JP5916749B2 - ばねエレメントを有する薬物送達デバイス - Google Patents
ばねエレメントを有する薬物送達デバイス Download PDFInfo
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- JP5916749B2 JP5916749B2 JP2013540392A JP2013540392A JP5916749B2 JP 5916749 B2 JP5916749 B2 JP 5916749B2 JP 2013540392 A JP2013540392 A JP 2013540392A JP 2013540392 A JP2013540392 A JP 2013540392A JP 5916749 B2 JP5916749 B2 JP 5916749B2
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Classifications
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Landscapes
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
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EP10192835 | 2010-11-29 | ||
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US201161433683P | 2011-01-18 | 2011-01-18 | |
US61/433,683 | 2011-01-18 | ||
PCT/EP2011/071117 WO2012072541A1 (en) | 2010-11-29 | 2011-11-28 | Drug delivery device having a spring element |
Publications (3)
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JP2014501572A JP2014501572A (ja) | 2014-01-23 |
JP2014501572A5 JP2014501572A5 (enrdf_load_stackoverflow) | 2014-11-27 |
JP5916749B2 true JP5916749B2 (ja) | 2016-05-11 |
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JP2013540392A Expired - Fee Related JP5916749B2 (ja) | 2010-11-29 | 2011-11-28 | ばねエレメントを有する薬物送達デバイス |
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EP (1) | EP2646076B1 (enrdf_load_stackoverflow) |
JP (1) | JP5916749B2 (enrdf_load_stackoverflow) |
CN (1) | CN103347553B (enrdf_load_stackoverflow) |
DK (1) | DK2646076T3 (enrdf_load_stackoverflow) |
WO (1) | WO2012072541A1 (enrdf_load_stackoverflow) |
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Publication number | Priority date | Publication date | Assignee | Title |
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GB2497375A (en) * | 2012-06-29 | 2013-06-12 | Sanofi Aventis Deutschland | Multiple medicament delivery system |
CN105377339A (zh) * | 2013-07-17 | 2016-03-02 | 赛诺菲 | 用于药物输送装置的驱动机构 |
US9579257B2 (en) | 2013-08-20 | 2017-02-28 | Anutra Medical, Inc. | Haptic feedback and audible output syringe |
WO2015074979A2 (en) * | 2013-11-22 | 2015-05-28 | Sanofi-Aventis Deutschland Gmbh | Spring assisted drug delivery device |
US10549084B2 (en) | 2014-01-10 | 2020-02-04 | Bayer Healthcare Llc | Single-use disposable set connector |
CN106456881A (zh) * | 2014-05-28 | 2017-02-22 | 赛诺菲-安万特德国有限公司 | 用于药物输送装置的剂量设定机构和药物输送装置 |
JP6647221B2 (ja) * | 2014-05-28 | 2020-02-14 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイス用のハウジングおよび薬物送達デバイス |
USD763433S1 (en) * | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
US10507319B2 (en) | 2015-01-09 | 2019-12-17 | Bayer Healthcare Llc | Multiple fluid delivery system with multi-use disposable set and features thereof |
JP2018502653A (ja) | 2015-01-21 | 2018-02-01 | アンタレス・ファーマ・インコーポレーテッド | 可変投与量を有する注入デバイス |
US20170100738A1 (en) * | 2015-10-13 | 2017-04-13 | The Werc Shop, LLC | Metered Dosing Method and Mechanisms Thereof |
WO2016188983A1 (en) * | 2015-05-27 | 2016-12-01 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
US20190046734A1 (en) * | 2015-10-01 | 2019-02-14 | Novo Nordisk A/S | Torsion spring fixation in automatic drug delivery device |
US11383036B2 (en) | 2015-12-30 | 2022-07-12 | Novo Nordisk A/S | Mechanism for sequential dose delivery |
CN109496146A (zh) * | 2016-05-27 | 2019-03-19 | 优尼瓦健康公司 | 用于使用药剂装置的装置和方法 |
TWI746569B (zh) | 2016-06-08 | 2021-11-21 | 瑞士商瑞健醫療股份有限公司 | 計量器具、注射裝置、及其應用 |
WO2017218372A1 (en) * | 2016-06-15 | 2017-12-21 | Bayer Healthcare Llc | Multi-use disposable system and syringe therefor |
WO2018096149A1 (de) | 2016-11-28 | 2018-05-31 | Idorsia Pharmaceuticals Ltd | Vorrichtung zur abgabe einer substanz |
