JP5769940B2 - 歯の知覚過敏処置用組成物 - Google Patents
歯の知覚過敏処置用組成物 Download PDFInfo
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- JP5769940B2 JP5769940B2 JP2010173428A JP2010173428A JP5769940B2 JP 5769940 B2 JP5769940 B2 JP 5769940B2 JP 2010173428 A JP2010173428 A JP 2010173428A JP 2010173428 A JP2010173428 A JP 2010173428A JP 5769940 B2 JP5769940 B2 JP 5769940B2
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- composition
- potassium
- optionally
- titanium
- group
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 184
- 206010020751 Hypersensitivity Diseases 0.000 title claims description 11
- 208000026935 allergic disease Diseases 0.000 title claims description 7
- 230000009610 hypersensitivity Effects 0.000 title claims description 7
- 238000011282 treatment Methods 0.000 claims description 44
- 150000001875 compounds Chemical class 0.000 claims description 39
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical group OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- MUBZPKHOEPUJKR-UHFFFAOYSA-N oxalic acid group Chemical group C(C(=O)O)(=O)O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 23
- 239000010936 titanium Substances 0.000 claims description 18
- -1 troche Substances 0.000 claims description 15
- 229910052791 calcium Inorganic materials 0.000 claims description 14
- 239000011575 calcium Substances 0.000 claims description 14
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 229910052719 titanium Inorganic materials 0.000 claims description 11
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 210000000214 mouth Anatomy 0.000 claims description 10
- 239000002324 mouth wash Substances 0.000 claims description 9
- 229940090898 Desensitizer Drugs 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 6
- 235000006408 oxalic acid Nutrition 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 229910052700 potassium Inorganic materials 0.000 claims description 6
- 239000004323 potassium nitrate Substances 0.000 claims description 6
- 235000010333 potassium nitrate Nutrition 0.000 claims description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 239000000551 dentifrice Substances 0.000 claims description 5
- 229940051866 mouthwash Drugs 0.000 claims description 5
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000011775 sodium fluoride Substances 0.000 claims description 4
- 235000013024 sodium fluoride Nutrition 0.000 claims description 4
- FOXQHLUMSTZYRV-UHFFFAOYSA-L C(C(=O)[O-])(=[O+][O-])[O-].[Ti+4].[K+] Chemical compound C(C(=O)[O-])(=[O+][O-])[O-].[Ti+4].[K+] FOXQHLUMSTZYRV-UHFFFAOYSA-L 0.000 claims description 3
- QYZRVELNRGMGAK-UHFFFAOYSA-K C(CC(O)(C(=O)[O-])CC(=O)[O-])(=[O+][O-])[O-].[Ti+4].[K+] Chemical compound C(CC(O)(C(=O)[O-])CC(=O)[O-])(=[O+][O-])[O-].[Ti+4].[K+] QYZRVELNRGMGAK-UHFFFAOYSA-K 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- 108010001441 Phosphopeptides Proteins 0.000 claims description 3
- QDPQFNLYTUSQME-UHFFFAOYSA-L [Ca+2].C(C(=O)[O-])(=O)[O-].[K+] Chemical compound [Ca+2].C(C(=O)[O-])(=O)[O-].[K+] QDPQFNLYTUSQME-UHFFFAOYSA-L 0.000 claims description 3
- 239000005313 bioactive glass Substances 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims description 3
- 239000001103 potassium chloride Substances 0.000 claims description 3
- 235000011164 potassium chloride Nutrition 0.000 claims description 3
- 239000001508 potassium citrate Substances 0.000 claims description 3
