JP5833824B2 - 吸入器 - Google Patents
吸入器 Download PDFInfo
- Publication number
- JP5833824B2 JP5833824B2 JP2010543498A JP2010543498A JP5833824B2 JP 5833824 B2 JP5833824 B2 JP 5833824B2 JP 2010543498 A JP2010543498 A JP 2010543498A JP 2010543498 A JP2010543498 A JP 2010543498A JP 5833824 B2 JP5833824 B2 JP 5833824B2
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- JP
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- Prior art keywords
- blister
- blister strip
- strip
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- 230000007246 mechanism Effects 0.000 claims description 45
- 239000003814 drug Substances 0.000 claims description 43
- 229940079593 drug Drugs 0.000 claims description 27
- 230000004044 response Effects 0.000 claims description 3
- -1 vitorterol Chemical compound 0.000 description 136
- 150000001875 compounds Chemical class 0.000 description 44
- 239000001257 hydrogen Substances 0.000 description 33
- 229910052739 hydrogen Inorganic materials 0.000 description 33
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 229910052731 fluorine Chemical group 0.000 description 24
- 239000011737 fluorine Chemical group 0.000 description 24
- 239000000546 pharmaceutical excipient Substances 0.000 description 24
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical group [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 23
- 238000000034 method Methods 0.000 description 20
- 150000003839 salts Chemical class 0.000 description 20
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 19
- 239000000203 mixture Substances 0.000 description 18
- 150000002431 hydrogen Chemical class 0.000 description 17
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 16
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 16
- 239000003795 chemical substances by application Substances 0.000 description 15
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 14
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 14
- 229910052736 halogen Chemical group 0.000 description 14
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 13
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- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 10
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 9
- 239000000460 chlorine Substances 0.000 description 9
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- 239000008194 pharmaceutical composition Substances 0.000 description 9
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 8
- 229910004013 NO 2 Inorganic materials 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 150000003431 steroids Chemical class 0.000 description 8
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 8
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- 125000000217 alkyl group Chemical group 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 7
