JP5908884B2 - 気道炎症及び粘液線毛輸送機能異常治療用のエアロゾル化したダプソン - Google Patents

気道炎症及び粘液線毛輸送機能異常治療用のエアロゾル化したダプソン Download PDF

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Publication number
JP5908884B2
JP5908884B2 JP2013500079A JP2013500079A JP5908884B2 JP 5908884 B2 JP5908884 B2 JP 5908884B2 JP 2013500079 A JP2013500079 A JP 2013500079A JP 2013500079 A JP2013500079 A JP 2013500079A JP 5908884 B2 JP5908884 B2 JP 5908884B2
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Prior art keywords
dapsone
pharmaceutical composition
lps
per
administration
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Japanese (ja)
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JP2013522295A (ja
JP2013522295A5 (enExample
Inventor
ルービン,ブルース,ケー.
宗一郎 叶
宗一郎 叶
毅 田名部
毅 田名部
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Virginia Commonwealth University
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Virginia Commonwealth University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10Sulfides; Sulfoxides; Sulfones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013500079A 2010-03-15 2011-03-08 気道炎症及び粘液線毛輸送機能異常治療用のエアロゾル化したダプソン Active JP5908884B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31387710P 2010-03-15 2010-03-15
US61/313,877 2010-03-15
US41635310P 2010-11-23 2010-11-23
US61/416,353 2010-11-23
PCT/US2011/027494 WO2011115778A2 (en) 2010-03-15 2011-03-08 Aerosolized dapsone as a therapy for inflammation of the airway and abnormal mucociliary transport

Publications (3)

Publication Number Publication Date
JP2013522295A JP2013522295A (ja) 2013-06-13
JP2013522295A5 JP2013522295A5 (enExample) 2014-05-01
JP5908884B2 true JP5908884B2 (ja) 2016-04-26

Family

ID=44649767

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013500079A Active JP5908884B2 (ja) 2010-03-15 2011-03-08 気道炎症及び粘液線毛輸送機能異常治療用のエアロゾル化したダプソン

Country Status (8)

Country Link
US (3) US20130005822A1 (enExample)
EP (1) EP2547335A4 (enExample)
JP (1) JP5908884B2 (enExample)
KR (1) KR101924162B1 (enExample)
AU (1) AU2011227613B2 (enExample)
BR (1) BR112012023877A2 (enExample)
CA (1) CA2793170C (enExample)
WO (1) WO2011115778A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104619321A (zh) * 2012-04-06 2015-05-13 Uab研究基金会 用于增加cftr活性的方法
JP6944701B2 (ja) * 2016-10-21 2021-10-06 国立大学法人山口大学 CD11bアンタゴニストを含む劇症型急性肺炎治療用組成物
CA3126367A1 (en) * 2020-03-30 2021-09-30 Pulmonem Inc. Dapsone formulations and methods of using same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0617610B1 (en) 1991-12-18 1997-03-19 Minnesota Mining And Manufacturing Company Suspension aerosol formulations
NZ298169A (en) 1994-12-22 1999-09-29 Astra Ab Aerosol drug formulation; comprises hydrofluoroalkane propellant, medicament for inhalation and a surfactant
US20030082107A1 (en) * 1997-10-01 2003-05-01 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
GB9820886D0 (en) 1998-09-26 1998-11-18 Glaxo Group Ltd Inhalation device
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
JP2002543122A (ja) * 1999-04-30 2002-12-17 エイピーティー ファーマスーティカルズ エルエルスィー 抗マラリア治療剤についての新規使用
AU2001257022B2 (en) * 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
GB2362101A (en) * 2000-05-12 2001-11-14 Astrazeneca Ab Treatment of chronic obstructive pulmonary disease
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
AUPS017702A0 (en) * 2002-01-25 2002-02-14 Atopic Pty Ltd Methods and compositions for the treatment of asthma and related disorders
CN1700934B (zh) 2002-09-06 2011-08-03 菲利普莫里斯美国公司 液体气溶胶制剂和用于制备气溶胶的气溶胶产生装置及方法
US7497214B2 (en) 2002-09-16 2009-03-03 3M Innovative Properties Company Aerosol dispensers and adaptors therefor
DE60319719T2 (de) * 2002-09-30 2009-03-12 Novartis Ag Verfahren zur voraussage der erhöhung von cholesterin während einer immunosuppresiven therapie
US20040086469A1 (en) * 2002-10-30 2004-05-06 Osborne David W. Protectant for UV-induced skin damage
US7683029B2 (en) 2003-05-07 2010-03-23 Philip Morris Usa Inc. Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin
CN102060806A (zh) * 2003-09-11 2011-05-18 iTherX药品公司 细胞因子抑制剂
MXPA06004499A (es) * 2003-10-21 2006-06-27 Pharmacia Corp Metodo para el tratamiento o la prevencion de inflamacion respiratoria con un inhibidor de ciclooxigenasa 2 en combinacion con un inhibidor de fosfodiesterasa 4 y sus composiciones.
WO2007059905A2 (en) * 2005-11-25 2007-05-31 Develogen Aktiengesellschaft Thienopyrimidines treating inflammatory diseases
US20080066739A1 (en) * 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
CA2714674A1 (en) * 2008-02-27 2009-09-03 John Steven Garrett Dapsone to treat rosacea
WO2010099523A1 (en) * 2009-02-27 2010-09-02 University Of Cincinnati Method of treating reactive airway disease

Also Published As

Publication number Publication date
KR101924162B1 (ko) 2018-11-30
AU2011227613B2 (en) 2015-09-03
KR20130055580A (ko) 2013-05-28
WO2011115778A9 (en) 2012-01-12
CA2793170C (en) 2018-04-17
US20180243213A1 (en) 2018-08-30
US20150040894A1 (en) 2015-02-12
EP2547335A2 (en) 2013-01-23
CA2793170A1 (en) 2011-09-22
US20130005822A1 (en) 2013-01-03
AU2011227613A1 (en) 2012-10-04
JP2013522295A (ja) 2013-06-13
WO2011115778A2 (en) 2011-09-22
EP2547335A4 (en) 2014-04-16
BR112012023877A2 (pt) 2016-08-02

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