- 229960002635 potassium citrate Drugs 0.000 claims description 3
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 3
- 235000011082 potassium citrates Nutrition 0.000 claims description 3
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 3
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims description 3
- 150000005846 sugar alcohols Polymers 0.000 claims description 3
- ZZJDZMZLCADFIR-UHFFFAOYSA-L C(CC(O)(C(=O)O)CC(=O)[O-])(=[O+][O-])[O-].[K+].[K+] Chemical compound C(CC(O)(C(=O)O)CC(=O)[O-])(=[O+][O-])[O-].[K+].[K+] ZZJDZMZLCADFIR-UHFFFAOYSA-L 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000004376 Sucralose Substances 0.000 claims 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims 2
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims 2
- 229940048848 lauryl glucoside Drugs 0.000 claims 2
- 229960003975 potassium Drugs 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 2
- 108700004121 sarkosyl Proteins 0.000 claims 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims 2
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 2
- 235000019408 sucralose Nutrition 0.000 claims 2
- QDJUIVJLUBDARU-UHFFFAOYSA-H [Ca++].[Ti+4].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O Chemical compound [Ca++].[Ti+4].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O QDJUIVJLUBDARU-UHFFFAOYSA-H 0.000 claims 1
- 210000004268 dentin Anatomy 0.000 description 51
- 239000002253 acid Substances 0.000 description 36
- 238000009472 formulation Methods 0.000 description 35
- 210000005239 tubule Anatomy 0.000 description 34
- 150000007513 acids Chemical class 0.000 description 30
- 229910052751 metal Inorganic materials 0.000 description 28
- 239000002184 metal Substances 0.000 description 28
- 239000002244 precipitate Substances 0.000 description 20
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical group [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 17
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 16
- 238000000034 method Methods 0.000 description 15
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 14
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 13
- 239000000341 volatile oil Substances 0.000 description 13
- 229910044991 metal oxide Inorganic materials 0.000 description 12
- 150000004706 metal oxides Chemical class 0.000 description 12
- 238000001000 micrograph Methods 0.000 description 12
- 239000004135 Bone phosphate Chemical class 0.000 description 11
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 11
- 229940041616 menthol Drugs 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 9
- 125000004432 carbon atom Chemical group C* 0.000 description 9
- 235000011180 diphosphates Nutrition 0.000 description 9
- 239000000606 toothpaste Substances 0.000 description 9
- 229960005069 calcium Drugs 0.000 description 8
- 239000011135 tin Substances 0.000 description 8
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 7
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 7
- 239000005844 Thymol Substances 0.000 description 7
- 229960005233 cineole Drugs 0.000 description 7
- 229910052748 manganese Inorganic materials 0.000 description 7
- 238000004626 scanning electron microscopy Methods 0.000 description 7
- 239000013049 sediment Substances 0.000 description 7
- 229960000790 thymol Drugs 0.000 description 7
- 229910052718 tin Inorganic materials 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 6
- 239000002738 chelating agent Substances 0.000 description 6