- 239000011888 foil Substances 0.000 description 7
- 150000004677 hydrates Chemical class 0.000 description 7
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 description 6
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 6
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 6
- 229960004436 budesonide Drugs 0.000 description 6
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
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- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 6
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 6
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 5
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
- 229940092705 beclomethasone Drugs 0.000 description 5
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
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- 229960002714 fluticasone Drugs 0.000 description 5
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 5
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- GBTODAKMABNGIJ-UHFFFAOYSA-N 3-[4-[6-[[2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]hexoxy]butyl]benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC(CCCCOCCCCCCNCC(O)C=2C=C(CO)C(O)=CC=2)=C1 GBTODAKMABNGIJ-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
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- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 4
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- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 1
- 229960003688 tropisetron Drugs 0.000 description 1
- UIVFDCIXTSJXBB-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C[C]2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CN=C21 UIVFDCIXTSJXBB-ITGUQSILSA-N 0.000 description 1
- 229960001491 trospium Drugs 0.000 description 1
- OYYDSUSKLWTMMQ-JKHIJQBDSA-N trospium Chemical compound [N+]12([C@@H]3CC[C@H]2C[C@H](C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 OYYDSUSKLWTMMQ-JKHIJQBDSA-N 0.000 description 1
- 239000002750 tryptase inhibitor Substances 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 description 1
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 description 1
- 229960003732 tyramine Drugs 0.000 description 1
- DZGWFCGJZKJUFP-UHFFFAOYSA-O tyraminium Chemical compound [NH3+]CCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-O 0.000 description 1
- 229960001130 urapidil Drugs 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 229960002004 valdecoxib Drugs 0.000 description 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 229960004699 valsartan Drugs 0.000 description 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
- 229960004751 varenicline Drugs 0.000 description 1
- JQSHBVHOMNKWFT-DTORHVGOSA-N varenicline Chemical compound C12=CC3=NC=CN=C3C=C2[C@H]2C[C@@H]1CNC2 JQSHBVHOMNKWFT-DTORHVGOSA-N 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 229950005577 vesnarinone Drugs 0.000 description 1
- PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 description 1
- 229960005318 vigabatrin Drugs 0.000 description 1
- 229960001255 viloxazine Drugs 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229960004740 voriconazole Drugs 0.000 description 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229960000833 xylometazoline Drugs 0.000 description 1
- GQDDNDAYOVNZPG-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C[C]2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3N=C21 GQDDNDAYOVNZPG-SCYLSFHTSA-N 0.000 description 1
- AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 description 1
- 229960004764 zafirlukast Drugs 0.000 description 1
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 1
- 229960004010 zaleplon Drugs 0.000 description 1
- AERLHOTUXIJQFV-RCPZPFRWSA-N zalospirone Chemical compound O=C([C@@H]1[C@@H]([C@@H]2C=C[C@H]1[C@H]1C=C[C@H]12)C1=O)N1CCCCN(CC1)CCN1C1=NC=CC=N1 AERLHOTUXIJQFV-RCPZPFRWSA-N 0.000 description 1
- 229950005255 zalospirone Drugs 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
- 229960001028 zanamivir Drugs 0.000 description 1
- REZGGXNDEMKIQB-UHFFFAOYSA-N zaprinast Chemical compound CCCOC1=CC=CC=C1C1=NC(=O)C2=NNNC2=N1 REZGGXNDEMKIQB-UHFFFAOYSA-N 0.000 description 1
- 229950005371 zaprinast Drugs 0.000 description 1
- HJMQDJPMQIHLPB-UHFFFAOYSA-N zardaverine Chemical compound C1=C(OC(F)F)C(OC)=CC(C2=NNC(=O)C=C2)=C1 HJMQDJPMQIHLPB-UHFFFAOYSA-N 0.000 description 1
- 229950001080 zardaverine Drugs 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
- 229960005332 zileuton Drugs 0.000 description 1
- MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
- 229960004276 zoledronic acid Drugs 0.000 description 1
- 229960001360 zolmitriptan Drugs 0.000 description 1
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 description 1
- 229960002911 zonisamide Drugs 0.000 description 1
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 description 1
- 229960004496 zotepine Drugs 0.000 description 1
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 1
- WFPIAZLQTJBIFN-DVZOWYKESA-N zuclopenthixol Chemical compound C1CN(CCO)CCN1CC\C=C\1C2=CC(Cl)=CC=C2SC2=CC=CC=C2/1 WFPIAZLQTJBIFN-DVZOWYKESA-N 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/008—Electronic counters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Description
a)チオトロピウム塩1a、
b)式1cの化合物、
Aは、
X−は、単一負電荷をもつアニオン、好ましくは、フッ化物、塩化物、臭化物、ヨウ化物、硫酸塩、リン酸塩、メタンスルホン酸塩、硝酸塩、マレイン酸塩、酢酸塩、クエン酸塩、フマル酸塩、酒石酸塩、シュウ酸塩、コハク酸塩、安息香酸塩、およびp−トルエンスルホン酸塩からなる群から選択されるアニオンを示し、
R1およびR2は、同一であっても異なっていてもよく、メチル、エチル、n−プロピル、およびイソプロピルから選択される基を示し、これらは、必要に応じて、ヒドロキシまたはフッ素で置換されており、好ましくは、未置換メチルである;
R3、R4、R5、およびR6は、同一であっても異なっていてもよく、水素、メチル、エチル、メチルオキシ、エチルオキシ、ヒドロキシ、フッ素、塩素、臭素、CN、CF3、またはNO2を示し;
