JP5860409B2 - 徐放性核酸マトリックス組成物 - Google Patents

徐放性核酸マトリックス組成物 Download PDF

Info

Publication number
JP5860409B2
JP5860409B2 JP2012548536A JP2012548536A JP5860409B2 JP 5860409 B2 JP5860409 B2 JP 5860409B2 JP 2012548536 A JP2012548536 A JP 2012548536A JP 2012548536 A JP2012548536 A JP 2012548536A JP 5860409 B2 JP5860409 B2 JP 5860409B2
Authority
JP
Japan
Prior art keywords
another embodiment
matrix composition
nucleic acid
lipid
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012548536A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013517265A (ja
JP2013517265A5 (cg-RX-API-DMAC10.html
Inventor
エマヌエル，ノアム
ローゼンフェルド，ヨセフ
Original Assignee
ポリピッド リミテッド
ポリピッド リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ポリピッド リミテッド, ポリピッド リミテッド filed Critical ポリピッド リミテッド
Publication of JP2013517265A publication Critical patent/JP2013517265A/ja
Publication of JP2013517265A5 publication Critical patent/JP2013517265A5/ja
Application granted granted Critical
Publication of JP5860409B2 publication Critical patent/JP5860409B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
JP2012548536A 2010-01-19 2011-01-18 徐放性核酸マトリックス組成物 Active JP5860409B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29604010P 2010-01-19 2010-01-19
US61/296,040 2010-01-19
PCT/IL2011/000054 WO2011089595A2 (en) 2010-01-19 2011-01-18 Sustained-release nucleic acid matrix compositions

Publications (3)

Publication Number Publication Date
JP2013517265A JP2013517265A (ja) 2013-05-16
JP2013517265A5 JP2013517265A5 (cg-RX-API-DMAC10.html) 2014-03-06
JP5860409B2 true JP5860409B2 (ja) 2016-02-16

Family

ID=44307336

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012548536A Active JP5860409B2 (ja) 2010-01-19 2011-01-18 徐放性核酸マトリックス組成物

Country Status (7)

Country Link
US (2) US8795726B2 (cg-RX-API-DMAC10.html)
EP (1) EP2525778B1 (cg-RX-API-DMAC10.html)
JP (1) JP5860409B2 (cg-RX-API-DMAC10.html)
CN (1) CN102892406B (cg-RX-API-DMAC10.html)
AU (1) AU2011208374B2 (cg-RX-API-DMAC10.html)
CA (1) CA2783001C (cg-RX-API-DMAC10.html)
WO (1) WO2011089595A2 (cg-RX-API-DMAC10.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2299953B1 (en) 2008-07-14 2017-04-12 Polypid Ltd. Sustained-release drug carrier composition
CN102470105B (zh) 2009-07-14 2015-07-29 波利皮得有限公司 持续释放药物载体组合物
CN103500847B (zh) * 2013-10-02 2016-08-17 中国地质大学（武汉） 锂硫电池添加剂、含有该添加剂的正极材料及其制备方法
WO2015069870A1 (en) * 2013-11-07 2015-05-14 The University Of North Carolina At Chapel Hill Particles containing phospholipids or bioactive fatty acid
WO2015114633A1 (en) 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same
JP2016023148A (ja) * 2014-07-17 2016-02-08 富士フイルム株式会社 脂質粒子の製造法および脂質粒子を有する核酸送達キャリア
PL3200748T3 (pl) * 2014-10-02 2022-02-07 Polypid Ltd. Kompozycje i sposoby leczenia i profilaktyki zakażeń miejsca operowanego
US11052046B2 (en) * 2017-09-26 2021-07-06 Nanomi B.V. Method for preparing micro-particles by double emulsion technique
CN107823725B (zh) * 2017-10-11 2020-10-09 上海君联医疗设备有限公司 一种可延期回收的血栓滤器及其制作方法
JP6388700B2 (ja) * 2017-10-20 2018-09-12 富士フイルム株式会社 脂質粒子の製造法および脂質粒子を有する核酸送達キャリア
EP3700965A1 (en) 2017-10-27 2020-09-02 Massachusetts Institute of Technology Poly (beta-amino esters) and uses thereof
DK3864163T3 (da) 2018-10-09 2024-05-06 Univ British Columbia Sammensætninger og systemer omfattende transfektionskompetente vesikler fri for organiske opløsningsmidler og rengøringsmidler og fremgangsmåder forbundet dermed
AU2019366996A1 (en) * 2018-10-26 2021-05-27 Massachusetts Institute Of Technology Polymer-lipids and compositions
EP4305088A1 (en) 2021-03-09 2024-01-17 Massachusetts Institute of Technology Branched poly(-amino esters) for the delivery of nucleic acids
US20240108545A1 (en) 2022-10-03 2024-04-04 West Pharmaceutical Services, Inc. Methods and adapters for mixing pharmaceutical complexes

