JP5824351B2 - Medical sheet cutting method and cutting jig - Google Patents

Description

  The present invention relates to a medical sheet cutting method and a cutting jig for cutting various sheets used for medical treatment, and in particular, it is necessary to cut into a predetermined shape in an aseptic state and free from endotoxin and having no foreign matter attached thereto. The present invention relates to a medical sheet cutting method and a cutting jig for cutting a medical sheet.

  Conventionally, in order to cut a sheet-like product into a predetermined shape, for example, a cutting jig shown in FIGS. 5 and 6 is used. The cutting jig shown in FIGS. 5 and 6 will be described. FIG. 5 is a schematic perspective view of a cutting jig using a Thomson blade. FIG. 6 is a schematic perspective view of a cutting jig using a die set.

  The cutting jig using the Thomson blade shown in FIG. 5 is a Thomson blade 520 for cutting the sheet 510 that is a workpiece, a table 530 that supports the Thomson blade 520, and presses the sheet 510 against the Thomson blade 520. And a push plate 540 for the purpose.

  The sheet 510 is placed on the Thomson blade 520, and the push plate 540 cuts the sheet 510 by pushing the sheet 510 toward the Thomson blade 520. The push plate 540 is formed of a veneer plate, resin, or the like. When the sheet 510 is cut, the Thomson blade 520 penetrates the sheet 510 and bites into the push plate 540.

  The cutting jig using the die set shown in FIG. 6 includes a punch (upper blade) 610 and a die (lower blade) 620 for punching and cutting a sheet 510 as a workpiece, a punch 610 and a die 620. Are fixed so that they do not move in the parallel direction, and a die set 630 configured so that the punch 610 can be accurately inserted into the die 620.

  The sheet 510 is set between the punch 610 and the die 620, and the sheet 510 is punched by the punch 610 and the die 620 to cut the sheet 510.

  Patent Document 1 discloses a method and apparatus for cutting a sheet-form preparation for percutaneous absorption using a substantially square Thomson blade. In the method disclosed in Patent Document 1, a long-running percutaneous absorption therapeutic preparation is transdermalized while a Thomson blade having a substantially square shape moves back and forth in a direction perpendicular to the surface of the percutaneous absorption therapeutic preparation. The preparation for absorption treatment is punched and cut.

Japanese Patent Laid-Open No. 10-203713

  However, in the conventional cutting jig as shown in FIG. 5, the Thomson blade bites into the pressing plate 540, so that the pressing plate 540 is scraped, and shavings may be mixed into the sheet 510. In addition, when a hard material is used so that the push plate 540 is not scraped, the Thomson blade 520 may be worn or damaged, and there is a possibility that wear debris or the like may be mixed into the sheet 510.

  The conventional cutting jig as shown in FIG. 6 requires high-precision alignment between the punch 610 and the die 620, so the die set 630 is necessary. The die set 630 is a sliding part that moves up and down. In this case, oil for reducing friction is used, and the oil may be mixed into the sheet 510.

  In addition, the punch 610 and the die 620 are rubbed and worn, and wear debris may be mixed into the sheet 510. Furthermore, a jig that has a sliding portion like the die set 630 and uses oil is a steam sterilization that is a severe sterilization treatment imposed on a jig that cuts a medical sheet containing an injection or the like. It cannot withstand dry heat sterilization, hydrogen peroxide sterilization, γ-ray sterilization, and normal water washing is difficult.

  In the cutting jig as shown in Patent Document 1, since the structure is such that the surface of the sheet is pressed and cut only from one side with a blade, it can be cut if it is a soft film-like sheet. In the case of a hard sheet such as a polymer sheet having a microneedle containing protein or the like formed on the surface, it cannot be cut.

  In view of such circumstances, the present invention intends to provide a medical sheet cutting method and a cutting jig for cutting a medical sheet in a sterilized state without attaching foreign matter by sterilizing the cutting jig. is there.

