AU2010218109B2 - Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents - Google Patents

Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents Download PDF

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Publication number
AU2010218109B2
AU2010218109B2 AU2010218109A AU2010218109A AU2010218109B2 AU 2010218109 B2 AU2010218109 B2 AU 2010218109B2 AU 2010218109 A AU2010218109 A AU 2010218109A AU 2010218109 A AU2010218109 A AU 2010218109A AU 2010218109 B2 AU2010218109 B2 AU 2010218109B2
Authority
AU
Australia
Prior art keywords
compound
hooi
ammonium
tumor
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010218109A
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English (en)
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AU2010218109A1 (en
AU2010218109A2 (en
Inventor
Lee Roy Morgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dekk Tek Inc
Original Assignee
Dekk Tek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dekk Tek Inc filed Critical Dekk Tek Inc
Publication of AU2010218109A1 publication Critical patent/AU2010218109A1/en
Publication of AU2010218109A2 publication Critical patent/AU2010218109A2/en
Application granted granted Critical
Publication of AU2010218109B2 publication Critical patent/AU2010218109B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2010218109A 2009-02-24 2010-02-24 Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents Ceased AU2010218109B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15507209P 2009-02-24 2009-02-24
US61/155,072 2009-02-24
PCT/US2010/025252 WO2010099213A1 (en) 2009-02-24 2010-02-24 Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents

Publications (3)

Publication Number Publication Date
AU2010218109A1 AU2010218109A1 (en) 2011-09-22
AU2010218109A2 AU2010218109A2 (en) 2011-09-22
AU2010218109B2 true AU2010218109B2 (en) 2015-04-09

Family

ID=42111918

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010218109A Ceased AU2010218109B2 (en) 2009-02-24 2010-02-24 Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents

Country Status (6)

Country Link
US (1) US8361992B2 (https=)
EP (1) EP2401285B1 (https=)
JP (1) JP5779106B2 (https=)
AU (1) AU2010218109B2 (https=)
CA (1) CA2753041A1 (https=)
WO (1) WO2010099213A1 (https=)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421559A (en) * 1972-04-05 1976-01-21 Shionogi & Co Cyclic phosphorus derivatives having pharmaceutical properties

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
EP0334083B1 (de) * 1988-03-19 1991-07-24 ASTA Pharma Aktiengesellschaft Ifosfamid-Mesna-Lyophilisat und Verfahren zu dessen Herstellung
CA2130578A1 (en) 1992-04-17 1993-10-28 Geewananda P. Gunawardana Taxol derivatives
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
EP2186811A1 (en) 2002-08-23 2010-05-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
WO2006000422A1 (de) * 2004-06-29 2006-01-05 Baxter International Inc. Verfahren zur herstellung von lagerstabiler mafosfamid-lysin-salz lyophilisat bulkware
EP2336140B1 (en) * 2004-10-25 2016-01-27 Dekk-Tec, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
MX2009010820A (es) * 2007-04-06 2010-03-18 Ziopharm Oncology Inc Sales de mostaza isofosforamida y analogos de la misma.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421559A (en) * 1972-04-05 1976-01-21 Shionogi & Co Cyclic phosphorus derivatives having pharmaceutical properties

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STYCZYNSKI, J. et al. ACTS BIOCHIMICA POLONICA 49(1) pages 221 to 225 *

Also Published As

Publication number Publication date
JP5779106B2 (ja) 2015-09-16
EP2401285A1 (en) 2012-01-04
CA2753041A1 (en) 2010-09-02
US20110319365A1 (en) 2011-12-29
US8361992B2 (en) 2013-01-29
EP2401285B1 (en) 2012-10-10
AU2010218109A1 (en) 2011-09-22
JP2012518659A (ja) 2012-08-16
AU2010218109A2 (en) 2011-09-22
HK1165805A1 (en) 2012-10-12
WO2010099213A1 (en) 2010-09-02

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 01 SEP 2011

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired