JP5881692B2 - 双極性障害を治療する方法 - Google Patents
双極性障害を治療する方法 Download PDFInfo
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- JP5881692B2 JP5881692B2 JP2013518241A JP2013518241A JP5881692B2 JP 5881692 B2 JP5881692 B2 JP 5881692B2 JP 2013518241 A JP2013518241 A JP 2013518241A JP 2013518241 A JP2013518241 A JP 2013518241A JP 5881692 B2 JP5881692 B2 JP 5881692B2
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- 229940005581 sodium lactate Drugs 0.000 description 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-N sodium;2-hydroxybenzoic acid Chemical class [Na+].OC(=O)C1=CC=CC=C1O ABBQHOQBGMUPJH-UHFFFAOYSA-N 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
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- 230000000707 stereoselective effect Effects 0.000 description 1
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- 239000008223 sterile water Substances 0.000 description 1
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- 210000002784 stomach Anatomy 0.000 description 1
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- 201000009032 substance abuse Diseases 0.000 description 1
- 231100000736 substance abuse Toxicity 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/827,505 | 2010-06-30 | ||
| US12/827,505 US9610274B2 (en) | 2010-06-30 | 2010-06-30 | Methods for treating bipolar disorder |
| PCT/KR2011/004676 WO2012002687A2 (en) | 2010-06-30 | 2011-06-27 | Methods for treating bipolar disorder |
Publications (3)
| Publication Number | Publication Date |
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| JP2013533253A JP2013533253A (ja) | 2013-08-22 |
| JP2013533253A5 JP2013533253A5 (cg-RX-API-DMAC7.html) | 2014-08-07 |
| JP5881692B2 true JP5881692B2 (ja) | 2016-03-09 |
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| JP2013518241A Active JP5881692B2 (ja) | 2010-06-30 | 2011-06-27 | 双極性障害を治療する方法 |
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| EP (1) | EP2590645B1 (cg-RX-API-DMAC7.html) |
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| CN (1) | CN102985085B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011272156B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012033738A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2801241C (cg-RX-API-DMAC7.html) |
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| RU (1) | RU2653408C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012002687A2 (cg-RX-API-DMAC7.html) |
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| KR101335941B1 (ko) | 2005-06-08 | 2013-12-04 | 에스케이바이오팜 주식회사 | 수면-각성 장애의 치료 |
| MX2012000034A (es) | 2009-06-22 | 2012-02-21 | Sk Biopharmaceuticals Co Ltd | Metodos para el tratamiento o la prevencion de la fatiga. |
| RU2019114940A (ru) | 2013-03-13 | 2019-06-28 | ЭРИЭЛ БАЙОФАРМА, ЭлЭлСи | Лечение катаплексии |
| US9226910B2 (en) | 2013-07-18 | 2016-01-05 | Jazz Pharmaceuticals International Iii Limited | Treatment for obesity |
| TWI655179B (zh) | 2014-02-28 | 2019-04-01 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
| US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
| CA3036071A1 (en) | 2016-09-06 | 2018-03-15 | Jazz Pharmaceuticals International Iii Limited | Solvate form of (r)-2-amino-3-phenylpropyl carbamate |
| US10195151B2 (en) | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
| US10710958B2 (en) | 2016-10-06 | 2020-07-14 | Jazz Pharmaceuticals Ireland Limited | Carbamoyl phenylalaninol compounds and uses thereof |
| KR102635938B1 (ko) * | 2016-12-14 | 2024-02-13 | 에스케이바이오팜 주식회사 | 양극성 장애의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
| BR112019025286A2 (pt) | 2017-06-02 | 2020-06-23 | Jazz Pharmaceuticals Ireland Limited | Métodos e composições para tratamento de sonolência excessiva |