  The problems of the present invention can be solved by the following inventions.

  That is, the medical sheet cutting method of the present invention is a medical sheet cutting method that cuts a medical sheet into a predetermined shape using a medical sheet cutting jig, and cuts the medical sheet that constitutes the medical sheet cutting jig. A cutting portion having a blade for cutting, an abutting surface on the same plane as the tip of the blade, and a plane portion for contacting the surface of the medical sheet and pressing the medical sheet toward the blade A preparatory step for preparing a pressing part, and placing the medical sheet on the cutting part, and placing the pressing part on the medical sheet, thereby bringing the medical sheet into the cutting part By sandwiching with the pressing portion, and after the sandwiching step, by pressing the medical sheet in the direction of the blade until the pressing portion hits the abutting surface A cutting step for cutting the serial medical sheet, further comprising a being the key features.

  Thereby, at the time of a cutting | disconnection, since a blade only contacts a press part and does not hit a press part strongly, a medical sheet can be cut | disconnected, without a foreign material adhering at all.

  In the medical sheet cutting method of the present invention, the pressing portion is made of austenitic stainless steel, and the cut portion including the blade is hardened martensitic stainless steel or hardened precipitation hardened system. The main feature is that it is made of stainless steel.

  Thereby, even if sterilization treatment such as hydrogen peroxide sterilization, steam sterilization, dry heat sterilization, and γ-ray sterilization is performed on the medical sheet cutting jig, the medical sheet cutting jig does not corrode.

  Furthermore, the medical sheet cutting method of the present invention is mainly characterized in that the pressing portion is made of SUS304 or SUS316, and the cut portion including the blade is made of a hardened SUS630. .

  Thereby, corrosion of the medical sheet cutting jig due to sterilization treatment such as hydrogen peroxide sterilization, steam sterilization, dry heat sterilization, and γ-ray sterilization can be further reliably prevented.

  Furthermore, in the medical sheet cutting method of the present invention, the medical sheet cutting jig further includes heating means for directly or indirectly heating the medical sheet, and in the cutting step, the medical sheet is converted into the medical sheet. The main feature is that the medical sheet is cut while being heated to the softening point or glass transition point.

  Thereby, even if the medical sheet is a very brittle substance or the medical sheet is warped, the medical sheet is softened and cut by heating, so that it is cut without causing cracks or cracks. be able to.

  Moreover, the medical sheet cutting method of the present invention is characterized in that the heating means indirectly heats the medical sheet by heating the blade.

  Thereby, since only the cutting part of a medical sheet is selectively heated, even when the medical sheet contains a component that is modified by heating, the medical sheet can be heated and cut while preventing the modification of the component.

  Furthermore, the medical sheet cutting method of the present invention is characterized by further comprising a sterilization step for sterilizing the cut portion and the pressing portion before the sandwiching step.

  Thereby, the medical sheet can be cut in a sterilized state.

  Furthermore, the medical sheet cutting jig of the present invention is a medical sheet cutting jig for cutting a medical sheet, and is on the same plane as the blade for cutting the medical sheet and the tip of the blade. A cut portion having an abutment surface, and a pressing portion having a flat portion for contacting the surface of the medical sheet and pressing the medical sheet toward the blade, and the medical device on the cut portion Place the sheet, place the pressing part on the medical sheet, and cut the medical sheet by pressing the medical sheet in the direction of the blade until the pressing part hits the abutting surface. This is the main feature.

  As a result, sterilization treatment such as hydrogen peroxide sterilization, steam sterilization, dry heat sterilization, and γ-ray sterilization can be performed on the medical sheet cutting jig. Therefore, the medical sheet can be cut in a sterile state without any foreign matter adhering.

  Further, in the medical sheet cutting jig of the present invention, the pressing portion is made of austenitic stainless steel, and the cut portion including the blade is hardened martensitic stainless steel or hardened precipitation hardened. The main feature is that it is made of stainless steel.

