JP5824038B2 - ルミネセンスベースセンサシステム - Google Patents
ルミネセンスベースセンサシステム Download PDFInfo
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- JP5824038B2 JP5824038B2 JP2013509567A JP2013509567A JP5824038B2 JP 5824038 B2 JP5824038 B2 JP 5824038B2 JP 2013509567 A JP2013509567 A JP 2013509567A JP 2013509567 A JP2013509567 A JP 2013509567A JP 5824038 B2 JP5824038 B2 JP 5824038B2
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- luminescence
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- 238000004020 luminiscence type Methods 0.000 title claims description 17
- 239000000758 substrate Substances 0.000 claims description 98
- 230000003287 optical effect Effects 0.000 claims description 33
- 230000001902 propagating effect Effects 0.000 claims description 10
- 230000005284 excitation Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 238000005401 electroluminescence Methods 0.000 claims description 2
- 238000005452 bending Methods 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000000059 patterning Methods 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000000198 fluorescence anisotropy Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Description
・不要な波長をフィルタするフィルタ
・(通常コリメートされた)光を検出器へ向かって集束するレンズ
・付加的な不要な光を遮断するように集束される光を通すピンホール
・実際の検出器
ステップ、または構成要素の存在を明示することになるが、1つまたは複数の他の特徴、
完全体、ステップ、構成要素、またはこれらの群の存在または追加を排除しない。
Claims (7)
- センサシステムであって、
検出器と、
前記検出器の上方に配置される基板であって、前記基板は、第1の平面および該第1の平面と平行な第2の平面を有し、および、前記基板に形成されたリング型の光学素子を有し、前記リング型の光学素子はリングレンズであり、前記第1の平面は、前記基板上に提供される少なくとも1つのセンサ位置を有し、前記基板は、前記センサ位置に提供されるサンプルの励起中に、前記センサ位置から生じるルミネセンスが前記基板内へ伝搬するように構成され、前記基板の前記第2の平面に形成された前記リング型の光学素子は、臨界角より大きい角度で前記基板内を伝搬する前記ルミネセンスを前記基板外へ選択的に伝送するように構成された、基板と、
前記少なくとも1つのセンサ位置を通る軸に沿って見たときに回転対称である反射面を備え、および、該軸は、前記基板の前記第1および第2の平面と垂直である、別個の光学素子であって、検出されるところの前記検出器に向かって伝送される光のリダイレクションを提供するように前記基板と協働して配置される、別個の光学素子と
を備え、
前記別個の光学素子は円錐形のミラーであり、前記光が前記リングレンズを介して前記基板から出射し、前記円錐形のミラーによりコリメートされることを特徴とするセンサシステム。 - 前記第2の平面は、前記臨界角より大きい角度で前記基板内を伝搬する前記ルミネセンスを、屈折作用によって前記基板外へ伝送させるように構成されたことを特徴とする請求項1に記載のセンサシステム。
- 前記第1の平面は、連続した平面であることを特徴とする請求項1又は請求項2に記載のセンサシステム。
- 前記第2の平面は、該第2の平面で定義された少なくとも1つの摂動を備え、前記摂動は、超臨界角より大きい角度で前記基板内を伝搬する前記ルミネセンスの選択可能な前記基板外への伝送を提供することを特徴とする請求項1から請求項3のいずれか一項に記載のセンサシステム。
- 前記超臨界角より大きい角度で前記基板内を伝搬する前記ルミネセンスは、蛍光信号の1つであり、化学的ルミネセンス信号、または電気的ルミネセンス信号であることを特徴とする請求項1から請求項4のいずれか一項に記載のセンサシステム。
- 複数のセンサ位置を備え、前記センサ位置の各々は、バイオレコグニションサイト(bio-recognition site)を提供する請求項1から請求項5のいずれか一項に記載のセンサシステム。
- サンプルを検出する方法であって、
請求項1から請求項6のいずれか一項に記載されているようなセンサシステムを提供するステップと、
ルミネセンス信号を生成するように前記サンプルを励起するステップと、
前記ルミネセンス信号を検出するステップと
を備えることを特徴とする方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1007921A GB2480293A (en) | 2010-05-12 | 2010-05-12 | A luminescence based sensor |
GB1007921.8 | 2010-05-12 | ||
PCT/EP2011/057653 WO2011141530A2 (en) | 2010-05-12 | 2011-05-11 | A luminescence based sensor |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013527451A JP2013527451A (ja) | 2013-06-27 |
JP2013527451A5 JP2013527451A5 (ja) | 2014-10-02 |
JP5824038B2 true JP5824038B2 (ja) | 2015-11-25 |
Family
ID=42334657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013509567A Active JP5824038B2 (ja) | 2010-05-12 | 2011-05-11 | ルミネセンスベースセンサシステム |
Country Status (6)
Country | Link |
---|---|
US (1) | US9291558B2 (ja) |
EP (1) | EP2569613B1 (ja) |
JP (1) | JP5824038B2 (ja) |
