JP5851500B2 - マイクロ流体分析システムで使用するためのチップ・アッセンブリ - Google Patents
マイクロ流体分析システムで使用するためのチップ・アッセンブリ Download PDFInfo
- Publication number
- JP5851500B2 JP5851500B2 JP2013517374A JP2013517374A JP5851500B2 JP 5851500 B2 JP5851500 B2 JP 5851500B2 JP 2013517374 A JP2013517374 A JP 2013517374A JP 2013517374 A JP2013517374 A JP 2013517374A JP 5851500 B2 JP5851500 B2 JP 5851500B2
- Authority
- JP
- Japan
- Prior art keywords
- chip
- carrier structure
- wall
- carrier
- aperture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
- B32B37/12—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by using adhesives
- B32B37/1284—Application of adhesive
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J5/00—Adhesive processes in general; Adhesive processes not provided for elsewhere, e.g. relating to primers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36292610P | 2010-07-09 | 2010-07-09 | |
| US61/362,926 | 2010-07-09 | ||
| EP11157598 | 2011-03-10 | ||
| EP11157598.1 | 2011-03-10 | ||
| PCT/EP2011/061390 WO2012004297A1 (en) | 2010-07-09 | 2011-07-06 | A chip assembly for use in a microfluidic analysis system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536407A JP2013536407A (ja) | 2013-09-19 |
| JP2013536407A5 JP2013536407A5 (enExample) | 2014-08-21 |
| JP5851500B2 true JP5851500B2 (ja) | 2016-02-03 |
Family
ID=43983374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013517374A Active JP5851500B2 (ja) | 2010-07-09 | 2011-07-06 | マイクロ流体分析システムで使用するためのチップ・アッセンブリ |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20130136673A1 (enExample) |
| EP (1) | EP2590743B1 (enExample) |
| JP (1) | JP5851500B2 (enExample) |
| CN (1) | CN103068486B (enExample) |
| CA (1) | CA2804564A1 (enExample) |
| DK (1) | DK2590743T3 (enExample) |
| WO (2) | WO2012004297A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2681550T3 (en) | 2011-03-01 | 2016-09-12 | Sophion Bioscience As | Hand-held device for electrophysiological analysis |
| CA2860501C (en) | 2012-01-09 | 2021-05-18 | Sophion Bioscience A/S | Improved patch area cell adhesion |
| DE102012112306A1 (de) | 2012-12-14 | 2014-06-18 | Thinxxs Microtechnology Ag | Verfahren zur Verbindung von Komponenten einer mikrofluidischen Flusszelle |
| CN104122226B (zh) * | 2013-04-25 | 2016-06-01 | 黄辉 | 一种光学微流控生物传感器的封装方法 |
| KR102447394B1 (ko) * | 2015-12-03 | 2022-09-27 | 프리시젼바이오 주식회사 | 유체분석 카트리지 및 이를 포함하는 유체분석장치 |
| CN106391151B (zh) * | 2016-08-31 | 2018-11-09 | 清华大学 | 适合于批量化生产的多层微流体芯片制作方法 |
| CN107199060B (zh) * | 2017-05-17 | 2019-07-26 | 清华大学深圳研究生院 | 一种用于固相微萃取的三维电聚焦微流控芯片及其制作方法 |
| CN109097264B (zh) * | 2018-07-31 | 2021-10-15 | 大连理工大学 | 一种用于细胞膜片钳的微流控细胞吸附芯片 |
| CN109647557B (zh) * | 2019-02-27 | 2021-04-02 | 哈尔滨工业大学 | 基于诱导电荷电渗微旋涡的直接颗粒分离芯片及其应用和分离方法 |
| CN110482483B (zh) * | 2019-08-07 | 2022-05-20 | 北京自动化控制设备研究所 | 用于mems器件的敏感结构贴片系统及方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68507A (en) * | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
| US6758961B1 (en) | 1997-12-17 | 2004-07-06 | Ecole Polytechnique Federale De Lausanne | Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers |
| CA2385482C (en) * | 1999-10-01 | 2011-01-18 | Jon Wulff Petersen | A substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
| US7175980B2 (en) * | 2000-10-30 | 2007-02-13 | Sru Biosystems, Inc. | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities |
| CN1369709A (zh) * | 2001-02-12 | 2002-09-18 | 阎小君 | 组合式生物芯片及其制造方法 |
| DK1495105T3 (da) | 2002-04-17 | 2007-06-04 | Sophion Bioscience As | Substrat og fremgangsmåde til måling af elektrofysiologiske egenskaber for cellemenbraner |
| GB2398635A (en) | 2003-02-21 | 2004-08-25 | Sophion Bioscience As | A substrate providing a cell gigaseal for a patch clamp |
| AU2003231300A1 (en) * | 2002-05-04 | 2003-11-17 | Aviva Biosciences Corporation | Apparatus including ion transport detecting structures and methods of use |
| JP4552423B2 (ja) * | 2003-11-21 | 2010-09-29 | パナソニック株式会社 | 細胞外電位測定デバイスおよびこれを用いた細胞外電位の測定方法 |
| DE10345817A1 (de) * | 2003-09-30 | 2005-05-25 | Boehringer Ingelheim Microparts Gmbh | Verfahren und Vorrichtung zum Koppeln von Hohlfasern an ein mikrofluidisches Netzwerk |
