JP5823287B2 - 分解能の向上したルミネセンス顕微鏡 - Google Patents
分解能の向上したルミネセンス顕微鏡 Download PDFInfo
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- JP5823287B2 JP5823287B2 JP2011506602A JP2011506602A JP5823287B2 JP 5823287 B2 JP5823287 B2 JP 5823287B2 JP 2011506602 A JP2011506602 A JP 2011506602A JP 2011506602 A JP2011506602 A JP 2011506602A JP 5823287 B2 JP5823287 B2 JP 5823287B2
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/58—Optics for apodization or superresolution; Optical synthetic aperture systems
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Microscoopes, Condenser (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008021641.0 | 2008-04-30 | ||
| DE102008021641A DE102008021641A1 (de) | 2008-04-30 | 2008-04-30 | Auflösungsgesteigerte Lumineszenzmikroskopie |
| PCT/EP2009/003036 WO2009132811A1 (de) | 2008-04-30 | 2009-04-25 | Auflösungsgesteigerte lumineszenzmikroskopie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519038A JP2011519038A (ja) | 2011-06-30 |
| JP2011519038A5 JP2011519038A5 (enExample) | 2013-01-31 |
| JP5823287B2 true JP5823287B2 (ja) | 2015-11-25 |
Family
ID=40908471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506602A Expired - Fee Related JP5823287B2 (ja) | 2008-04-30 | 2009-04-25 | 分解能の向上したルミネセンス顕微鏡 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110043619A1 (enExample) |
| EP (1) | EP2277029B1 (enExample) |
| JP (1) | JP5823287B2 (enExample) |
| DE (1) | DE102008021641A1 (enExample) |
| WO (1) | WO2009132811A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009031231A1 (de) * | 2009-06-26 | 2010-12-30 | Carl Zeiss Microlmaging Gmbh | Verfahren und Anordnungen für die Fluoreszenzmikroskopie |
| DE102009060793A1 (de) * | 2009-12-22 | 2011-07-28 | Carl Zeiss Microlmaging GmbH, 07745 | Hochauflösendes Mikroskop und Verfahren zur zwei- oder dreidimensionalen Positionsbestimmung von Objekten |
| US8237786B2 (en) * | 2009-12-23 | 2012-08-07 | Applied Precision, Inc. | System and method for dense-stochastic-sampling imaging |
| DE102010007730B4 (de) * | 2010-02-12 | 2021-08-26 | Leica Microsystems Cms Gmbh | Verfahren und Vorrichtung zum Einstellen eines geeigneten Auswerteparameters für ein Fluoreszenzmikroskop |
| DE102011001091C5 (de) * | 2010-10-19 | 2022-07-14 | Leica Microsystems Cms Gmbh | Verfahren und Einrichtung zur mikroskopischen Bildaufnahme einer Probenstruktur |
| DE102010044013A1 (de) * | 2010-11-16 | 2012-05-16 | Carl Zeiss Microimaging Gmbh | Tiefenauflösungsgesteigerte Mikroskopie |
| EP2663856B1 (en) * | 2011-01-12 | 2025-03-05 | Leica Microsystems CMS GmbH | Cameras and methods for camera-based image processing in microscopy instruments |
| DE102012224306A1 (de) * | 2012-12-21 | 2014-06-26 | Carl Zeiss Microscopy Gmbh | Verfahren zur hochauflösenden 3D-Lokalisierungsmikroskopie |
| DE102013208926A1 (de) * | 2013-05-14 | 2014-11-20 | Carl Zeiss Microscopy Gmbh | Verfahren zur 3D-hochauflösenden Lokalisierungsmikroskopie |
| JP6408796B2 (ja) | 2014-06-11 | 2018-10-17 | オリンパス株式会社 | レーザ顕微鏡装置 |