CA (1) | CA2799159C (ja) |
GB (1) | GB2480293A (ja) |
WO (1) | WO2011141530A2 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5575159B2 (ja) * | 2012-01-26 | 2014-08-20 | シャープ株式会社 | 蛍光情報読み取り装置および蛍光情報読み取り方法 |
FI128503B (en) | 2013-02-27 | 2020-06-30 | Teknologian Tutkimuskeskus Vtt Oy | Sample plate and assay procedure |
US9733188B2 (en) | 2015-09-21 | 2017-08-15 | International Business Machines Corporation | Enhancing on-chip fluorescence detection |
TWI789343B (zh) | 2016-02-01 | 2023-01-11 | 丹麥商碩騰丹麥有限公司 | 微流體分析系統、執行分析的微流體匣及方法 |
CN108700730B (zh) * | 2016-02-23 | 2020-12-29 | 株式会社岛津制作所 | 显微分析装置 |
WO2018046689A1 (en) * | 2016-09-08 | 2018-03-15 | Danmarks Tekniske Universitet | A polymeric chip system and uses thereof |
EP3336524A1 (en) * | 2016-12-19 | 2018-06-20 | Universität Zürich | Supercritical angle raman (sar) microscopy |
EP3460456B1 (en) | 2017-09-20 | 2020-08-26 | IMEC vzw | A biosensor system for detecting supercritical angle fluorescent light |
DE102017223851B4 (de) * | 2017-12-28 | 2020-08-06 | Biochip Systems GmbH | Sensoranordnung zur Detektion wenigstens einer stofflichen Eigenschaft einer Probe sowie Mikrotiter-Platte mit einer Vielzahl von Sensoranordnungen |
EP3705875B1 (en) * | 2019-03-05 | 2022-11-30 | IMEC vzw | An apparatus and method for detecting photoluminescent light emitted from a sample |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IES20020041A2 (en) * | 2001-01-23 | 2002-09-04 | Univ Dublin City | A luminescence-based sensor |
US20050009198A1 (en) * | 2001-09-11 | 2005-01-13 | Maccraith Brian | Luminescence-based sensor assembly |
JP4436704B2 (ja) * | 2004-03-12 | 2010-03-24 | オリンパス株式会社 | 光学部材及び複合光学部材並びに照明装置 |
EP2016393A2 (en) * | 2006-05-05 | 2009-01-21 | Dublin City University | Optical probe |
US7750316B2 (en) * | 2006-05-10 | 2010-07-06 | Dublin City University | Polymer biochip for detecting fluorescence |
DE102007020610A1 (de) * | 2007-04-30 | 2008-11-20 | Thomas Dr. Ruckstuhl | Behälter und Verfahren zum Nachweis von Fluoreszenz |
JP2008298771A (ja) | 2007-05-02 | 2008-12-11 | Ritsumeikan | 蛍光顕微鏡用全反射バイオチップ及びその製法、並びに蛍光顕微鏡用全反射バイオチップアセンブリ |
EP2017354A1 (en) | 2007-07-20 | 2009-01-21 | Eppendorf Ag | Detection and/or quantification of target molecules on a solid support |
WO2009021964A2 (en) | 2007-08-13 | 2009-02-19 | Dublin City University | Optical biochip platform with plasmonic structure |
-
2010
- 2010-05-12 GB GB1007921A patent/GB2480293A/en not_active Withdrawn
-
2011
- 2011-05-11 JP JP2013509567A patent/JP5824038B2/ja active Active
- 2011-05-11 WO PCT/EP2011/057653 patent/WO2011141530A2/en active Application Filing
- 2011-05-11 EP EP11723338.7A patent/EP2569613B1/en active Active
- 2011-05-11 US US13/697,278 patent/US9291558B2/en active Active
- 2011-05-11 CA CA2799159A patent/CA2799159C/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2011141530A3 (en) | 2012-02-16 |
EP2569613A2 (en) | 2013-03-20 |
GB201007921D0 (en) | 2010-06-30 |
JP2013527451A (ja) | 2013-06-27 |
EP2569613B1 (en) | 2014-11-12 |
CA2799159C (en) | 2018-10-30 |
GB2480293A (en) | 2011-11-16 |
CA2799159A1 (en) | 2011-11-17 |
US9291558B2 (en) | 2016-03-22 |
WO2011141530A2 (en) | 2011-11-17 |
US20130236982A1 (en) | 2013-09-12 |
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