JP7262463B2 (ja) * | 2017-12-04 | 2023-04-21 | ノボ・ノルデイスク・エー/エス | トーションばねベース装置用のばね変形機構 |
JP7064013B2 (ja) | 2018-04-19 | 2022-05-09 | ベクトン・ディキンソン・アンド・カンパニー | 自己ポンプ式注射器 |
US10947105B2 (en) * | 2018-11-22 | 2021-03-16 | Maksim Nilov | Hand held, volumetric multi material dispenser |
KR102640172B1 (ko) | 2019-07-03 | 2024-02-23 | 삼성전자주식회사 | 기판 처리 장치 및 이의 구동 방법 |
DE102019123731A1 (de) * | 2019-09-04 | 2021-03-04 | Henke-Sass, Wolf Gmbh | Vorrichtung zum Applizieren eines Fluids |
DE102019123733A1 (de) * | 2019-09-04 | 2021-03-04 | Henke-Sass, Wolf Gmbh | Vorrichtung zum Applizieren eines Fluids |
DE102019123735A1 (de) | 2019-09-04 | 2021-03-04 | Henke-Sass, Wolf Gmbh | Vorrichtung zum Applizieren eines Fluids |
DE102019123734A1 (de) * | 2019-09-04 | 2021-03-04 | Henke-Sass, Wolf Gmbh | Vorrichtung zum Applizieren eines Fluids |
CN113576551B (zh) * | 2021-07-21 | 2024-05-07 | 湖北汽车工业学院 | 一种肠道用螺旋式定点操作机构 |
US20240181442A1 (en) * | 2022-08-23 | 2024-06-06 | Maksim Nilov | Parametric Multi Component Dispenser |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5423752A (en) * | 1992-07-31 | 1995-06-13 | Habley Medical Technology Corporation | Variable proportion dispenser with cartridge replacement assembly |
US5271527A (en) | 1992-04-02 | 1993-12-21 | Habley Medical Technology Corporation | Reusable pharmaceutical dispenser with full stroke indicator |
US5378233A (en) | 1992-11-18 | 1995-01-03 | Habley Medical Technology Corporation | Selected dose pharmaceutical dispenser |
ZA941881B (en) | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
ATE353020T1 (de) * | 2003-05-30 | 2007-02-15 | Lilly Co Eli | Mehrkammer medikamentenverabreichungsvorrichtung |
WO2010077279A1 (en) * | 2008-12-09 | 2010-07-08 | Becton, Dickinson And Company | Multi-stroke delivery pumping mechanism for a drug delivery device for high pressure injections |
US9220851B2 (en) | 2008-12-09 | 2015-12-29 | Becton, Dickinson And Company | Open and closed valve medication delivery system for high pressure injections |
AR076624A1 (es) * | 2009-06-02 | 2011-06-22 | Sanofi Aventis Deutschland | Suministro de dos o mas medicametos por medio de una unica seleccion de dosis y una unica interfaz de dispensacion |
US9248239B2 (en) * | 2010-11-29 | 2016-02-02 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device having linked dose dial components |
US9333303B2 (en) * | 2010-11-29 | 2016-05-10 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device having a trigger |
WO2012072565A1 (en) * | 2010-11-29 | 2012-06-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device having a collar and a linkage component |
US9089645B2 (en) * | 2010-11-29 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
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2011
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- 2011-11-28 WO PCT/EP2011/071117 patent/WO2012072541A1/en active Application Filing
- 2011-11-28 US US13/885,326 patent/US9402961B2/en active Active
- 2011-11-28 JP JP2013540392A patent/JP5916749B2/ja not_active Expired - Fee Related
- 2011-11-28 CN CN201180066267.5A patent/CN103347553B/zh not_active Expired - Fee Related
- 2011-11-28 DK DK11788159.9T patent/DK2646076T3/da active
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HK1190347A1 (en) | 2014-07-04 |
EP2646076A1 (en) | 2013-10-09 |
US9402961B2 (en) | 2016-08-02 |
CN103347553A (zh) | 2013-10-09 |
CN103347553B (zh) | 2015-08-26 |
JP2014501572A (ja) | 2014-01-23 |
WO2012072541A1 (en) | 2012-06-07 |
EP2646076B1 (en) | 2014-07-30 |
DK2646076T3 (da) | 2014-10-27 |
US20130245565A1 (en) | 2013-09-19 |
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