- 239000003906 humectant Substances 0.000 description 6
- 229960001047 methyl salicylate Drugs 0.000 description 6
- 235000021317 phosphate Nutrition 0.000 description 6
- 229940048084 pyrophosphate Drugs 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 229910052712 strontium Inorganic materials 0.000 description 6
- 239000011593 sulfur Substances 0.000 description 6
- 229910052717 sulfur Inorganic materials 0.000 description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 5
- 229910052788 barium Inorganic materials 0.000 description 5
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 5
- UHWHMHPXHWHWPX-UHFFFAOYSA-J dipotassium;oxalate;oxotitanium(2+) Chemical compound [K+].[K+].[Ti+2]=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O UHWHMHPXHWHWPX-UHFFFAOYSA-J 0.000 description 5
- 229910052749 magnesium Inorganic materials 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- 229910052726 zirconium Inorganic materials 0.000 description 5
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000003093 cationic surfactant Substances 0.000 description 4
- 201000002170 dentin sensitivity Diseases 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- JWHYYKXQCVSNLS-UHFFFAOYSA-L oxalate;oxygen(2-);titanium(4+) Chemical compound [O-2].[Ti+4].[O-]C(=O)C([O-])=O JWHYYKXQCVSNLS-UHFFFAOYSA-L 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000000120 Artificial Saliva Substances 0.000 description 3
- DDBIPMYLCPSATR-UHFFFAOYSA-L C(C(=O)[O-])(=[O+][O-])[O-].[K+].[K+] Chemical compound C(C(=O)[O-])(=[O+][O-])[O-].[K+].[K+] DDBIPMYLCPSATR-UHFFFAOYSA-L 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 238000000586 desensitisation Methods 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229910052744 lithium Inorganic materials 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- YFVBASFBIJFBAI-UHFFFAOYSA-M 1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=CC=C1 YFVBASFBIJFBAI-UHFFFAOYSA-M 0.000 description 2
- WXUAQHNMJWJLTG-UHFFFAOYSA-N 2-methylbutanedioic acid Chemical compound OC(=O)C(C)CC(O)=O WXUAQHNMJWJLTG-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- ANAAMBRRWOGKGU-UHFFFAOYSA-M 4-ethyl-1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=C(CC)C=C1 ANAAMBRRWOGKGU-UHFFFAOYSA-M 0.000 description 2
- 241000605059 Bacteroidetes Species 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 240000001746 Betula lenta Species 0.000 description 2
- 235000010921 Betula lenta Nutrition 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229910052693 Europium Inorganic materials 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- 229920000388 Polyphosphate Polymers 0.000 description 2
- 229910052774 Proactinium Inorganic materials 0.000 description 2
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
- 229910052770 Uranium Inorganic materials 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229910052769 Ytterbium Inorganic materials 0.000 description 2
- 229960000250 adipic acid Drugs 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- QVQLCTNNEUAWMS-UHFFFAOYSA-N barium oxide Chemical compound [Ba]=O QVQLCTNNEUAWMS-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
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- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- HHDOORYZQSEMGM-UHFFFAOYSA-L potassium;oxalate;titanium(4+) Chemical compound [K+].[Ti+4].[O-]C(=O)C([O-])=O HHDOORYZQSEMGM-UHFFFAOYSA-L 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- NJKRDXUWFBJCDI-UHFFFAOYSA-N propane-1,1,2,3-tetracarboxylic acid Chemical compound OC(=O)CC(C(O)=O)C(C(O)=O)C(O)=O NJKRDXUWFBJCDI-UHFFFAOYSA-N 0.000 description 1
- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
- 229950000975 salicylanilide Drugs 0.000 description 1
- 229940084560 sanguinarine Drugs 0.000 description 1
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- AYGJDUHQRFKLBG-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;dihydrate Chemical compound O.O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 AYGJDUHQRFKLBG-UHFFFAOYSA-M 0.000 description 1
- UVVPZMPJAYXZDN-UHFFFAOYSA-M sodium;benzoic acid;benzoate Chemical compound [Na+].OC(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 UVVPZMPJAYXZDN-UHFFFAOYSA-M 0.000 description 1
- YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical group [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 1
- 229910001432 tin ion Inorganic materials 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- ARCGXLSVLAOJQL-UHFFFAOYSA-N trimellitic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C(C(O)=O)=C1 ARCGXLSVLAOJQL-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- LEAHFJQFYSDGGP-UHFFFAOYSA-K trisodium;dihydrogen phosphate;hydrogen phosphate Chemical compound [Na+].[Na+].[Na+].OP(O)([O-])=O.OP([O-])([O-])=O LEAHFJQFYSDGGP-UHFFFAOYSA-K 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
Description
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]、
b)所望により香味料、
c)所望により甘味剤
d)所望によりpH緩衝剤、並びに、
e)少なくとも1つの、口腔内で許容できる溶媒、を含み、
口腔用組成物は2.0(又は約2)を超える(又は少なくとも2の)pHを有する、口腔用組成物を提供する。
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]、並びに、
b)少なくとも1つの、口腔内で許容できる溶媒、を含み、
組成物は実質的に水を含まない、口腔用組成物に関する。
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]、
b)少なくとも1つの追加の減感剤、並びに、
c)少なくとも1つの、口腔内で許容できる溶媒、を含む、口腔用組成物に関する。
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]、並びに、
b)少なくとも1つの、口腔内で許容できる溶媒、を含み、
適用の間隔は12時間(又は約12時間)を超えない(又は12時間未満)。
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]を含み、
b)歯を組成物に少なくとも10秒間(又は約10秒間)(又は10秒間を超えて)接触させて、
細管を少なくとも約5%(又は約5%を超えて)閉鎖させる工程を含む。
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]を含み、
b)歯を組成物にカルシウムの存在下で少なくとも20秒間接触させる工程を含み、
化合物はカルシウムとともに沈殿物を歯の上又は近傍に生成し、これにより、2分間(又は約2分間)の超音波処理した後に、生成した沈殿物の少なくとも30%(又は約30%)(又は30%を超える沈殿物)が歯の上に残るようにする。
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]を含み、
b)歯を組成物にカルシウムの存在下で少なくとも20秒間(又は約20秒間)(又は20秒を超えて)接触させる工程を含み、
M2は、堆積した沈殿物の少なくとも5%(又は約5%)(又は5%を超える)の濃度で沈殿物中に存在する。
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又はその金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸、所望によりC2〜C4の二塩基酸又は三塩基酸、所望によりC2〜C3の二塩基酸又は三塩基酸、あるいは所望によりC2の二塩基酸からなる群から選択される]を含む。
幾つかの実施形態では、本発明の組成物は他の歯の減感剤を更に含む。追加の歯の減感剤の例には、クエン酸カリウム、塩化カリウム、硝酸カリウム、クエン酸、クエン酸塩、塩化ストロンチウム及びこれらの混合物が挙げられるが、これらに限定されるものではない。更に、米国特許第5735942号、第5891233号、第6086374号、第6244871号、第6338751号及び第6365132号に記載されている生理活性ガラス材料は本明細書で有用であり、それぞれの内容全体を本明細書に参照により援用する。また米国特許第5015628号、第5981475号、第6448374号及び第6780844号に記載されているホスホペプチドも本明細書で有用であり、それぞれの内容全体を本明細書に参照により援用する。
本明細書において解説的に開示した発明は、本明細書において明確には開示されていないいかなる構成成分、成分、又は工程がなくても実行することができる。
液体の口内洗浄剤を調製し、酸化シュウ酸チタンカリウム(KTO)製剤の象牙質閉鎖効率を評価した。調製の方法は次の通りである。
KTO化合物及び本発明の製剤の象牙質閉鎖の有効性が以下のように論証された。
エッチングされた象牙質小片試料(全部で10枚)はすべてランダム化し、5つの処理グループに分けた。KTO製剤による細管閉鎖及び表面堆積の観察のために、走査型電子顕微鏡法(SEM)及び電子分散型分光法(EDS)による表面化学分析を行った。5つの処理グループは次の通りであった。
グループ1:製剤Aで処理した。
グループ2:製剤Bで処理した。
グループ3:製剤Cで処理した。
グループ4:製剤Dで処理した。
グループ5:製剤E(すなわち、KTOもKOも含まない)で処理した。