  Thereby, even if sterilization treatment such as hydrogen peroxide sterilization, steam sterilization, dry heat sterilization, and γ-ray sterilization is performed on the medical sheet cutting jig, the medical sheet cutting jig does not corrode.

  The medical sheet cutting jig according to the present invention is mainly characterized in that the pressing portion is made of SUS304 or SUS316, and the cut portion including the blade is made of a hardened SUS630. .

  Thereby, the overmedical sheet cutting jig of the present invention can more reliably withstand corrosion caused by sterilization treatment such as hydrogen oxide sterilization, steam sterilization, dry heat sterilization, and γ-ray sterilization.

  Furthermore, the medical sheet cutting jig of the present invention is mainly characterized in that the medical sheet cutting jig further includes a heating means for directly or indirectly heating the medical sheet.

  Thereby, even if the medical sheet is a very brittle substance or the medical sheet is warped, the medical sheet is softened and cut by heating, so that it is cut without causing cracks or cracks. be able to.

  Furthermore, the medical sheet cutting jig of the present invention is mainly characterized in that the heating means heats the blade.

  Thereby, since only the cutting part of a medical sheet is selectively heated, even when the medical sheet contains a component that is modified by heating, the medical sheet can be heated and cut while preventing the modification of the component.

  The medical sheet can be cut without adhering foreign matter.

It is a perspective view of a medical sheet cutting jig. It is the schematic showing a film manufacturing line. It is the figure which showed the top view and sectional drawing of a cut part. It is sectional drawing of the press part and cut part in the state which cut | disconnected the sheet | seat. It is the cross-sectional schematic diagram of a part of the wound film. It is the schematic which shows the state which set the medical sheet cutting jig to the servo press machine. It is a schematic perspective view of the cutting jig using a Thomson blade. It is a schematic perspective view of the cutting jig using a die set.

  Hereinafter, embodiments for carrying out the present invention will be described in detail with reference to the accompanying drawings. Here, in the drawing, portions indicated by the same symbols are similar elements having similar functions.

<Medical sheet cutting jig>
An embodiment of a medical sheet cutting jig according to the present invention (hereinafter sometimes simply referred to as a cutting jig) will be described with reference to FIG. FIG. 1 is a perspective view of a medical sheet cutting jig.

  As shown in FIG. 1, a medical sheet cutting jig 100 according to the present invention includes a pressing portion 110 having a flat portion 112 for pressing a sheet 115 that is a workpiece, and a blade 117 for cutting the sheet 115. It is comprised mainly including the cut part 120 which has.

  Although the pressing portion 110 is shown as a plate-like member in FIG. 1, the pressing portion 110 is not limited to the plate-like member, and has any other shape as long as it has a plane portion for pressing the sheet 115. It may be.

  Here, the sheet 115 is a medical sheet. The medical sheet is, for example, a polymer sheet (hereinafter, referred to as a microneedle containing a percutaneous absorption drug or a polysaccharide or protein that is an injection drug). In this case, it may be simply referred to as an injection drug). However, the sheet 115 is not limited to this, and may be a sheet-like cosmetic product, or may be a medicine, an instrument, or the like used for sheet-like medical treatment.

  That is, the medical sheet cutting jig according to the present invention can be suitably applied to a sheet that is sterile, endotoxin-free, and needs to be cut into a predetermined shape without any foreign matter adhering thereto. Therefore, in the present invention, the medical sheet means all sheets that need to be cut into a predetermined shape under aseptic conditions, endotoxin-free, or without any foreign matter adhering.

  The cut part 120 mainly includes a blade 117 for cutting the sheet 115 into a predetermined shape and an abutting surface 130. As the blade 117, for example, an engraving blade can be suitably used, but the blade 117 is not limited to this, and a Thomson blade may be used. The blade 117 is formed in the same shape as the outer shape of the predetermined shape in order to cut the sheet 115 into a predetermined shape.

