JP5855098B2 - 癌の処置のための三環式ラクトン類 - Google Patents

癌の処置のための三環式ラクトン類 Download PDF

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JP5855098B2
JP5855098B2 JP2013520108A JP2013520108A JP5855098B2 JP 5855098 B2 JP5855098 B2 JP 5855098B2 JP 2013520108 A JP2013520108 A JP 2013520108A JP 2013520108 A JP2013520108 A JP 2013520108A JP 5855098 B2 JP5855098 B2 JP 5855098B2
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alkyl
alkylene
5alkyl
formula
compound
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JP2013531051A (ja
JP2013531051A5 (enExample
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リタ ギドレーフ
リタ ギドレーフ
マルティン ヨハンソン
マルティン ヨハンソン
オロフ ステルナー
オロフ ステルナー
エドゥアルド ムニョース
エドゥアルド ムニョース
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グラクトーン ファーマ デヴェロップメント アーベー
グラクトーン ファーマ デヴェロップメント アーベー
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    • C07ORGANIC CHEMISTRY
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    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
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    • A61K31/365Lactones
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JP2013520108A 2010-07-19 2011-07-18 癌の処置のための三環式ラクトン類 Expired - Fee Related JP5855098B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1050815-8 2010-07-19
SE1050815 2010-07-19
PCT/EP2011/062243 WO2012010555A1 (en) 2010-07-19 2011-07-18 Tricyclic lactones for treatment of cancer

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JP2013531051A JP2013531051A (ja) 2013-08-01
JP2013531051A5 JP2013531051A5 (enExample) 2014-09-04
JP5855098B2 true JP5855098B2 (ja) 2016-02-09

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JP2013520108A Expired - Fee Related JP5855098B2 (ja) 2010-07-19 2011-07-18 癌の処置のための三環式ラクトン類

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US (1) US9150531B2 (enExample)
EP (1) EP2595972B1 (enExample)
JP (1) JP5855098B2 (enExample)
CN (1) CN103097368B (enExample)
ES (1) ES2553248T3 (enExample)
WO (1) WO2012010555A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2925728A4 (en) * 2012-11-27 2016-11-02 Glaxosmithkline Llc COMBINATION
EP3114114B1 (en) * 2014-03-07 2018-10-10 Glactone Pharma Development AB Tricyclic prodrugs
JP2016193870A (ja) * 2015-04-01 2016-11-17 国立大学法人広島大学 慢性骨髄性白血病治療剤
SE539204C2 (en) 2015-06-05 2017-05-09 Glactone Pharma Dev Ab Ether analogues of galiellalactone
SE540295C2 (en) 2016-12-05 2018-05-29 Glactone Pharma Dev Ab Sulfonamide analogues of galiellalactone
CN111297898B (zh) * 2020-02-18 2022-01-25 山东大学齐鲁医院 间充质干细胞来源的细胞外囊泡在脑缺血再灌注损伤中的应用
CN114507203B (zh) * 2020-11-17 2025-09-30 华东理工大学 具有抗炎和抗癌活性的倍半萜内酯衍生物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002109A1 (de) 2000-07-03 2002-01-10 Institut Für Biotechnologie Und Wirkstoff-Forschung E.V. Verwendung von galiella-lacton
WO2008135419A2 (en) 2007-05-04 2008-11-13 Charité Universitätsmedizin Berlin Anti-il-6-agents for improving primary functioning of allogenic grafts

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ES2553248T3 (es) 2015-12-07
JP2013531051A (ja) 2013-08-01
EP2595972A1 (en) 2013-05-29
EP2595972B1 (en) 2015-08-19
US20130310451A1 (en) 2013-11-21
WO2012010555A1 (en) 2012-01-26
US9150531B2 (en) 2015-10-06
CN103097368B (zh) 2015-08-05
CN103097368A (zh) 2013-05-08

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