1.各グループの小片試料をそれぞれの処理製剤20mLで30秒間震盪させながら処理した。
2.各グループの小片試料を脱イオンH2Oで1分間すすいだ。
3.処理の間は小片試料を人工唾液組成物に浸漬し、1日に2回を超える処理は行わなかった。
4.工程1〜3の処理を合計28回繰り返した。
5.7、14、21及び28回の処理の後、象牙質試料をSEM及び/又はEDSにより分析した。分析の前に、小片を脱イオンH2Oで3分間すすぎ、風乾してSEM分析を行った。
処理サイクル中に象牙質小片試料の上に堆積したKTO沈殿物の持続性(すなわち、沈殿物が歯の表面に留まる能力)を測定するために以下を行った。製剤B(0.5%KO)及び製剤D(0.5%KTO)で28回処理された象牙質小片を、通常のパルス(約42KHz)で超音波処理機CD−4800を使用して2分間(約2分間でもよい)超音波処理した。超音波処理をした小片(図11及び12)の画像をそれらに対応する図4及び図8に描かれる28日処理の画像と比較すると、KTOにより生成された沈殿堆積物(KTOにより生成された沈殿物の約92%が小片試料上に残っていた)は、KOにより生成された沈殿物(KOにより生成された沈殿物の約38%が小片試料上に残っていた)より超音波処理に対する抵抗性が高く、KTOにより生成された沈殿堆積物がKOにより生成された沈殿堆積物と比較して高い安定性を与えることを示している。理論に制限されるものではないが、式Iの化合物により生成された沈殿堆積物のこの改善された安定性は、より大きい歯の脱感作のみならず、より長い期間継続する歯の脱感作をも提供すると考えられる。
(1) 口腔用組成物において、
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]、並びに、
b)少なくとも1つの、口腔内で許容できる溶媒、
を含み、
前記組成物は実質的に水を含まない、口腔用組成物。
(2) M1及びM3は、独立して、Na、K及びLiからなる群から選択される一価の金属である、実施態様1に記載の組成物。
(3) 前記M1及びM3がKである、実施態様2に記載の組成物。
(4) M2が、Ti、Sr、Sn、Mg、Ca、Mn及びZrからなる群から選択される多価金属である、実施態様1に記載の組成物。
(5) M2がTiである、実施態様4に記載の組成物。
(6) M2が、酸化バリウム(Ba)、酸化チタン(Ti)、酸化ストロンチウム(Sr)、酸化スズ(Sn)及び酸化ジルコニウム(Zr)からなる群から選択される金属酸化物である、実施態様1に記載の組成物。
(7) M2が酸化チタン(Ti)である、実施態様6に記載の組成物。
(8) 前記式Iの化合物が、酸化シュウ酸チタンカリウム、シュウ酸チタンカルシウム、酸化クエン酸チタンカリウム、シュウ酸チタンカルシウムカリウム及びこれらの混合物からなる群から選択される、実施態様1に記載の組成物。
(9) 前記式Iの化合物が酸化シュウ酸チタンカリウムである、実施態様8に記載の組成物。
(10) 前記式Iの化合物が酸化クエン酸チタンカリウムである、実施態様8に記載の組成物。
(12) 前記組成物が、歯ブラシ、歯ブラシの毛、デンタルフロス及びデンタルピックからなる群から選択される歯科用具のコーティング又は含浸剤である、実施態様1に記載の組成物。
(13) 知覚敏感な歯の治療方法において、
前記知覚敏感な歯を、実施態様1に記載の組成物に少なくとも約10秒間接触させる工程を含む、方法。
(14) 口腔用組成物において、
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、一価又は二価の金属であり、M2は多価金属又は金属酸化物であり、A及びBは、独立して、C2〜C6の二塩基酸、三塩基酸及び四塩基酸からなる群から選択される]、
b)少なくとも1つの追加の減感剤、並びに、
c)少なくとも1つの、口腔内で許容できる溶媒、
を含み、
前記組成物は実質的に水を含まない、口腔用組成物。
(15) 前記追加の減感剤が、クエン酸カリウム、塩化カリウム、硝酸カリウム、クエン酸、クエン酸塩、塩化ストロンチウム、生理活性ガラス材料、ホスホペプチド及びこれらの混合物からなる群から選択される、実施態様14に記載の組成物。
Claims (12)
- 歯の知覚過敏処置のための口腔用組成物において、
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、カリウムおよびカルシウムから選択され、M2は、チタンまたは酸化チタンであり、A及びBは、独立して、シュウ酸およびクエン酸から選択される]、並びに、
b)エタノール、n−プロパノール、多価アルコール、ポリエチレングリコール、およびこれらの任意の混合物からなる群より選択される、少なくとも1つの、口腔内で許容できる溶媒、
を含み、
前記組成物は実質的に水を含まない、口腔用組成物。 - 前記M1及びM3がKである、請求項1に記載の組成物。
- M2がTiである、請求項1に記載の組成物。
- M2が酸化チタンである、請求項1に記載の組成物。
- 前記式Iの化合物が、酸化シュウ酸チタンカリウム、シュウ酸チタンカルシウム、酸化クエン酸チタンカリウム、シュウ酸チタンカルシウムカリウム及びこれらの混合物からなる群から選択される、請求項1に記載の組成物。
- 前記式Iの化合物が酸化シュウ酸チタンカリウムである、請求項5に記載の組成物。
- 前記式Iの化合物が酸化クエン酸チタンカリウムである、請求項5に記載の組成物。
- 前記組成物が、うがい剤、口内洗浄剤、歯磨剤、ペースト、粉末、ゲル、錠剤、トローチ、マイクロカプセル、ストリップ又はストリップコーティングの形態である、請求項1に記載の組成物。
- 前記組成物が、歯ブラシ、歯ブラシの毛、デンタルフロス及びデンタルピックからなる群から選択される歯科用具のコーティング又は含浸剤である、請求項1に記載の組成物。
- カルボキシメチルセルロースナトリウム、サッカリンナトリウム、スクラロース、フッ化ナトリウム、水酸化ケイ素、硝酸カリウム、非晶質シリカ、ラウロイルサルコシン酸ナトリウム、ラウリルグルコシド、コカミドプロピルベタイン、および香味料から選択される少なくとも1つの追加の成分をさらに含む、請求項1〜9のいずれかに記載の組成物。
- 口腔用組成物において、
a)少なくとも1つの、式Iの化合物
M1−A−M2−B−M3 (I)
[式中、M1及びM3は、独立して、カリウムおよびカルシウムから選択され、M2は、チタンまたは酸化チタンであり、A及びBは、独立して、シュウ酸およびクエン酸から選択される]、
b)クエン酸カリウム、塩化カリウム、硝酸カリウム、クエン酸、クエン酸塩、塩化ストロンチウム、生理活性ガラス材料、ホスホペプチド及びこれらの混合物からなる群から選択される、少なくとも1つの追加の減感剤、並びに、
c)エタノール、n−プロパノール、多価アルコール、ポリエチレングリコール、およびこれらの任意の混合物からなる群より選択される、少なくとも1つの、口腔内で許容できる溶媒、
を含み、
前記組成物は実質的に水を含まない、歯の知覚過敏処置のための口腔用組成物。 - カルボキシメチルセルロースナトリウム、サッカリンナトリウム、スクラロース、フッ化ナトリウム、水酸化ケイ素、非晶質シリカ、ラウロイルサルコシン酸ナトリウム、ラウリルグルコシド、コカミドプロピルベタイン、および香味料から選択される少なくとも1つの追加の成分をさらに含む、請求項11に記載の組成物。
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HK1153949A1 (zh) | 2012-04-20 |
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US9060947B2 (en) | 2015-06-23 |
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