  The abutting surface 130 and the tip of the blade 117 are installed so as to exist on the same plane. When the sheet 115 is cut, the abutting surface 130 abuts against the planar portion 112, so that the planar portion 112 is This prevents strong contact with the blade 117.

  Here, the abutting surface 130 and the blade 117 are present on the same plane in the present invention, not only that the abutting surface 130 and the blade 117 are on the same same plane, but also the following ranges: Shall be included. That is, when the flat surface portion 112 is abutted against the abutting surface 130, the blade 117 and the flat surface portion 112 are not in contact with each other and a gap is left (that is, the tip of the blade 117 is slightly away from the flat surface including the abutting surface 130. If the sheet 115 can be cut even if they are located apart from each other, the abutting surface 130 and the tip of the blade 117 at that time are within the same plane.

  As a result, shavings generated when the flat portion 112 is scraped off by the blade 117, wear scrap generated when the blade 117 is worn or damaged due to the blade 117 coming into strong contact with the flat portion 112, and the like are sheeted. The sheet 115 can be reliably cut while being prevented from adhering to the sheet 115.

  All members constituting the medical sheet cutting jig 100 are made of stainless steel. The pressing portion 110 is preferably made of stainless steel having a relatively low hardness such as austenite, such as SUS304 or SUS316. Further, from the viewpoint of cutting a sheet, the cut portion 120 and the blade 117 are made of stainless steel obtained by hardening a martensite stainless steel having a relatively high hardness, or stainless steel obtained by hardening a precipitation hardening stainless steel. It is preferable. Among these, it is preferable to be made of a hardened SUS630 that is a precipitation hardening stainless steel.

  SUS304 and SUS316 have a proven track record as medical materials with corrosion resistance that can withstand cleaning and sterilization operations. SUS630 is a precipitation hardening stainless steel, and even when it is subjected to hardening treatment (age hardening, heating at 450 ° C to 550 ° C for 1 to 10 hours, then air cooling to increase hardness), the same hardening treatment is applied. Although the hardness was about 20% lower than that of the martensitic stainless steel, the corrosion resistance was good, and a sheet cut test and a hydrogen peroxide decontamination test were also conducted, but good results were obtained. That is, the sheet could be cut well, and no corrosion was observed even after performing hydrogen peroxide decontamination. This suggests that SUS630 can withstand not only hydrogen peroxide sterilization but also steam sterilization, dry heat sterilization, γ-ray sterilization, and the like.

  Therefore, by using these materials, the medical sheet cutting jig of the present invention is a severe sterilization treatment imposed on the jig for cutting the medical sheet, steam sterilization, dry heat sterilization, hydrogen peroxide sterilization It is considered that it can sufficiently withstand γ-ray sterilization. Here, the medical sheet cutting jig according to the present invention is not limited to the above SUS304, SUS316, and cured SUS630, and any material that can withstand the severe sterilization treatment is suitable. Can be used as material.

  Here, a heater for heating the blade 117 or the sheet 115 may be further installed. Thereby, when the heater which heats the blade 117 is installed, the blade 117 is heated, so that the heated blade 117 can heat and cut the sheet 115. For this reason, the sheet 115 becomes soft and becomes easy to cut by being heated by the blade 117.

  Similarly, when a heater for heating the sheet 115 is installed, the sheet 115 becomes soft when heated, so that cutting becomes easy. At this time, in order to heat the sheet 115, for example, a heater may be installed in the pressing unit 110, and the pressing unit 110 may heat the sheet 115 by heating the pressing unit 110. A configuration in which the sheet 115 is directly heated by a halogen heater or the like through a hole surrounded by the blade 117 in FIG. 1 may be employed.

  In any of the above cases, the heater needs to be configured to heat the sheet 115 to the softening point or glass transition point. Further, since the heater itself does not contact the sheet 115, the heater itself does not need to be subjected to sterilization treatment in a harsh environment.

