JP5850932B2 - 吸入器 - Google Patents
吸入器 Download PDFInfo
- Publication number
- JP5850932B2 JP5850932B2 JP2013520211A JP2013520211A JP5850932B2 JP 5850932 B2 JP5850932 B2 JP 5850932B2 JP 2013520211 A JP2013520211 A JP 2013520211A JP 2013520211 A JP2013520211 A JP 2013520211A JP 5850932 B2 JP5850932 B2 JP 5850932B2
- Authority
- JP
- Japan
- Prior art keywords
- mouthpiece
- inhaler
- disk
- housing
- type assembly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000003814 drug Substances 0.000 claims description 60
- 229940079593 drug Drugs 0.000 claims description 42
- -1 4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl Chemical group 0.000 claims description 34
- 230000007246 mechanism Effects 0.000 claims description 28
- 230000033001 locomotion Effects 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 15
- 230000002093 peripheral effect Effects 0.000 claims description 11
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- QZZUEBNBZAPZLX-QFIPXVFZSA-N indacaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-QFIPXVFZSA-N 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
- 229960004436 budesonide Drugs 0.000 claims description 5
- 229960004078 indacaterol Drugs 0.000 claims description 5
- GHQXRNRNBBBEQN-UHFFFAOYSA-N n-cyclohexyl-3-[2-(3-fluorophenyl)ethylamino]-n-[2-[2-(4-hydroxy-2-oxo-3h-1,3-benzothiazol-7-yl)ethylamino]ethyl]propanamide Chemical compound C1=2SC(=O)NC=2C(O)=CC=C1CCNCCN(C(=O)CCNCCC=1C=C(F)C=CC=1)C1CCCCC1 GHQXRNRNBBBEQN-UHFFFAOYSA-N 0.000 claims description 5
- STTGOFBGRUQUOE-NDEPHWFRSA-N 2-[(4-chlorophenyl)methoxy]ethyl-[[2-[(r)-cyclohexyl-hydroxy-phenylmethyl]-1,3-oxazol-5-yl]methyl]-dimethylazanium Chemical class C=1N=C([C@@](O)(C2CCCCC2)C=2C=CC=CC=2)OC=1C[N+](C)(C)CCOCC1=CC=C(Cl)C=C1 STTGOFBGRUQUOE-NDEPHWFRSA-N 0.000 claims description 4
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 4
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- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 3
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 3
- 229950000210 beclometasone dipropionate Drugs 0.000 claims description 3
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- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 3
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- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 claims description 2
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- WOVFJBGKJQEQQD-UHFFFAOYSA-N acridine;hydrobromide Chemical compound [Br-].C1=CC=CC2=CC3=CC=CC=C3[NH+]=C21 WOVFJBGKJQEQQD-UHFFFAOYSA-N 0.000 claims description 2
- 229960001117 clenbuterol Drugs 0.000 claims description 2
- STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 claims description 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 2
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- 229960001361 ipratropium bromide Drugs 0.000 claims description 2
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 claims description 2
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- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims description 2
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 claims description 2
- 229960004398 nedocromil Drugs 0.000 claims description 2
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims description 2
- 229960002720 reproterol Drugs 0.000 claims description 2
- WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 claims description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 2
- IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 claims description 2
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- 239000011734 sodium Substances 0.000 claims description 2
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- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229960005105 terbutaline sulfate Drugs 0.000 claims description 2
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 claims description 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims description 2
