JP5779106B2 - 抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体 - Google Patents

抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体 Download PDF

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Publication number
JP5779106B2
JP5779106B2 JP2011551313A JP2011551313A JP5779106B2 JP 5779106 B2 JP5779106 B2 JP 5779106B2 JP 2011551313 A JP2011551313 A JP 2011551313A JP 2011551313 A JP2011551313 A JP 2011551313A JP 5779106 B2 JP5779106 B2 JP 5779106B2
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Prior art keywords
hooi
compound
pharmaceutical composition
lysine
item
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JP2011551313A
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Japanese (ja)
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JP2012518659A (ja
JP2012518659A5 (https=
Inventor
リー ロイ モーガン，
リー ロイ モーガン，
Original Assignee
デック−テック， インコーポレイテッド
デック−テック， インコーポレイテッド
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2011551313A 2009-02-24 2010-02-24 抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体 Expired - Fee Related JP5779106B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15507209P 2009-02-24 2009-02-24
US61/155,072 2009-02-24
PCT/US2010/025252 WO2010099213A1 (en) 2009-02-24 2010-02-24 Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents

Publications (3)

Publication Number Publication Date
JP2012518659A JP2012518659A (ja) 2012-08-16
JP2012518659A5 JP2012518659A5 (https=) 2013-02-21
JP5779106B2 true JP5779106B2 (ja) 2015-09-16

Family

ID=42111918

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011551313A Expired - Fee Related JP5779106B2 (ja) 2009-02-24 2010-02-24 抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体

Country Status (6)

Country Link
US (1) US8361992B2 (https=)
EP (1) EP2401285B1 (https=)
JP (1) JP5779106B2 (https=)
AU (1) AU2010218109B2 (https=)
CA (1) CA2753041A1 (https=)
WO (1) WO2010099213A1 (https=)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5230519B2 (https=) * 1972-04-05 1977-08-09
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
EP0334083B1 (de) * 1988-03-19 1991-07-24 ASTA Pharma Aktiengesellschaft Ifosfamid-Mesna-Lyophilisat und Verfahren zu dessen Herstellung
JPH07505887A (ja) 1992-04-17 1995-06-29 アボツト・ラボラトリーズ タキソール誘導体
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
DE60330407D1 (de) 2002-08-23 2010-01-14 Sloan Kettering Inst Cancer Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung
WO2006000422A1 (de) * 2004-06-29 2006-01-05 Baxter International Inc. Verfahren zur herstellung von lagerstabiler mafosfamid-lysin-salz lyophilisat bulkware
ES2565929T3 (es) 2004-10-25 2016-04-07 Dekk-Tec, Inc. Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales
ES2547302T3 (es) * 2007-04-06 2015-10-05 Ziopharm Oncology, Inc. Sales de mostaza de isofosforamida y análogos de las mismas

Also Published As

Publication number Publication date
AU2010218109A2 (en) 2011-09-22
US8361992B2 (en) 2013-01-29
JP2012518659A (ja) 2012-08-16
EP2401285A1 (en) 2012-01-04
AU2010218109B2 (en) 2015-04-09
HK1165805A1 (en) 2012-10-12
CA2753041A1 (en) 2010-09-02
US20110319365A1 (en) 2011-12-29
EP2401285B1 (en) 2012-10-10
WO2010099213A1 (en) 2010-09-02
AU2010218109A1 (en) 2011-09-22

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