  Therefore, the heater can be configured to be removable. In that case, the heater does not need to be able to withstand sterilization treatment, and the heater may be removed and sterilization treatment other than the heater may be performed. Of course, the heat may be sterilized by using, for example, a ceramic heater that can withstand the sterilization.

<Operation of medical sheet cutting jig and medical sheet cutting method>
Next, an embodiment of the operation of the medical sheet cutting jig and the medical sheet cutting method will be described with reference to FIGS. FIG. 2 shows a plan view and a cross-sectional view of the cut portion. FIG. 3 is a cross-sectional view of the pressing portion and the cutting portion in a state where the sheet is cut. FIG. 4 is a schematic view showing a state in which a medical sheet cutting jig is set in the servo press machine.

  First, as preparation, when the sheet 115 is a medical sheet and is a transdermal drug or injection, the pressing part 110 and the cut part 120 are sufficiently cleaned and washed, and then sterilized with hydrogen peroxide. Apply sterilization such as steam sterilization, dry heat sterilization, and γ-ray sterilization, and then install in a sterile room to manage the sterility according to medical GMP. In particular, when the sheet 115 is an injection drug, endotoxin management is also performed.

  Here, the cleaning and sterilization processing of the pressing unit 110 and the cutting unit 120 may be performed as long as the pressing unit 110 and the cutting unit 120 are cleaned and sterilized before the sheet 115 is cut. That is, the steps of cleaning and sterilization may be performed before cutting the medical sheet or may be performed after cutting the medical sheet.

  That is, if the pressing unit 110 and the cut unit 120 are cleaned and sterilized at the time of cutting the sheet 115, the cleaning and sterilization processing step is performed before or after any of the steps of cutting the medical sheet. May be executed.

  Thus, for example, washing and sterilization may be performed after the step of cutting the medical sheet. In this case, the cleaning and sterilization processing is cleaning and sterilization processing for the next step of cutting the medical sheet. . Moreover, you may perform a washing | cleaning and a sterilization process before the process of preparing the press part 110 and the cut part 120. FIG. In this case, the cleaning and sterilization process is a cleaning and sterilization process for the step of cutting the medical sheet immediately thereafter.

  Next, referring to FIG. 1, the sheet 115 is set between the pressing portion 110 and the cut portion 120. Next, the sheet 115 is sandwiched between the pressing part 110 and the cutting part 120 by moving the pressing part in the downward direction in the figure.

  For example, as the pressing means, the pressing portion is further pressed downward in the drawing by the servo press 400 shown in FIG. 4, thereby pressing the sheet 115 toward the blade 117 with the flat portion 112 of the pressing portion 110. Accordingly, the blade 117 cuts the sheet 115 into a predetermined shape (a shape formed by the blade 117).

  Next, the cutting of the sheet 115 will be described from the cross-sectional direction of the cutting jig. Referring to FIG. 2, (1) in FIG. 2 shows a plan view of the cut portion 120, and (2) in FIG. 2 shows a cross-sectional view along A-A 'in (1).

  As shown in FIG. 2, the sheet 115 is pressed in the direction indicated by the arrow in FIG. The state cut by the blade 117 is shown in FIG.

  Referring to FIG. 3, the pressing part 110 is in a state in which the sheet 115 cannot be pressed any more by abutting against the abutting surface 130 of the cut part 120. At this time, since the tip of the blade 117 and the abutting surface 130 are arranged on the same plane, the tip of the blade 117 is in close contact with the flat portion 112 of the pressing portion 110.

  Here, in FIG. 3, a clearance is provided between the pressing portion 110 and the tip of the blade 117 and the abutting surface 130 for easy viewing. However, if this clearance is removed, It can be seen that the flat portion 112 is in contact with the tip of the blade 117 and the abutting surface 130.

  Thus, since the abutting surface 130 and the tip of the blade 117 are arranged on the same plane, the blade 117 is not strongly pressed against the flat portion 112 of the pressing portion 110, and the pressing portion 110 is not pressed. Are not cut by the blade 117 and shavings are not generated, and conversely, the blade 117 is not worn or broken due to wear or breakage. Therefore, no foreign matter is mixed into the sheet 115.

  Here, when cutting the sheet 115, it is also possible to cut the sheet 115 by directly or indirectly heating the sheet 115 to its softening point or glass transition point using a heater. Thereby, since the sheet | seat 115 is soft, it can cut | disconnect easily.

  In particular, in the case of a brittle substance such as a polymer sheet on the surface of which microneedles containing polysaccharides or proteins are formed, the sheet is cracked by cutting by heating and softening, Breaking can be prevented. Even when the sheet is warped, it is softened by heating, so that it can be cut without causing cracks or cracks even when pressed by the pressing portion.

  As the heating by the heater, the heater is installed in the pressing unit, and the sheet 115 contacting the pressing unit is indirectly heated by heating the pressing unit. A method of heating the sheet 115 indirectly by heating can be used. Furthermore, a method of directly heating the sheet 115 in a non-contact manner using a halogen heater or an infrared heater can be used.

  Among them, when a heater is installed on the blade 117, only the portion to be cut of the sheet can be heated, and it is not necessary to heat the other part of the sheet. It is particularly preferable when priority is given not to apply heat to the needle portion.

  Next, the medical sheet cutting method when the servo press 400 is used as the pressing means will be further described with reference to FIG. The servo press 400 mainly includes a base 410, an arm 420, a servo motor (not shown), and an elevating unit 430. The arm 420 is installed on the base 410, and the elevating unit 430 is supported by the arm 420. A servo motor (not shown) moves the elevating unit 430 up and down.

  A fixing member 440 for fixing the cut part 120 is installed on the base 410. The cut part 120 is installed on the base 410 and fixed by a fixing member 440 so as not to move in the plane direction.

  The sheet 115 is placed on the cut part 120, and the pressing part 110 is placed on the sheet 115. At this time, when the sheet 115 is placed and when the pressing portion 110 is placed, the sheet 115 can be placed without fine alignment. For this reason, the work load is reduced, and the man-hour for cutting the sheet 115 and the lead time can be reduced.

  Next, the sheet 115 can be cut by operating the servo motor to lower the elevating unit 430 and pressing the pressing unit 110 downward. At this time, in the case where the sheet 115 uses a polymer in which polysaccharides and / or proteins are mixed, in order to push the blade 117 to the root of the sheet 115, it is necessary to apply a pressure of 1500 N or more per 60 mm of the cut circumference. . This is the same even if other pressurizing means are used without using the servo press 400.

<Medical sheet cutting method>
Next, a method for heating and cutting the medical sheet will be described. In this method, a heater is mounted on the blade 117, and the sheet 115 is cut while the blade 117 is heated.

  As the medical sheet cutting jig, a jig mounted with a heater on the blade 117 of the jig shown in FIG. 1 was used. As the sheet to be cut, a hyaluronic acid / dextran mixed sheet having a thickness of 1 mm was used.

  First, the medical cutting jig 100 was washed and sterilized with hydrogen peroxide. Next, the hyaluronic acid / dextran mixed sheet was set on the blade 117 of the cut portion 120 that had been cleaned and sterilized. The pressing part was placed on the hyaluronic acid / dextran mixed sheet set in the cutting part 120, and the cutting part 120 and the pressing part 110 were set in the servo press shown in FIG.

  Next, an electric current was supplied to the heater mounted on the blade 117 to heat the blade 117, and the current was controlled so that the temperature of the blade 117 became 120 ° C., thereby adjusting the amount of heat generated by the heater. When the temperature of the blade 117 reaches 120 ° C., the elevating part 430 of the servo press 400 is lowered at a speed of 3 mm / s until the pressing part 110 comes into contact with the surface 130 of the cut part 120, and hyaluronic acid / dextran mixing is performed. The sheet was cut.