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Natural products CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 2
- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 claims 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 claims 1
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| EP3653207A1 (en) | 2014-02-10 | 2020-05-20 | Respivant Sciences GmbH | Mast cell stabilizers treatment for systemic disorders |
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| US10238625B2 (en) | 2015-08-07 | 2019-03-26 | Respivant Sciences Gmbh | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
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| JP4104672B2 (ja) * | 1997-05-23 | 2008-06-18 | ピィ・エイ・ノレッジ・リミテッド | 吸入器機構 |
| US6810872B1 (en) | 1999-12-10 | 2004-11-02 | Unisia Jecs Corporation | Inhalant medicator |
| US6427688B1 (en) * | 2000-02-01 | 2002-08-06 | Dura Pharmaceuticals, Icn. | Dry powder inhaler |
| SE0104251D0 (sv) | 2001-12-14 | 2001-12-14 | Astrazeneca Ab | Novel compounds |
| GB0315509D0 (en) * | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
| GB2407042B (en) * | 2003-10-17 | 2007-10-24 | Vectura Ltd | Inhaler |
| US7451761B2 (en) * | 2003-10-27 | 2008-11-18 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances |
| US7605168B2 (en) | 2004-09-03 | 2009-10-20 | Plexxikon, Inc. | PDE4B inhibitors |
| KR20090030347A (ko) | 2006-07-19 | 2009-03-24 | 아스트라제네카 아베 | 신규 트리시클릭 스피로피페리딘 화합물, 이들의 합성 및 이들의 케모킨 수용체 활성의 조절제로서의 용도 |
| GB0704928D0 (en) * | 2007-03-14 | 2007-04-25 | Cambridge Consultants | Dry powder inhalers |
| JP5528336B2 (ja) * | 2007-07-06 | 2014-06-25 | マンタ デバイシス，エルエルシー | デリバリー装置及び関連方法 |
| JP2011507593A (ja) | 2007-12-20 | 2011-03-10 | アストラゼネカ・アクチエボラーグ | 粉末８５４を脱凝集解体する装置ならびに方法 |
| JP5632848B2 (ja) * | 2008-10-08 | 2014-11-26 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | カバーの動作にリンクしてインデックス動作を行う吸入器 |
| NZ597009A (en) | 2009-07-01 | 2014-05-30 | Astrazeneca Ab | Dispenser and method for entraining powder in an airflow |
| WO2011116293A2 (en) * | 2010-03-19 | 2011-09-22 | Manta Devices, Llc | Delivery device and related methods |
-
2011
- 2011-07-19 MX MX2013000518A patent/MX2013000518A/es not_active Application Discontinuation
- 2011-07-19 IN IN222MUN2013 patent/IN2013MN00222A/en unknown
- 2011-07-19 KR KR1020137001438A patent/KR20130090877A/ko not_active Withdrawn
- 2011-07-19 JP JP2013520211A patent/JP5850932B2/ja not_active Expired - Fee Related
- 2011-07-19 ES ES11735691.5T patent/ES2535979T3/es active Active
- 2011-07-19 BR BR112013001342A patent/BR112013001342A2/pt not_active IP Right Cessation
- 2011-07-19 CN CN201180045541.0A patent/CN103118726B/zh not_active Expired - Fee Related
- 2011-07-19 EP EP11735691.5A patent/EP2595683B1/en not_active Not-in-force
- 2011-07-19 AU AU2011281317A patent/AU2011281317B2/en not_active Ceased
- 2011-07-19 CA CA2805953A patent/CA2805953A1/en not_active Abandoned
- 2011-07-19 RU RU2013104024/14A patent/RU2013104024A/ru not_active Application Discontinuation
- 2011-07-19 US US13/811,100 patent/US20140083422A1/en not_active Abandoned
- 2011-07-19 NZ NZ605149A patent/NZ605149A/en not_active IP Right Cessation
- 2011-07-19 WO PCT/GB2011/051349 patent/WO2012010877A2/en not_active Ceased
- 2011-07-21 AR ARP110102639A patent/AR082309A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130090877A (ko) | 2013-08-14 |
| CN103118726A (zh) | 2013-05-22 |
| JP2013532504A (ja) | 2013-08-19 |
| BR112013001342A2 (pt) | 2016-05-17 |
| CN103118726B (zh) | 2015-07-22 |
| WO2012010877A3 (en) | 2012-03-29 |
| HK1185295A1 (en) | 2014-02-14 |
| MX2013000518A (es) | 2013-02-27 |
| AR082309A1 (es) | 2012-11-28 |
| NZ605149A (en) | 2014-08-29 |
| EP2595683A2 (en) | 2013-05-29 |
| WO2012010877A2 (en) | 2012-01-26 |
| AU2011281317B2 (en) | 2013-09-12 |
| CA2805953A1 (en) | 2012-01-26 |
| AU2011281317A1 (en) | 2013-01-24 |
| US20140083422A1 (en) | 2014-03-27 |
| EP2595683B1 (en) | 2015-03-04 |
| RU2013104024A (ru) | 2014-08-27 |
| IN2013MN00222A (cg-RX-API-DMAC7.html) | 2015-05-29 |
| ES2535979T3 (es) | 2015-05-19 |
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