JP5775568B2 - 診断方法 - Google Patents

診断方法 Download PDF

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Publication number
JP5775568B2
JP5775568B2 JP2013510677A JP2013510677A JP5775568B2 JP 5775568 B2 JP5775568 B2 JP 5775568B2 JP 2013510677 A JP2013510677 A JP 2013510677A JP 2013510677 A JP2013510677 A JP 2013510677A JP 5775568 B2 JP5775568 B2 JP 5775568B2
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JP
Japan
Prior art keywords
protein
panel
polypeptide
sample
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013510677A
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English (en)
Japanese (ja)
Other versions
JP2013531784A (ja
JP2013531784A5 (enExample
Inventor
ロイク ジェラルド ダヨン
ロイク ジェラルド ダヨン
ジャン−チャールズ サンチェス
ジャン−チャールズ サンチェス
ヴィラロンガ ジュアン モンタナ
ヴィラロンガ ジュアン モンタナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Geneve
Fundacio Institut de Recerca Hospital Universitari Vall dHebron
Proteome Sciences PLC
Original Assignee
Universite de Geneve
Fundacio Institut de Recerca Hospital Universitari Vall dHebron
Electrophoretics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Universite de Geneve, Fundacio Institut de Recerca Hospital Universitari Vall dHebron, Electrophoretics Ltd filed Critical Universite de Geneve
Publication of JP2013531784A publication Critical patent/JP2013531784A/ja
Publication of JP2013531784A5 publication Critical patent/JP2013531784A5/ja
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0065Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088Glutathione transferase (2.5.1.18)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2013510677A 2010-05-21 2011-05-23 診断方法 Expired - Fee Related JP5775568B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1008541.3A GB201008541D0 (en) 2010-05-21 2010-05-21 Diagnostic methods
GB1008541.3 2010-05-21
PCT/GB2011/000784 WO2011144914A2 (en) 2010-05-21 2011-05-23 Diagnostic methods

Publications (3)

Publication Number Publication Date
JP2013531784A JP2013531784A (ja) 2013-08-08
JP2013531784A5 JP2013531784A5 (enExample) 2014-05-08
JP5775568B2 true JP5775568B2 (ja) 2015-09-09

Family

ID=42341144

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013510677A Expired - Fee Related JP5775568B2 (ja) 2010-05-21 2011-05-23 診断方法

Country Status (7)

Country Link
US (1) US20130252834A1 (enExample)
EP (1) EP2572202A2 (enExample)
JP (1) JP5775568B2 (enExample)
AU (1) AU2011254386B2 (enExample)
CA (1) CA2800038A1 (enExample)
GB (1) GB201008541D0 (enExample)
WO (1) WO2011144914A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012051519A2 (en) * 2010-10-14 2012-04-19 The Johns Hopkins University Biomarkers of brain injury
WO2012155134A2 (en) 2011-05-12 2012-11-15 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
WO2013104720A2 (en) * 2012-01-12 2013-07-18 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Brain damage marker
US9709573B2 (en) 2012-03-13 2017-07-18 The Johns Hopkins University Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration
EP3022322A4 (en) 2013-07-17 2017-05-17 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
CN103432574B (zh) * 2013-08-25 2015-04-08 浙江大学 一种过氧化物酶在制备防治脑血管疾病药物中的应用
WO2015038784A1 (en) * 2013-09-13 2015-03-19 The Board Of Trustees Of The Leland Stanford Junior University Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry
US20180238907A1 (en) * 2014-10-06 2018-08-23 Université de Genéve Markers and their use in brain injury
WO2017174557A2 (en) 2016-04-04 2017-10-12 Brains Online Holding B.V. Use of push pull microdialysis in combination with shotgun proteomics for analyzing the proteome in extracellular space of brain
WO2018148294A2 (en) * 2017-02-07 2018-08-16 Bioregency, Inc. S100β AND ISOFORMS FOR DETECTION OF NEUROLOGICAL CONDITIONS
CN107748263A (zh) * 2017-08-31 2018-03-02 北京臻惠康生物科技有限公司 一种纤维蛋白溶酶原的新用途及试剂盒
CN109536469B (zh) * 2018-11-23 2021-02-09 北华大学 突变改造Prx6蛋白及其表达基因、制备方法和应用
MX2022009880A (es) * 2020-02-14 2022-08-22 Galaxy Ccro Inc Dispositivos y metodos para tratar la isquemia y sindromes de dificultad respiratoria aguda.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2263063C (en) * 1999-02-26 2004-08-10 Skye Pharmatech Incorporated Method for diagnosing and distinguishing stroke and diagnostic devices for use therein
AU2004274710B2 (en) * 2003-09-20 2011-05-19 Electrophoretics Limited Diagnostic method for brain damage-related disorders
US20080307537A1 (en) * 2005-03-31 2008-12-11 Dana-Farber Cancer Institute, Inc. Compositions and Methods for the Identification, Assessment, Prevention, and Therapy of Neurological Diseases, Disorders and Conditions
JP4521512B2 (ja) * 2005-06-15 2010-08-11 独立行政法人産業技術総合研究所 痴呆症の診断方法及び診断キット
GB2428240A (en) * 2005-07-14 2007-01-24 Univ Gen Ve Diagnostic method for brain damage-related disorders
EP2057465A4 (en) * 2006-08-09 2010-04-21 Homestead Clinical Corp ORGANIC PROTEINS AND METHOD OF USE THEREOF

Also Published As

Publication number Publication date
AU2011254386A1 (en) 2012-12-06
AU2011254386B2 (en) 2017-01-12
EP2572202A2 (en) 2013-03-27
US20130252834A1 (en) 2013-09-26
CA2800038A1 (en) 2011-11-24
JP2013531784A (ja) 2013-08-08
GB201008541D0 (en) 2010-07-07
WO2011144914A3 (en) 2012-03-29
WO2011144914A2 (en) 2011-11-24

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