  As a result, the hyaluronic acid / dextran mixed sheet was satisfactorily cut without adhering foreign matter. Further, when the hyaluronic acid / dextran mixed sheet was cut under the same conditions as described above except in the heater off state, that is, in the non-heated state, similarly, the sheet was cut well without foreign matter adhering to the sheet.

  However, cutting with heating was easier because the cut part of the sheet was softened. Therefore, when cutting a harder and more fragile medical sheet, cutting in an overheated state can be cut while preventing cracking of the sheet.

  DESCRIPTION OF SYMBOLS 100 ... Medical sheet cutting jig, 110 ... Press part, 112 ... Plane part, 115 ... Sheet, 117 ... Blade, 120 ... Cut part, 130 ... Surface, 400 ... Servo press machine, 410 ... Base, 420 ... Arm, 430 ... lifting part, 440 ... fixing member, 510 ... sheet, 520 ... Thomson blade, 530 ... stand, 540 ... plate, 610 ... punch, 620 ... die, 630 ... die set

Claims (11)

A medical sheet cutting method for cutting a medical sheet into a predetermined shape using a medical sheet cutting jig,
Constituting the medical sheet cutting jig,
A cutting portion having a blade for cutting the medical sheet, and an abutting surface that is flush with a tip of the blade;
A pressing portion having a flat portion for contacting the surface of the medical sheet and pressing the medical sheet toward the blade;
Preparation steps to prepare,
A step of sandwiching the medical sheet between the cut part and the pressing part by placing the medical sheet on the cut part and placing the pressing part on the medical sheet;
After the sandwiching step, a cutting step of cutting the medical sheet by pressing the medical sheet in the direction of the blade until the pressing portion hits the abutting surface;
A medical sheet cutting method comprising: The pressing portion is made of austenitic stainless steel,
The medical sheet cutting method according to claim 1, wherein the cut portion including the blade is made of a hardened martensitic stainless steel or a hardened precipitation hardened stainless steel. The pressing portion is made of SUS304 or SUS316,
The medical sheet cutting method according to claim 2, wherein the cut portion including the blade is made of SUS630 that has been cured. The medical sheet cutting jig further comprises heating means for directly or indirectly heating the medical sheet,
The medical sheet cutting method according to any one of claims 1 to 3, wherein in the cutting step, the medical sheet is cut while heating the medical sheet to a softening point or a glass transition point of the medical sheet.   The medical sheet cutting method according to claim 4, wherein the heating means indirectly heats the medical sheet by heating the blade.   The medical sheet cutting method according to any one of claims 1 to 5, further comprising a sterilization step of sterilizing the cut portion and the pressing portion before the sandwiching step. A medical sheet cutting jig for cutting a medical sheet,
A cutting portion having a blade for cutting the medical sheet, and an abutting surface that is flush with a tip of the blade;
A pressing portion having a flat surface portion for contacting the surface of the medical sheet and pressing the medical sheet toward the blade;
The medical sheet is placed on the cut portion, the pressing portion is placed on the medical sheet, and the medical sheet is pressed in the direction of the blade until the pressing portion hits the abutting surface. Cutting the medical sheet by
Medical sheet cutting jig. The pressing portion is made of austenitic stainless steel,
The medical sheet cutting jig according to claim 7, wherein the cutting portion including the blade is made of a hardened martensitic stainless steel or a hardened precipitation hardening stainless steel. The pressing portion is made of SUS304 or SUS316,
The medical sheet cutting jig according to claim 8, wherein the cut portion including the blade is made of SUS630 that has been subjected to a curing process.   The medical sheet cutting jig according to any one of claims 7 to 9, further comprising heating means for directly or indirectly heating the medical sheet.   The medical sheet cutting jig according to claim 10, wherein the heating means heats the blade.

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