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4882167A (en) 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
US4578384A (en) 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
JPS6163613A (ja) 1984-09-04 1986-04-01 Mitsui Toatsu Chem Inc 顆粒状に調整された徐放性製剤
US5043166A (en) 1987-01-09 1991-08-27 Hadasit Medical Research, Inc. Liposome/anthraquinone drug composition and method
IL91664A (en) 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
AU655162B2 (en) 1989-11-13 1994-12-08 Nova Pharmaceutical Corporation Lipospheres for controlled delivery of substances
US6120805A (en) 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
JPH046115A (ja) 1990-04-25 1992-01-10 Olympus Optical Co Ltd 光学素子成形用型
JPH0418035A (ja) 1990-05-10 1992-01-22 Nkk Corp 徐放性製剤および製造法
JPH0446115A (ja) 1990-06-13 1992-02-17 Eisai Co Ltd マイクロスフィアの製造法
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
EP0804249A2 (en) 1994-03-15 1997-11-05 Brown University Research Foundation Polymeric gene delivery system
US6156337A (en) 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6040295A (en) 1995-01-13 2000-03-21 Genemedicine, Inc. Formulated nucleic acid compositions and methods of administering the same for gene therapy
US5919480A (en) 1996-06-24 1999-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal influenza vaccine composition and method
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
WO1998007412A1 (en) 1996-08-21 1998-02-26 Alkermes Controlled Therapeutics, Inc. Controlled release microparticles with a hydrophobic material
PT977597E (pt) 1996-09-11 2003-06-30 Imarx Pharmaceutical Corp Metodos melhorados para imagiologia de diagnosticoutilizando um agente de contraste e um vasodil atador
US6048551A (en) 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors
IL129951A0 (en) 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
US6287587B2 (en) 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
US6787132B1 (en) 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
CA2329768C (en) 1998-04-27 2008-06-10 Opperbas Holding B.V. Pharmaceutical composition comprising factor viii and neutral liposomes
US6423345B2 (en) 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
WO2000003660A1 (en) 1998-07-17 2000-01-27 Skyepharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
ATE237312T1 (de) * 1998-07-20 2003-05-15 Protiva Biotherapeutics Inc In liposomen verkapselte nukleinsäurekomplexe
IL140892A0 (en) 1998-08-12 2002-02-10 Yissum Res Dev Co Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
US6153217A (en) * 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
US6083482A (en) 1999-05-11 2000-07-04 Icn Pharmaceuticals, Inc. Conformationally locked nucleosides and oligonucleotides
AU5624400A (en) 1999-06-18 2001-01-09 Collaborative Group, Ltd., The Hyaluronic acid film and matrix for sustained gene transfer
DE10001172A1 (de) 2000-01-13 2001-07-26 Max Planck Gesellschaft Templatieren von Feststoffpartikeln mit Polymermultischichten
US6967028B2 (en) 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
IL155204A0 (en) 2000-10-02 2003-11-23 Arizeke Pharmaceuticals Inc Compositions and methods for the transport of biologically active agents across cellular barriers
FI20010540A0 (fi) 2001-03-16 2001-03-16 Yli Urpo Antti Komposiitti pehmyt- ja kovakudosvammojen korjaamiseksi ja mainitun komposiitin käyttö
US20020137433A1 (en) * 2001-03-26 2002-09-26 Lee Lawrence K. Abrasive drill bit
MXPA04002973A (es) 2001-09-28 2005-06-20 Johnson & Johnson Formas de dosis de liberacion modificada.