R7は、水素、メチル、エチル、メチルオキシ、エチルオキシ、−CH2−F、−CH2−CH2−F、−O−CH2−F、−O−CH2−CH2−F、−CH2−OH、−CH2−CH2−OH、CF3、−CH2−OMe、−CH2−CH2−OMe、−CH2−OEt、−CH2−CH2−OEt、−O−COMe、−O−COEt、−O−COCF3、−O−COCF3、フッ素、塩素、または臭素を示す;
c)式1dの化合物、
A、X−、R1、およびR2は、前述した意味を有していてもよく、
R7、R8、R9、R10、R11、およびR12は、同一であっても異なっていてもよく、水素、メチル、エチル、メチルオキシ、エチルオキシ、ヒドロキシ、フッ素、塩素、臭素、CN、CF3、またはNO2を示す、但し、R7、R8、R9、R10、R11、およびR12基の少なくとも1つは水素ではない;
d)式1eの化合物、
AおよびX−は、前述した意味を有していてもよく、
R15は、水素、ヒドロキシ、メチル、エチル、−CF3、CHF2、またはフッ素を示し;
R1’およびR2’は、同一であっても異なっていてもよく、必要に応じて、C3−C6−シクロアルキル、ヒドロキシ、またはハロゲンで置換されていてもよいC1−C5−アルキルを示し、
R1’およびR2’は共に、−C3−C5−アルキレンブリッジを示し;
R13、R14、R13’およびR14’は、同一であっても異なっていてもよく、水素、−C1−C4−アルキル、−C1−C4−アルキルオキシ、ヒドロキシ、−CF3、−CHF2、CN、NO2、またはハロゲンを示す;
e)式1fの化合物、
X−は、前述した意味を有していてもよく、
DおよびBは、同一であっても異なっていてもよいが、同一であるのが好ましく、−O、−S、−NH、−CH2、−CH=CH、または−N(C1−C4−アルキル)−を示し;
R16は、水素、ヒドロキシ、−C1−C4−アルキル、−C1−C4−アルキルオキシ、−C1−C4−アルキレン−ハロゲン、−O−C1−C4−アルキレン−ハロゲン、−C1−C4−アルキレン−OH、−CF3、CHF2、−C1−C4−アルキレン−C1−C4−アルキルオキシ、−O−COC1−C4−アルキル、−O−COC1−C4−アルキレン−ハロゲン、−C1−C4−アルキレン−C3−C6−シクロアルキル、−O−COCF3、またはハロゲンを示し;
R1’’およびR2’’は、同一であっても異なっていてもよく、必要に応じて、−C3−C6−シクロアルキル、ヒドロキシ、またはハロゲンで置換されていてもよい−C1−C5−アルキルを示し;または、
R1’’およびR2’’は共に、−C3−C5−アルキレンブリッジを示し;
R17、R18、R17’およびR18’は、同一であっても異なっていてもよく、水素、C1−C4−アルキル、C1−C4−アルキルオキシ、ヒドロキシ、−CF3、−CHF2、CN、NO2、またはハロゲンを示し;
RxおよびRx’は、同一であっても異なっていてもよく、水素、C1−C4−アルキル、C1−C4−アルキルオキシ、ヒドロキシ、−CF3、−CHF2、CN、NO2、またはハロゲンを示し;または
RxおよびRx’は共に、単結合、または、−O、−S、−NH、−CH2、−CH2−CH2−、−N(C1−C4−アルキル)、−CH(C1−C4−アルキル)−、および−C(C1−C4−アルキル)2の架橋から選択される架橋基を示す;
f)式1gの化合物、
X−は、前述した意味を有していてもよく、
A’は、
R19は、ヒドロキシ、メチル、ヒドロキシメチル、エチル、−CF3、CHF2、またはフッ素を示し;
R1’’’およびR2’’’は、同一であっても異なっていてもよく、必要に応じて、C3−C6−シクロアルキル、ヒドロキシ、またはハロゲンで置換されていてもよいC1−C5−アルキルを示し、または
R1’’’およびR2’’’は共に、−C3−C5−アルキレンブリッジを示し;
R20、R21、R20’およびR21’は、同一であっても異なっていてもよく、水素、−C1−C4−アルキル、−C1−C4−アルキルオキシ、ヒドロキシ、−CF3、−CHF2、CN、NO2、またはハロゲンを示す。
式中、
X−は、臭化物を示し;
R1およびR2は、同一であっても異なっていてもよく、メチルおよびエチルから選択される基、好ましくはメチルを示し;
R3、R4、R5、およびR6は、同一であっても異なっていてもよく、水素、メチル、メチルオキシ、塩素、またはフッ素を示し;
R7は、水素、メチル、またはフッ素を示し、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
トロペノール2,2−ジフェニルプロピオン酸エステルメトブロミド、
スコピン2,2−ジフェニルプロピオン酸エステルメトブロミド、
スコピン2−フルオロ−2,2−ジフェニル酢酸エステルメトブロミド、および
トロペノール2−フルオロ−2,2−ジフェニル酢酸エステルメトブロミドである。
式中、
Aは、
X−は、臭化物を示し;
R1およびR2は、同一であっても異なっていてもよく、メチルおよびエチル、好ましくはメチルを示し;
R7、R8、R9、R10、R11、およびR12は、同一であっても異なっていてもよく、水素、フッ素、塩素、または臭素、好ましくはフッ素を示し、但し、R7、R8、R9、R10、R11、およびR12基の少なくとも1つは水素ではなく、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
トロペノール3,3’,4,4’−テトラフルオロベンジル酸エステルメトブロミド、
スコピン3,3’,4,4’−テトラフルオロベンジル酸エステルメトブロミド、
スコピン4,4’−ジフルオロベンジル酸エステルメトブロミド、
トロペノール4,4’−ジフルオロベンジル酸エステルメトブロミド、
スコピン3,3’−ジフルオロベンジル酸エステルメトブロミド、および
トロペノール3,3’−ジフルオロベンジル酸エステルメトブロミドである。
式中、
Aは、
X−は、塩化物、臭化物、およびメタンスルホン酸塩から選択される、好ましくは臭化物のアニオンを示し;
R15は、ヒドロキシ、メチル、またはフッ素、好ましくはメチルまたはヒドロキシを示し;
R1’およびR2’は、同一であっても異なっていてもよく、メチルまたはエチル、好ましくはメチルを示し;
R13、R14、R13’、およびR14’は、同一であっても異なっていてもよく、水素、−CF3、−CHF2、またはフッ素、好ましくは水素またはフッ素を示し、これらは、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
