JP5770161B2 - 血小板への第ｖｉｉｉ因子タンパク質の標的送達 - Google Patents
血小板への第ｖｉｉｉ因子タンパク質の標的送達 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21200409P | 2009-04-06 | 2009-04-06 | |
| US61/212,004 | 2009-04-06 | ||
| US18607509P | 2009-06-11 | 2009-06-11 | |
| US61/186,075 | 2009-06-11 | ||
| PCT/EP2010/054495 WO2010115866A1 (en) | 2009-04-06 | 2010-04-06 | Targeted delivery of factor viii proteins to platelets |
Related Child Applications (1)
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| EP (1) | EP2417155B1 (OSRAM) |
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| CN (1) | CN102482340B (OSRAM) |
| ES (1) | ES2427627T3 (OSRAM) |
| WO (1) | WO2010115866A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015166391A (ja) * | 2009-04-06 | 2015-09-24 | ノヴォ ノルディスク アー／エス | 血小板への第ｖｉｉｉ因子タンパク質の標的送達 |
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| JP5997443B2 (ja) * | 2008-05-16 | 2016-09-28 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ | 標的化凝固因子およびそれを使用する方法 |
| US20130040888A1 (en) * | 2010-02-16 | 2013-02-14 | Novo Nordisk A/S | Factor VIII Molecules With Reduced VWF Binding |
| CN102812039B (zh) * | 2010-02-16 | 2016-01-20 | 诺沃—诺迪斯克有限公司 | 缀合蛋白质 |
| SI2591006T1 (sl) | 2010-07-09 | 2019-10-30 | Bioverativ Therapeutics Inc | Enoverižne molekule, ki jih lahko obdelujemo in polipeptidi izdelani z njihovo uporabo |
| CA2828769A1 (en) * | 2011-03-02 | 2012-09-07 | Novo Nordisk A/S | Coagulation factor-targeting to tlt-1 on activated platelets |
| US10202595B2 (en) | 2012-06-08 | 2019-02-12 | Bioverativ Therapeutics Inc. | Chimeric clotting factors |
| JP2015521589A (ja) | 2012-06-08 | 2015-07-30 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | プロコアグラント化合物 |
| WO2014041500A2 (en) * | 2012-09-12 | 2014-03-20 | Centre For Bioseparation Technology-Vit | Double mutant coagulation factor viii and methods thereof |
| CN104661685A (zh) | 2012-10-15 | 2015-05-27 | 诺和诺德保健Ag（股份有限公司） | 因子vii缀合物 |
| EP2914293A4 (en) | 2012-10-30 | 2016-04-20 | Biogen Ma Inc | METHOD OF USE OF FVIII POLYPEPTIDE |
| DK3889173T5 (da) | 2013-02-15 | 2024-08-05 | Bioverativ Therapeutics Inc | Optimeret faktor viii-gen |
| TWI745671B (zh) | 2013-03-15 | 2021-11-11 | 美商百歐維拉提夫治療公司 | 因子ｉｘ多肽調配物 |
| UY35462A (es) * | 2013-03-15 | 2014-10-31 | Biogen Idec Inc | Formulación de un polipéptido del factor viii. |
| US10364288B2 (en) | 2013-05-24 | 2019-07-30 | Biogen Ma Inc. | Anti-GPIIB/IIIA antibodies or uses thereof |
| AU2014336252A1 (en) | 2013-10-15 | 2016-04-07 | Novo Nordisk Health Care Ag | Coagulation factor VII polypeptides |
| US10325687B2 (en) | 2013-12-06 | 2019-06-18 | Bioverativ Therapeutics Inc. | Population pharmacokinetics tools and uses thereof |
| EP3097118B1 (en) | 2014-01-20 | 2018-07-18 | Octapharma AG | A process for manufacturing factor viii having an improved ratio of fviii:c/fviii:ag |
| EP3160478A4 (en) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimized factor ix gene |
| PL3177317T3 (pl) | 2014-08-04 | 2020-07-27 | Csl Limited | Formulacja czynnika viii |
| MA40835A (fr) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
| CA2978374A1 (en) | 2015-03-06 | 2016-09-15 | Csl Behring Recombinant Facility Ag | Modified von willebrand factor having improved half-life |
| JP2018533017A (ja) * | 2015-10-02 | 2018-11-08 | ティージーアール バイオサイエンシス ピーティーワイ エルティーディー． | 多基体による検体検出 |
| AU2016353353B2 (en) | 2015-11-13 | 2020-07-09 | Takeda Pharmaceutical Company Limited | Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A |
| EP3411478B1 (en) | 2016-02-01 | 2022-06-08 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
