JP5847085B2 - チアゾリジンジオンエネルギー制限模倣剤 - Google Patents

チアゾリジンジオンエネルギー制限模倣剤 Download PDF

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Publication number
JP5847085B2
JP5847085B2 JP2012533376A JP2012533376A JP5847085B2 JP 5847085 B2 JP5847085 B2 JP 5847085B2 JP 2012533376 A JP2012533376 A JP 2012533376A JP 2012533376 A JP2012533376 A JP 2012533376A JP 5847085 B2 JP5847085 B2 JP 5847085B2
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Prior art keywords
thiazolidine
dione
benzylidene
trifluoromethyl
ampk
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Japanese (ja)
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JP2013507397A5 (enExample
JP2013507397A (ja
Inventor
チン−シー チェン,
チン−シー チェン,
ジー−ファ グー,
ジー−ファ グー,
Original Assignee
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2012533376A 2009-10-09 2010-10-11 チアゾリジンジオンエネルギー制限模倣剤 Expired - Fee Related JP5847085B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25004509P 2009-10-09 2009-10-09
US61/250,045 2009-10-09
US30488110P 2010-02-16 2010-02-16
US61/304,881 2010-02-16
PCT/US2010/052151 WO2011044548A1 (en) 2009-10-09 2010-10-11 Thiazolidinedione energy restriction-mimetic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015036155A Division JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

Publications (3)

Publication Number Publication Date
JP2013507397A JP2013507397A (ja) 2013-03-04
JP2013507397A5 JP2013507397A5 (enExample) 2013-11-14
JP5847085B2 true JP5847085B2 (ja) 2016-01-20

Family

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Family Applications (2)

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JP2012533376A Expired - Fee Related JP5847085B2 (ja) 2009-10-09 2010-10-11 チアゾリジンジオンエネルギー制限模倣剤
JP2015036155A Withdrawn JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

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JP2015036155A Withdrawn JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

Country Status (6)

Country Link
US (1) US8383656B2 (enExample)
EP (1) EP2488027A4 (enExample)
JP (2) JP5847085B2 (enExample)
CN (1) CN102638980A (enExample)
CA (1) CA2777406A1 (enExample)
WO (1) WO2011044548A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012153775A1 (ja) * 2011-05-10 2012-11-15 国立大学法人神戸大学 Ras機能阻害作用を有するチオキソチアゾリジン誘導体
WO2013148994A1 (en) * 2012-03-28 2013-10-03 The Ohio State University Research Foundation Glucose transporter inhibitors
CA2898732A1 (en) * 2013-01-18 2014-07-24 Mao CHENGJIAN Estrogen receptor inhibitors
CN105315223B (zh) * 2015-11-06 2017-08-25 河南大学 一种高立体和高对映选择性噻唑烷二酮类化合物、其制备方法及应用
CN111675673B (zh) * 2020-06-22 2022-06-24 郑州大学 3,4-二羟基肉桂酸酯类衍生物及其制备方法和应用
US12150935B1 (en) 2024-04-16 2024-11-26 Imam Mohammad Ibn Saud Islamic University 3-(3-(1,3-dioxoisoindolin-2-yl) propyl)-5-(4-fluorobenzylidene) thiazolidine-2,4-dione as a potential antitumor and apoptotic inducer

Family Cites Families (27)

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GB1003083A (en) 1961-01-21 1965-09-02 Toshiyasu Kasai Novel 4-alkoxynaphthalimides
GB962019A (en) 1961-04-12 1964-06-24 Mitsubishi Chem Ind Naphthalimide optical whitening agents
JPS4957048A (enExample) 1972-10-04 1974-06-03
JPS5697277A (en) 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
JPH07116352B2 (ja) 1986-10-07 1995-12-13 三菱化学株式会社 熱可塑性ポリエステル樹脂組成物
JPS6424852A (en) 1987-07-21 1989-01-26 Mitsubishi Chem Ind Polyamide resin composition
US4965302A (en) 1988-03-29 1990-10-23 Mitsubishi Kasei Corporation Thermoplastic polyester resin composition and molded articles produced therefrom
JP2792111B2 (ja) 1989-06-16 1998-08-27 三菱化学株式会社 ポリエステル樹脂成形体の製造方法
EP0454501B1 (en) 1990-04-27 2001-09-05 Sankyo Company Limited Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides
JP3020353B2 (ja) 1992-07-21 2000-03-15 ポーラ化成工業株式会社 化粧料
US6046222A (en) 1993-09-15 2000-04-04 Warner-Lambert Company Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
JPH07247978A (ja) 1994-03-14 1995-09-26 Hitachi Ltd 冷媒ポンプ
ES2225833T3 (es) 1994-05-12 2005-03-16 Ciba Specialty Chemicals Holding Inc. Tratamiento textil.
GB9409466D0 (en) 1994-05-12 1994-06-29 Ciba Geigy Ag Textile treatment
US5801173A (en) 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
JP2817708B2 (ja) 1996-05-29 1998-10-30 日本電気株式会社 有機非線形光学材料及び有機非線形光学素子
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6515003B1 (en) 1999-08-31 2003-02-04 Maxia Pharmaceuticals, Inc. Heterocyclic derivatives for the treatment of diabetes and other diseases
DE10353328A1 (de) 2003-11-14 2005-06-16 Basf Ag Verwendung von Naphthalin-1,8-dicarbonsäuremonoimiden
EP1781271A1 (en) * 2004-07-14 2007-05-09 Janssen Pharmaceutica N.V. Arylidenes for the treatment of estrogen related receptor-alpha mediated diseases
US7714005B2 (en) * 2004-12-22 2010-05-11 The Ohio State University Research Foundation Small molecule Bcl-xL/Bcl-2 binding inhibitors
US7566787B2 (en) 2004-12-22 2009-07-28 The Ohio State University Small molecule cyclin D1 ablative agents
US7608715B2 (en) 2005-11-21 2009-10-27 Sabic Innovative Plastics Ip B.V. Fluorescent brighteners, methods of preparation thereof, fluorescent brightener compositions, and methods of preparation and uses thereof
CL2008000670A1 (es) * 2007-03-07 2008-11-03 Janssen Pharmaceutica Nv Compuestos derivados de tiazolidindionas y oxazolidindionas sustituidas; composicion farmaceutica; proceso de preparacion de la composicion farmaceutica; y uso en el tratamiento de enfermedades tales como artritis reumatoide, epoc, cancer, entre otras.
GB0715284D0 (en) * 2007-08-06 2007-09-12 Medical Res Council Crystal structure of ampk and uses thereof
EP2217235A4 (en) * 2007-11-15 2011-01-12 Musc Found For Res Dev INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
US7973062B2 (en) * 2008-02-22 2011-07-05 The Ohio State University Research Foundation Androgen receptor-ablative agents

Also Published As

Publication number Publication date
US20110086895A1 (en) 2011-04-14
CA2777406A1 (en) 2011-04-14
EP2488027A4 (en) 2013-04-17
WO2011044548A1 (en) 2011-04-14
CN102638980A (zh) 2012-08-15
JP2015098492A (ja) 2015-05-28
EP2488027A1 (en) 2012-08-22
US8383656B2 (en) 2013-02-26
JP2013507397A (ja) 2013-03-04

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