式中、
Aは、
X−は、臭化物を示し;
R15は、ヒドロキシまたはメチル、好ましくはメチルを示し;
R1’およびR2’は、同一であっても異なっていてもよく、メチルまたはエチル、好ましくはメチルを示し;
R13、R14、R13’およびR14’は、同一であっても異なっていてもよく、水素またはフッ素を示し、これらは、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
トロペノール9−ヒドロキシ−フルオレン−9−カルボキシレートメトブロミド ;
トロペノール9−フルオロ−フルオレン−9−カルボキシレートメトブロミド;
スコピン9−ヒドロキシ−フルオレン−9−カルボキシレートメトブロミド;
スコピン9−フルオロ−フルオレン−9−カルボキシレートメトブロミド;
トロペノール9−メチル−フルオレン−9−カルボキシレートメトブロミド;および
スコピン9−メチル−フルオレン−9−カルボキシレートメトブロミドである。
式中、
X−は、塩化物、臭化物、またはメタンスルホン酸塩、好ましくは臭化物を示し;
DおよびBは、同一であっても異なっていてもよいが、同一であるのが好ましく、−O、−S、−NH、または−CH=CH−を示し;
R16は、水素、ヒドロキシ、−C1−C4−アルキル、−C1−C4−アルキルオキシ、−CF3、−CHF2、フッ素、塩素、または臭素を示し;
R1’’およびR2’’は、同一であっても異なっていてもよく、必要に応じて、ヒドロキシ、フッ素、塩素、または臭素で置換されていてもよいC1−C4−アルキルを示し、または、
R1’’およびR2’’は共に、−C3−C4−アルキレンブリッジを示し;
R17、R18、R17’およびR18’は、同一であっても異なっていてもよく、水素、C1−C4−アルキル、C1−C4−アルキルオキシ、ヒドロキシ、−CF3、−CHF2、CN、NO2、フッ素、塩素、または臭素を示し;
RxおよびRx’は、同一であっても異なっていてもよく、水素、C1−C4−アルキル、C1−C4−アルキルオキシ、ヒドロキシ、−CF3、−CHF2、CN、NO2、フッ素、塩素、または臭素を示し、または、
RxおよびRx’は共に、単結合、または、−O、−S、−NH−、および−CH2−の架橋から選択される架橋基を示し、これらは、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
式中、
X−は、塩化物、臭化物、またはメタンスルホン酸塩、好ましくは臭化物を示し;
DおよびBは、同一であっても異なっていてもよいが、同一であるのが好ましく、−S−または−CH=CH−を示し;
R16は、水素、ヒドロキシ、またはメチルを示し;
R1’’およびR2’’は、同一であっても異なっていてもよく、メチルまたはエチルを示し;
R17、R18、R17’およびR18’は、同一であっても異なっていてもよく、水素、−CF3、またはフッ素、好ましくは水素を示し;
RxおよびRx’は、同一であっても異なっていてもよく、水素、−CF3、またはフッ素、好ましくは水素を示し、または、
RxおよびRx’は共に、単結合、または架橋基−O−を示し、これは、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
式中、
X−は、臭化物を示し;
DおよびBは、−CH=CH−を示し;
R16は、水素、ヒドロキシ、またはメチルを示し;
R1’’およびR2’’は、メチルを示し;
R17、R18、R17’、およびR18’は、同一であっても異なっていてもよく、水素またはフッ素、好ましくは水素を示し;
RxおよびRx’は、同一であっても異なっていてもよく、水素またはフッ素、好ましくは水素を示し、または、
RxおよびRx’は共に、単結合、または架橋基−O−を示し、これは、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
シクロプロピルトロピンベンジレートメトブロミド;
シクロプロピルトロピン2,2−ジフェニルプロピオネートメトブロミド;
シクロプロピルトロピン9−ヒドロキシ−キサンテン−9−カルボキシレートメトブロミド;
シクロプロピルトロピン9−メチル−フルオレン−9−カルボキシレートメトブロミド;
シクロプロピルトロピン9−メチル−キサンテン−9−カルボキシレートメトブロミド;
シクロプロピルトロピン9−ヒドロキシ−フルオレン−9−カルボキシレートメトブロミド;および
シクロプロピルトロピンメチル4,4’−ジフルオロベンジレートメトブロミドである。
式中、
A’は、
X’’は、塩化物、臭化物、またはメタンスルホン酸塩、好ましくは臭化物を示し;
R19は、ヒドロキシまたはメチルを示し;
R1’’’およびR2’’’は、同一であっても異なっていてもよく、メチルまたはエチル、好ましくはメチルを示し;
R20、R21、R20’、およびR21’は、同一であっても異なっていてもよく、水素、−CF3、−CHF2、またはフッ素、好ましくは水素またはフッ素を示し、これらは、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
式中、
A’は、
X−は、臭化物を示し;
R19は、ヒドロキシまたはメチル、好ましくはメチルを示し;
R1’’’およびR2’’’は、同一であっても異なっていてもよく、メチルまたはエチル、好ましくはメチルを示し;
R3、R4、R3’、およびR4’は、同一であっても異なっていてもよく、水素またはフッ素を示し、これらは、必要に応じて、医薬的に許容される賦形剤と一緒でもよい。
トロペノール9−ヒドロキシ−キサンテン−9−カルボキシレートメトブロミド;
スコピン9−ヒドロキシ−キサンテン−9−カルボキシレートメトブロミド;
トロペノール9−メチル−キサンテン−9−カルボキシレートメトブロミド;
スコピン9−メチル−キサンテン−9−カルボキシレートメトブロミド;
トロペノール9−エチル−キサンテン−9−カルボキシレートメトブロミド;
トロペノール9−ジフルオロメチル−キサンテン−9−カルボキシレートメトブロミド;および
スコピン9−ヒドロキシメチル−キサンテン−9−カルボキシレートメトブロミドである。
Claims (14)
- ハウジングと、
前記ハウジング内に収容されるブリスターストリップであって、前記ブリスターストリップは、表面と、前記表面から垂れ下がる複数のブリスターポケットと、を有し、各ブリスターポケットは、ユーザによる吸入のための一服の薬剤を含有する、ブリスターポケットと、
