JP5805071B2 - Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤 - Google Patents

Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤 Download PDF

Info

Publication number
JP5805071B2
JP5805071B2 JP2012504909A JP2012504909A JP5805071B2 JP 5805071 B2 JP5805071 B2 JP 5805071B2 JP 2012504909 A JP2012504909 A JP 2012504909A JP 2012504909 A JP2012504909 A JP 2012504909A JP 5805071 B2 JP5805071 B2 JP 5805071B2
Authority
JP
Japan
Prior art keywords
dna damaging
chk1 inhibitor
cancer
pyrrolo
bromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2012504909A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012523435A (ja
JP2012523435A5 (enExample
Inventor
マイケル ジェイ. ハンフリーズ,
マイケル ジェイ. ハンフリーズ,
シャノン エル. ウィンスキー,
シャノン エル. ウィンスキー,
Original Assignee
アレイ バイオファーマ、インコーポレイテッド
アレイ バイオファーマ、インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アレイ バイオファーマ、インコーポレイテッド, アレイ バイオファーマ、インコーポレイテッド filed Critical アレイ バイオファーマ、インコーポレイテッド
Publication of JP2012523435A publication Critical patent/JP2012523435A/ja
Publication of JP2012523435A5 publication Critical patent/JP2012523435A5/ja
Application granted granted Critical
Publication of JP5805071B2 publication Critical patent/JP5805071B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012504909A 2009-04-11 2010-04-09 Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤 Expired - Fee Related JP5805071B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16856309P 2009-04-11 2009-04-11
US61/168,563 2009-04-11
PCT/US2010/030634 WO2010118390A1 (en) 2009-04-11 2010-04-09 Checkpoint kinase 1 inhibitors for potentiating dna damaging agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014153687A Division JP2014198741A (ja) 2009-04-11 2014-07-29 Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤

Publications (3)

Publication Number Publication Date
JP2012523435A JP2012523435A (ja) 2012-10-04
JP2012523435A5 JP2012523435A5 (enExample) 2013-05-09
JP5805071B2 true JP5805071B2 (ja) 2015-11-04

Family

ID=42651200

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012504909A Expired - Fee Related JP5805071B2 (ja) 2009-04-11 2010-04-09 Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤
JP2014153687A Withdrawn JP2014198741A (ja) 2009-04-11 2014-07-29 Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014153687A Withdrawn JP2014198741A (ja) 2009-04-11 2014-07-29 Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤

Country Status (15)

Country Link
EP (1) EP2416773B1 (enExample)
JP (2) JP5805071B2 (enExample)
KR (1) KR101676062B1 (enExample)
CN (1) CN102612365B (enExample)
AU (1) AU2010233122B2 (enExample)
BR (1) BRPI1013920A2 (enExample)
CA (1) CA2758300C (enExample)
ES (1) ES2608656T3 (enExample)
IL (1) IL215709A (enExample)
MX (1) MX341368B (enExample)
NZ (1) NZ596125A (enExample)
RU (1) RU2567044C2 (enExample)
SG (3) SG10201900212QA (enExample)
WO (1) WO2010118390A1 (enExample)
ZA (1) ZA201108273B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009089352A1 (en) 2008-01-08 2009-07-16 Array Biopharma Inc. Pyrrolopyridines as kinase inhibitors
JP5608098B2 (ja) 2008-01-09 2014-10-15 アレイ バイオファーマ、インコーポレイテッド キナーゼ阻害薬としてのピラゾロピリジン
US8481557B2 (en) 2009-04-11 2013-07-09 Array Biopharma Inc. Method of treatment using checkpoint kinase 1 inhibitors
GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
WO2012074754A1 (en) 2010-11-16 2012-06-07 Array Biopharma Inc. Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors
GB201119799D0 (en) 2011-11-16 2011-12-28 Sentinel Oncology Ltd Pharmaceutical compounds
WO2015053402A1 (ja) 2013-10-11 2015-04-16 国立大学法人東京医科歯科大学 脊髄小脳変性症を予防又は治療するための薬剤
GB201402277D0 (en) 2014-02-10 2014-03-26 Sentinel Oncology Ltd Pharmaceutical compounds
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
WO2020150417A2 (en) * 2019-01-17 2020-07-23 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
KR102285996B1 (ko) * 2019-08-08 2021-08-05 차의과학대학교 산학협력단 혈관신생을 억제하는 데 사용하기 위한 조성물 및 그 용도
WO2021113661A1 (en) 2019-12-05 2021-06-10 Seagen Inc. Amorphous and polymorphic form of a specific chk1 inhibitor
GB202107924D0 (en) 2021-06-03 2021-07-21 Sentinel Oncology Ltd A pharmaceutical salt
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ras相關疾病或病症之組合療法
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003028724A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
CN1882342A (zh) * 2003-09-17 2006-12-20 艾科斯有限公司 Chk1抑制剂在控制细胞增殖中的应用
UY29177A1 (es) * 2004-10-25 2006-05-31 Astex Therapeutics Ltd Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
RU2409361C2 (ru) * 2006-04-04 2011-01-20 Пфайзер Продактс Инк. КОМБИНИРОВАННАЯ ТЕРАПИЯ (2R,Z)-2-АМИНО-2-ЦИКЛОГЕКСИЛ-N-(5-(1-МЕТИЛ-1Н-ПИРАЗОЛ-4-ИЛ)-1-ОКСО-2,6-ДИГИДРО-1Н-[1,2]ДИАЗЕПИНО[4,5,6-cd]ИНДОЛ-8-ИЛ)АЦЕТАМИДОМ
US20100143332A1 (en) * 2006-11-17 2010-06-10 Schering Corporation Combination therapy for proliferative disorders
AR071717A1 (es) * 2008-05-13 2010-07-07 Array Biopharma Inc Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer.