TWI226249B (en) 2001-12-19 2005-01-11 Ind Tech Res Inst Biodegradable composite matrix for enhancing angiogenesis
CA2752143C (en) 2002-05-15 2014-09-23 Sutter West Bay Hospitals Delivery of nucleic acid-like compounds
TWI367113B (en) 2003-02-12 2012-07-01 Syncera Inc Random and non-random alkylene oxide polymer alloy compositions
WO2004081196A2 (en) 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
GB0305941D0 (en) 2003-03-14 2003-04-23 Camurus Ab Composition
KR20050118725A (ko) 2003-04-10 2005-12-19 데이진 가부시키가이샤 허니콤 구조를 갖는 생분해성 필름
US20040247624A1 (en) 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20060188573A1 (en) 2003-06-10 2006-08-24 Anna Imberg Composite materials and particles
US20050249697A1 (en) 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
EP1693075B1 (en) 2003-11-21 2012-10-03 Teijin Limited Substrate for tissue regeneration
JP2007520481A (ja) * 2004-01-15 2007-07-26 アルザ・コーポレーシヨン 治療薬を送達するためのリポソーム組成物
US20050181928A1 (en) * 2004-02-12 2005-08-18 Hayward Peter J. Reaction-bonded porous magnesia body
US8277831B2 (en) 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
US7744644B2 (en) 2004-03-19 2010-06-29 Boston Scientific Scimed, Inc. Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
PL1768650T3 (pl) 2004-06-04 2009-01-30 Camurus Ab Ciekłe formulacje depot
JP2008502690A (ja) 2004-06-15 2008-01-31 アンドリュー シァン チェン， リン脂質組成物ならびにその調製方法および使用方法
CA2574958A1 (en) 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
WO2006116565A2 (en) * 2005-04-25 2006-11-02 Amgen Inc. Biodegradable peptide sustained release compositions containing porogens
GB2430929A (en) * 2005-10-04 2007-04-11 Acco Uk Ltd Apparatus for dividing a bundle of sheet material from a larger bundle
US20070141134A1 (en) 2005-12-16 2007-06-21 Kosak Matthew K Shielded micelles for polynucleotide delivery
US20090318355A1 (en) 2006-02-15 2009-12-24 Chen Thomas T Compositions and methods for promoting tissue repair and wound healing
WO2008105773A2 (en) 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
US8703167B2 (en) 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
US20080181928A1 (en) * 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
KR101612901B1 (ko) 2007-03-02 2016-04-15 테이카 세이야쿠 가부시키가이샤 경피흡수 의약조성물, 의약조성물 저장유닛 및 이것을 이용하는 경피흡수제제
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
WO2009006311A2 (en) 2007-06-29 2009-01-08 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
US20090110713A1 (en) 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
CN101970687A (zh) 2007-11-09 2011-02-09 东北大学 用于体内基因输送的自组装胶束样纳米颗粒
WO2009110939A2 (en) 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation
US8128983B2 (en) * 2008-04-11 2012-03-06 Abbott Cardiovascular Systems Inc. Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network
EP2279254B1 (en) 2008-04-15 2017-07-05 Protiva Biotherapeutics Inc. Novel lipid formulations for nucleic acid delivery
BRPI0910198A2 (pt) * 2008-06-30 2016-01-12 Silenseed Ltd composição para administração a partir de um sítio local de um agente baseado em nucleotídeos e método para tratar um sujeito sofrendo de uma doença requerendo tratamento local com um agente baseado em nucleotídeo.
EP2299953B1 (en) 2008-07-14 2017-04-12 Polypid Ltd. Sustained-release drug carrier composition
WO2010078517A2 (en) 2008-12-31 2010-07-08 Sirnaomics, Inc. Compositions and methods using sirna molecules and sirna cocktails for the treatment of breast cancer
CA2762095A1 (en) 2009-05-16 2010-11-25 Kunyuan Cui Compositions comprising cationic amphiphiles and colipids for delivering therapeutic molecules
CN102470105B (zh) 2009-07-14 2015-07-29 波利皮得有限公司 持续释放药物载体组合物

Also Published As

Publication number Publication date
EP2525778A2 (en) 2012-11-28
JP2013517265A (ja) 2013-05-16
WO2011089595A3 (en) 2011-10-20
EP2525778A4 (en) 2013-07-03
US20120294944A1 (en) 2012-11-22
CA2783001C (en) 2017-12-12
AU2011208374A1 (en) 2012-06-21
EP2525778B1 (en) 2018-08-01
US20140335165A1 (en) 2014-11-13
US9616032B2 (en) 2017-04-11
CN102892406B (zh) 2015-04-08
US8795726B2 (en) 2014-08-05
AU2011208374B2 (en) 2016-09-08
CA2783001A1 (en) 2011-07-28
WO2011089595A2 (en) 2011-07-28
CN102892406A (zh) 2013-01-23

Similar Documents

Publication Publication Date Title
US9616032B2 (en) Sustained-release nucleic acid matrix compositions
JP7256824B2 (ja) 粒子状製剤用の凍結保護剤
CN120129532A (zh) 稳定的脂质或类脂质纳米颗粒悬浮液
US20100297242A1 (en) Ldl-like cationic nanoparticles for deliverying nucleic acid gene, method for preparing thereof and method for deliverying nucleic acid gene using the same
JP5571308B2 (ja) 両性リポソームにおけるまたはそれに関する改善
TW202329986A (zh) 脂質化合物及脂質奈米顆粒組合物
US20220259597A1 (en) Oligonucleotide antagonists for rna guided genome editing
JP2008520600A (ja) 局所投与のための医薬組成物におけるまたはそれに関する改善
US20260069541A1 (en) Compositions and methods for the delivery of active agents including nucleic acids
WO2024167924A2 (en) Multi-functional lipid nanoparticles and uses thereof
RU2820713C2 (ru) Криопротективные агенты для содержащих частицы составов
Nally Nanodelivery of MicroRNA Based Therapeutics to Macrophages
CA2753703A1 (en) Nucleic acid complex and nucleic acid-delivering composition
WO2025061842A1 (en) Gene editing tgm1 mutations for treating autosomal recessive congenital ichthyosis (arci)
WO2026006618A1 (en) Lipid nanoparticle spherical nucleic acids for genome engineering
KR20250092049A (ko) mRNA/LNP 백신의 면역원성 향상용 지질
CN121729225A (zh) 具有增强药物应用的特定表面活性剂性质的稳定脂质和类脂质纳米颗粒制剂
WO2025171319A1 (en) Photoreactive compositions and methods for producing circular polyribonucleotides
KR20240118489A (ko) 단일 용기를 이용하는 유기 용매를 사용하지 않는 열순환기법에 의한 핵산 전달용 지질나노입자의 제조방법
JP2006158314A (ja) 化合物の細胞内導入用キャリア剤およびそれを用いた化合物の細胞内導入方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140116

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140116

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140117

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150401

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150825

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151124

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20151215

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20151218

R150 Certificate of patent or registration of utility model

Ref document number: 5860409

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250