複数のスポークを備える駆動ホイールと、1つのブリスターポケットおよび前記表面の間の折り目によって画定される線に沿って前記ブリスターストリップと接触し、前記ブリスターストリップを駆動させるような形状にされたブリスターストリップ駆動部材と、を含むブリスターストリップ駆動機構であって、前記複数のスポークのそれぞれは、前記ブリスターストリップ駆動機構のアームを形成し、前記ブリスターストリップ駆動部材は、前記アームおよび前記ブリスターストリップ駆動部材を貫通して半径方向に延びている軸の両側に先端ブリスターストリップ接触縁部および後端ブリスターストリップ接触縁部を有し、このため、前記ブリスターストリップ駆動部材が1つの方向に回転されるときに、前記先端ブリスターストリップ接触縁部が1つのブリスターポケットおよび前記表面の間の折り目によって画定される線に沿って前記ブリスターストリップと接触し、前記ブリスターストリップ駆動部材が反対の方向に回転するときに、前記後端ブリスターストリップ接触縁部が隣接するブリスターポケットおよび前記表面の間の折り目によって画定される線に沿って前記ブリスターストリップと接触し、前記駆動ホイールのピッチは、前記ブリスターストリップのピッチよりも大きいように選択され、前記ブリスターストリップ上の隣接するブリスターボウルの折り目間の距離は、前記ブリスターストリップ駆動部材の先端ブリスターストリップ接触縁部および後端ブリスターストリップ接触縁部の間の距離と同じである、ブリスターストリップ駆動機構と、
を備える吸入器。 - 前記ブリスターストリップ駆動部材が、ブリスターポケットに向けられた力の成分に対して、前記ブリスターストリップの表面に沿った方向に力のより大きな成分を向けるように構成されている請求項1に記載の吸入器。
- 前記ブリスターストリップ駆動機構が前記アームの端部に配置されている請求項1に記載の吸入器。
- 前記ブリスターストリップ接触縁部が円形であり、かつ0mm超過乃至0.2mm未満の半径を有する請求項1乃至3のいずれか1項に記載の吸入器。
- 前記ブリスターストリップ駆動部材が、前記アームから前記ブリスターストリップ接触縁部まで次第に細くなっている前記アームの端部上に拡大ヘッドを備える請求項1に記載の吸入器。
- 前記ブリスターストリップ駆動部材および前記アームが、前記ブリスターストリップとの接触が前記接触縁部に限定されるように構成されている請求項1に記載の吸入器。
- 前記アームおよび/または前記ブリスターストリップ駆動部材が、前記ブリスターストリップ接触縁部が成形ブリスターポケットおよび前記ブリスターストリップの表面の間の折り目と接触するような形状にされる請求項1に記載の吸入器。
- 前記アームおよび/または前記ブリスターストリップ駆動部材が、前記ブリスターストリップ接触縁部が成形ブリスターポケットおよび前記ブリスターストリップの表面の間の折り目により画定される少なくとも部分的に湾曲した線と接触するように、少なくとも形状において部分的に湾曲している請求項1に記載の吸入器。
- 前記ブリスターストリップ駆動部材の端面が、形状において三角形あるいは部分的に三角形であり、前記三角形の尖端が、前記アームの長さに沿って半径内向き方向を指している請求項1に記載の吸入器。
- 前記ブリスターストリップ駆動部材が、前記ブリスターストリップ接触縁部間に延びている平坦あるいは凹状の端面を有する請求項1に記載の吸入器。
- 前記端面が、前記アームの平面に対して直角に位置する平面に延在する請求項10に記載の吸入器。
- 前記ブリスターストリップ駆動機構が、ブリスターを順次移動させて、ブリスター開口部材と位置合わせするように構成されている請求項1に記載の吸入器。
- 前記吸入器が、マウスピースと、前記マウスピースを覆うためのキャップとを備え、前記ブリスターストリップ駆動機構が、ユーザによる前記キャップの動きに応じて動作可能である請求項10に記載の吸入器。
- 各ブリスターポケットが、一部が円筒状の中央領域と、一部が半球状の端部領域とを有する請求項1に記載の吸入器。
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FR2881117B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
FR2881118B1 (fr) * | 2005-01-25 | 2007-04-20 | Valois Sas | Dispositif de distribution de produit fluide. |
FR2881111B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
FR2881119B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
GB0509952D0 (en) * | 2005-05-16 | 2005-06-22 | Glaxo Group Ltd | Fault indicator |
WO2007096111A2 (de) * | 2006-02-20 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Inhalator |
DE102006023662A1 (de) * | 2006-05-18 | 2007-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
FR2904228B1 (fr) * | 2006-07-25 | 2009-05-29 | Valois Sas | Dispositif de distribution de produit fluide. |
FR2904297B1 (fr) * | 2006-07-25 | 2008-10-10 | Valois Sas | Dispositif de distribution de produit fluide. |
GB0621957D0 (en) * | 2006-11-03 | 2006-12-13 | Vectura Group Plc | Inhaler devices and bespoke pharmaceutical compositions |
FR2909641B1 (fr) * | 2006-12-11 | 2011-03-04 | Valois Sas | Dispositif de distribution de produit fluide |