| RU2020108634A (ru) | 2017-07-31 | 2021-09-02 | Джаз Фармасьютикалз Айрлэнд Лимитед | Аналоги карбамоилфенилаланинола и способы их применения |
| US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
| WO2025006965A1 (en) | 2023-06-29 | 2025-01-02 | Axsome Therapeutics, Inc. | Methods of administering solriamfetol to lactating women |
| WO2025165760A1 (en) * | 2024-01-29 | 2025-08-07 | Axsome Therapeutics, Inc. | Phenylalkylamino carbamates for use in the treatment of attention deficit/hyperactivity disorder |
Family Cites Families (41)
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|---|---|---|---|---|
| IL109872A (en) | 1993-06-10 | 2000-12-06 | Lilly Co Eli | Tetrahydrobenz ¬CD¾ indole-6-carboxamides for use in preventing emesis and pharmaceutical compositions comprising same |
| KR100197892B1 (ko) | 1994-09-09 | 1999-06-15 | 남창우 | 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 |
| US5756817C1 (en) | 1995-02-11 | 2001-04-17 | Sk Corp | O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same |
| KR0173862B1 (ko) | 1995-02-11 | 1999-04-01 | 조규향 | O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| IT1275903B1 (it) | 1995-03-14 | 1997-10-24 | Boehringer Ingelheim Italia | Esteri e ammidi della 1,4-piperidina disostituita |
| KR0173863B1 (ko) | 1995-04-10 | 1999-04-01 | 조규향 | 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| DE69618663T2 (de) | 1996-10-10 | 2002-08-14 | Sk Corp., Seoul/Soul | O-carbamoyl-phenylalaninol-zusammensetzungen und ihre pharmazeutisch anwendbaren salzen |
| WO1998017636A1 (en) | 1996-10-22 | 1998-04-30 | Ortho Pharmaceutical Corporation | Phenylalaninol derivatives for the treatment of central nervous system disorders |
| TW548103B (en) | 1997-07-11 | 2003-08-21 | Janssen Pharmaceutica Nv | Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| RU2214400C2 (ru) | 1998-04-28 | 2003-10-20 | Дайниппон Фармасьютикал Ко., Лтд. | Производные 1-[(1-замещенного-4-пиперидинил)метил]-4-пиперидина, способы их получения, фармацевтическая композиция на их основе и промежуточные вещества |
| US20010029262A1 (en) | 1998-06-29 | 2001-10-11 | Sethi Kapil Dev | Method of treatment or prophylaxis |
| TW518218B (en) | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
| US20010034320A1 (en) | 2000-01-18 | 2001-10-25 | Hans-Michael Brecht | NK1-receptor antagonists for treating restless legs syndrome |
| PT1347971E (pt) | 2000-12-21 | 2006-06-30 | Bristol Myers Squibb Co | Inibidores tiazolilicos de tirosina-cinases da familia tec |
| WO2002067922A1 (en) | 2001-02-27 | 2002-09-06 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in the treatment of pain |
| KR100858232B1 (ko) | 2001-02-27 | 2008-09-12 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 카바메이트 화합물을 포함하는 거동 장애 예방 또는 치료용 약제학적 조성물 |
| CA2443108A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| CA2449249A1 (en) | 2001-06-12 | 2002-12-19 | Merck & Co., Inc. | Nr2b receptor antagonists for the treatment or prevention of migraines |
| US20040115263A1 (en) | 2002-08-26 | 2004-06-17 | Robertson David W. | Use of bupropion for treating restless legs syndrome |
| BR0314584A (pt) | 2002-09-20 | 2005-08-09 | Pfizer | Compostos piperidinil-imidazopiridina n-substituìda como moduladores e receptores 5-ht4 |
| CA2523077A1 (en) | 2003-04-21 | 2004-11-04 | Pfizer Inc. | Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity |
| HRP20120077T1 (hr) | 2003-09-03 | 2012-02-29 | Pfizer Inc. | Benzimidazolonski spojevi s aktivnošću agonista 5-ht4 receptora |
| US20050080268A1 (en) | 2003-10-08 | 2005-04-14 | Yong-Moon Choi | Process of preparing O-carbamoyl compounds in the presence of active amine group |
| EP1548011A1 (en) | 2003-12-23 | 2005-06-29 | Neuro3D | Benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof |
| WO2005092882A1 (en) | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
| KR20070083826A (ko) | 2004-10-28 | 2007-08-24 | 에스케이 주식회사 | 우울증을 위한 부가 요법 |
| EP1869019B1 (en) | 2005-04-08 | 2014-08-27 | Pfizer Products Inc. | Bicyclic [3.1.0] heteroaryl amides as type i glycine transport inhibitors |
| US7598279B2 (en) | 2005-04-22 | 2009-10-06 | Sk Holdings Co., Ltd. | Neurotherapeutic azole compounds |
| KR101335941B1 (ko) | 2005-06-08 | 2013-12-04 | 에스케이바이오팜 주식회사 | 수면-각성 장애의 치료 |
| JP5298334B2 (ja) | 2005-06-22 | 2013-09-25 | エスケー ホルディングス カンパニー リミテッド | 性機能障害を治療する方法 |
| EP1928451B1 (en) | 2005-07-26 | 2011-12-28 | SK Biopharmaceuticals Co., LTD | Methods for treating substance-related disorders |
| EP1754476A1 (en) | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| BRPI0719275A2 (pt) | 2006-10-13 | 2014-04-29 | Janssen Pharmaceutica Nv | Composições de carbamatos de fenil-alquil-amino |
| HUP0700370A2 (en) * | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania |
| US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
| MX2012000034A (es) | 2009-06-22 | 2012-02-21 | Sk Biopharmaceuticals Co Ltd | Metodos para el tratamiento o la prevencion de la fatiga. |
| US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| KR101097605B1 (ko) | 2009-11-04 | 2011-12-22 | 알.에프 에이치아이씨 주식회사 | 도허티 증폭기 |
| AU2010316172B2 (en) | 2009-11-06 | 2015-11-12 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating fibromyalgia syndrome |
| EP2496228B1 (en) | 2009-11-06 | 2014-01-15 | SK Biopharmaceuticals Co., Ltd. | Methods for treating attention-deficit/hyperactivity disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
-
2010
- 2010-06-30 US US12/827,505 patent/US9610274B2/en active Active
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2011
- 2011-06-27 PL PL11801093T patent/PL2590645T3/pl unknown
- 2011-06-27 CN CN201180032698.XA patent/CN102985085B/zh active Active
- 2011-06-27 WO PCT/KR2011/004676 patent/WO2012002687A2/en not_active Ceased
- 2011-06-27 KR KR1020127032128A patent/KR101828934B1/ko active Active
- 2011-06-27 JP JP2013518241A patent/JP5881692B2/ja active Active
- 2011-06-27 AU AU2011272156A patent/AU2011272156B2/en active Active
- 2011-06-27 ES ES11801093.3T patent/ES2654615T3/es active Active
- 2011-06-27 MX MX2016002438A patent/MX360030B/es unknown
- 2011-06-27 CA CA2801241A patent/CA2801241C/en not_active Expired - Fee Related
- 2011-06-27 RU RU2012155118A patent/RU2653408C2/ru active
- 2011-06-27 BR BR112012033738A patent/BR112012033738A2/pt not_active Application Discontinuation
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- 2011-06-27 MX MX2012014686A patent/MX2012014686A/es not_active Application Discontinuation
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| KR101828934B1 (ko) | 2018-03-29 |
| CN102985085A (zh) | 2013-03-20 |
| PL2590645T3 (pl) | 2018-03-30 |
| EP2590645A2 (en) | 2013-05-15 |
| WO2012002687A3 (en) | 2012-04-26 |
| AU2011272156A1 (en) | 2013-02-07 |
| US20170151209A1 (en) | 2017-06-01 |
| BR112012033738A2 (pt) | 2017-08-08 |
| EP2590645B1 (en) | 2017-10-04 |
| CA2801241A1 (en) | 2012-01-05 |
| MX2012014686A (es) | 2013-02-11 |
| CN102985085B (zh) | 2018-10-02 |
| AU2011272156B2 (en) | 2015-02-12 |
| US20120004300A1 (en) | 2012-01-05 |
| US9907777B2 (en) | 2018-03-06 |
| KR20130112706A (ko) | 2013-10-14 |
| WO2012002687A2 (en) | 2012-01-05 |
| RU2012155118A (ru) | 2014-08-10 |
| EP2590645A4 (en) | 2014-01-22 |
| MX360030B (es) | 2018-10-19 |
| RU2653408C2 (ru) | 2018-05-08 |
| CA2801241C (en) | 2018-07-17 |
| ES2654615T3 (es) | 2018-02-14 |
| JP2013533253A (ja) | 2013-08-22 |
| US9610274B2 (en) | 2017-04-04 |
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