JP5836940B2 - ソリシジン由来ペプチドならびにtrpv−6がんの検出および薬剤送達のための方法 - Google Patents

ソリシジン由来ペプチドならびにtrpv−6がんの検出および薬剤送達のための方法 Download PDF

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JP5836940B2
JP5836940B2 JP2012516450A JP2012516450A JP5836940B2 JP 5836940 B2 JP5836940 B2 JP 5836940B2 JP 2012516450 A JP2012516450 A JP 2012516450A JP 2012516450 A JP2012516450 A JP 2012516450A JP 5836940 B2 JP5836940 B2 JP 5836940B2
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trpv6
cancer
binding peptide
sample
tumor
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ジョン・エム・スチュワート
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ソリシメド・バイオファーマ・インコーポレーテッド
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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JP2012516450A 2009-06-26 2010-06-28 ソリシジン由来ペプチドならびにtrpv−6がんの検出および薬剤送達のための方法 Active JP5836940B2 (ja)

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Application Number Priority Date Filing Date Title
US22083309P 2009-06-26 2009-06-26
US61/220,833 2009-06-26
US24463409P 2009-09-22 2009-09-22
US61/244,634 2009-09-22
PCT/CA2010/000971 WO2010148501A1 (en) 2009-06-26 2010-06-28 Soricidin derived peptides and methods for the detection of trpv-6 cancers and drug delivery

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JP2012530725A JP2012530725A (ja) 2012-12-06
JP2012530725A5 JP2012530725A5 (https=) 2013-08-15
JP5836940B2 true JP5836940B2 (ja) 2015-12-24

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US (4) US20100329983A1 (https=)
EP (1) EP2445932B1 (https=)
JP (1) JP5836940B2 (https=)
BR (1) BRPI1012675A2 (https=)
CA (1) CA2766272C (https=)
ES (1) ES2670588T3 (https=)
MX (1) MX2012000086A (https=)
WO (1) WO2010148501A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5836940B2 (ja) 2009-06-26 2015-12-24 ソリシメド・バイオファーマ・インコーポレーテッド ソリシジン由来ペプチドならびにtrpv−6がんの検出および薬剤送達のための方法
US20130116404A1 (en) * 2011-11-08 2013-05-09 Case Western Reserve University Targeted non-invasive imaging probes of egfr expressing cells
CA2924224C (en) 2012-09-14 2023-03-21 John M. Stewart Trpv3 agonists for the treatment of skin conditions
WO2019183633A1 (en) 2018-03-23 2019-09-26 Case Western Reserve Univeristy Psma targeted conjugate compounds and uses thereof
CN111484982A (zh) * 2020-05-14 2020-08-04 西南民族大学 一种人结直肠腺癌细胞trpv1基因敲除细胞株及应用
JP2024505430A (ja) * 2021-01-15 2024-02-06 コヒレント バイオファーマ (スーチョウ),リミテッド 抗trpv6モノクローナル抗体及びその応用
JP2024538787A (ja) * 2021-10-14 2024-10-23 ユニベルシテ・ドゥ・リール ヒトtrpv6チャネルの細胞外エピトープに対する抗体並びにこれらの診断的及び治療的使用
CA3237590A1 (en) 2021-11-09 2023-05-08 James Basilion Psma targeted conjugate compounds and uses thereof
CN118846104A (zh) * 2024-06-27 2024-10-29 河北工业大学 一种近红外响应纳米复合物及其制备方法和应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7002A (en) * 1850-01-08 Obe-washek
GB2161165A (en) 1984-06-12 1986-01-08 Cambridge Patent Dev Secondary antibodies
DK255887D0 (da) 1987-05-20 1987-05-20 Claus Koch Immunoassay
US5496548A (en) 1987-09-18 1996-03-05 National Blood Authority Human anti-RH(D) monoclonal antibodies, cell lines and methods of use of antibodies in immunoassays
GB8722018D0 (en) 1987-09-18 1987-10-28 Central Blood Lab Authority Human anti-rh(d)monoclonal antibodies
US5688657A (en) 1988-03-31 1997-11-18 International Bio-Immune Systems, Inc. Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
EP0374510B1 (en) 1988-12-19 1997-01-15 American Cyanamid Company Products for the treatment of endotoxic shock in a mammal
EP0463110B1 (en) 1989-03-14 1998-01-07 Board Of Regents Of The University Of Nebraska Monoclonal antibodies for metallic cations
US5500345A (en) 1989-04-25 1996-03-19 Iatron Laboratories, Inc. Hybridomas producing monoclonal antibodies specific for C-reactive protein and methods for detection of C-reactive protein
CA2025266A1 (en) 1989-10-04 1991-04-05 Kiyoshi Kobayashi Anti-hcg-.beta. core monoclonal antibody, its production and use
WO1991014452A1 (en) 1990-03-27 1991-10-03 The Salk Institute For Biological Studies Method for inhibiting cell growth and compositions useful therefor
US5510241A (en) 1990-10-01 1996-04-23 The Minister Of Agriculture, Fisheries And Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britian And Northern Ireland Method of testing for the presence of Salmonella serotypes expressing Salmonella enteritidis fimbrial antigen (SEFA) and reagents therefore
US5225331A (en) 1991-04-25 1993-07-06 National Research Council Of Canada Immunoassay for detecting group b streptococcus
WO1993018784A1 (en) 1992-03-26 1993-09-30 Microcarb, Inc. Monospecific polyclonal antibodies to shiga-like toxins
AU4231393A (en) 1992-05-08 1993-12-13 Genentech Inc. Antibodies to leukemia inhibitory factor
US5424286A (en) * 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US5683693A (en) 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
JPH10236963A (ja) 1997-02-26 1998-09-08 Sagami Chem Res Center カルシウムチャンネル拮抗剤
WO1998051290A2 (en) * 1997-05-16 1998-11-19 Children's Medical Center Corporation Local anesthetic formulations comprising a site 1 sodium channel blocker combined with a second active agent
US6946475B1 (en) * 1999-04-07 2005-09-20 University Of Virginia Patent Foundation Anticancer calcium channel blockers
JP4932994B2 (ja) 1999-04-07 2012-05-16 ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン 抗癌性カルシウムチャンネル遮断薬
US6534642B1 (en) * 1999-07-09 2003-03-18 Matthias A. Hediger Compositions corresponding to a calcium transporter and methods of making and using same
US6348317B1 (en) 1999-11-18 2002-02-19 The Arizona Board Of Regents Fluorescent and DNA cleavage properties of peptide/dye conjugates
US20040001827A1 (en) 2002-06-28 2004-01-01 Dennis Mark S. Serum albumin binding peptides for tumor targeting
US7176037B2 (en) 2000-07-13 2007-02-13 The Scripps Research Institute Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
US7205108B2 (en) 2000-07-28 2007-04-17 Ulrich Wissenbach Trp8, Trp9 and Trp10, novel markers for cancer
ES2350687T3 (es) 2002-07-03 2011-01-26 Ono Pharmaceutical Co., Ltd. Composiciones de inmunopotenciación.
US7119168B2 (en) 2002-11-18 2006-10-10 Bioprospecting Nb Inc. Paralytic peptide for use in neuromuscular therapy
CA2544467C (en) * 2002-11-18 2014-02-18 John M. Stewart Paralytic peptide for use in neuromuscular therapy
RU2494107C2 (ru) 2005-05-09 2013-09-27 Оно Фармасьютикал Ко., Лтд. Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
CN104356236B (zh) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
WO2009114943A1 (en) * 2008-03-19 2009-09-24 Bioprospecting Nb, Inc. Peptide composition for cancer treatment by inhibiting trpv6 calcium channel activity
JP5794917B2 (ja) 2008-09-12 2015-10-14 アイシス・イノベーション・リミテッドIsis Innovationlimited Pd−1特異抗体およびその使用
KR101814408B1 (ko) 2008-09-26 2018-01-04 다나-파버 캔서 인스티튜트 인크. 인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도
JP5245853B2 (ja) 2009-01-19 2013-07-24 セイコーエプソン株式会社 画像形成装置
WO2010089411A2 (en) 2009-02-09 2010-08-12 Universite De La Mediterranee Pd-1 antibodies and pd-l1 antibodies and uses thereof
JP5836940B2 (ja) * 2009-06-26 2015-12-24 ソリシメド・バイオファーマ・インコーポレーテッド ソリシジン由来ペプチドならびにtrpv−6がんの検出および薬剤送達のための方法
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
CN102892786B (zh) 2010-03-11 2016-03-16 Ucb医药有限公司 Pd-1抗体
CA2924224C (en) 2012-09-14 2023-03-21 John M. Stewart Trpv3 agonists for the treatment of skin conditions
EA034666B1 (ru) 2013-09-13 2020-03-04 Бейджин Свитзерланд Гмбх Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
SG10201900002QA (en) 2014-01-24 2019-02-27 Dana Farber Cancer Institue Inc Antibody molecules to pd-1 and uses thereof
CN106572988B (zh) 2014-04-08 2022-04-08 卫理公会医院 Inos抑制性组合物及其作为乳腺癌治疗剂的用途
CN108135881B (zh) 2015-08-11 2020-11-13 同宜医药(苏州)有限公司 多配体药物偶联体及其用途
AU2017246228B2 (en) 2016-04-04 2021-04-15 Chemocentryx, Inc. Soluble C5aR antagonists
JP7038353B2 (ja) 2016-04-13 2022-03-18 ヴィヴィア バイオテック,エス.エル エクスビボのbite活性化t細胞
CA3083950A1 (en) 2017-12-01 2019-06-06 Soricimed Biopharma Inc. Trpv6 inhibitors and combination therapies for treating cancers

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