JP5099722B2 (ja) * | 2006-12-11 | 2012-12-19 | アプター フランス エスアーエス | 流体ディスペンサ装置 |
EP2011537A1 (en) * | 2007-07-06 | 2009-01-07 | Vectura Delivery Devices Limited | Inhaler |
US20090151722A1 (en) * | 2007-07-06 | 2009-06-18 | Vectura Delivery Devices Limited | Inhaler |
ES2569359T3 (es) * | 2007-07-06 | 2016-05-10 | Vectura Delivery Devices Limited | Inhalador |
-
2008
- 2008-01-24 EP EP08100881A patent/EP2082767A1/en not_active Withdrawn
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2009
- 2009-01-22 ES ES09703134.8T patent/ES2573940T3/es active Active
- 2009-01-22 RU RU2010135351/14A patent/RU2481860C2/ru active
- 2009-01-22 AU AU2009207607A patent/AU2009207607B2/en active Active
- 2009-01-22 SG SG2013002423A patent/SG187459A1/en unknown
- 2009-01-22 WO PCT/EP2009/050730 patent/WO2009092768A1/en active Application Filing
- 2009-01-22 JP JP2010543498A patent/JP5833824B2/ja active Active
- 2009-01-22 CA CA2713102A patent/CA2713102C/en active Active
- 2009-01-22 CN CN201410219073.XA patent/CN103961772B/zh active Active
- 2009-01-22 NZ NZ586976A patent/NZ586976A/xx unknown
- 2009-01-22 CN CN200980110498.4A patent/CN101980740B/zh active Active
- 2009-01-22 EP EP09703134.8A patent/EP2252352B1/en active Active
- 2009-01-22 KR KR1020107018589A patent/KR101510204B1/ko active IP Right Grant
- 2009-01-22 MX MX2010008069A patent/MX2010008069A/es active IP Right Grant
- 2009-01-22 BR BRPI0906369A patent/BRPI0906369B8/pt active IP Right Grant
- 2009-01-22 US US12/864,339 patent/US8944055B2/en active Active
- 2009-01-23 TW TW98102953A patent/TWI466696B/zh active
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Also Published As
Publication number | Publication date |
---|---|
WO2009092768A1 (en) | 2009-07-30 |
IL207157A0 (en) | 2010-12-30 |
BRPI0906369A2 (pt) | 2015-07-07 |
IL207157A (en) | 2014-01-30 |
BRPI0906369B8 (pt) | 2021-05-25 |
TW200950835A (en) | 2009-12-16 |
CN101980740B (zh) | 2015-04-15 |
AU2009207607B2 (en) | 2014-07-24 |
ZA201005620B (en) | 2015-05-27 |
BRPI0906369B1 (pt) | 2019-05-21 |
AU2009207607A1 (en) | 2009-07-30 |
CN103961772A (zh) | 2014-08-06 |
AR070239A1 (es) | 2010-03-25 |
US20110048420A1 (en) | 2011-03-03 |
CN103961772B (zh) | 2016-07-06 |
CN101980740A (zh) | 2011-02-23 |
NZ586976A (en) | 2012-09-28 |
KR20100118120A (ko) | 2010-11-04 |
CA2713102A1 (en) | 2009-07-30 |
EP2252352A1 (en) | 2010-11-24 |
KR101510204B1 (ko) | 2015-04-08 |
SG187459A1 (en) | 2013-02-28 |
JP2011509781A (ja) | 2011-03-31 |
EP2082767A1 (en) | 2009-07-29 |
RU2010135351A (ru) | 2012-02-27 |
EP2252352B1 (en) | 2016-03-23 |
CA2713102C (en) | 2016-03-15 |
RU2481860C2 (ru) | 2013-05-20 |
TWI466696B (zh) | 2015-01-01 |
MX2010008069A (es) | 2010-10-04 |
US8944055B2 (en) | 2015-02-03 |
ES2573940T3 (es) | 2016-06-13 |
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