏｃｉａｔｅ' Ｊ　Ｉｍｍｕｎｏｌ　Ｍｅｔｈｏｄｓ． Ｖｏｌ．３０２，　Ｎｏ．１-２, 2005, ｐｐ．１２５-１３５ *
JPN6014048553; Ｋｏｌｂｅｒｇ　Ｊ．　ｅｔ　ａｌ．: 'Ｐｒｏｄｕｃｔｉｏｎ　ａｎｄ　ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ　ｏｆ　ａ　ｍｏｕｓｅ　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ｓｐｅｃｉｆｉｃ　ｆｏｒ　ｌｅｎｔｉｌ　ｌｅｃｔｉｎ．' Ｂｉｏｌ　Ｃｈｅｍ　Ｈｏｐｐｅ　Ｓｅｙｌｅｒ． Ｖｏｌ．３７２，　Ｎｏ．１, 1991, ｐｐ．５７-６１ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016183153A (ja) * 2013-03-11 2016-10-20 学校法人関西文理総合学園 モノクローナルＩｇＡ抗体の製造方法

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CN105246917A (zh) 2016-01-13
US20160039944A1 (en) 2016-02-11
EP2995679A1 (en) 2016-03-16
JPWO2014142084A1 (ja) 2017-02-16
EP2995679A4 (en) 2016-12-14
JP2016183153A (ja) 2016-10-20
US20180009906A1 (en) 2018-01-11
US9765151B2 (en) 2017-09-19
WO2014142084A1 (ja) 2014-09-18

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