| US20080205017A1 (en) * | 2005-07-25 | 2008-08-28 | Koninklijke Philips Electronics, N.V. | Interconnection and Packaging Method for Biomedical Devices with Electronic and Fluid Functions |
| JP4661539B2 (ja) * | 2005-11-11 | 2011-03-30 | パナソニック株式会社 | 細胞電気生理センサおよびその製造方法 |
| KR100705642B1 (ko) * | 2005-12-29 | 2007-04-09 | 삼성전자주식회사 | 잉크젯 프린터 헤드의 노즐 및 그 제작 방법 |
| CN101588868B (zh) * | 2007-01-17 | 2012-01-04 | 安捷伦科技有限公司 | 具有用于流体引入的侧面开口的微流体芯片 |
| CN201066356Y (zh) * | 2007-07-06 | 2008-05-28 | 徐涵 | 植物混合微阵列生物芯片 |
| CN201066365Y (zh) | 2007-08-14 | 2008-05-28 | 周兆强 | 一种电能计量装置接线盒 |
| WO2009081521A1 (ja) * | 2007-12-20 | 2009-07-02 | Panasonic Corporation | 細胞電気生理センサの製造方法およびその製造装置 |
| JP4973618B2 (ja) * | 2007-12-20 | 2012-07-11 | パナソニック株式会社 | 細胞電気生理センサの製造方法および製造装置 |
| US8835247B2 (en) * | 2008-05-13 | 2014-09-16 | Nxp, B.V. | Sensor array and a method of manufacturing the same |
| JP2010043928A (ja) * | 2008-08-12 | 2010-02-25 | Seiko Epson Corp | バイオチップの製造方法およびバイオチップ |
| JP2010101819A (ja) * | 2008-10-27 | 2010-05-06 | Panasonic Corp | 細胞電気生理センサ |
-
2011
- 2011-07-06 CN CN201180040062.XA patent/CN103068486B/zh not_active Expired - Fee Related
- 2011-07-06 WO PCT/EP2011/061390 patent/WO2012004297A1/en not_active Ceased
- 2011-07-06 JP JP2013517374A patent/JP5851500B2/ja active Active
- 2011-07-06 DK DK11731321.3T patent/DK2590743T3/en active
- 2011-07-06 CA CA2804564A patent/CA2804564A1/en not_active Abandoned
- 2011-07-06 EP EP11731321.3A patent/EP2590743B1/en active Active
- 2011-07-06 WO PCT/EP2011/061388 patent/WO2012004296A1/en not_active Ceased
- 2011-07-06 US US13/809,097 patent/US20130136673A1/en not_active Abandoned
-
2016
- 2016-07-25 US US15/218,642 patent/US9975120B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012004296A1 (en) | 2012-01-12 |
| DK2590743T3 (en) | 2016-09-12 |
| EP2590743B1 (en) | 2016-06-29 |
| US20160332160A1 (en) | 2016-11-17 |
| CN103068486A (zh) | 2013-04-24 |
| CA2804564A1 (en) | 2012-01-12 |
| EP2590743A1 (en) | 2013-05-15 |
| US9975120B2 (en) | 2018-05-22 |
| JP2013536407A (ja) | 2013-09-19 |
| CN103068486B (zh) | 2015-09-23 |
| US20130136673A1 (en) | 2013-05-30 |
| WO2012004297A1 (en) | 2012-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5851500B2 (ja) | マイクロ流体分析システムで使用するためのチップ・アッセンブリ | |
| CN100520407C (zh) | 电生理测量系统 | |
| US8354271B2 (en) | Biosensor | |
| JP6782296B2 (ja) | 血漿分離マイクロ流体デバイス | |
| CN101501485B (zh) | 通过毛细管电泳法分析试样的方法 | |
| DK2394156T3 (en) | Device and method for electrochemical measurement of biochemical reactions as well as method of preparation for the device. | |
| AU2017237981A1 (en) | Wafer-scale assembly of insulator-membrane-insulator devices for nanopore sensing | |
| CN108120755B (zh) | 检测装置及其应用 | |
| US9201058B2 (en) | Apparatus and method for sensing a time varying ionic current in an electrolytic system | |
| CN102539485B (zh) | 细胞迁移高分辨率阻抗实时跟踪测控装置及其制造方法和应用方法 | |
| CN205700594U (zh) | 一种用于粘度测试的微流控芯片 | |
| CN105932151A (zh) | 用于粘度测试的微流控芯片及制作方法 | |
| US20100203621A1 (en) | Biosensor | |
| CN105530988A (zh) | 具有电极的纳米通道形装置和相关方法 | |
| Zhang et al. | Recent advances of nanopore technique in single cell analysis | |
| CN111912766B (zh) | 免疫检测与细胞分析用组合检测卡及联合检测方法 | |
| US20080206828A1 (en) | Device For Introducing Substance Into Cell, Cell Clamping Device and Flow Path Forming Method | |
| JP4821319B2 (ja) | 細胞電気生理センサアレイおよびその製造方法 | |
| JP2008039624A (ja) | 細胞電気生理センサおよびその製造方法 | |
| JPWO2012077325A1 (ja) | シリコン構造体およびこれを用いたアレイ基板およびシリコン構造体の製造方法 | |
| JP2008000079A (ja) | 細胞電気生理センサ | |
| JP2007218716A (ja) | 細胞電気生理センサ | |
| JP4597710B2 (ja) | 微少質量検出チップ | |
| JP2011205995A (ja) | 電気生理測定デバイス | |
| JP4682884B2 (ja) | 細胞電気生理センサおよびこれを用いた細胞電気生理現象の測定方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140704 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140704 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20150320 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150407 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150702 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151006 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20151110 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20151202 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5851500 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |