JP5908839B2 - 超音波感受性物質を含む腫瘍増殖抑制剤および腫瘍増殖抑制剤と低出力超音波を用いた腫瘍増殖抑制方法 - Google Patents
超音波感受性物質を含む腫瘍増殖抑制剤および腫瘍増殖抑制剤と低出力超音波を用いた腫瘍増殖抑制方法 Download PDFInfo
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- JP5908839B2 JP5908839B2 JP2012531890A JP2012531890A JP5908839B2 JP 5908839 B2 JP5908839 B2 JP 5908839B2 JP 2012531890 A JP2012531890 A JP 2012531890A JP 2012531890 A JP2012531890 A JP 2012531890A JP 5908839 B2 JP5908839 B2 JP 5908839B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
- A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Description
実施例1と実質的に同様にして、DEG単独を用いて超音波処置を行った。その結果を比較例として図2に示す。
Claims (5)
- 請求項1または請求項2に記載の腫瘍増殖抑制剤であって、前記音響キャビテーション現象増強物質が、ガス封入バブル(気泡)であることを特徴とする腫瘍増殖抑制剤。
- 請求項3に記載の腫瘍増殖抑制剤であって、前記ガス封入バブルが、マイクロバブルまたはナノバブルであることを特徴とする腫瘍増殖抑制剤。
- 請求項3または請求項4に記載の腫瘍増殖抑制剤であって、前記ガス封入バブルが、ソナゾイド(sonazoid)またはレボビスト(levovist)であることを特徴とする腫瘍増殖抑制剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2010192916 | 2010-08-30 | ||
JP2010192916 | 2010-08-30 | ||
PCT/JP2011/069590 WO2012029771A1 (ja) | 2010-08-30 | 2011-08-30 | 超音波感受性物質を含む腫瘍増殖抑制剤および腫瘍増殖抑制剤と低出力超音波を用いた腫瘍増殖抑制方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2012029771A1 JPWO2012029771A1 (ja) | 2013-10-28 |
JP5908839B2 true JP5908839B2 (ja) | 2016-04-27 |
Family
ID=45772854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012531890A Active JP5908839B2 (ja) | 2010-08-30 | 2011-08-30 | 超音波感受性物質を含む腫瘍増殖抑制剤および腫瘍増殖抑制剤と低出力超音波を用いた腫瘍増殖抑制方法 |
Country Status (3)
Country | Link |
---|---|
US (2) | US20130129799A1 (ja) |
JP (1) | JP5908839B2 (ja) |
WO (1) | WO2012029771A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6218263B2 (ja) * | 2012-08-29 | 2017-10-25 | 学校法人福岡大学 | 水溶性チタニア・シリカ複合体を用いた抗腫瘍剤 |
US20210213307A1 (en) * | 2013-03-06 | 2021-07-15 | B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Low intensity ultrasound therapy |
US10960233B2 (en) * | 2013-03-06 | 2021-03-30 | B.G. Negev Technologies And Applications Ltd. | Low intensity ultrasound therapy |
RU2581353C2 (ru) * | 2014-05-08 | 2016-04-20 | Федеральное государственное казенное учреждение Главный клинический военный госпиталь ФСБ России | Способ лечения злокачественных новообразований кожи в проблемных зонах местной химиотерапией, усиленной близкофокусным ультразвуковым воздействием в адъювантном и неоадъювантном режимах |
JP2019000001A (ja) * | 2015-09-29 | 2019-01-10 | 株式会社日立製作所 | 細胞培養装置 |
CA3128067A1 (en) | 2019-02-13 | 2020-08-20 | Alpheus Medical, Inc. | Non-invasive sonodynamic therapy |
-
2011
- 2011-08-30 JP JP2012531890A patent/JP5908839B2/ja active Active
- 2011-08-30 US US13/812,922 patent/US20130129799A1/en not_active Abandoned
- 2011-08-30 WO PCT/JP2011/069590 patent/WO2012029771A1/ja active Application Filing
-
2014
- 2014-02-21 US US14/186,859 patent/US9764029B2/en active Active
Non-Patent Citations (4)
Title |
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JPN6011055488; KINOSHITA et al.: 'Mechanism of Porphyrin-Induced Sonodynamic Effect:Possible Role of Hyperthermia' RADIATION RESEARCH Vol.165, 2006, p.299-306 * |
JPN6011055489; 水流弘文他: '新しいポルフィリン誘導体DEG-Mn-DP-Hを用いた癌の超音波力学療法' 超音波医学 Vol.37 Supplement, 20100415, S468 83-AP-001 * |
JPN6011055491; 岩瀬他: '新規ポルフィリン誘導体DCPH-P-Na(I)の音響化学的活性化によるアポトーシス誘導' 応用薬理 Vol.78,No.5/6, 20100813, p.45 * |
JPN6011055492; YANAGISAWA et al.: 'PHAGOCYTOSIS OF ULTRASOUND CONTRASR AGENT MICROBUBBLES BY KUPFFER CELLS' Ultrasound in Med. & Biol. Vol.33,No.2, 2007, p.318-325 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012029771A1 (ja) | 2012-03-08 |
US20140287000A1 (en) | 2014-09-25 |
US9764029B2 (en) | 2017-09-19 |
JPWO2012029771A1 (ja) | 2013-10-28 |
US20130129799A1 (en) | 2013-05-23 |
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