Also Published As

Publication number Publication date
RU2011145773A (ru) 2013-05-20
SG10201404012RA (en) 2014-09-26
EP2416773A1 (en) 2012-02-15
MX341368B (es) 2016-08-17
IL215709A (en) 2017-06-29
SG10201900212QA (en) 2019-02-27
AU2010233122A1 (en) 2011-11-24
IL215709A0 (en) 2012-01-31
EP2416773B1 (en) 2016-09-28
JP2012523435A (ja) 2012-10-04
BRPI1013920A2 (pt) 2016-04-05
AU2010233122B2 (en) 2015-09-17
ES2608656T3 (es) 2017-04-12
WO2010118390A1 (en) 2010-10-14
JP2014198741A (ja) 2014-10-23
RU2567044C2 (ru) 2015-10-27
CN102612365A (zh) 2012-07-25
CA2758300C (en) 2017-07-25
NZ596125A (en) 2012-08-31
CN102612365B (zh) 2017-04-12
KR101676062B1 (ko) 2016-11-14
SG175242A1 (en) 2011-11-28
ZA201108273B (en) 2013-07-31
CA2758300A1 (en) 2010-10-14
KR20120004523A (ko) 2012-01-12
MX2011010675A (es) 2012-03-16

Similar Documents

Publication Publication Date Title
JP5805071B2 (ja) Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤
KR101884960B1 (ko) 체크포인트 키나제 1 억제제 및 wee 1 키나제 억제제의 조합
US9155726B2 (en) Method of treatment using checkpoint kinase 1 inhibitors
WO2015070020A2 (en) Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
TW201107327A (en) Therapeutic combination comprising a PLK1 inhibitor and an antineoplastic agent
TW201127384A (en) Therapeutic combination comprising a Cdc7 inhibitor and an antineoplastic agent
KR20110025172A (ko) 약제학적 병용물
CN112022871A (zh) 金诺芬在制备用于治疗去势抵抗性前列腺癌药物中的应用
EP2344156B1 (en) Therapeutic combination comprising an aurora kinase inhibitor and an antineoplastic agent
HK1165273B (en) Checkpoint kinase 1 inhibitors for potentiating dna damaging agents
TW201605449A (zh) 馬賽替尼治療結腸直腸癌的用途
Conkel et al. Afuresertib: Protein kinase B (PKB) inhibitor oncolytic
HK1183792B (en) Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors
HK1183792A (en) Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130321

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130321

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140410

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140709

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140716

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140729

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20141225

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150324

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150427

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150806

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150901

R150 Certificate of patent or registration of utility model

Ref document number: 5805071

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees