JP5795699B2 - 人工免疫システム：作製および使用方法 - Google Patents

人工免疫システム：作製および使用方法 Download PDF

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JP5795699B2
JP5795699B2 JP2007510930A JP2007510930A JP5795699B2 JP 5795699 B2 JP5795699 B2 JP 5795699B2 JP 2007510930 A JP2007510930 A JP 2007510930A JP 2007510930 A JP2007510930 A JP 2007510930A JP 5795699 B2 JP5795699 B2 JP 5795699B2
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cells
cell
matrix
culture
lte
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JP2007537732A5 (https=
JP2007537732A (ja
Inventor
ウィリアム エル． ウォーレン，
ウィリアム エル． ウォーレン，
へザー ファーレンカンプ，
へザー ファーレンカンプ，
ラッセル ヒグビー，
ラッセル ヒグビー，
アナトリー カチュリン，
アナトリー カチュリン，
コナン ケー． エヌ． リー，
コナン ケー． エヌ． リー，
マイク グエン，
マイク グエン，
ロバート パークヒル，
ロバート パークヒル，
グスマン サンチェス，
グスマン サンチェス，
ダレル ジェイ． アーバイン，
ダレル ジェイ． アーバイン，
グウェンダリン ランドルフ，
グウェンダリン ランドルフ，
ニール ハコーエン，
ニール ハコーエン，
ブルース トーベット，
ブルース トーベット，
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サノフィ パスツール ヴァックスデザイン コーポレーション
サノフィ パスツール ヴァックスデザイン コーポレーション
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    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
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    • C12N2535/00—Supports or coatings for cell culture characterised by topography
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  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2007510930A 2004-04-28 2005-04-28 人工免疫システム：作製および使用方法 Expired - Lifetime JP5795699B2 (ja)

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US56584604P 2004-04-28 2004-04-28
US60/565,846 2004-04-28
PCT/US2005/014444 WO2005104755A2 (en) 2004-04-28 2005-04-28 Artificial immune system: methods for making and use

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JP2013098855A Division JP2013208120A (ja) 2004-04-28 2013-05-08 人工免疫システム：作製および使用方法

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JP2007537732A JP2007537732A (ja) 2007-12-27
JP2007537732A5 JP2007537732A5 (https=) 2015-08-27
JP5795699B2 true JP5795699B2 (ja) 2015-10-14

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JP2007510930A Expired - Lifetime JP5795699B2 (ja) 2004-04-28 2005-04-28 人工免疫システム：作製および使用方法
JP2013098855A Withdrawn JP2013208120A (ja) 2004-04-28 2013-05-08 人工免疫システム：作製および使用方法
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EP (1) EP1758985B1 (https=)
JP (3) JP5795699B2 (https=)
AU (2) AU2005237588B2 (https=)
CA (1) CA2564512C (https=)
WO (1) WO2005104755A2 (https=)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7785883B2 (en) * 2004-04-28 2010-08-31 Vax Design Corp. Automatable artificial immune system (AIS)
US7771999B2 (en) 2004-04-28 2010-08-10 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US8071373B2 (en) 2004-04-28 2011-12-06 Sanofi Pasteur Vaxdesign Corp. Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
US8298824B2 (en) 2004-04-28 2012-10-30 Sanofi Pasteur Vaxdesign Corporation Methods of evaluating a test agent in a diseased cell model
US7785806B2 (en) 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
JP5795699B2 (ja) * 2004-04-28 2015-10-14 サノフィ パスツール ヴァックスデザイン コーポレーション 人工免疫システム：作製および使用方法
US7709256B2 (en) * 2004-04-28 2010-05-04 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US20070141552A1 (en) * 2004-04-28 2007-06-21 Warren William L Automatable artificial immune system (AIS)
US20060275270A1 (en) * 2004-04-28 2006-12-07 Warren William L In vitro mucosal tissue equivalent
US7855074B2 (en) 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
US8030070B2 (en) * 2004-04-28 2011-10-04 Sanofi Pasteur Vaxdesign Corp. Artificial lymphoid tissue equivalent
WO2007066684A1 (ja) 2005-12-07 2007-06-14 Effector Cell Institute, Inc. 細胞運動計測方法およびシステム
WO2007070660A2 (en) 2005-12-13 2007-06-21 President And Fellows Of Harvard College Scaffolds for cell transplantation
US20070178076A1 (en) * 2005-12-21 2007-08-02 Drake Donald Iii Porous membrane device that promotes the differentiation of monocytes into dendritic cells
WO2007075979A2 (en) 2005-12-21 2007-07-05 Vaxdesign Corporation In vitro germinal centers
US20090041825A1 (en) * 2006-02-10 2009-02-12 Kotov Nicholas A Cell culture well-plates having inverted colloidal crystal scaffolds
EP2409715A1 (en) * 2006-06-27 2012-01-25 Sanofi Pasteur VaxDesign Corporation Models for vaccine assessment
US20080003670A1 (en) * 2006-06-30 2008-01-03 Corning Incorporated High density permeable supports for high throughput screening
WO2009048661A1 (en) 2007-07-16 2009-04-16 Vaxdesign Corporation Artificial tissue constructs comprising alveolar cells and methods for using the same
CN101918532B (zh) * 2007-08-22 2016-03-30 普罗柏欧贞股份公司 用于体外测试免疫原性和免疫功能的培养系统和方法
PL2210080T3 (pl) * 2007-10-24 2015-06-30 Biomarker Strategies Llc Ulepszone sposoby i urządzenia do analizy komórkowej
EP2238447B1 (en) 2008-01-10 2015-02-25 L'Oreal, S.A. Immune system modeling devices and methods
CN102006891B (zh) 2008-02-13 2017-04-26 哈佛学院董事会 连续的细胞程序化装置
EP2260097B1 (en) * 2008-03-12 2017-04-26 Sanofi Pasteur VaxDesign Corporation Disease model incorporation into an artificial immune system (ais)
AU2010278702C1 (en) 2009-07-31 2016-07-14 Forsyth Dental Infirmary For Children Programming of cells for tolerogenic therapies
JP5734595B2 (ja) * 2010-08-03 2015-06-17 オリンパス株式会社 コロニーの特性評価方法
CN107648668B (zh) 2010-10-06 2021-06-18 哈佛学院董事会 用于基于材料的细胞疗法的可注射的成孔水凝胶
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
DK2838515T3 (da) 2012-04-16 2020-02-24 Harvard College Mesoporøse siliciumdioxidsammensætninger til modulering af immunresponser
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
EP3137105A4 (en) 2014-04-30 2017-12-27 President and Fellows of Harvard College Combination vaccine devices and methods of killing cancer cells
US11786457B2 (en) 2015-01-30 2023-10-17 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
WO2016164705A1 (en) 2015-04-10 2016-10-13 Omar Abdel-Rahman Ali Immune cell trapping devices and methods for making and using the same
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
JP6755085B2 (ja) * 2015-11-10 2020-09-16 日機装株式会社 細胞支持複合体および細胞支持複合体の製造方法
US11752238B2 (en) 2016-02-06 2023-09-12 President And Fellows Of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN109789092A (zh) 2016-07-13 2019-05-21 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
AU2017298298B2 (en) 2016-07-18 2024-03-07 President And Fellows Of Harvard College Human lymphoid tissue-on-chip
IL264557B2 (en) 2016-08-02 2024-01-01 Harvard College Biological agents for regulating immune responses
AU2017325009B2 (en) * 2016-09-08 2023-07-20 Sanofi Pasteur Vaxdesign Corp. In vitro neonatal biomimetic (NMIMIC) model and methods of using same
KR102492455B1 (ko) * 2016-11-24 2023-01-27 알베오릭스 테크놀러지스 아게 세포 배양 시스템 및 방법
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
US12104149B2 (en) 2018-05-15 2024-10-01 The University Of North Carolina At Chapel Hill Devices, systems and apparatuses for generating self-sustaining hypoxic conditions and gaseous and non-gaseous chemical gradients for in vitro cell culture
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
EP3880785A4 (en) 2018-11-16 2022-08-24 The University of North Carolina at Chapel Hill In vitro cell culture mucus systems
EP4031866A4 (en) * 2019-09-16 2023-10-11 University of Delaware EX VIVO LYMPHATIC NODE AND ITS USES
WO2021061837A1 (en) 2019-09-23 2021-04-01 President And Fellows Of Harvard College Biomaterial-based antigen free vaccine and the use thereof
JP2022099325A (ja) * 2020-12-22 2022-07-04 株式会社日本触媒 スフェロイド及びその作製方法
WO2023228182A1 (en) * 2022-05-23 2023-11-30 Pluri Biotech Ltd. System and methods for immune cells expansion and activation in large scale
US20260028593A1 (en) * 2022-07-15 2026-01-29 Parallel Biosystems, Inc. Compositions and methods for producing antibody-generating immune organoids

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5160490A (en) * 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US5008116A (en) * 1988-11-14 1991-04-16 Frederick Cahn Immunostimulatory microsphere
JPH0310674A (ja) * 1989-06-09 1991-01-18 Terumo Corp 細胞培養用多孔質膜およびそれを用いた細胞培養器
US5514555A (en) * 1993-03-12 1996-05-07 Center For Blood Research, Inc. Assays and therapeutic methods based on lymphocyte chemoattractants
US5695996A (en) * 1994-09-23 1997-12-09 The United States Of America As Represented By The Department Of Health And Human Services Artificial organ culture system
JP3593032B2 (ja) * 1997-09-10 2004-11-24 純一 益山 ヒト単核球に対するモノクローナル抗体
CN1272878A (zh) * 1997-09-25 2000-11-08 基质细胞有限责任公司 造血祖细胞长时培养的方法和设备
AU2797799A (en) * 1998-02-27 1999-09-15 Anticancer, Inc. (in vitro) model for viral infection and immune response
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
CN1423523A (zh) 1999-11-17 2003-06-11 罗切斯特大学 来自人体内的免疫系统
AU2003275421A1 (en) * 2002-10-03 2004-04-23 Andrea Bottaro Three-dimensional peripheral lymphoid organ cell cultures
EP1479760A1 (de) * 2003-05-19 2004-11-24 ProBioGen AG Künstliches Immunorgan
JP5795699B2 (ja) * 2004-04-28 2015-10-14 サノフィ パスツール ヴァックスデザイン コーポレーション 人工免疫システム：作製および使用方法

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WO2005104755A2 (en) 2005-11-10
AU2010212355B2 (en) 2012-01-12
EP1758985A2 (en) 2007-03-07
JP2015180202A (ja) 2015-10-15
CA2564512A1 (en) 2005-11-10
JP2007537732A (ja) 2007-12-27
EP1758985B1 (en) 2015-06-03
JP2013208120A (ja) 2013-10-10
AU2005237588B2 (en) 2010-07-08
WO2005104755A3 (en) 2008-08-21
EP1758985A4 (en) 2009-04-29
AU2005237588A1 (en) 2005-11-10
AU2010212355A1 (en) 2010-09-09
CA2564512C (en) 2014-03-18

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