| EP3205665A1 (en) * | 2016-02-11 | 2017-08-16 | Octapharma AG | Method of separating factor viii from blood products |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| US12091675B2 (en) | 2018-07-16 | 2024-09-17 | Takeda Pharmaceutical Company Limited | Gene therapy of hemophilia a using viral vectors encoding recombinant FVIII variants with increased expression |
| TWI851647B (zh) | 2019-01-16 | 2024-08-11 | 日商武田藥品工業股份有限公司 | 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體 |
| US20220389082A1 (en) | 2019-07-04 | 2022-12-08 | CSL Behring Lengnau AG | A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii |
| CN115279896A (zh) | 2019-09-30 | 2022-11-01 | 比奥维拉迪维治疗股份有限公司 | 慢病毒载体配制品 |
| JP7680442B2 (ja) | 2019-11-11 | 2025-05-20 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 第ｖｉｉｉ因子に対する寛容を誘導するためのポリペプチド |
| KR20230074703A (ko) | 2020-06-24 | 2023-05-31 | 바이오버라티브 테라퓨틱스 인크. | 유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법 |
| CN113248594B (zh) * | 2021-04-26 | 2022-08-30 | 北京美康基免生物科技有限公司 | 一种重组凝血因子viii及其应用 |
| WO2024165823A2 (fr) | 2023-02-09 | 2024-08-15 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Fragment fab mutant pour l'obtention de conjugués mono- ou bi-fonctionnalisés site-spécifiques |
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| AU2645588A (en) * | 1987-12-04 | 1989-06-15 | Scripps Clinic And Research Foundation | The von willebrand factor binding domain of factor viii |
| KR940009084B1 (ko) * | 1988-05-18 | 1994-09-29 | 체크 포인트 시스템스, 인코오퍼레이티드 | 자기 및 공명회로 검출용 안테나 시스템 |
| JPH0433A (ja) | 1990-04-11 | 1992-01-06 | Nissan Motor Co Ltd | 粘度可変流体封入制御型エンジンマウント |
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| ATE198712T1 (de) * | 1994-07-11 | 2001-02-15 | Univ Texas | Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
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| WO2006013202A2 (en) | 2004-08-02 | 2006-02-09 | Novo Nordisk Health Care Ag | Conjugation of fvii |
| DE602005008071D1 (de) | 2004-08-13 | 2008-08-21 | Hoffmann La Roche | C-terminale modifikation von polypeptiden |
| US20080227691A1 (en) * | 2005-04-01 | 2008-09-18 | Novo Nordisk Health Care Ag | Blood Coagulation FVIII Analogues |
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| KR101542752B1 (ko) * | 2006-12-22 | 2015-08-10 | 체에스엘 베링 게엠베하 | 연장된 생체내 반감기를 갖는 변형된 응고 인자 |
| RU2573587C2 (ru) * | 2008-02-27 | 2016-01-20 | Ново Нордиск А/С | Конъюгированные молекулы фактора viii |
| JP5997443B2 (ja) * | 2008-05-16 | 2016-09-28 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ | 標的化凝固因子およびそれを使用する方法 |
| WO2010115866A1 (en) * | 2009-04-06 | 2010-10-14 | Novo Nordisk A/S | Targeted delivery of factor viii proteins to platelets |
-
2010
- 2010-04-06 WO PCT/EP2010/054495 patent/WO2010115866A1/en not_active Ceased
- 2010-04-06 JP JP2012503990A patent/JP5770161B2/ja not_active Expired - Fee Related
- 2010-04-06 CN CN201080015319.1A patent/CN102482340B/zh not_active Expired - Fee Related
- 2010-04-06 ES ES10715162T patent/ES2427627T3/es active Active
- 2010-04-06 US US13/262,178 patent/US20120093840A1/en not_active Abandoned
- 2010-04-06 EP EP10715162.3A patent/EP2417155B1/en not_active Not-in-force
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2015
- 2015-06-23 JP JP2015125394A patent/JP2015166391A/ja active Pending
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015166391A (ja) * | 2009-04-06 | 2015-09-24 | ノヴォ ノルディスク アー／エス | 血小板への第ｖｉｉｉ因子タンパク質の標的送達 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20160251409A1 (en) | 2016-09-01 |
| JP2015166391A (ja) | 2015-09-24 |
| JP2012522529A (ja) | 2012-09-27 |
| EP2417155B1 (en) | 2013-06-19 |
| WO2010115866A1 (en) | 2010-10-14 |
| US20120093840A1 (en) | 2012-04-19 |
| ES2427627T3 (es) | 2013-10-31 |
| CN102482340B (zh) | 2015-05-13 |
| CN102482340A (zh) | 2012-05-30 |
| EP2417155A1 (en) | 2012-02-15 |
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