| JP6375239B2 (ja) * | 2015-02-05 | 2018-08-15 | オリンパス株式会社 | レーザ顕微鏡装置 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4625106A (en) * | 1984-06-29 | 1986-11-25 | The United States Of America As Represented By The Secretary Of The Army | Nonlinear gain microchannel plate image intensifier tube |
| DE4416558C2 (de) | 1994-02-01 | 1997-09-04 | Hell Stefan | Verfahren zum optischen Messen eines Probenpunkts einer Probe und Vorrichtung zur Durchführung des Verfahrens |
| US5866911A (en) | 1994-07-15 | 1999-02-02 | Baer; Stephen C. | Method and apparatus for improving resolution in scanned optical system |
| WO1998028592A1 (de) * | 1996-12-23 | 1998-07-02 | Ruprecht-Karls-Universität Heidelberg | Verfahren und vorrichtungen zur distanzmessung zwischen objektstrukturen |
| DE19908883A1 (de) | 1999-03-02 | 2000-09-07 | Rainer Heintzmann | Verfahren zur Erhöhung der Auflösung optischer Abbildung |
| JP4397993B2 (ja) * | 1999-03-24 | 2010-01-13 | オリンパス株式会社 | 顕微鏡写真撮影装置 |
| JP2002062261A (ja) | 2000-08-21 | 2002-02-28 | Olympus Optical Co Ltd | 光学装置および顕微鏡 |
| GB2399971B (en) * | 2003-01-22 | 2006-07-12 | Proneta Ltd | Imaging sensor optical system |
| DE10325460A1 (de) | 2003-04-13 | 2004-11-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Räumlich hochauflösendes Abbilden |
| DE102004024810A1 (de) * | 2004-05-17 | 2005-12-08 | Soft Imaging System Gmbh | Verfahren und Vorrichtung zur optischen Abtastung einer Probe |
| JP4673000B2 (ja) * | 2004-05-21 | 2011-04-20 | 株式会社キーエンス | 蛍光顕微鏡、蛍光顕微鏡装置を使用した表示方法、蛍光顕微鏡画像表示プログラム及びコンピュータで読み取り可能な記録媒体並びに記憶した機器 |
| EP2453238B1 (en) | 2005-05-23 | 2016-12-21 | Harald F. Hess | Optical microscopy with phototransformable optical labels |
| ATE441103T1 (de) | 2005-07-22 | 2009-09-15 | Zeiss Carl Microimaging Gmbh | Auflísungsgesteigerte lumineszenz-mikroskopie |
| US7619732B2 (en) * | 2006-03-01 | 2009-11-17 | Leica Microsystems Cms Gmbh | Method and microscope for high spatial resolution examination of samples |
| DE102006021317B3 (de) | 2006-05-06 | 2007-10-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren und Fluoreszenzlichtmikroskop zum räumlich hochauflösenden Abbilden einer Struktur einer Probe |
| DE102006026203A1 (de) * | 2006-05-31 | 2007-12-06 | Carl Zeiss Microimaging Gmbh | Verfahren zum räumlich hochauflösenden Abbilden |
| US8421035B2 (en) * | 2006-08-11 | 2013-04-16 | The Regents Of The University Of California | High-resolution microscope using optical amplification |
| DE102008059328A1 (de) * | 2008-11-27 | 2010-06-02 | Carl Zeiss Microimaging Gmbh | Auflösungsgesteigerte Mikroskopie |
-
2008
- 2008-04-30 DE DE102008021641A patent/DE102008021641A1/de not_active Withdrawn
-
2009
- 2009-04-25 JP JP2011506602A patent/JP5823287B2/ja not_active Expired - Fee Related
- 2009-04-25 WO PCT/EP2009/003036 patent/WO2009132811A1/de not_active Ceased
- 2009-04-25 EP EP09737855.8A patent/EP2277029B1/de not_active Not-in-force
- 2009-04-25 US US12/990,455 patent/US20110043619A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE102008021641A1 (de) | 2009-11-05 |
| JP2011519038A (ja) | 2011-06-30 |
| EP2277029B1 (de) | 2017-12-06 |
| EP2277029A1 (de) | 2011-01-26 |
| WO2009132811A1 (de) | 2009-11-05 |
| US20110043619A1 (en) | 2011-02-24 |
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